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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.1.1.205 (IMP dehydrogenase) inhibitor
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Accession:CHEBI:53746 term browser browse the term
Definition:An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of IMP dehydrogenase (EC 1.1.1.205), so blocking de novo biosynthesis of purine nucleotides.
Synonyms:related_synonym: EC 1.1.1.205 (IMP dehydrogenase) inhibitors;   EC 1.1.1.205 inhibitor;   EC 1.1.1.205 inhibitors;   IMP dehydrogenase inhibitor;   IMP dehydrogenase inhibitors;   IMP oxidoreductase inhibitor;   IMP oxidoreductase inhibitors;   IMP:NAD(+) oxidoreductase inhibitor;   IMP:NAD(+) oxidoreductase inhibitors;   inosinate dehydrogenase inhibitor;   inosinate dehydrogenase inhibitors;   inosine 5'-monophosphate dehydrogenase inhibitors;   inosine monophosphate dehydrogenase inhibitor;   inosine monophosphate dehydrogenase inhibitors;   inosine monophosphate oxidoreductase inhibitor;   inosine monophosphate oxidoreductase inhibitors;   inosinic acid dehydrogenase inhibitor;   inosinic acid dehydrogenase inhibitors


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  CHEBI ontology 494
    role 501
      biological role 494
        biochemical role 454
          enzyme inhibitor 367
            EC 1.* (oxidoreductase) inhibitor 34
              EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor 9
                EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor 6
                  EC 1.1.1.205 (IMP dehydrogenase) inhibitor 0
                    curcumin + 0
                    mycophenolate mofetil 0
                    mycophenolate sodium 0
                    mycophenolic acid + 0
                    ribavirin 5'-monophosphate 0
                    tiazofurine 0
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