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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:guanethidine
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Accession:CHEBI:5557 term browser browse the term
Definition:A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
Synonyms:exact_synonym: 1-(2-azocan-1-ylethyl)guanidine
 related_synonym: (2-(Octahydro-1-azocinyl)ethyl)guanidine;   2-(1'-Azacyclooctyl)ethylguanidine;   2-(1-N,N-Heptamethyleneimino)ethylguanidine;   Azocine, 1-(2-guanidinoethyl)octahydro-;   Formula=C10H22N4;   Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-;   Heptamethylenimine, 1-(2-guanidinoethyl)-;   InChI=1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13);   InChIKey=ACGDKVXYNVEAGU-UHFFFAOYSA-N;   N-(2-Perhydroazocin-1-ylethyl)guanidine;   SMILES=NC(=N)NCCN1CCCCCCC1;   guanethidinum;   guanetidina
 xref: CAS:55-65-2;   DrugBank:DB01170;   Drug_Central:1342;   HMDB:HMDB0015301;   KEGG:C07036;   KEGG:D08030;   LINCS:LSM-6719
 xref_mesh: MESH:D006145
 xref: PMID:13690338;   PMID:13824829;   PMID:13873008;   Patent:US2928829;   Reaxys:1343950;   Wikipedia:Guanethidine


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guanethidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Guanethidine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant affects expression
increases expression		 EXP Guanethidine affects the expression of ACP5 protein
Guanethidine results in increased expression of ACP5 mRNA		 CTD PMID:14527964 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Ctsk cathepsin K increases expression
affects expression		 EXP Guanethidine results in increased expression of CTSK mRNA
Guanethidine affects the expression of CTSK protein		 CTD PMID:14527964 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Guanethidine inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein] CTD PMID:16510159 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression EXP Guanethidine results in increased expression of MMP13 mRNA CTD PMID:14527964 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Npy neuropeptide Y decreases expression
decreases secretion		 EXP
ISO		 Guanethidine results in decreased expression of NPY protein
Guanethidine results in decreased secretion of NPY protein		 CTD PMID:9460767 PMID:14527964 PMID:15003356 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Guanethidine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA] CTD PMID:15850565 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Th tyrosine hydroxylase decreases expression EXP Guanethidine results in decreased expression of TH protein CTD PMID:9460767 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Vip vasoactive intestinal peptide decreases expression EXP Guanethidine results in decreased expression of VIP protein CTD PMID:14527964 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      application 19713
        pharmaceutical 19549
          drug 19549
            cardiovascular drug 8743
              antihypertensive agent 1949
                guanethidine 9
                  guanethidine monosulfate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19725
                              organic cyclic compound 19517
                                organic heterocyclic compound 18894
                                  organic heteromonocyclic compound 17817
                                    saturated organic heteromonocyclic parent 11322
                                      azocane 9
                                        guanethidine 9
                                          guanethidine monosulfate + 0
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