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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,2-benzisothiazole
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Accession:CHEBI:55505 term browser browse the term
Definition:A benzothiazole consisting of a benzene ring fused to an isothiazole.
Synonyms:related_synonym: 1,2-benzisothiazoles


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saccharin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein increases expression ISO Saccharin results in increased expression of AFP mRNA CTD PMID:26272751 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Car13 carbonic anhydrase 13 increases expression ISO Saccharin results in increased expression of CAR13 mRNA CTD PMID:19000923 NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525 		JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions ISO Saccharin binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Saccharin results in increased expression of CDK1 mRNA CTD PMID:26272751 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist increases expression ISO Saccharin results in increased expression of CER1 mRNA CTD PMID:26272751 NCBI chr 5:97,306,427...97,309,783
Ensembl chr 5:97,306,431...97,309,783 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Saccharin results in increased expression of CHEK1 mRNA CTD PMID:19000923 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Saccharin results in increased expression of FOSL1 mRNA CTD PMID:19000923 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Gnat3 G protein subunit alpha transducin 3 affects response to substance ISO GNAT3 protein affects the susceptibility to Saccharin CTD PMID:16740645 NCBI chr 4:17,162,500...17,212,283
Ensembl chr 4:17,162,490...17,212,283 		JBrowse link
G Hdac7 histone deacetylase 7 decreases expression ISO Saccharin results in decreased expression of HDAC7 mRNA CTD PMID:26272751 NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Saccharin results in increased expression of HELLS mRNA CTD PMID:19000923 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Saccharin results in increased expression of IL1RL1 mRNA CTD PMID:19000923 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Saccharin results in increased expression of JUN mRNA CTD PMID:19000923 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Saccharin results in increased expression of JUNB mRNA CTD PMID:19000923 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kdr kinase insert domain receptor increases expression ISO Saccharin results in increased expression of KDR mRNA CTD PMID:26272751 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Saccharin results in increased expression of MCM3 mRNA CTD PMID:19000923 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 decreases expression ISO Saccharin results in decreased expression of MESP1 mRNA CTD PMID:26272751 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Saccharin results in increased expression of MYC mRNA CTD PMID:26272751 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myo1e myosin IE increases expression ISO Saccharin results in increased expression of MYO1E mRNA CTD PMID:26272751 NCBI chr 8:70,887,934...71,080,180
Ensembl chr 8:70,887,870...71,080,169 		JBrowse link
G Nes nestin increases expression ISO Saccharin results in increased expression of NES mRNA CTD PMID:26272751 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Saccharin results in increased expression of NOS2 mRNA CTD PMID:28472674 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nup54 nucleoporin 54 increases expression ISO Saccharin results in increased expression of NUP54 mRNA CTD PMID:19000923 NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028 		JBrowse link
G Orm1 orosomucoid 1 increases expression ISO Saccharin results in increased expression of ORM1 mRNA CTD PMID:19000923 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO Saccharin results in increased expression of PHEX mRNA CTD PMID:19000923 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO Saccharin results in increased expression of PIK3R5 mRNA CTD PMID:19000923 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression ISO Saccharin results in decreased expression of PNPLA6 mRNA CTD PMID:26272751 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Saccharin co-treated with Glucose] binds to PPARA protein; Saccharin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rad21 RAD21 cohesin complex component increases expression ISO Saccharin results in increased expression of RAD21 mRNA CTD PMID:19000923 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Rif1 replication timing regulatory factor 1 increases expression ISO Saccharin results in increased expression of RIF1 mRNA CTD PMID:19000923 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO Saccharin results in increased expression of SCARB1 mRNA CTD PMID:19000923 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression ISO Saccharin results in decreased expression of SHH mRNA CTD PMID:26272751 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Saccharin results in increased expression of SLC2A1 mRNA CTD PMID:19000923 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Stmn1 stathmin 1 increases expression ISO Saccharin results in increased expression of STMN1 mRNA CTD PMID:19000923 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Tas1r3 taste 1 receptor member 3 affects response to substance
multiple interactions		 ISO TAS1R3 protein affects the susceptibility to Saccharin
TRPV1 protein affects the reaction [TAS1R3 protein affects the susceptibility to Saccharin]		 CTD PMID:18804451 NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742 		JBrowse link
G Tas2r136 taste receptor, type 2, member 136 increases activity ISO Saccharin results in increased activity of TAS2R31 protein CTD PMID:21629661 NCBI chr 4:166,098,848...166,099,840
Ensembl chr 4:166,098,848...166,099,840 		JBrowse link
G Tfrc transferrin receptor increases expression ISO Saccharin results in increased expression of TFRC mRNA CTD PMID:19000923 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Saccharin results in increased expression of TNF mRNA CTD PMID:28472674 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases activity		 ISO TRPV1 protein affects the reaction [TAS1R3 protein affects the susceptibility to Saccharin]
Saccharin results in increased activity of TRPV1 protein		 CTD PMID:17567713 PMID:18804451 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Saccharin results in increased expression of VEGFA mRNA CTD PMID:19000923 PMID:26272751 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wnt3 Wnt family member 3 increases expression ISO Saccharin results in increased expression of WNT3 mRNA CTD PMID:26272751 NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099 		JBrowse link
ziprasidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding		 EXP
ISO		 ziprasidone results in decreased expression of and results in increased reduction of ALB protein
ziprasidone binds to ALB protein
[ziprasidone results in increased reduction of Cysteine] which results in increased activity of ALB protein; stearic acid inhibits the reaction [ziprasidone binds to ALB protein]		 CTD PMID:31400341 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cat catalase increases expression EXP ziprasidone results in increased expression of CAT mRNA CTD PMID:32937854 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO ziprasidone results in increased expression of HMGCR mRNA CTD PMID:17052361 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO ziprasidone results in increased expression of HMGCS1 mRNA CTD PMID:17052361 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP ziprasidone results in increased expression of HMOX1 mRNA CTD PMID:32937854 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to ziprasidone CTD PMID:15996562 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein] CTD PMID:16314884 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO ziprasidone results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP ziprasidone results in increased expression of NQO1 mRNA CTD PMID:32937854 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO ziprasidone results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO ziprasidone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:30465787 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO ziprasidone results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      atom 19829
        nonmetal atom 19767
          nitrogen atom 18955
            nitrogen molecular entity 18955
              organonitrogen compound 18804
                organonitrogen heterocyclic compound 18148
                  benzothiazoles 151
                    1,2-benzisothiazole 51
                      N-benzyl-N-methyl-2-(3-oxo-1,2-benzothiazol-2-yl)acetamide 0
                      lurasidone 0
                      probenazole 0
                      saccharin + 39
                      ziprasidone + 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteropolycyclic compound 18295
                                    organic heterobicyclic compound 17240
                                      benzothiazoles 151
                                        1,2-benzisothiazole 51
                                          N-benzyl-N-methyl-2-(3-oxo-1,2-benzothiazol-2-yl)acetamide 0
                                          lurasidone 0
                                          probenazole 0
                                          saccharin + 39
                                          ziprasidone + 12
paths to the root