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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha-phenylglycine
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Accession:CHEBI:55484 term browser browse the term
Definition:An amino acid with a structure in which a phenyl ring is bonded to the alpha-carbon of glycine.
Synonyms:related_synonym: 2-Amino-2-phenylacetic acid;   2-Phenylglycine;   Amino(phenyl)acetic acid;   DL-2-phenylglycine;   DL-alpha-phenylglycine;   DL-phenylglycine;   Formula=C8H9NO2;   InChI=1S/C8H9NO2/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H,10,11);   InChIKey=ZGUNAGUHMKGQNY-UHFFFAOYSA-N;   SMILES=NC(C(O)=O)c1ccccc1;   alpha-Aminobenzeneacetic acid;   alpha-Aminophenylacetic acid;   alpha-amino-alpha-Toluic acid
 alt_id: CHEBI:316276
 xref: Beilstein:608018;   CAS:2835-06-5;   HMDB:HMDB0002210;   PMID:22996274;   PMID:23479412;   PMID:24464217;   Reaxys:608018


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(S)-3,5-dihydroxyphenylglycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor decreases activity ISO BDNF protein results in decreased activity of 3,5-dihydroxyphenylglycine CTD PMID:20554863 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP
ISO
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein] CTD PMID:16600209 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions
affects localization
ISO
EXP
3,5-dihydroxyphenylglycine inhibits the reaction [FMR1 gene mutant form results in increased activity of MGLL]
3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA; 3,5-dihydroxyphenylglycine affects the localization of FMR1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 protein]; Ro 32-0432 inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA]; Ro 32-0432 inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 protein]
CTD PMID:15028757, PMID:20393458 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
increases phosphorylation
EXP 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein] CTD PMID:16600209 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions
increases activity
EXP 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; 2-aminoethoxydiphenyl borate inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; 2-aminoethoxydiphenylborane inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium; [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased phosphorylation of MAP2 protein; Flufenamic Acid inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Flufenamic Acid inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; Potassium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Ruthenium Red inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Ruthenium Red inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; Sodium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] CTD PMID:14622174, PMID:15893642 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Grm5 glutamate metabotropic receptor 5 multiple interactions
increases activity
ISO
EXP
[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [3,5-dihydroxyphenylglycine binds to and results in increased activity of GRM5 protein]
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM5 protein]; [3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [3,5-dihydroxyphenylglycine binds to and results in increased activity of GRM5 protein]
CTD PMID:15608073, PMID:17179862 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Map2 microtubule-associated protein 2 increases phosphorylation
multiple interactions
EXP 3,5-dihydroxyphenylglycine results in increased phosphorylation of MAP2 protein
[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased phosphorylation of MAP2 protein; Ammonia inhibits the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAP2 protein]
CTD PMID:15893642 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK1 protein
3,5-dihydroxyphenylglycine promotes the reaction [Permethrin results in increased phosphorylation of MAPK1 protein]
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK1 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK1 protein]
CTD PMID:16600209, PMID:30205134 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]
3,5-dihydroxyphenylglycine promotes the reaction [Permethrin results in increased phosphorylation of MAPK3 protein]
CTD PMID:16600209, PMID:30205134 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mgll monoglyceride lipase multiple interactions ISO 3,5-dihydroxyphenylglycine inhibits the reaction [FMR1 gene mutant form results in increased activity of MGLL] CTD PMID:20393458 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        biochemical role 19241
          metabolite 19218
            eukaryotic metabolite 18842
              animal metabolite 18569
                mammalian metabolite 18558
                  human metabolite 18231
                    alpha-phenylglycine 10
                      D-alpha-phenylglycine + 0
                      L-alpha-phenylglycine + 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      carboxylic acid 18079
                                        amino acid 14080
                                          alpha-amino acid 11547
                                            non-proteinogenic alpha-amino acid 1542
                                              alpha-phenylglycine 10
                                                D-alpha-phenylglycine + 0
                                                L-alpha-phenylglycine + 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.