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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bambuterol
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Accession:CHEBI:553827 term browser browse the term
Definition:A carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline.
Synonyms:exact_synonym: 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diyl bis(dimethylcarbamate)
 related_synonym: (+-)-5-(2-(tert-butylamino)-1-hydroxyethyl)-m-phenylene bis(dimethylcarbamate);   Formula=C18H29N3O5;   InChI=1S/C18H29N3O5/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7/h8-10,15,19,22H,11H2,1-7H3;   InChIKey=ANZXOIAKUNOVQU-UHFFFAOYSA-N;   SMILES=CN(C)C(=O)Oc1cc(OC(=O)N(C)C)cc(c1)C(O)CNC(C)(C)C;   bambuterolum;   terbutaline bis(dimethylcarbamate);   terbutaline bisdimethylcarbamate
 xref: Beilstein:8158052;   CAS:81732-65-2;   DrugBank:DB01408;   Drug_Central:285;   KEGG:D07377;   LINCS:LSM-4346
 xref_mesh: MESH:C047766
 xref: PMID:18582854;   Patent:EP43807;   Patent:US4419364;   Reaxys:8158052



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bambuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO bambuterol results in decreased activity of ACHE protein CTD PMID:18582854 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adrb2 adrenoceptor beta 2 increases activity ISO bambuterol results in increased activity of ADRB2 protein CTD PMID:34601065 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO bambuterol results in decreased activity of BCHE protein CTD PMID:15652380 PMID:18582854 PMID:18977317 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19715
    role 19690
      application 19522
        anti-asthmatic agent 9290
          anti-asthmatic drug 8662
            bambuterol 3
              (R)-bambuterol 0
              (S)-bambuterol 0
              bambuterol hydrochloride + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19715
    subatomic particle 19713
      composite particle 19713
        hadron 19713
          baryon 19713
            nucleon 19713
              atomic nucleus 19713
                atom 19713
                  main group element atom 19662
                    main group molecular entity 19662
                      s-block molecular entity 19511
                        hydrogen molecular entity 19504
                          hydrides 18967
                            inorganic hydride 17790
                              pnictogen hydride 17773
                                nitrogen hydride 17658
                                  azane 17428
                                    ammonia 17427
                                      organic amino compound 17427
                                        amino alcohol 1038
                                          ethanolamines 802
                                            phenylethanolamines 593
                                              terbutaline 52
                                                bambuterol 3
                                                  (R)-bambuterol 0
                                                  (S)-bambuterol 0
                                                  bambuterol hydrochloride + 0
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