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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Grepafloxacin
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Accession:CHEBI:5543 term browser browse the term
Definition:A fluoroquinolone antibiotic that has formula C19H22FN3O3.
Synonyms:related_synonym: Formula=C19H22FN3O3;   InChI=1S/C19H22FN3O3/c1-10-8-22(6-5-21-10)15-7-14-16(11(2)17(15)20)18(24)13(19(25)26)9-23(14)12-3-4-12/h7,9-10,12,21H,3-6,8H2,1-2H3,(H,25,26);   InChIKey=AIJTTZAVMXIJGM-UHFFFAOYSA-N;   SMILES=CC1CN(CCN1)c1cc2n(cc(C(O)=O)c(=O)c2c(C)c1F)C1CC1;   grepafloxacin HCl;   grepafloxacin hydrochloride;   grepafloxacin hydrochloride hydrate;   tomefloxacin
 xref: CAS:119914-60-2;   Drug_Central:1330;   HMDB:HMDB0014509;   KEGG:C11368
 xref_mesh: MESH:C075375



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Grepafloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects export ISO ABCC1 protein affects the export of grepafloxacin CTD PMID:15948026 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO grepafloxacin results in decreased activity of KCNH2 protein CTD PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO grepafloxacin affects the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:16928358 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of grepafloxacin CTD PMID:15769885 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of grepafloxacin CTD PMID:15769885 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of grepafloxacin CTD PMID:15769885 NCBI chr 9:88,696,981...88,808,465 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        antimicrobial agent 17472
          quinolone antibiotic 610
            Grepafloxacin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  heterocyclic antibiotic 1639
                                    organonitrogen heterocyclic antibiotic 1617
                                      quinolone antibiotic 610
                                        Grepafloxacin 6
paths to the root