biguanides - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	biguanides	go back to main search page
Accession:	CHEBI:53662	browse the term
Definition:	A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton.
Synonyms:	alt_id:	CHEBI:35529
	xref_mesh:	MESH:D001645

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Rat (456 ) Mouse (428 ) Human (433 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (456)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

increases phosphorylation

EXP

Biguanides results in increased phosphorylation of ACACA protein

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,511,857...69,773,888

G

catalase

increases activity

EXP

Biguanides results in increased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

GATA binding protein 5

affects expression

ISO

Biguanides analog affects the expression of GATA5 mRNA

NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:187,796,142...187,804,327

G

H3.4 histone, cluster member

affects methylation

ISO

Biguanides analog affects the methylation of H3-4 protein

NCBI chr10:43,740,702...43,741,262

G

lysine demethylase 1A

decreases activity

ISO

Biguanides analog results in decreased activity of KDM1A protein

NCBI chr 5:154,066,436...154,121,913
Ensembl chr 5:154,065,543...154,121,775

G

ribosomal protein S6

decreases phosphorylation

EXP

Biguanides results in decreased phosphorylation of RPS6 protein

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:106,417,680...106,420,566

G

secreted frizzled-related protein 1

affects expression

ISO

Biguanides analog affects the expression of SFRP1 mRNA

NCBI chr16:75,278,325...75,316,736
Ensembl chr16:75,278,325...75,316,736

G

secreted frizzled-related protein 4

affects expression

ISO

Biguanides analog affects the expression of SFRP4 mRNA

NCBI chr17:49,974,532...50,026,448
Ensembl chr17:50,015,812...50,026,395

G

secreted frizzled-related protein 5

affects expression

ISO

Biguanides analog affects the expression of SFRP5 mRNA

NCBI chr 1:250,956,050...250,960,512
Ensembl chr 1:250,956,050...250,960,512

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 3

increases expression
multiple interactions

ISO

alexidine results in increased expression of ATF3 mRNA
MTF1 protein affects the reaction [alexidine results in increased expression of ATF3 mRNA]

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:105,282,440...105,295,750

G

C-C motif chemokine ligand 2

decreases expression

ISO

alexidine results in decreased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

decreases expression

ISO

alexidine results in decreased expression of CCL3 protein

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 4

decreases expression

ISO

alexidine results in decreased expression of CCL4 protein

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,950,289...68,965,722

G

C-C motif chemokine ligand 5

decreases expression

ISO

alexidine results in decreased expression of CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,738,651...68,824,884

G

heme oxygenase 1

increases expression

ISO

alexidine results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

interleukin 6 receptor

decreases expression

ISO

alexidine results in decreased expression of IL6R protein modified form

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

microtubule-associated protein tau

decreases expression

ISO

alexidine results in decreased expression of MAPT protein

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

metallothionein 2

increases expression

ISO

alexidine results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,837,927...10,838,709

G

metal-regulatory transcription factor 1

multiple interactions

ISO

MTF1 protein affects the reaction [alexidine results in increased expression of ATF3 mRNA]; MTF1 protein affects the reaction [alexidine results in increased expression of MT1M mRNA]

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:142,347,054...142,391,810

G

vascular endothelial growth factor A

decreases expression

ISO

alexidine results in decreased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

ISO

Chlorhexidine results in decreased activity of ACHE protein

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

heat shock protein family A (Hsp70) member 5

increases expression

ISO

Chlorhexidine results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

iodotyrosine deiodinase

multiple interactions

ISO

Chlorhexidine inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]

NCBI chr 1:42,410,099...42,425,414
Ensembl chr 1:42,410,130...42,426,386

G

solute carrier family 22 member 2

multiple interactions

ISO

Chlorhexidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

chlorhexidine gluconate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutamic--pyruvic transaminase

increases secretion

EXP

chlorhexidine gluconate results in increased secretion of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

m-Chlorophenylbiguanide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

1-(3-chlorophenyl)biguanide results in increased expression of FOS protein

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

5-hydroxytryptamine receptor 3A

multiple interactions
decreases expression

EXP

BESEB CDRI-08 inhibits the reaction [1-(3-chlorophenyl)biguanide results in decreased expression of HTR3A mRNA]

NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

decreases expression

EXP

Phenformin results in decreased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:156,569,860...156,619,868

