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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyridochromene
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Accession:CHEBI:53792 term browser browse the term
Definition:An organic heterotricyclic compound composed of a pyridine ring fused to a chromene.
Synonyms:related_synonym: chromenopyridine;   chromenopyridines;   pyridochromenes


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amlexanox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
amlexanox results in decreased expression of BAX protein
CTD PMID:31697998 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein] CTD PMID:31697998 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA] CTD PMID:31697998 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL2 mRNA] CTD PMID:31697998 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL1 mRNA] CTD PMID:31697998 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO [amlexanox binds to FGF1 protein] inhibits the reaction [cupric chloride results in increased oxidation of FGF1 protein]; amlexanox binds to and results in increased stability of and results in decreased secretion of FGF1 protein; amlexanox inhibits the reaction [FGF1 protein binds to FGF1 protein] CTD PMID:16300395 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLC mRNA; [Acetaminophen co-treated with amlexanox] affects the expression of GCLC mRNA
amlexanox results in increased expression of GCLC mRNA
CTD PMID:31697998 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLM mRNA CTD PMID:31697998 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:31697998 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO amlexanox affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA; amlexanox promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; dorsomorphin inhibits the reaction [[amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA]
amlexanox results in increased expression of HMOX1 mRNA
CTD PMID:31697998 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases activity
multiple interactions
ISO amlexanox results in decreased activity of IKBKE protein
amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of IKBKE protein]
CTD PMID:25321315, PMID:31697998 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA] CTD PMID:31697998 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA] CTD PMID:31697998 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
ISO amlexanox results in increased expression of NFE2L2 protein
[Acetaminophen co-treated with amlexanox] results in increased expression of NFE2L2 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]]
CTD PMID:31697998 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO dorsomorphin inhibits the reaction [[Acetaminophen co-treated with amlexanox] affects the expression of NQO1 mRNA] CTD PMID:31697998 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation
multiple interactions
ISO amlexanox results in increased phosphorylation of PRKAA1 protein
[Acetaminophen co-treated with amlexanox] results in increased phosphorylation of PRKAA1 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]]
CTD PMID:31697998 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of RELA protein] CTD PMID:31697998 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tbk1 TANK-binding kinase 1 decreases activity
decreases phosphorylation
multiple interactions
ISO amlexanox results in decreased activity of TBK1 protein
amlexanox results in decreased phosphorylation of TBK1 protein
amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of TBK1 protein]
CTD PMID:25321315, PMID:31697998 NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA] CTD PMID:31697998 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization ISO amlexanox affects the localization of UPF1 protein CTD PMID:28743738 NCBI chr16:20,824,888...20,845,632
Ensembl chr16:20,824,864...20,845,243
JBrowse link
Pranoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO pyranoprofen results in increased expression of AIFM1 protein CTD PMID:31765691 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO pyranoprofen results in increased phosphorylation of ATM protein CTD PMID:31765691 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO pyranoprofen results in increased expression of BAD protein CTD PMID:31765691 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO pyranoprofen results in increased expression of BAX protein CTD PMID:31765691 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO pyranoprofen results in decreased expression of BCL2 protein CTD PMID:31765691 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO pyranoprofen results in decreased expression of BCL2L1 protein CTD PMID:31765691 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO BDKRB2 protein affects the reaction [pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]] CTD PMID:16473424 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Casp2 caspase 2 increases activity ISO pyranoprofen results in increased activity of CASP2 protein CTD PMID:31765691 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases activity ISO pyranoprofen results in increased activity of CASP3 protein CTD PMID:31765691 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO pyranoprofen results in increased activity of CASP8 protein CTD PMID:31765691 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO pyranoprofen results in increased activity of CASP9 protein CTD PMID:31765691 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO B 4162 inhibits the reaction [pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]]; BDKRB2 protein affects the reaction [pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]]; pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium] CTD PMID:16473424 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase increases expression ISO pyranoprofen results in increased expression of MLKL protein CTD PMID:31765691 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO pyranoprofen results in increased activity of PPARG protein CTD PMID:12065695 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO pyranoprofen results in increased expression of PTGS2 mRNA CTD PMID:10594327 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases expression ISO pyranoprofen results in increased expression of RIPK1 protein CTD PMID:31765691 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression ISO pyranoprofen results in increased expression of RIPK3 protein CTD PMID:31765691 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19769
      molecular entity 19767
        polyatomic entity 19677
          molecule 19494
            cyclic compound 19271
              polycyclic compound 18259
                heteropolycyclic compound 17812
                  heterotricyclic compound 14569
                    organic heterotricyclic compound 14569
                      pyridochromene 36
                        10-hydroxy-3-methyl-8-pentyl-2,4-dihydro-1H-[1]benzopyrano[3,4-c]pyridin-5-one 0
                        2-amino-4-(4-bromophenyl)-5-oxo-1,4-dihydro[1]benzopyrano[4,3-b]pyridine-3-carbonitrile 0
                        4-[1-oxo-2-(1-piperidinyl)ethyl]-9-phenylmethoxy-2,3-dihydro-1H-[1]benzopyrano[3,4-b]pyridin-5-one 0
                        4-methoxy-N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)benzamide 0
                        6-methyl-4-(trifluoromethyl)-7,8,9,10-tetrahydropyrano[2,3-f]quinolin-2-one 0
                        7,8-dihydroxy-3-methyl-10-oxo-10H-chromeno[3,2-c]pyridine-9-carboxylic acid 0
                        9-hydroxy-4-[1-oxo-2-[4-(phenylmethyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-[1]benzopyrano[3,4-b]pyridin-5-one 0
                        Mepranoprofen arbamel 0
                        N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)-2-phenylacetamide 0
                        N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)-4-(1-pyrrolidinylsulfonyl)benzamide 0
                        Pranoprofen 17
                        amlexanox 21
                        traxanox 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic molecule 19461
                              organic cyclic compound 19232
                                organic heterocyclic compound 18404
                                  organic heteropolycyclic compound 17812
                                    organic heterotricyclic compound 14569
                                      pyridochromene 36
                                        10-hydroxy-3-methyl-8-pentyl-2,4-dihydro-1H-[1]benzopyrano[3,4-c]pyridin-5-one 0
                                        2-amino-4-(4-bromophenyl)-5-oxo-1,4-dihydro[1]benzopyrano[4,3-b]pyridine-3-carbonitrile 0
                                        4-[1-oxo-2-(1-piperidinyl)ethyl]-9-phenylmethoxy-2,3-dihydro-1H-[1]benzopyrano[3,4-b]pyridin-5-one 0
                                        4-methoxy-N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)benzamide 0
                                        6-methyl-4-(trifluoromethyl)-7,8,9,10-tetrahydropyrano[2,3-f]quinolin-2-one 0
                                        7,8-dihydroxy-3-methyl-10-oxo-10H-chromeno[3,2-c]pyridine-9-carboxylic acid 0
                                        9-hydroxy-4-[1-oxo-2-[4-(phenylmethyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-[1]benzopyrano[3,4-b]pyridin-5-one 0
                                        Mepranoprofen arbamel 0
                                        N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)-2-phenylacetamide 0
                                        N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)-4-(1-pyrrolidinylsulfonyl)benzamide 0
                                        Pranoprofen 17
                                        amlexanox 21
                                        traxanox 0
paths to the root

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