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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gliotoxin
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Accession:CHEBI:5385 term browser browse the term
Definition:A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.
Synonyms:exact_synonym: (3R,5aS,6S,10aR)-6-hydroxy-3-(hydroxymethyl)-2-methyl-2,3,6,10-tetrahydro-5aH-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
 related_synonym: Aspergillin;   Formula=C13H14N2O4S2;   InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1;   InChIKey=FIVPIPIDMRVLAY-RBJBARPLSA-N;   SMILES=[H][C@@]12[C@@H](O)C=CC=C1C[C@@]13SS[C@@](CO)(N(C)C1=O)C(=O)N23
 xref: Beilstein:50675;   CAS:67-99-2;   KEGG:C10595;   KNApSAcK:C00002340
 xref_mesh: MESH:D005912
 xref: PMID:16020669;   PMID:23832115;   PMID:24368570;   PMID:24847038;   PMID:25062268;   PMID:25494483;   PMID:25766143;   PMID:25816130;   PMID:25982450;   PPDB:2793;   Reaxys:50675;   Wikipedia:Gliotoxin


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gliotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA] CTD PMID:14527959 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP Gliotoxin results in increased cleavage of and results in increased activity of CASP3 protein; Mercuric Chloride inhibits the reaction [Gliotoxin results in increased activity of CASP3 protein] CTD PMID:17466404 PMID:20958918 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 decreases expression EXP Gliotoxin results in decreased expression of CYP2B2 mRNA CTD PMID:18346771 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 decreases expression EXP Gliotoxin results in decreased expression of DECR2 mRNA CTD PMID:18346771 NCBI chr10:15,104,907...15,113,281 JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression EXP Gliotoxin results in increased expression of DNAJB1 mRNA CTD PMID:18346771 NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458
JBrowse link
G Dpys dihydropyrimidinase decreases expression EXP Gliotoxin results in decreased expression of DPYS mRNA CTD PMID:18346771 NCBI chr 7:70,822,648...70,929,255
Ensembl chr 7:70,835,789...70,929,231
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Gliotoxin results in decreased expression of ECH1 mRNA CTD PMID:18346771 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Gliotoxin results in increased expression of GADD45A mRNA CTD PMID:18346771 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP Gliotoxin results in decreased expression of GJB1 mRNA CTD PMID:18346771 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gnmt glycine N-methyltransferase decreases expression EXP Gliotoxin results in decreased expression of GNMT mRNA CTD PMID:18346771 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Gliotoxin results in decreased expression of GSTM2 mRNA CTD PMID:18346771 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Hal histidine ammonia lyase decreases expression EXP Gliotoxin results in decreased expression of HAL mRNA CTD PMID:18346771 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Gliotoxin results in decreased expression of HIF1A mRNA CTD PMID:20432243 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO Gliotoxin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein] CTD PMID:19739265 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Ifng interferon gamma decreases expression
decreases secretion
ISO Gliotoxin results in decreased expression of IFNG mRNA
Gliotoxin results in decreased secretion of IFNG protein
CTD PMID:12112629 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression EXP Gliotoxin results in increased expression of IFRD1 mRNA CTD PMID:18346771 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Gliotoxin results in increased expression of JUNB mRNA CTD PMID:18346771 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:17466404 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:17466404 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK8 protein CTD PMID:17466404 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mbl1 mannose binding lectin 1 decreases expression EXP Gliotoxin results in decreased expression of MBL1 mRNA CTD PMID:18346771 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:14527959 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP Gliotoxin results in increased expression of PPP1R15A mRNA CTD PMID:18346771 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:14527959 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SOD2 mRNA] CTD PMID:10653605 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 decreases expression EXP Gliotoxin results in decreased expression of SULT1B1 mRNA CTD PMID:18346771 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:10653605 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ttpa alpha tocopherol transfer protein decreases expression EXP Gliotoxin results in decreased expression of TTPA mRNA CTD PMID:18346771 NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073
JBrowse link
G Upb1 beta-ureidopropionase 1 decreases expression EXP Gliotoxin results in decreased expression of UPB1 mRNA CTD PMID:18346771 NCBI chr20:13,217,252...13,243,590
Ensembl chr20:13,217,258...13,243,590
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        immunomodulator 14903
          immunosuppressive agent 13724
            gliotoxin 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                peptide 9444
                                                  oligopeptide 1266
                                                    dipeptide 375
                                                      gliotoxin 29
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