G

ATP binding cassette subfamily B member 4

increases expression

EXP

Phenformin results in increased expression of ABCB4 mRNA

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 3

increases expression

EXP

Phenformin results in increased expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily D member 2

increases expression

EXP

Phenformin results in increased expression of ABCD2 mRNA

NCBI chr 7:124,142,597...124,191,202
Ensembl chr 7:124,142,595...124,191,202

G

ATP binding cassette subfamily G member 2

decreases expression

EXP

Phenformin results in decreased expression of ABCG2 mRNA

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

ATP binding cassette subfamily G member 5

increases expression

EXP

Phenformin results in increased expression of ABCG5 mRNA

NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376

G

ATP binding cassette subfamily G member 8

increases expression

EXP

Phenformin results in increased expression of ABCG8 mRNA

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:15,698,448...15,717,730

G

actin-binding Rho activating protein

decreases expression

EXP

Phenformin results in decreased expression of ABRA mRNA

NCBI chr 7:72,970,187...72,974,255
Ensembl chr 7:74,855,007...74,859,076

G

acetyl-CoA carboxylase alpha

decreases expression

EXP

Phenformin results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,511,857...69,773,888

G

atypical chemokine receptor 3

decreases expression

EXP

Phenformin results in decreased expression of ACKR3 mRNA

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:98,246,605...98,260,214

G

ATP citrate lyase

decreases expression

EXP

Phenformin results in decreased expression of ACLY mRNA

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,912,402...85,963,631

G

aminocarboxymuconate semialdehyde decarboxylase

increases expression

EXP

Phenformin results in increased expression of ACMSD mRNA

NCBI chr13:39,200,412...39,245,954
Ensembl chr13:41,752,875...41,798,427

G

acyl-CoA synthetase long-chain family member 3

decreases expression

EXP

Phenformin results in decreased expression of ACSL3 mRNA

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:87,563,601...87,613,097

G

actin, gamma 1

decreases expression

EXP

Phenformin results in decreased expression of ACTG1 mRNA

NCBI chr10:106,118,106...106,120,951
Ensembl chr10:106,118,108...106,120,951

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

decreases expression

EXP

Phenformin results in decreased expression of ADAMTS1 mRNA

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:38,418,101...38,427,390

G

alcohol dehydrogenase 4 (class II), pi polypeptide

increases expression

EXP

Phenformin results in increased expression of ADH4 mRNA

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:229,622,095...229,641,879

G

alcohol dehydrogenase 6 (class V)

increases expression

EXP

Phenformin results in increased expression of ADH6 mRNA

NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:229,576,636...229,607,914

G

arylformamidase

decreases expression

EXP

Phenformin results in decreased expression of AFMID mRNA

NCBI chr10:103,046,129...103,061,718
Ensembl chr10:103,544,841...103,560,408

G

alanine--glyoxylate aminotransferase

increases expression

EXP

Phenformin results in increased expression of AGXT mRNA

NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:101,122,793...101,132,745

G

aldo-keto reductase family 1, member B8, pseudogene 2

decreases expression

EXP

Phenformin results in decreased expression of AKR1B8-PS2 mRNA

NCBI chr 6:77,569,720...77,571,967

G

AKT serine/threonine kinase 1

increases phosphorylation

ISO

Phenformin results in increased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

5'-aminolevulinate synthase 2

decreases expression

EXP

Phenformin results in decreased expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:22,890,689...22,914,043

G

aldehyde dehydrogenase 1 family, member A1

increases expression

EXP

Phenformin results in increased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase family 1, subfamily A7

increases expression

EXP

Phenformin results in increased expression of ALDH1A7 mRNA

NCBI chr 1:218,201,443...218,241,410
Ensembl chr 1:227,627,448...227,672,523

G

arachidonate 15-lipoxygenase

decreases expression

EXP

Phenformin results in decreased expression of ALOX15 mRNA

NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723

G

alpha-methylacyl-CoA racemase

increases expression

EXP

Phenformin results in increased expression of AMACR mRNA

NCBI chr 2:61,673,291...61,685,381
Ensembl chr 2:61,670,475...61,685,379

G

amidohydrolase domain containing 1

increases expression

EXP

Phenformin results in increased expression of AMDHD1 mRNA

NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:29,929,965...29,959,683

G

amylase 2a3

increases expression

EXP

Phenformin results in increased expression of AMY2A3 mRNA

NCBI chr 2:201,317,916...201,326,487
Ensembl chr 2:204,005,840...204,014,413

G

angiopoietin-like 4

affects expression

EXP

Phenformin affects the expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:15,252,473...15,258,681

