CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 4-tolyl isocyanate
Accession: CHEBI:53732
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Definition: An isocyanate comprising a benzene core with isocyanato and methyl substituents para to each other.
Synonyms: exact_synonym: 1-isocyanato-4-methylbenzene
related_synonym: 4-Isocyanatotoluene; 4-Methylphenyl isocyanate; 4-Tol-NCO; Formula=C8H7NO; InChI=1S/C8H7NO/c1-7-2-4-8(5-3-7)9-6-10/h2-5H,1H3; InChIKey=MGYGFNQQGAQEON-UHFFFAOYSA-N; Isocyanic acid, p-tolyl ester; PTI; SMILES=Cc1ccc(cc1)N=C=O; TMI; p-Isocyanatotoluene; p-Methylphenyl isocyanate; p-TMI; p-Toluene isocyanate; p-Tolyl isocyanate; p-tolylmonoisocyanate; para-tolyl monoisocyanate
xref: Beilstein:471494; CAS:622-58-2
xref_mesh: MESH:C025637
xref: PMID:211841; PMID:21878336; PMID:24553658; PMID:2979745; PMID:3810654; PMID:4037253; PMID:6268767; PMID:6296214; PMID:6299614; PMID:6821040; Reaxys:471494
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Il10
interleukin 10
increases expression
EXP
4-tolyl isocyanate results in increased expression of IL10 mRNA
CTD
PMID:15664275
NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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Il13
interleukin 13
increases expression
EXP
4-tolyl isocyanate results in increased expression of IL13 mRNA
CTD
PMID:15664275
NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
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Il2
interleukin 2
increases expression
EXP
4-tolyl isocyanate results in increased expression of IL2 protein
CTD
PMID:22381623
NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
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Il4
interleukin 4
increases expression
EXP
4-tolyl isocyanate results in increased expression of IL4 mRNA; 4-tolyl isocyanate results in increased expression of IL4 protein
CTD
PMID:15664275 PMID:22381623
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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Il4ra
interleukin 4 receptor, alpha
increases expression
EXP
4-tolyl isocyanate results in increased expression of IL4RA protein
CTD
PMID:22381623
NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646
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