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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyridochromene
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Accession:CHEBI:53792 term browser browse the term
Definition:An organic heterotricyclic compound composed of a pyridine ring fused to a chromene.
Synonyms:related_synonym: chromenopyridine;   chromenopyridines;   pyridochromenes


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amlexanox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions
decreases expression
EXP amlexanox inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
amlexanox results in decreased expression of BAX protein
CTD PMID:31697998 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP amlexanox inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein] CTD PMID:31697998 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions EXP amlexanox inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA] CTD PMID:31697998 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 multiple interactions EXP amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL2 mRNA] CTD PMID:31697998 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 multiple interactions EXP amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL1 mRNA] CTD PMID:31697998 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO [amlexanox binds to FGF1 protein] inhibits the reaction [cupric chloride results in increased oxidation of FGF1 protein]; amlexanox binds to and results in increased stability of and results in decreased secretion of FGF1 protein; amlexanox inhibits the reaction [FGF1 protein binds to FGF1 protein] CTD PMID:16300395 NCBI chr18:38,838,672...38,929,470
Ensembl chr18:38,838,673...38,929,472
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
EXP amlexanox results in increased expression of GCLC mRNA
[Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLC mRNA; [Acetaminophen co-treated with amlexanox] affects the expression of GCLC mRNA
CTD PMID:31697998 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions EXP [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLM mRNA CTD PMID:31697998 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP amlexanox inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:31697998 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO amlexanox affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP amlexanox results in increased expression of HMOX1 mRNA
[amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA; amlexanox promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; dorsomorphin inhibits the reaction [[amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA]
CTD PMID:31697998 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Ikbke inhibitor of kappaB kinase epsilon decreases activity
multiple interactions
ISO
EXP
amlexanox results in decreased activity of IKBKE protein
amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of IKBKE protein]
CTD PMID:25321315 PMID:31697998 NCBI chr 1:131,254,600...131,279,601
Ensembl chr 1:131,254,343...131,279,606
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP amlexanox inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA] CTD PMID:31697998 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions EXP amlexanox inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA] CTD PMID:31697998 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases expression
EXP [Acetaminophen co-treated with amlexanox] results in increased expression of NFE2L2 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]]
amlexanox results in increased expression of NFE2L2 protein
CTD PMID:31697998 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions EXP dorsomorphin inhibits the reaction [[Acetaminophen co-treated with amlexanox] affects the expression of NQO1 mRNA] CTD PMID:31697998 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit multiple interactions
increases phosphorylation
EXP [Acetaminophen co-treated with amlexanox] results in increased phosphorylation of PRKAA1 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]]
amlexanox results in increased phosphorylation of PRKAA1 protein
CTD PMID:31697998 NCBI chr15:5,143,861...5,181,899
Ensembl chr15:5,143,861...5,181,899
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of RELA protein] CTD PMID:31697998 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tbk1 TANK-binding kinase 1 decreases phosphorylation
multiple interactions
decreases activity
EXP
ISO
amlexanox results in decreased phosphorylation of TBK1 protein
amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of TBK1 protein]
amlexanox results in decreased activity of TBK1 protein
CTD PMID:25321315 PMID:31697998 NCBI chr10:121,546,455...121,586,794
Ensembl chr10:121,546,455...121,586,787
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP amlexanox inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA] CTD PMID:31697998 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Upf1 UPF1 regulator of nonsense transcripts homolog (yeast) affects localization ISO amlexanox affects the localization of UPF1 protein CTD PMID:28743738 NCBI chr 8:70,331,493...70,353,423
Ensembl chr 8:70,331,525...70,353,278
JBrowse link
Pranoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 increases expression ISO pyranoprofen results in increased expression of AIFM1 protein CTD PMID:31765691 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Atm ataxia telangiectasia mutated increases phosphorylation ISO pyranoprofen results in increased phosphorylation of ATM protein CTD PMID:31765691 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO pyranoprofen results in increased expression of BAD protein CTD PMID:31765691 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bax BCL2-associated X protein increases expression ISO pyranoprofen results in increased expression of BAX protein CTD PMID:31765691 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO pyranoprofen results in decreased expression of BCL2 protein CTD PMID:31765691 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO pyranoprofen results in decreased expression of BCL2L1 protein CTD PMID:31765691 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 multiple interactions EXP BDKRB2 protein affects the reaction [pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]] CTD PMID:16473424 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link