G

angiopoietin-like 8

decreases expression

EXP

Phenformin results in decreased expression of ANGPTL8 mRNA

NCBI chr 8:20,376,462...20,378,488
Ensembl chr 8:28,652,555...28,654,581

G

ANKH inorganic pyrophosphate transport regulator

decreases expression

EXP

Phenformin results in decreased expression of ANKH mRNA

NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:79,883,544...80,011,699

G

anillin, actin binding protein-like 1

decreases expression

EXP

Phenformin results in decreased expression of ANLNL1 mRNA

NCBI chr17:57,985,340...57,995,824
Ensembl chr17:62,678,232...62,681,718

G

anoctamin 5

decreases expression

EXP

Phenformin results in decreased expression of ANO5 mRNA

NCBI chr 1:101,086,490...101,187,547
Ensembl chr 1:110,222,446...110,323,501

G

APC down-regulated 1

increases expression

EXP

Phenformin results in increased expression of APCDD1 mRNA

NCBI chr18:58,655,696...58,686,359
Ensembl chr18:58,655,919...58,686,356

G

aph-1 homolog B, gamma secretase subunit

decreases expression

EXP

Phenformin results in decreased expression of APH1B mRNA

NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:76,310,380...76,331,428

G

apelin receptor

increases expression

EXP

Phenformin results in increased expression of APLNR mRNA

NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:90,624,012...90,627,908

G

apolipoprotein A4

decreases expression

EXP

Phenformin results in decreased expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:55,434,168...55,438,164

G

apolipoprotein C4

increases expression

EXP

Phenformin results in increased expression of APOC4 mRNA

NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:88,463,713...88,468,044

G

apolipoprotein F

increases expression

EXP

Phenformin results in increased expression of APOF mRNA

NCBI chr 7:700,688...702,130
Ensembl chr 7:1,285,222...1,286,659

G

apolipoprotein L domain containing 1

decreases expression

EXP

Phenformin results in decreased expression of APOLD1 mRNA

NCBI chr 4:167,768,437...167,825,706
Ensembl chr 4:169,549,679...169,559,176

G

aquaporin 7

increases expression

EXP

Phenformin results in increased expression of AQP7 mRNA

NCBI chr 5:60,968,495...60,982,618
Ensembl chr 5:60,967,558...60,982,618

G

aquaporin 9

increases expression

EXP

Phenformin results in increased expression of AQP9 mRNA

NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240

G

androgen receptor

decreases expression

EXP

Phenformin results in decreased expression of AR mRNA

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

Rho GTPase activating protein 11A

decreases expression

EXP

Phenformin results in decreased expression of ARHGAP11A mRNA

NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:121,045,187...121,061,468

G

arrestin domain containing 4

increases expression

EXP

Phenformin results in increased expression of ARRDC4 mRNA

NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:131,779,437...131,793,565

G

argininosuccinate lyase

increases expression

EXP

Phenformin results in increased expression of ASL mRNA

NCBI chr12:26,659,664...26,677,136
Ensembl chr12:32,295,633...32,317,261

G

assembly factor for spindle microtubules

decreases expression

EXP

Phenformin results in decreased expression of ASPM mRNA

NCBI chr13:53,625,584...53,674,489
Ensembl chr13:53,625,584...53,674,489

G

asporin

decreases expression

EXP

Phenformin results in decreased expression of ASPN mRNA

NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,287,065...15,310,632

G

activating transcription factor 3

decreases expression

EXP

Phenformin results in decreased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:105,282,440...105,295,750

