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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amidotrizoic acid
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Accession:CHEBI:53691 term browser browse the term
Definition:A member of the class of benzoic acids that is benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, mainly as its N-methylglucamine and sodium salts, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography.
Synonyms:exact_synonym: 3,5-diacetamido-2,4,6-triiodobenzoic acid
 related_synonym: 2,4,6-Triiodo-3,5-diacetamidobenzoic acid;   3,5-Bis(acetylamino)-2,4,6-triiodobenzoic acid;   Acide amidotrizoique;   Acidum amidotrizoicum;   Acidum diacetylaminotrijodbenzoicum;   Amidotrizoate;   Diatrizoate;   Diatrizoesaure;   Diatrizoic acid;   Formula=C11H9I3N2O4;   InChI=1S/C11H9I3N2O4/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18/h1-2H3,(H,15,17)(H,16,18)(H,19,20);   InChIKey=YVPYQUNUQOZFHG-UHFFFAOYSA-N;   Methalamic acid;   SMILES=CC(=O)Nc1c(I)c(NC(C)=O)c(I)c(C(O)=O)c1I;   Triombrin;   Urografin acid;   Urogranoic acid;   amidotrizoic acid (anhydrous);   diatrizoic acid (anhydrous)
 xref: Beilstein:2225144;   CAS:117-96-4;   DrugBank:DB00271;   Drug_Central:851;   HMDB:HMDB0014416;   KEGG:D02240
 xref_mesh: MESH:D003973
 xref: PMID:15206581;   PMID:1742128;   PMID:1910999;   PMID:24662206;   PMID:7756847;   Reaxys:2225144;   Wikipedia:Diatrizoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:59731



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amidotrizoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Diatrizoate results in increased expression of AGT protein] CTD PMID:19452295 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO Plant Extracts inhibits the reaction [Diatrizoate results in decreased phosphorylation of AKT1 protein] CTD PMID:25603236 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased expression of BAX protein CTD PMID:17173243 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased expression of BCL2 protein CTD PMID:17173243 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 affects expression
multiple interactions
increases activity
ISO
EXP
Diatrizoate affects the expression of CASP3 protein
[Diatrizoate co-treated with Iodine] results in increased activity of CASP3 protein
telmisartan inhibits the reaction [Diatrizoate results in increased activity of CASP3 protein]
CTD PMID:17173243 PMID:19452295 PMID:21036957 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G F2 coagulation factor II multiple interactions ISO Diatrizoate inhibits the reaction [F2 protein binds to SERPINC1 protein] CTD PMID:2020943 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation
multiple interactions
ISO Diatrizoate results in decreased phosphorylation of FOXO1 protein
Plant Extracts inhibits the reaction [Diatrizoate results in decreased phosphorylation of FOXO1 protein]
CTD PMID:25603236 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Foxo3 forkhead box O3 affects phosphorylation ISO Diatrizoate affects the phosphorylation of FOXO3 protein CTD PMID:21036957 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation
multiple interactions
ISO Diatrizoate affects the phosphorylation of MAPK1 protein
Plant Extracts affects the reaction [Diatrizoate affects the phosphorylation of MAPK1 protein]
CTD PMID:25603236 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
affects phosphorylation
ISO Plant Extracts affects the reaction [Diatrizoate affects the phosphorylation of MAPK3 protein] CTD PMID:25603236 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Diatrizoate results in increased phosphorylation of MAPK8 protein CTD PMID:21036957 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Diatrizoate results in increased phosphorylation of MAPK9 protein CTD PMID:21036957 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase decreases expression
multiple interactions
ISO Diatrizoate results in decreased expression of PIM1 protein
Plant Extracts inhibits the reaction [Diatrizoate results in decreased expression of PIM1 protein]
CTD PMID:25603236 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation ISO Diatrizoate results in increased phosphorylation of RELA protein CTD PMID:21036957 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO Diatrizoate inhibits the reaction [F2 protein binds to SERPINC1 protein] CTD PMID:2020943 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects expression ISO Diatrizoate affects the expression of STAT3 protein modified form CTD PMID:21036957 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        xenobiotic 18434
          amidotrizoic acid 16
            amidotrizoic acid dihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      carboxylic acid 18341
                                        carboacyl group 17466
                                          univalent carboacyl group 17466
                                            carbamoyl group 17282
                                              carboxamide 17282
                                                acetamides 12410
                                                  amidotrizoic acid 16
                                                    amidotrizoic acid dihydrate 0
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