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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha-phenylglycine
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Accession:CHEBI:55484 term browser browse the term
Definition:An amino acid with a structure in which a phenyl ring is bonded to the alpha-carbon of glycine.
Synonyms:related_synonym: 2-Amino-2-phenylacetic acid;   2-Phenylglycine;   Amino(phenyl)acetic acid;   DL-2-phenylglycine;   DL-alpha-phenylglycine;   DL-phenylglycine;   Formula=C8H9NO2;   InChI=1S/C8H9NO2/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H,10,11);   InChIKey=ZGUNAGUHMKGQNY-UHFFFAOYSA-N;   SMILES=NC(C(O)=O)c1ccccc1;   alpha-Aminobenzeneacetic acid;   alpha-Aminophenylacetic acid;   alpha-amino-alpha-Toluic acid
 alt_id: CHEBI:316276
 xref: Beilstein:608018;   CAS:2835-06-5;   HMDB:HMDB0002210;   PMID:22996274;   PMID:23479412;   PMID:24464217;   Reaxys:608018


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(S)-3,5-dihydroxyphenylglycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor decreases activity ISO BDNF protein results in decreased activity of 3,5-dihydroxyphenylglycine CTD PMID:20554863 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP
ISO
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of CREB1 protein] CTD PMID:16600209 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions
affects localization
ISO
EXP
3,5-dihydroxyphenylglycine inhibits the reaction [FMR1 gene mutant form results in increased activity of MGLL]
3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA; 3,5-dihydroxyphenylglycine affects the localization of FMR1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 protein]; Ro 32-0432 inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA]; Ro 32-0432 inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 protein]
CTD PMID:15028757 PMID:20393458 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
increases phosphorylation
EXP 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein] CTD PMID:16600209 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions
increases activity
EXP 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; 2-aminoethoxydiphenyl borate inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; 2-aminoethoxydiphenylborane inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium; [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased phosphorylation of MAP2 protein; Flufenamic Acid inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Flufenamic Acid inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; Potassium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Ruthenium Red inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Ruthenium Red inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium]; Sodium promotes the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] CTD PMID:14622174 PMID:15893642 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Grm5 glutamate metabotropic receptor 5 multiple interactions
increases activity
ISO
EXP
[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [3,5-dihydroxyphenylglycine binds to and results in increased activity of GRM5 protein]
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM5 protein]; [3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [3,5-dihydroxyphenylglycine binds to and results in increased activity of GRM5 protein]
CTD PMID:15608073 PMID:17179862 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Map2 microtubule-associated protein 2 increases phosphorylation
multiple interactions
EXP 3,5-dihydroxyphenylglycine results in increased phosphorylation of MAP2 protein
[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased phosphorylation of MAP2 protein; Ammonia inhibits the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAP2 protein]
CTD PMID:15893642 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK1 protein
3,5-dihydroxyphenylglycine promotes the reaction [Permethrin results in increased phosphorylation of MAPK1 protein]
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK1 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK1 protein]
CTD PMID:16600209 PMID:30205134 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]]; N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAPK3 protein]
3,5-dihydroxyphenylglycine promotes the reaction [Permethrin results in increased phosphorylation of MAPK3 protein]
CTD PMID:16600209 PMID:30205134 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mgll monoglyceride lipase multiple interactions ISO 3,5-dihydroxyphenylglycine inhibits the reaction [FMR1 gene mutant form results in increased activity of MGLL] CTD PMID:20393458 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            eukaryotic metabolite 19052
              animal metabolite 18892
                mammalian metabolite 18891
                  human metabolite 18351
                    alpha-phenylglycine 10
                      D-alpha-phenylglycine + 0
                      L-alpha-phenylglycine + 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        amino acid 14879
                                          alpha-amino acid 12854
                                            non-proteinogenic alpha-amino acid 1740
                                              alpha-phenylglycine 10
                                                D-alpha-phenylglycine + 0
                                                L-alpha-phenylglycine + 10
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