G

aurora kinase B

decreases expression

EXP

Phenformin results in decreased expression of AURKB mRNA

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:54,242,850...54,252,285

G

brain expressed X-linked 2

increases expression

EXP

Phenformin results in increased expression of BEX1 mRNA

NCBI chr X:99,019,847...99,021,375
Ensembl chr X:103,808,935...103,812,092

G

basic helix-loop-helix family, member e40

decreases expression

EXP

Phenformin results in decreased expression of BHLHE40 mRNA

NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:143,174,048...143,180,783

G

BTG anti-proliferation factor 2

decreases expression

EXP

Phenformin results in decreased expression of BTG2 mRNA

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

EXP

Phenformin results in decreased expression of BUB1 mRNA

NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:135,472,582...135,504,921

G

similar to human chromosome 11 open reading frame 54

decreases expression

EXP

Phenformin results in decreased expression of C8H11ORF54 mRNA

NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:20,405,241...20,427,811

G

carbonic anhydrase 5A

increases expression

EXP

Phenformin results in increased expression of CAR5A mRNA

NCBI chr19:66,881,678...66,911,486
Ensembl chr19:66,881,693...66,911,486

G

carbonic anhydrase 5B

decreases expression

EXP

Phenformin results in decreased expression of CAR5B mRNA

NCBI chr X:30,474,697...30,534,797
Ensembl chr X:34,067,403...34,166,653

G

coiled-coil domain containing 141

decreases expression

EXP

Phenformin results in decreased expression of CCDC141 mRNA

NCBI chr 3:82,357,046...82,517,199
Ensembl chr 3:82,357,681...82,517,710

G

coiled-coil domain containing 38

increases expression

EXP

Phenformin results in increased expression of CCDC38 mRNA

NCBI chr 7:28,055,883...28,129,938
Ensembl chr 7:29,946,783...30,017,504

G

coiled-coil domain containing 77

increases expression

EXP

Phenformin results in increased expression of CCDC77 mRNA

NCBI chr 4:153,534,184...153,566,059
Ensembl chr 4:155,193,275...155,239,207

G

C-C motif chemokine ligand 2

decreases expression

EXP

Phenformin results in decreased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cellular communication network factor 2

decreases expression

EXP

Phenformin results in decreased expression of CCN2 mRNA

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cyclin A2

decreases expression

EXP

Phenformin results in decreased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

decreases expression

EXP

Phenformin results in decreased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin B2

affects expression

EXP

Phenformin affects the expression of CCNB2 mRNA

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682

G

cyclin D1

increases expression

EXP

Phenformin results in increased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin E2

decreases expression

EXP

Phenformin results in decreased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

CD226 molecule

decreases expression

EXP

Phenformin results in decreased expression of CD226 mRNA

NCBI chr18:84,723,330...84,819,836
Ensembl chr18:84,725,242...84,819,835

G

CD274 molecule

increases expression

EXP

Phenformin results in increased expression of CD274 mRNA

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:236,496,463...236,549,951

G

Cd5 molecule-like

increases expression

EXP

Phenformin results in increased expression of CD5L mRNA

NCBI chr 2:175,088,915...175,099,928
Ensembl chr 2:175,088,884...175,099,926

G

Cd63 molecule

increases expression

EXP

Phenformin results in increased expression of CD63 mRNA

NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,922,169...1,924,938

G

CD74 molecule

increases expression

EXP

Phenformin results in increased expression of CD74 mRNA

NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410

G

cell division cycle 20

decreases expression

EXP

Phenformin results in decreased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cyclin-dependent kinase 1

decreases expression

EXP

Phenformin results in decreased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase inhibitor 1A

increases expression
decreases expression

ISO
EXP

Phenformin results in increased expression of CDKN1A protein
Phenformin results in decreased expression of CDKN1A mRNA

PMID:14623034 PMID:31324951

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 3

decreases expression

EXP

Phenformin results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:22,502,382...22,513,722

G

cell migration inducing hyaluronidase 2

decreases expression

EXP

Phenformin results in decreased expression of CEMIP2 mRNA

NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:228,757,466...228,832,906

G

centromere protein E

decreases expression

EXP

Phenformin results in decreased expression of CENPE mRNA

NCBI chr 2:226,310,970...226,369,636
Ensembl chr 2:226,300,798...226,369,636

G

centromere protein F

decreases expression

EXP

Phenformin results in decreased expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:103,715,344...103,760,886

G

carboxylesterase 2C

increases expression

EXP

Phenformin results in increased expression of CES2C mRNA

NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:270,374,913...270,384,801

G

carboxylesterase 4A

decreases expression

EXP

Phenformin results in decreased expression of CES4A mRNA

NCBI chr19:33,011,731...33,030,119
Ensembl chr19:49,921,608...49,939,461

G

choline kinase alpha

decreases expression

EXP

Phenformin results in decreased expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:210,506,056...210,554,752

G

cytokine inducible SH2-containing protein

decreases expression

EXP

Phenformin results in decreased expression of CISH mRNA

NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:116,850,773...116,855,986

G

cytoskeleton associated protein 2

decreases expression

EXP

Phenformin results in decreased expression of CKAP2 mRNA

NCBI chr16:76,542,114...76,567,297
Ensembl chr16:76,542,104...76,567,352

G

CDC28 protein kinase regulatory subunit 2

decreases expression

EXP

Phenformin results in decreased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770
Ensembl chr17:13,722,361...13,727,519