G Casp2 caspase 2 increases activity ISO pyranoprofen results in increased activity of CASP2 protein CTD PMID:31765691 NCBI chr 6:42,264,902...42,282,508
Ensembl chr 6:42,264,985...42,282,508
JBrowse link
G Casp3 caspase 3 increases activity ISO pyranoprofen results in increased activity of CASP3 protein CTD PMID:31765691 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 increases activity ISO pyranoprofen results in increased activity of CASP8 protein CTD PMID:31765691 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 increases activity ISO pyranoprofen results in increased activity of CASP9 protein CTD PMID:31765691 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Kng2 kininogen 2 multiple interactions EXP B 4162 inhibits the reaction [pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]]; BDKRB2 protein affects the reaction [pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]]; pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium] CTD PMID:16473424 NCBI chr16:22,985,852...23,029,101
Ensembl chr16:22,985,854...23,029,482
JBrowse link
G Mlkl mixed lineage kinase domain-like increases expression ISO pyranoprofen results in increased expression of MLKL protein CTD PMID:31765691 NCBI chr 8:111,311,255...111,338,479
Ensembl chr 8:111,311,797...111,338,177
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases activity ISO pyranoprofen results in increased activity of PPARG protein CTD PMID:12065695 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO pyranoprofen results in increased expression of PTGS2 mRNA CTD PMID:10594327 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 increases expression ISO pyranoprofen results in increased expression of RIPK1 protein CTD PMID:31765691 NCBI chr13:34,002,225...34,035,170
Ensembl chr13:34,002,363...34,037,147
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression ISO pyranoprofen results in increased expression of RIPK3 protein CTD PMID:31765691 NCBI chr14:55,784,995...55,788,857
Ensembl chr14:55,784,995...55,788,865
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21530
    chemical entity 21529
      molecular entity 21513
        polyatomic entity 21386
          molecule 21007
            cyclic compound 20549
              polycyclic compound 19743
                heteropolycyclic compound 18905
                  heterotricyclic compound 15300
                    organic heterotricyclic compound 15300
                      pyridochromene 36
                        10-hydroxy-3-methyl-8-pentyl-2,4-dihydro-1H-[1]benzopyrano[3,4-c]pyridin-5-one 0
                        2-amino-4-(4-bromophenyl)-5-oxo-1,4-dihydro[1]benzopyrano[4,3-b]pyridine-3-carbonitrile 0
                        4-[1-oxo-2-(1-piperidinyl)ethyl]-9-phenylmethoxy-2,3-dihydro-1H-[1]benzopyrano[3,4-b]pyridin-5-one 0
                        4-methoxy-N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)benzamide 0
                        6-methyl-4-(trifluoromethyl)-7,8,9,10-tetrahydropyrano[2,3-f]quinolin-2-one 0
                        7,8-dihydroxy-3-methyl-10-oxo-10H-chromeno[3,2-c]pyridine-9-carboxylic acid 0
                        9-hydroxy-4-[1-oxo-2-[4-(phenylmethyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-[1]benzopyrano[3,4-b]pyridin-5-one 0
                        Mepranoprofen arbamel 0
                        N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)-2-phenylacetamide 0
                        N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)-4-(1-pyrrolidinylsulfonyl)benzamide 0
                        Pranoprofen 17
                        amlexanox 21
                        traxanox 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21530
    subatomic particle 21516
      composite particle 21516
        hadron 21516
          baryon 21516
            nucleon 21516
              atomic nucleus 21516
                atom 21516
                  main group element atom 21417
                    p-block element atom 21417
                      carbon group element atom 21203
                        carbon atom 21103
                          organic molecular entity 21103
                            organic molecule 20994
                              organic cyclic compound 20548
                                organic heterocyclic compound 19375
                                  organic heteropolycyclic compound 18905
                                    organic heterotricyclic compound 15300
                                      pyridochromene 36
                                        10-hydroxy-3-methyl-8-pentyl-2,4-dihydro-1H-[1]benzopyrano[3,4-c]pyridin-5-one 0
                                        2-amino-4-(4-bromophenyl)-5-oxo-1,4-dihydro[1]benzopyrano[4,3-b]pyridine-3-carbonitrile 0
                                        4-[1-oxo-2-(1-piperidinyl)ethyl]-9-phenylmethoxy-2,3-dihydro-1H-[1]benzopyrano[3,4-b]pyridin-5-one 0
                                        4-methoxy-N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)benzamide 0
                                        6-methyl-4-(trifluoromethyl)-7,8,9,10-tetrahydropyrano[2,3-f]quinolin-2-one 0
                                        7,8-dihydroxy-3-methyl-10-oxo-10H-chromeno[3,2-c]pyridine-9-carboxylic acid 0
                                        9-hydroxy-4-[1-oxo-2-[4-(phenylmethyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-[1]benzopyrano[3,4-b]pyridin-5-one 0
                                        Mepranoprofen arbamel 0
                                        N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)-2-phenylacetamide 0
                                        N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)-4-(1-pyrrolidinylsulfonyl)benzamide 0
                                        Pranoprofen 17
                                        amlexanox 21
                                        traxanox 0
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