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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bambuterol
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Accession:CHEBI:553827 term browser browse the term
Definition:A carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline.
Synonyms:exact_synonym: 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diyl bis(dimethylcarbamate)
 related_synonym: (+-)-5-(2-(tert-butylamino)-1-hydroxyethyl)-m-phenylene bis(dimethylcarbamate);   Formula=C18H29N3O5;   InChI=1S/C18H29N3O5/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7/h8-10,15,19,22H,11H2,1-7H3;   InChIKey=ANZXOIAKUNOVQU-UHFFFAOYSA-N;   SMILES=CN(C)C(=O)Oc1cc(OC(=O)N(C)C)cc(c1)C(O)CNC(C)(C)C;   bambuterolum;   terbutaline bis(dimethylcarbamate);   terbutaline bisdimethylcarbamate
 xref: Beilstein:8158052;   CAS:81732-65-2;   DrugBank:DB01408;   Drug_Central:285;   KEGG:D07377;   LINCS:LSM-4346
 xref_mesh: MESH:C047766
 xref: PMID:18582854;   Patent:EP43807;   Patent:US4419364;   Reaxys:8158052


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bambuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO bambuterol results in decreased activity of ACHE protein CTD PMID:18582854 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G Bche butyrylcholinesterase decreases activity ISO bambuterol results in decreased activity of BCHE protein CTD PMID:15652380 PMID:18582854 PMID:18977317 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        anti-asthmatic agent 9230
          anti-asthmatic drug 8597
            bambuterol 2
              (R)-bambuterol 0
              (S)-bambuterol 0
              bambuterol hydrochloride + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        amino alcohol 1032
                                          ethanolamines 799
                                            phenylethanolamines 592
                                              terbutaline 52
                                                bambuterol 2
                                                  (R)-bambuterol 0
                                                  (S)-bambuterol 0
                                                  bambuterol hydrochloride + 0
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