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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glyceraldehyde
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Accession:CHEBI:5445 term browser browse the term
Definition:An aldotriose comprising propanal having hydroxy groups at the 2- and 3-positions. It plays role in the formation of advanced glycation end-products (AGEs), a deleterious accompaniment to ageing.
Synonyms:related_synonym: 2,3-Dihydroxypropanal;   2,3-Dihydroxypropionaldehyde;   Aldotriose;   DL-glyceraldehyde;   Formula=C3H6O3;   Glyceraldehyd;   Glycerinaldehyd;   Glyzerinaldehyd;   InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2;   InChIKey=MNQZXJOMYWMBOU-UHFFFAOYSA-N;   SMILES=[H]C(=O)C(O)CO;   alpha,beta-dihydroxypropionaldehyde;   gliceraldehido;   glyceric aldehyde;   glycerinaldehyde;   glycerinformal;   glycerose
 alt_id: CHEBI:24343;   CHEBI:387614
 xref: Beilstein:635844;   CAS:367-47-5;   CAS:56-82-6;   DrugBank:DB02536;   Gmelin:164389;   HMDB:HMDB0001051;   KEGG:C02154;   KNApSAcK:C00007413
 xref_mesh: MESH:D005985
 xref: MetaCyc:CPD0-1551;   PMID:18087047;   PMID:18256486;   PMID:18791692;   PMID:20371493;   PMID:21707087;   PMID:23543734;   PMID:9506998;   Reaxys:635844;   Wikipedia:Glyceraldehyde


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glyceraldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of Glyceraldehyde CTD PMID:19014918 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
increases metabolic processing
increases reduction		 ISO [AKR1B10 protein co-treated with NADP] affects the reduction of Glyceraldehyde; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]
AKR1B10 protein results in increased metabolism of Glyceraldehyde		 CTD PMID:17329238 PMID:18325492 PMID:19014918 PMID:19028477 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases metabolic processing ISO AKR1B15 protein results in increased metabolism of Glyceraldehyde CTD PMID:21276782 NCBI chr 4:62,997,241...63,009,815
Ensembl chr 4:62,997,161...63,010,097 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde CTD PMID:21376711 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases metabolic processing ISO DHRS3 protein results in increased metabolism of Glyceraldehyde CTD PMID:25451588 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417 		JBrowse link
G Ins1 insulin 1 increases secretion EXP Glyceraldehyde results in increased secretion of INS1 protein CTD PMID:11377826 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP PLCB1 protein promotes the reaction [Glyceraldehyde results in increased abundance of Inositol Phosphates] CTD PMID:11377826 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
D-glyceraldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of Glyceraldehyde CTD PMID:19014918 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
increases reduction
increases metabolic processing		 ISO [AKR1B10 protein co-treated with NADP] affects the reduction of Glyceraldehyde; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]
AKR1B10 protein results in increased metabolism of Glyceraldehyde		 CTD PMID:17329238 PMID:18325492 PMID:19014918 PMID:19028477 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases metabolic processing ISO AKR1B15 protein results in increased metabolism of Glyceraldehyde CTD PMID:21276782 NCBI chr 4:62,997,241...63,009,815
Ensembl chr 4:62,997,161...63,010,097 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde CTD PMID:21376711 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases metabolic processing ISO DHRS3 protein results in increased metabolism of Glyceraldehyde CTD PMID:25451588 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417 		JBrowse link
G Ins1 insulin 1 increases secretion EXP Glyceraldehyde results in increased secretion of INS1 protein CTD PMID:11377826 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP PLCB1 protein promotes the reaction [Glyceraldehyde results in increased abundance of Inositol Phosphates] CTD PMID:11377826 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
glyceraldehyde 3-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbp1 fructose-bisphosphatase 1 multiple interactions ISO [Enzyme Inhibitors results in decreased activity of FBP1 protein] which results in decreased abundance of Glyceraldehyde 3-Phosphate metabolite CTD PMID:31974165 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog; Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; NAD analog inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; NADP inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] CTD PMID:15788719 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 multiple interactions
decreases chemical synthesis		 ISO PFKFB1 gene mutant form inhibits the reaction [Metformin results in increased abundance of Glyceraldehyde 3-Phosphate metabolite]
PFKFB1 gene mutant form results in decreased chemical synthesis of Glyceraldehyde 3-Phosphate metabolite		 CTD PMID:31974165 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        biochemical role 19496
          metabolite 19484
            fundamental metabolite 14418
              glyceraldehyde 10
                (3E)-3-(methoxyimino)propane-1,2-diol 0
                D-glyceraldehyde + 7
                L-glyceraldehyde + 0
                glyceraldehyde 3-phosphate + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbohydrates and carbohydrate derivatives 15269
                                    carbohydrate 15284
                                      monosaccharide 4802
                                        aldose 3218
                                          aldotriose 10
                                            glyceraldehyde 10
                                              (3E)-3-(methoxyimino)propane-1,2-diol 0
                                              D-glyceraldehyde + 7
                                              L-glyceraldehyde + 0
                                              glyceraldehyde 3-phosphate + 3
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