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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:granisetron
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Accession:CHEBI:5537 term browser browse the term
Definition:A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 1-methyl-1H-indazole-3-carboxylic acid with the primary amino group of (3-endo)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine. A selective 5-HT3 receptor antagonist, it is used (generally as the monohydrochloride salt) to manage nausea and vomiting caused by cancer chemotherapy and radiotherapy, and to prevent and treat postoperative nausea and vomiting.
Synonyms:exact_synonym: 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
 related_synonym: 1-methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide;   APF 530;   APF530;   BRL 43694;   Formula=C18H24N4O;   InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13+,14-;   InChIKey=MFWNKCLOYSRHCJ-BTTYYORXSA-N;   Kevatril;   SMILES=CN1[C@H]2CCC[C@@H]1C[C@@H](C2)NC(=O)c1nn(C)c2ccccc12;   Sancuso;   Sustol;   granisetronum
 xref: CAS:109889-09-0;   DrugBank:DB00889;   Drug_Central:1329;   HMDB:HMDB0015026;   KEGG:C07023;   KEGG:D04370
 xref_mesh: MESH:D017829
 xref: PDBeChem:CWB;   PMID:1650335;   PMID:2169778;   PMID:22452942;   PMID:24388937;   PMID:2540014;   PMID:25834466;   PMID:25866983;   PMID:26289588;   PMID:26812081;   PMID:26925101;   PMID:26997579;   PMID:27073822;   PMID:27129842;   PMID:27162748;   PMID:27184113;   PMID:27186139;   PMID:27358385;   PMID:27382819;   PMID:27400689;   PMID:27571447;   PMID:27650869;   PMID:27703112;   PMID:27746523;   PMID:27809336;   PMID:27895421;   PMID:27915445;   PMID:28002447;   PMID:28061543;   PMID:28168082;   PMID:28211304;   Patent:EP200444;   Patent:US4886808;   Reaxys:3655275;   Wikipedia:Granisetron



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granisetron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions EXP Granisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:16545797 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Amy2a3 amylase 2a3 multiple interactions EXP Granisetron inhibits the reaction [Lithium Chloride results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 2:201,317,916...201,326,487
Ensembl chr 2:201,317,920...201,326,532
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of Granisetron CTD PMID:30950278 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Granisetron CTD PMID:15286053 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]] CTD PMID:30611738 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]] CTD PMID:30611738 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]] CTD PMID:30611738 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D multiple interactions ISO Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]] CTD PMID:30611738 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Granisetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions ISO Granisetron inhibits the reaction [Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of TPH1 protein]] CTD PMID:30611738 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19911
    role 19887
      application 19723
        pharmaceutical 19559
          drug 19559
            antiemetic 5357
              granisetron 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19909
          baryon 19909
            nucleon 19909
              atomic nucleus 19909
                atom 19909
                  main group element atom 19859
                    p-block element atom 19859
                      carbon group element atom 19803
                        carbon atom 19799
                          organic molecular entity 19799
                            organic group 18986
                              organic divalent group 18961
                                organodiyl group 18961
                                  carbonyl group 18917
                                    carbonyl compound 18917
                                      carboxylic acid 18641
                                        carboacyl group 17703
                                          univalent carboacyl group 17703
                                            carbamoyl group 17548
                                              carboxamide 17548
                                                monocarboxylic acid amide 15692
                                                  granisetron 10
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