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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:divinyl sulfone
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Accession:CHEBI:53729 term browser browse the term
Definition:A sulfone compound having two S-vinyl substituents.
Synonyms:exact_synonym: 1,1'-sulfonyldiethene
 related_synonym: (CH2=CH)2SO2;   1,1'-Sulphonylbisethene;   1-(Vinylsulfonyl)ethylene;   Bis(ethenyl)sulfone;   Divinyl sulphone;   Ethenesulfonyl-ethene;   Formula=C4H6O2S;   InChI=1S/C4H6O2S/c1-3-7(5,6)4-2/h3-4H,1-2H2;   InChIKey=AFOSIXZFDONLBT-UHFFFAOYSA-N;   SMILES=C=CS(=O)(=O)C=C;   Vinyl sulfone;   vinyl sulphone
 alt_id: CHEBI:373213
 xref: Beilstein:1071329;   CAS:77-77-0;   Gmelin:558721
 xref_mesh: MESH:C009873
 xref: PMID:11696055;   PMID:12639572;   PMID:23842569;   PMID:24299766;   Reaxys:1071329



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divinyl sulfone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO divinyl sulfone analog results in decreased phosphorylation of AKT1 protein
Acetylcysteine inhibits the reaction [divinyl sulfone analog results in decreased phosphorylation of AKT1 protein]
CTD PMID:24875536 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Becn1 beclin 1 increases expression ISO divinyl sulfone analog results in increased expression of BECN1 protein CTD PMID:24875536 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO 3-methyladenine inhibits the reaction [divinyl sulfone analog results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [divinyl sulfone analog results in increased cleavage of PARP1 protein] CTD PMID:24875536 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        reagent 17469
          cross-linking reagent 7409
            divinyl sulfone 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            heteroorganic entity 19273
                              organochalcogen compound 19047
                                organosulfur compound 15317
                                  sulfone 3735
                                    divinyl sulfone 3
paths to the root