G

C-type lectin domain family 1, member A

decreases expression

EXP

Phenformin results in decreased expression of CLEC1A mRNA

NCBI chr 4:162,875,360...162,902,571
Ensembl chr 4:164,563,374...164,587,269

G

C-type lectin domain family 1, member B

decreases expression

EXP

Phenformin results in decreased expression of CLEC1B mRNA

NCBI chr 4:162,847,978...162,856,291
Ensembl chr 4:164,534,055...164,542,867

G

copine 8

increases expression

EXP

Phenformin results in increased expression of CPNE8 mRNA

NCBI chr 7:121,615,293...121,789,507
Ensembl chr 7:123,494,865...123,669,060

G

carnitine palmitoyltransferase 1A

increases expression

EXP

Phenformin results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:209,993,875...210,056,326

G

carnitine O-acetyltransferase

increases expression

EXP

Phenformin results in increased expression of CRAT mRNA

NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:34,073,506...34,087,099

G

carnitine O-octanoyltransferase

increases expression

EXP

Phenformin results in increased expression of CROT mRNA

NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:26,052,516...26,088,064

G

cryptochrome circadian regulator 1

decreases expression

EXP

Phenformin results in decreased expression of CRY1 mRNA

NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:20,417,107...20,481,822

G

crystallin, lambda 1

increases expression

EXP

Phenformin results in increased expression of CRYL1 mRNA

NCBI chr15:31,427,011...31,545,997
Ensembl chr15:35,542,628...35,661,563

G

cysteine sulfinic acid decarboxylase

decreases expression

EXP

Phenformin results in decreased expression of CSAD mRNA

NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:135,187,175...135,215,581

G

cysteine and glycine-rich protein 1

decreases expression

EXP

Phenformin results in decreased expression of CSRP1 mRNA

NCBI chr13:47,158,171...47,179,388
Ensembl chr13:49,709,914...49,731,139

G

C-X-C motif chemokine ligand 1

decreases expression

EXP

Phenformin results in decreased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

decreases expression

EXP

Phenformin results in decreased expression of CXCL10 mRNA

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine receptor 4

increases expression

EXP

Phenformin results in increased expression of CXCR4 mRNA

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

EXP

Phenformin results in decreased expression of CYP17A1 mRNA

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

EXP

Phenformin results in increased expression of CYP2B1 mRNA

NCBI chr 1:81,518,387...81,544,999

G

cytochrome P450, family 2, subfamily c, polypeptide 12

decreases expression

EXP

Phenformin results in decreased expression of CYP2C12 mRNA

NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:248,619,882...248,677,042

G

cytochrome P450, family 2, subfamily c, polypeptide 24

increases expression

EXP

Phenformin results in increased expression of CYP2C24 mRNA

NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:246,286,341...246,348,607

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

EXP

Phenformin results in increased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 18

increases expression

EXP

Phenformin results in increased expression of CYP3A18 mRNA

NCBI chr12:8,880,509...8,930,382
Ensembl chr12:13,994,311...14,045,788

G

cytochrome P450, family 4, subfamily a, polypeptide 1

increases expression

EXP

Phenformin results in increased expression of CYP4A1 mRNA

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231

G

cytochrome P450, family 4, subfamily a, polypeptide 2

increases expression

EXP

Phenformin results in increased expression of CYP4A2 mRNA

NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:134,160,358...134,176,156

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

EXP

Phenformin results in decreased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytochrome P450 family 8 subfamily B member 1

increases expression

EXP

Phenformin results in increased expression of CYP8B1 mRNA

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689

G

D-box binding PAR bZIP transcription factor

increases expression

EXP

Phenformin results in increased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:105,312,108...105,317,205

G

decorin

decreases expression

EXP

Phenformin results in decreased expression of DCN mRNA

NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926

G

DDHD domain containing 1

increases expression

EXP

Phenformin results in increased expression of DDHD1 mRNA

NCBI chr15:21,304,053...21,370,608
Ensembl chr15:21,303,826...21,370,608

G

DNA-damage-inducible transcript 4

decreases expression

EXP

Phenformin results in decreased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:28,434,944...28,437,037

