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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ceftizoxime
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Accession:CHEBI:553473 term browser browse the term
Definition:A parenteral third-generation cephalosporin, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position.
Synonyms:exact_synonym: (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2,3-didehydropenam-2-carboxylic acid
 related_synonym: 7-[2-(2-Amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   CEFIZOX;   Formula=C13H13N5O5S2;   InChI=1S/C13H13N5O5S2/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22)/b17-7-/t8-,11-/m1/s1;   InChIKey=NNULBSISHYWZJU-LLKWHZGFSA-N;   SMILES=[H][C@]12SCC=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C(O)=O;   ceftizoxima;   ceftizoximum;   syn-7-(2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido)-3-cephem-4-carboxylic acid
 alt_id: CHEBI:112105;   CHEBI:3511
 xref: Beilstein:5777502;   CAS:68401-81-0;   DrugBank:DB01332;   Drug_Central:563;   KEGG:C06890;   KEGG:D07658
 xref_mesh: MESH:D015296
 xref: PMID:11452157;   PMID:11711261;   PMID:1384868;   PMID:15716453;   PMID:22726927;   PMID:23394621;   PMID:29017833;   Reaxys:5777502;   Wikipedia:Ceftizoxime
 cyclic_relationship: is_conjugate_acid_of CHEBI:55498


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ceftizoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase decreases activity ISO Ceftizoxime results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases uptake
ISO Ceftizoxime inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
SLC22A6 protein results in increased uptake of Ceftizoxime
CTD PMID:16098483 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake
multiple interactions
ISO SLC22A8 protein results in increased uptake of Ceftizoxime
Ceftizoxime inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
CTD PMID:16098483 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          antibacterial agent 13030
            antibacterial drug 3162
              ceftizoxime 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                lactam 8034
                                                  beta-lactam 792
                                                    beta-lactam antibiotic 780
                                                      cephem 546
                                                        cephalosporin 545
                                                          ceftizoxime 3
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