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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Goserelin
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Accession:CHEBI:5523 term browser browse the term
Synonyms:related_synonym: Decapeptide I;   Formula=C59H84N18O14;   Goserelin acetate;   InChI=1S/C59H84N18O14/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90)/t38-,39-,40-,41-,42-,43-,44-,45+,46-/m0/s1;   InChIKey=BLCLNMBMMGCOAS-URPVMXJPSA-N;   SMILES=C([C@H](NC([C@H](CC1=CNC=N1)NC(=O)[C@@H]2CCC(N2)=O)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(NNC(N)=O)=O)CCC4)CCCNC(=N)N)=O)CC(C)C)=O)COC(C)(C)C)=O)=O)CO)=O)C=5C6=C(NC5)C=CC=C6;   zoladex
 xref: CAS:65807-02-5;   Drug_Central:1327;   HMDB:HMDB0014259;   KEGG:D00573
 xref_mesh: MESH:D017273


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Goserelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO [Goserelin co-treated with bicalutamide] results in decreased expression of AR protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of AR protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide] results in decreased expression of AR protein; [Goserelin co-treated with Dutasteride] results in decreased expression of AR protein CTD PMID:24323034 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO Goserelin results in increased expression of BCL2 protein CTD PMID:16973256 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO [Goserelin co-treated with kuntai capsule] affects the expression of BGLAP protein CTD PMID:25566615 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Goserelin results in decreased expression of ESR1 protein CTD PMID:16973256 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
decreases expression
ISO [Goserelin co-treated with kuntai capsule] results in decreased expression of FSHB protein
Goserelin results in decreased expression of FSHB protein
CTD PMID:25566615 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Pgr progesterone receptor decreases expression ISO Goserelin results in decreased expression of PGR protein CTD PMID:16973256 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Tmprss2 transmembrane serine protease 2 multiple interactions ISO [Goserelin co-treated with bicalutamide] results in decreased expression of TMPRSS2 protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of TMPRSS2 protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide] results in decreased expression of TMPRSS2 protein; [Goserelin co-treated with Dutasteride] results in decreased expression of TMPRSS2 protein CTD PMID:24323034 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Goserelin results in decreased expression of TP53 protein CTD PMID:16973256 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          carbon atom 19588
            organic molecular entity 19588
              Goserelin 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            Goserelin 8
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