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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Grepafloxacin
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Accession:CHEBI:5543 term browser browse the term
Definition:A fluoroquinolone antibiotic that has formula C19H22FN3O3.
Synonyms:related_synonym: Formula=C19H22FN3O3;   InChI=1S/C19H22FN3O3/c1-10-8-22(6-5-21-10)15-7-14-16(11(2)17(15)20)18(24)13(19(25)26)9-23(14)12-3-4-12/h7,9-10,12,21H,3-6,8H2,1-2H3,(H,25,26);   InChIKey=AIJTTZAVMXIJGM-UHFFFAOYSA-N;   SMILES=CC1CN(CCN1)c1cc2n(cc(C(O)=O)c(=O)c2c(C)c1F)C1CC1;   grepafloxacin HCl;   grepafloxacin hydrochloride;   grepafloxacin hydrochloride hydrate;   tomefloxacin
 xref: CAS:119914-60-2;   Drug_Central:1330;   HMDB:HMDB0014509;   KEGG:C11368
 xref_mesh: MESH:C075375


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Grepafloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects export ISO ABCC1 protein affects the export of grepafloxacin CTD PMID:15948026 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO grepafloxacin results in decreased activity of KCNH2 protein CTD PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO grepafloxacin affects the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:16928358 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of grepafloxacin CTD PMID:15769885 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of grepafloxacin CTD PMID:15769885 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of grepafloxacin CTD PMID:15769885 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        antimicrobial agent 17329
          quinolone antibiotic 583
            Grepafloxacin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  heterocyclic antibiotic 1615
                                    organonitrogen heterocyclic antibiotic 1593
                                      quinolone antibiotic 583
                                        Grepafloxacin 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.