Goserelin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	Goserelin	go back to main search page
Accession:	CHEBI:5523	browse the term
Synonyms:	related_synonym:	Decapeptide I; Formula=C59H84N18O14; Goserelin acetate; InChI=1S/C59H84N18O14/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90)/t38-,39-,40-,41-,42-,43-,44-,45+,46-/m0/s1; InChIKey=BLCLNMBMMGCOAS-URPVMXJPSA-N; SMILES=C([C@H](NC([C@H](CC1=CNC=N1)NC(=O)[C@@H]2CCC(N2)=O)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(NNC(N)=O)=O)CCC4)CCCNC(=N)N)=O)CC(C)C)=O)COC(C)(C)C)=O)=O)CO)=O)C=5C6=C(NC5)C=CC=C6; zoladex
	xref:	CAS:65807-02-5; Drug_Central:1327; HMDB:HMDB0014259; KEGG:D00573
	xref_mesh:	MESH:D017273

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Genes (7)

Goserelin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

[Goserelin co-treated with bicalutamide] results in decreased expression of AR protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of AR protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide] results in decreased expression of AR protein; [Goserelin co-treated with Dutasteride] results in decreased expression of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

BCL2, apoptosis regulator

increases expression

Goserelin results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone gamma-carboxyglutamate protein

multiple interactions

[Goserelin co-treated with kuntai capsule] affects the expression of BGLAP protein

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

estrogen receptor 1

decreases expression

Goserelin results in decreased expression of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

follicle stimulating hormone subunit beta

multiple interactions
decreases expression

[Goserelin co-treated with kuntai capsule] results in decreased expression of FSHB protein
Goserelin results in decreased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

progesterone receptor

decreases expression

Goserelin results in decreased expression of PGR protein

NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

tumor protein p53

decreases expression

Goserelin results in decreased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19818
chemical entity	19816
atom	19816
nonmetal atom	19749
carbon atom	19698
organic molecular entity	19698
Goserelin	7
Path 2
Term	Annotations
CHEBI ontology	19818
subatomic particle	19816
composite particle	19816
hadron	19816
baryon	19816
nucleon	19816
atomic nucleus	19816
atom	19816
main group element atom	19761
p-block element atom	19761
carbon group element atom	19703
carbon atom	19698
organic molecular entity	19698
Goserelin	7

paths to the root