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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:5537 term browser browse the term
Definition:A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 1-methyl-1H-indazole-3-carboxylic acid with the primary amino group of (3-endo)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine. A selective 5-HT3 receptor antagonist, it is used (generally as the monohydrochloride salt) to manage nausea and vomiting caused by cancer chemotherapy and radiotherapy, and to prevent and treat postoperative nausea and vomiting.
Synonyms:exact_synonym: 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
 related_synonym: 1-methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide;   APF 530;   APF530;   BRL 43694;   Formula=C18H24N4O;   InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13+,14-;   InChIKey=MFWNKCLOYSRHCJ-BTTYYORXSA-N;   Kevatril;   SMILES=CN1[C@H]2CCC[C@@H]1C[C@@H](C2)NC(=O)c1nn(C)c2ccccc12;   Sancuso;   Sustol;   granisetronum
 xref: CAS:109889-09-0;   DrugBank:DB00889;   Drug_Central:1329;   HMDB:HMDB0015026;   KEGG:C07023;   KEGG:D04370
 xref_mesh: MESH:D017829
 xref: PDBeChem:CWB;   PMID:1650335;   PMID:2169778;   PMID:22452942;   PMID:24388937;   PMID:2540014;   PMID:25834466;   PMID:25866983;   PMID:26289588;   PMID:26812081;   PMID:26925101;   PMID:26997579;   PMID:27073822;   PMID:27129842;   PMID:27162748;   PMID:27184113;   PMID:27186139;   PMID:27358385;   PMID:27382819;   PMID:27400689;   PMID:27571447;   PMID:27650869;   PMID:27703112;   PMID:27746523;   PMID:27809336;   PMID:27895421;   PMID:27915445;   PMID:28002447;   PMID:28061543;   PMID:28168082;   PMID:28211304;   Patent:EP200444;   Patent:US4886808;   Reaxys:3655275;   Wikipedia:Granisetron

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granisetron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions EXP Granisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:16545797 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Amy2a3 amylase 2a3 multiple interactions EXP Granisetron inhibits the reaction [Lithium Chloride results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 2:216,373,674...216,382,260
Ensembl chr 2:216,339,154...216,382,260
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of Granisetron CTD PMID:30950278 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Granisetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antiemetic 5125
              granisetron 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  granisetron 3
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