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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amidotrizoic acid
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Accession:CHEBI:53691 term browser browse the term
Definition:A member of the class of benzoic acids that is benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, mainly as its N-methylglucamine and sodium salts, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography.
Synonyms:exact_synonym: 3,5-diacetamido-2,4,6-triiodobenzoic acid
 related_synonym: 2,4,6-Triiodo-3,5-diacetamidobenzoic acid;   3,5-Bis(acetylamino)-2,4,6-triiodobenzoic acid;   Acide amidotrizoique;   Acidum amidotrizoicum;   Acidum diacetylaminotrijodbenzoicum;   Amidotrizoate;   Diatrizoate;   Diatrizoesaure;   Diatrizoic acid;   Formula=C11H9I3N2O4;   InChI=1S/C11H9I3N2O4/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18/h1-2H3,(H,15,17)(H,16,18)(H,19,20);   InChIKey=YVPYQUNUQOZFHG-UHFFFAOYSA-N;   Methalamic acid;   SMILES=CC(=O)Nc1c(I)c(NC(C)=O)c(I)c(C(O)=O)c1I;   Triombrin;   Urografin acid;   Urogranoic acid;   amidotrizoic acid (anhydrous);   diatrizoic acid (anhydrous)
 xref: Beilstein:2225144;   CAS:117-96-4;   DrugBank:DB00271;   Drug_Central:851;   HMDB:HMDB0014416;   KEGG:D02240
 xref_mesh: MESH:D003973
 xref: PMID:15206581;   PMID:1742128;   PMID:1910999;   PMID:24662206;   PMID:7756847;   Reaxys:2225144;   Wikipedia:Diatrizoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:59731


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amidotrizoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions
increases expression		 ISO telmisartan inhibits the reaction [Diatrizoate results in increased expression of AGT protein] CTD PMID:19452295 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation		 ISO Plant Extracts inhibits the reaction [Diatrizoate results in decreased phosphorylation of AKT1 protein] CTD PMID:25603236 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased expression of BAX protein CTD PMID:17173243 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased expression of BCL2 protein CTD PMID:17173243 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 affects expression
multiple interactions
increases activity		 ISO Diatrizoate affects the expression of CASP3 protein
[Diatrizoate co-treated with Iodine] results in increased activity of CASP3 protein
telmisartan inhibits the reaction [Diatrizoate results in increased activity of CASP3 protein]		 CTD PMID:17173243 PMID:19452295 PMID:21036957 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases secretion ISO Diatrizoate results in increased secretion of CXCL8 protein CTD PMID:21036957 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G F2 coagulation factor II multiple interactions ISO Diatrizoate inhibits the reaction [F2 protein binds to SERPINC1 protein] CTD PMID:2020943 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation
multiple interactions		 ISO Diatrizoate results in decreased phosphorylation of FOXO1 protein
Plant Extracts inhibits the reaction [Diatrizoate results in decreased phosphorylation of FOXO1 protein]		 CTD PMID:25603236 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642 		JBrowse link
G Foxo3 forkhead box O3 affects phosphorylation ISO Diatrizoate affects the phosphorylation of FOXO3 protein CTD PMID:21036957 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 affects phosphorylation
multiple interactions		 ISO Diatrizoate affects the phosphorylation of MAPK1 protein
Plant Extracts affects the reaction [Diatrizoate affects the phosphorylation of MAPK1 protein]		 CTD PMID:25603236 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
affects phosphorylation		 ISO Plant Extracts affects the reaction [Diatrizoate affects the phosphorylation of MAPK3 protein] CTD PMID:25603236 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Diatrizoate results in increased phosphorylation of MAPK8 protein CTD PMID:21036957 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Diatrizoate results in increased phosphorylation of MAPK9 protein CTD PMID:21036957 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Pim1 proviral integration site 1 decreases expression
multiple interactions		 ISO Diatrizoate results in decreased expression of PIM1 protein
Plant Extracts inhibits the reaction [Diatrizoate results in decreased expression of PIM1 protein]		 CTD PMID:25603236 NCBI chr17:29,709,759...29,715,085
Ensembl chr17:29,709,727...29,715,086 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) increases phosphorylation ISO Diatrizoate results in increased phosphorylation of RELA protein CTD PMID:21036957 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 multiple interactions ISO Diatrizoate inhibits the reaction [F2 protein binds to SERPINC1 protein] CTD PMID:2020943 NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects expression ISO Diatrizoate affects the expression of STAT3 protein modified form CTD PMID:21036957 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        xenobiotic 19695
          amidotrizoic acid 17
            amidotrizoic acid dihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      carboacyl group 18277
                                        univalent carboacyl group 18277
                                          carbamoyl group 18088
                                            carboxamide 18106
                                              acetamides 14656
                                                amidotrizoic acid 17
                                                  amidotrizoic acid dihydrate 0
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