CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: granisetron
Accession: CHEBI:5537
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Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 1-methyl-1H-indazole-3-carboxylic acid with the primary amino group of (3-endo)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine. A selective 5-HT3 receptor antagonist, it is used (generally as the monohydrochloride salt) to manage nausea and vomiting caused by cancer chemotherapy and radiotherapy, and to prevent and treat postoperative nausea and vomiting.
Synonyms: exact_synonym: 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
related_synonym: 1-methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide; APF 530; APF530; BRL 43694; Formula=C18H24N4O; InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13+,14-; InChIKey=MFWNKCLOYSRHCJ-BTTYYORXSA-N; Kevatril; SMILES=CN1[C@H]2CCC[C@@H]1C[C@@H](C2)NC(=O)c1nn(C)c2ccccc12; Sancuso; Sustol; granisetronum
xref: CAS:109889-09-0; DrugBank:DB00889; Drug_Central:1329; HMDB:HMDB0015026; KEGG:C07023; KEGG:D04370
xref_mesh: MESH:D017829
xref: PDBeChem:CWB; PMID:1650335; PMID:2169778; PMID:22452942; PMID:24388937; PMID:2540014; PMID:25834466; PMID:25866983; PMID:26289588; PMID:26812081; PMID:26925101; PMID:26997579; PMID:27073822; PMID:27129842; PMID:27162748; PMID:27184113; PMID:27186139; PMID:27358385; PMID:27382819; PMID:27400689; PMID:27571447; PMID:27650869; PMID:27703112; PMID:27746523; PMID:27809336; PMID:27895421; PMID:27915445; PMID:28002447; PMID:28061543; PMID:28168082; PMID:28211304; Patent:EP200444; Patent:US4886808; Reaxys:3655275; Wikipedia:Granisetron
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Adra1a
adrenoceptor alpha 1A
multiple interactions
EXP
Granisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]
CTD
PMID:16545797
NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500
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Amy1
amylase alpha 1
multiple interactions
EXP
Granisetron inhibits the reaction [Lithium Chloride results in increased secretion of and results in increased activity of AMY1A protein]
CTD
PMID:21173550
NCBI chr 2:204,071,101...204,085,910
Ensembl chr 2:201,382,675...201,397,816
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases metabolic processing
ISO
CYP1A1 protein results in increased metabolism of Granisetron
CTD
PMID:30950278
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects metabolic processing
ISO
CYP3A4 protein affects the metabolism of Granisetron
CTD
PMID:15286053
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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Il1b
interleukin 1 beta
multiple interactions
ISO
Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]
CTD
PMID:30611738
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]
CTD
PMID:30611738
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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Mpo
myeloperoxidase
multiple interactions
ISO
Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]
CTD
PMID:30611738
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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Napepld
N-acyl phosphatidylethanolamine phospholipase D
multiple interactions
ISO
Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]]
CTD
PMID:30611738
NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:13,361,006...13,398,748
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Granisetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
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Tph1
tryptophan hydroxylase 1
multiple interactions
ISO
Granisetron inhibits the reaction [Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of TPH1 protein]]
CTD
PMID:30611738
NCBI chr 1:106,293,695...106,314,628
Ensembl chr 1:97,157,409...97,178,344
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