CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: homovanillic acid
Accession: CHEBI:545959
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Definition: A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
Synonyms: exact_synonym: 2-(4-hydroxy-3-methoxyphenyl)acetic acid
related_synonym: (4-hydroxy-3-methoxyphenyl)acetic acid; 3-Methoxy-4-hydroxyphenylacetate; 3-Methoxy-4-hydroxyphenylacetic acid; 4-Hydroxy-3-methoxybenzeneacetic acid; Formula=C9H10O4; HVA; InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12); InChIKey=QRMZSPFSDQBLIX-UHFFFAOYSA-N; SMILES=COc1cc(CC(O)=O)ccc1O; Vanillacetic acid
alt_id: CHEBI:5758
xref: CAS:306-08-1; HMDB:HMDB0000118; KEGG:C05582; KNApSAcK:C00029504
xref_mesh: MESH:D006719
xref: MetaCyc:CPD-7651; PMID:14688447; PMID:24007816; PMID:24416192; PMID:24423636; PMID:8353435; Reaxys:2213447; Wikipedia:Homovanillic_acid
cyclic_relationship: is_conjugate_acid_of CHEBI:133744
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Aqp9
aquaporin 9
multiple interactions
EXP
AQP9 gene mutant form inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased abundance of Homovanillic Acid]
CTD
PMID:29566083
NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964
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Comt
catechol-O-methyltransferase
multiple interactions
ISO
[tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid
CTD
PMID:11793163 PMID:15190105 PMID:16012872
NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
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Maob
monoamine oxidase B
multiple interactions
ISO
[Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Acid
CTD
PMID:16012872
NCBI chr X:16,575,520...16,683,605
Ensembl chr X:16,575,521...16,683,605
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Nos1
nitric oxide synthase 1, neuronal
multiple interactions
EXP
NOS1 protein affects the reaction [Methamphetamine results in decreased abundance of Homovanillic Acid]
CTD
PMID:11085313
NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
increases abundance
EXP
NR3C1 protein results in increased abundance of Homovanillic Acid
CTD
PMID:11226678
NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
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Oprm1
opioid receptor, mu 1
multiple interactions
ISO
[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid]
CTD
PMID:8884884
NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198
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Parp1
poly (ADP-ribose) polymerase family, member 1
multiple interactions
EXP
[PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased abundance of Homovanillic Acid
CTD
PMID:10318960
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
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Sct
secretin
increases abundance
ISO
SCT protein results in increased abundance of Homovanillic Acid
CTD
PMID:16168596
NCBI chr 7:140,858,243...140,859,082
Ensembl chr 7:140,858,243...140,859,046
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Slc22a8
solute carrier family 22 (organic anion transporter), member 8
multiple interactions
ISO
Homovanillic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
CTD
PMID:10224140
NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199
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Tfam
transcription factor A, mitochondrial
decreases abundance
EXP
TFAM gene mutant form results in decreased abundance of Homovanillic Acid
CTD
PMID:28595911
NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110
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Vdr
vitamin D (1,25-dihydroxyvitamin D3) receptor
multiple interactions increases abundance
ISO
Calcitriol promotes the reaction [VDR protein results in increased abundance of Homovanillic Acid]
CTD
PMID:27450565
NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
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