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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amidotrizoic acid
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Accession:CHEBI:53691 term browser browse the term
Definition:A member of the class of benzoic acids that is benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, mainly as its N-methylglucamine and sodium salts, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography.
Synonyms:exact_synonym: 3,5-diacetamido-2,4,6-triiodobenzoic acid
 related_synonym: 2,4,6-Triiodo-3,5-diacetamidobenzoic acid;   3,5-Bis(acetylamino)-2,4,6-triiodobenzoic acid;   Acide amidotrizoique;   Acidum amidotrizoicum;   Acidum diacetylaminotrijodbenzoicum;   Amidotrizoate;   Diatrizoate;   Diatrizoesaure;   Diatrizoic acid;   Formula=C11H9I3N2O4;   InChI=1S/C11H9I3N2O4/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18/h1-2H3,(H,15,17)(H,16,18)(H,19,20);   InChIKey=YVPYQUNUQOZFHG-UHFFFAOYSA-N;   Methalamic acid;   SMILES=CC(=O)Nc1c(I)c(NC(C)=O)c(I)c(C(O)=O)c1I;   Triombrin;   Urografin acid;   Urogranoic acid;   amidotrizoic acid (anhydrous);   diatrizoic acid (anhydrous)
 xref: Beilstein:2225144;   CAS:117-96-4;   DrugBank:DB00271;   Drug_Central:851;   HMDB:HMDB0014416;   KEGG:D02240
 xref_mesh: MESH:D003973
 xref: PMID:15206581;   PMID:1742128;   PMID:1910999;   PMID:24662206;   PMID:7756847;   Reaxys:2225144;   Wikipedia:Diatrizoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:59731


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amidotrizoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Diatrizoate results in increased expression of AGT protein] CTD PMID:19452295 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO Plant Extracts inhibits the reaction [Diatrizoate results in decreased phosphorylation of AKT1 protein] CTD PMID:25603236 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased expression of BAX protein CTD PMID:17173243 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Diatrizoate co-treated with Iodine] results in increased expression of BCL2 protein CTD PMID:17173243 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 affects expression
multiple interactions
increases activity
ISO
EXP
Diatrizoate affects the expression of CASP3 protein
[Diatrizoate co-treated with Iodine] results in increased activity of CASP3 protein
telmisartan inhibits the reaction [Diatrizoate results in increased activity of CASP3 protein]
CTD PMID:17173243 PMID:19452295 PMID:21036957 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G F2 coagulation factor II multiple interactions ISO Diatrizoate inhibits the reaction [F2 protein binds to SERPINC1 protein] CTD PMID:2020943 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation
multiple interactions
ISO Diatrizoate results in decreased phosphorylation of FOXO1 protein
Plant Extracts inhibits the reaction [Diatrizoate results in decreased phosphorylation of FOXO1 protein]
CTD PMID:25603236 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Foxo3 forkhead box O3 affects phosphorylation ISO Diatrizoate affects the phosphorylation of FOXO3 protein CTD PMID:21036957 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation
multiple interactions
ISO Diatrizoate affects the phosphorylation of MAPK1 protein
Plant Extracts affects the reaction [Diatrizoate affects the phosphorylation of MAPK1 protein]
CTD PMID:25603236 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
affects phosphorylation
ISO Plant Extracts affects the reaction [Diatrizoate affects the phosphorylation of MAPK3 protein] CTD PMID:25603236 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Diatrizoate results in increased phosphorylation of MAPK8 protein CTD PMID:21036957 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Diatrizoate results in increased phosphorylation of MAPK9 protein CTD PMID:21036957 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase decreases expression
multiple interactions
ISO Diatrizoate results in decreased expression of PIM1 protein
Plant Extracts inhibits the reaction [Diatrizoate results in decreased expression of PIM1 protein]
CTD PMID:25603236 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation ISO Diatrizoate results in increased phosphorylation of RELA protein CTD PMID:21036957 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO Diatrizoate inhibits the reaction [F2 protein binds to SERPINC1 protein] CTD PMID:2020943 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects expression ISO Diatrizoate affects the expression of STAT3 protein modified form CTD PMID:21036957 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        xenobiotic 18393
          amidotrizoic acid 16
            amidotrizoic acid dihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        carboacyl group 17412
                                          univalent carboacyl group 17412
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                acetamides 12395
                                                  amidotrizoic acid 16
                                                    amidotrizoic acid dihydrate 0
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