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Accession:CHEBI:5537 term browser browse the term
Definition:A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 1-methyl-1H-indazole-3-carboxylic acid with the primary amino group of (3-endo)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine. A selective 5-HT3 receptor antagonist, it is used (generally as the monohydrochloride salt) to manage nausea and vomiting caused by cancer chemotherapy and radiotherapy, and to prevent and treat postoperative nausea and vomiting.
Synonyms:exact_synonym: 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
 related_synonym: 1-methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide;   APF 530;   APF530;   BRL 43694;   Formula=C18H24N4O;   InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13+,14-;   InChIKey=MFWNKCLOYSRHCJ-BTTYYORXSA-N;   Kevatril;   SMILES=CN1[C@H]2CCC[C@@H]1C[C@@H](C2)NC(=O)c1nn(C)c2ccccc12;   Sancuso;   Sustol;   granisetronum
 xref: CAS:109889-09-0 "ChemIDplus";   CAS:109889-09-0 "KEGG COMPOUND";   DrugBank:DB00889;   Drug_Central:1329 "DrugCentral";   HMDB:HMDB0015026;   KEGG:C07023;   KEGG:D04370
 xref_mesh: MESH:D017829
 xref: PDBeChem:CWB;   PMID:1650335 "Europe PMC";   PMID:2169778 "Europe PMC";   PMID:22452942 "Europe PMC";   PMID:24388937 "Europe PMC";   PMID:2540014 "Europe PMC";   PMID:25834466 "Europe PMC";   PMID:25866983 "Europe PMC";   PMID:26289588 "Europe PMC";   PMID:26812081 "Europe PMC";   PMID:26925101 "Europe PMC";   PMID:26997579 "Europe PMC";   PMID:27073822 "Europe PMC";   PMID:27129842 "Europe PMC";   PMID:27162748 "Europe PMC";   PMID:27184113 "Europe PMC";   PMID:27186139 "Europe PMC";   PMID:27358385 "Europe PMC";   PMID:27382819 "Europe PMC";   PMID:27400689 "Europe PMC";   PMID:27571447 "Europe PMC";   PMID:27650869 "Europe PMC";   PMID:27703112 "Europe PMC";   PMID:27746523 "Europe PMC";   PMID:27809336 "Europe PMC";   PMID:27895421 "Europe PMC";   PMID:27915445 "Europe PMC";   PMID:28002447 "Europe PMC";   PMID:28061543 "Europe PMC";   PMID:28168082 "Europe PMC";   PMID:28211304 "Europe PMC";   Patent:EP200444;   Patent:US4886808;   Reaxys:3655275 "Reaxys";   Wikipedia:Granisetron

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granisetron term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:6480464
G Amy1a amylase, alpha 1A JBrowse link 2 216,428,709 216,443,518 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antiemetic 5083
              granisetron 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                monocarboxylic acid amide 13180
                                                  granisetron 4
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