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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Guanabenz
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Accession:CHEBI:5553 term browser browse the term
Definition:A dichlorobenzene that has formula C8H8Cl2N4.
Synonyms:related_synonym: Formula=C8H8Cl2N4;   InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+;   InChIKey=WDZVGELJXXEGPV-YIXHJXPBSA-N;   SMILES=NC(=N)N\\N=C\\c1c(Cl)cccc1Cl;   guanabenz acetate
 xref: CAS:5051-62-7;   Drug_Central:3952;   KEGG:C07034;   KEGG:D04375
 xref_mesh: MESH:D006143


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Guanabenz term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 multiple interactions ISO Guanabenz inhibits the reaction [Acetaminophen results in increased cleavage of ATF6 protein] CTD PMID:31524377 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP
ISO
Guanabenz inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]
Guanabenz inhibits the reaction [Acetaminophen results in increased expression of DDIT3 protein]
CTD PMID:24892553 PMID:31524377 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP
ISO
Guanabenz promotes the reaction [Tunicamycin results in increased phosphorylation of EIF2S1 protein]
Guanabenz inhibits the reaction [Acetaminophen results in decreased phosphorylation of EIF2S1 protein]
CTD PMID:24892553 PMID:31524377 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Guanabenz inhibits the reaction [Tunicamycin results in increased phosphorylation of ERN1 protein] CTD PMID:24892553 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Gnai1 G protein subunit alpha i1 affects response to substance ISO GNAI1 affects the susceptibility to Guanabenz CTD PMID:15207363 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnai3 G protein subunit alpha i3 affects response to substance ISO GNAI3 affects the susceptibility to Guanabenz CTD PMID:15207363 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Gnao1 G protein subunit alpha o1 affects response to substance ISO GNAO1 affects the susceptibility to Guanabenz CTD PMID:15207363 NCBI chr19:11,513,201...11,669,578
Ensembl chr19:11,513,201...11,669,578
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Guanabenz inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:31524377 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP
ISO
Guanabenz inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]
Guanabenz inhibits the reaction [Acetaminophen results in increased expression of HSPA5 protein]
CTD PMID:24892553 PMID:31524377 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Guanabenz results in increased expression of NPPA protein CTD PMID:18378355 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Guanabenz inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO Guanabenz results in increased activity of TAAR1 protein
[Guanabenz results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      molecular entity 19851
        polyatomic entity 19765
          heteroatomic molecular entity 19692
            halide 18112
              organohalogen compound 17866
                organochlorine compound 17650
                  chlorobenzenes 13535
                    dichlorobenzene 10554
                      Guanabenz 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon group molecular entity 19650
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic aromatic compound 19206
                                  benzenoid aromatic compound 17327
                                    benzenes 17067
                                      chlorobenzenes 13535
                                        dichlorobenzene 10554
                                          Guanabenz 12
paths to the root