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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glyceraldehyde
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Accession:CHEBI:5445 term browser browse the term
Definition:An aldotriose comprising propanal having hydroxy groups at the 2- and 3-positions. It plays role in the formation of advanced glycation end-products (AGEs), a deleterious accompaniment to ageing.
Synonyms:related_synonym: 2,3-Dihydroxypropanal;   2,3-Dihydroxypropionaldehyde;   Aldotriose;   DL-glyceraldehyde;   Formula=C3H6O3;   Glyceraldehyd;   Glycerinaldehyd;   Glyzerinaldehyd;   InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2;   InChIKey=MNQZXJOMYWMBOU-UHFFFAOYSA-N;   SMILES=[H]C(=O)C(O)CO;   alpha,beta-dihydroxypropionaldehyde;   gliceraldehido;   glyceric aldehyde;   glycerinaldehyde;   glycerinformal;   glycerose
 alt_id: CHEBI:24343;   CHEBI:387614
 xref: Beilstein:635844;   CAS:367-47-5;   CAS:56-82-6;   DrugBank:DB02536;   Gmelin:164389;   HMDB:HMDB0001051;   KEGG:C02154;   KNApSAcK:C00007413
 xref_mesh: MESH:D005985
 xref: MetaCyc:CPD0-1551;   PMID:18087047;   PMID:18256486;   PMID:18791692;   PMID:20371493;   PMID:21707087;   PMID:23543734;   PMID:9506998;   Reaxys:635844;   Wikipedia:Glyceraldehyde



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glyceraldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of Glyceraldehyde CTD PMID:19014918 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
increases metabolic processing
increases reduction
ISO [AKR1B10 protein co-treated with NADP] affects the reduction of Glyceraldehyde; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]
AKR1B10 protein results in increased metabolism of Glyceraldehyde
CTD PMID:17329238 PMID:18325492 PMID:19014918 PMID:19028477 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases metabolic processing ISO AKR1B15 protein results in increased metabolism of Glyceraldehyde CTD PMID:21276782 NCBI chr 4:62,997,241...63,009,815
Ensembl chr 4:62,997,161...63,010,097
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde CTD PMID:21376711 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases metabolic processing ISO DHRS3 protein results in increased metabolism of Glyceraldehyde CTD PMID:25451588 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP PLCB1 protein promotes the reaction [Glyceraldehyde results in increased abundance of Inositol Phosphates] CTD PMID:11377826 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
D-glyceraldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of Glyceraldehyde CTD PMID:19014918 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
increases reduction
increases metabolic processing
ISO [AKR1B10 protein co-treated with NADP] affects the reduction of Glyceraldehyde; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; pirinixic acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; sorbinil inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]; zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]
AKR1B10 protein results in increased metabolism of Glyceraldehyde
CTD PMID:17329238 PMID:18325492 PMID:19014918 PMID:19028477 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases metabolic processing ISO AKR1B15 protein results in increased metabolism of Glyceraldehyde CTD PMID:21276782 NCBI chr 4:62,997,241...63,009,815
Ensembl chr 4:62,997,161...63,010,097
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde CTD PMID:21376711 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases metabolic processing ISO DHRS3 protein results in increased metabolism of Glyceraldehyde CTD PMID:25451588 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP PLCB1 protein promotes the reaction [Glyceraldehyde results in increased abundance of Inositol Phosphates] CTD PMID:11377826 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
glyceraldehyde 3-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbp1 fructose-bisphosphatase 1 multiple interactions ISO [Enzyme Inhibitors results in decreased activity of FBP1 protein] which results in decreased abundance of Glyceraldehyde 3-Phosphate metabolite CTD PMID:31974165 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog; Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; NAD analog inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; NADP inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] CTD PMID:15788719 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 multiple interactions
decreases chemical synthesis
ISO PFKFB1 gene mutant form inhibits the reaction [Metformin results in increased abundance of Glyceraldehyde 3-Phosphate metabolite]
PFKFB1 gene mutant form results in decreased chemical synthesis of Glyceraldehyde 3-Phosphate metabolite
CTD PMID:31974165 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            fundamental metabolite 12818
              glyceraldehyde 9
                (3E)-3-(methoxyimino)propane-1,2-diol 0
                D-glyceraldehyde + 6
                L-glyceraldehyde + 0
                glyceraldehyde 3-phosphate + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            heteroorganic entity 19591
                              organochalcogen compound 19339
                                organooxygen compound 19273
                                  carbohydrates and carbohydrate derivatives 13952
                                    carbohydrate 13936
                                      monosaccharide 4373
                                        aldose 2715
                                          aldotriose 9
                                            glyceraldehyde 9
                                              (3E)-3-(methoxyimino)propane-1,2-diol 0
                                              D-glyceraldehyde + 6
                                              L-glyceraldehyde + 0
                                              glyceraldehyde 3-phosphate + 3
paths to the root