G

2,4-dienoyl-CoA reductase 1

increases expression

EXP

Phenformin results in increased expression of DECR1 mRNA

NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:34,208,195...34,236,033

G

DEP domain containing 1

decreases expression

EXP

Phenformin results in decreased expression of DEPDC1 mRNA

NCBI chr 2:248,684,508...248,717,951
Ensembl chr 2:251,343,281...251,376,709

G

diaphanous-related formin 3

decreases expression

EXP

Phenformin results in decreased expression of DIAPH3 mRNA

NCBI chr15:68,951,992...69,421,623
Ensembl chr15:68,951,989...69,421,552

G

iodothyronine deiodinase 1

decreases expression

EXP

Phenformin results in decreased expression of DIO1 mRNA

NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771

G

deleted in malignant brain tumors 1

increases expression

EXP

Phenformin results in increased expression of DMBT1 mRNA

NCBI chr 1:195,047,702...195,126,704
Ensembl chr 1:195,047,713...195,126,704

G

Dmx-like 2

decreases expression

EXP

Phenformin results in decreased expression of DMXL2 mRNA

NCBI chr 8:63,637,314...63,803,911
Ensembl chr 8:63,637,314...63,781,116

G

dual specificity phosphatase 1

decreases expression

EXP

Phenformin results in decreased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

enoyl-CoA hydratase 1

increases expression

EXP

Phenformin results in increased expression of ECH1 mRNA

NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:93,241,734...93,248,440

G

enoyl-CoA delta isomerase 1

increases expression

EXP

Phenformin results in increased expression of ECI1 mRNA

NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,961,218...13,974,773

G

epithelial cell transforming 2

decreases expression

EXP

Phenformin results in decreased expression of ECT2 mRNA

NCBI chr 2:111,904,522...111,966,786
Ensembl chr 2:111,904,522...111,966,626

G

ER degradation enhancing alpha-mannosidase like protein 1

decreases expression

EXP

Phenformin results in decreased expression of EDEM1 mRNA

NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:143,353,624...143,388,060

G

EGF like repeats and discoidin domains 3

decreases expression

EXP

Phenformin results in decreased expression of EDIL3 mRNA

NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:21,625,596...22,140,379

G

early growth response 1

decreases expression

EXP

Phenformin results in decreased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

elongation factor for RNA polymerase II 2

decreases expression

EXP

Phenformin results in decreased expression of ELL2 mRNA

NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:6,921,771...7,016,199

G

ELOVL fatty acid elongase 2

increases expression

EXP

Phenformin results in increased expression of ELOVL2 mRNA

NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,750,350...23,790,601

G

ELOVL fatty acid elongase 6

decreases expression

EXP

Phenformin results in decreased expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:220,738,064...220,845,549

G

glutamate-rich 5

decreases expression

EXP

Phenformin results in decreased expression of ERICH5 mRNA

NCBI chr 7:65,655,829...65,682,221
Ensembl chr 7:67,536,588...67,563,989

G

ERBB receptor feedback inhibitor 1

decreases expression

EXP

Phenformin results in decreased expression of ERRFI1 mRNA

NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:166,606,834...166,620,432

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

EXP

Phenformin results in decreased expression of ESCO2 mRNA

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:44,210,641...44,231,304
Ensembl chr15:44,210,641...44,231,304

G

endothelial cell-specific molecule 1

increases expression

EXP

Phenformin results in increased expression of ESM1 mRNA

NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:46,609,204...46,617,990

G

coagulation factor II (thrombin) receptor-like 2

decreases expression

EXP

Phenformin results in decreased expression of F2RL2 mRNA

NCBI chr 2:28,706,766...28,711,808
Ensembl chr 2:28,706,501...28,712,473

G

coagulation factor III, tissue factor

decreases expression

EXP

Phenformin results in decreased expression of F3 mRNA

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

fatty acid binding protein 5

decreases expression

EXP

Phenformin results in decreased expression of FABP5 mRNA

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:93,672,458...93,676,127

G

FAM111 trypsin like peptidase A

decreases expression

EXP

Phenformin results in decreased expression of FAM111A mRNA

NCBI chr 1:219,065,542...219,081,213
Ensembl chr 1:219,065,601...219,081,211

G

family with sequence similarity 117, member B

increases expression

EXP

Phenformin results in increased expression of FAM117B mRNA

NCBI chr 9:61,340,284...61,418,531
Ensembl chr 9:68,834,354...68,902,543

G

family with sequence similarity 149, member A

decreases expression

EXP

Phenformin results in decreased expression of FAM149A mRNA

NCBI chr16:46,855,377...46,914,553
Ensembl chr16:53,587,841...53,647,072

G

family with sequence similarity 83, member D

decreases expression

EXP

Phenformin results in decreased expression of FAM83D mRNA

NCBI chr 3:167,841,748...167,861,062
Ensembl chr 3:167,841,791...167,861,061

G

fatty acid synthase

decreases expression

EXP

Phenformin results in decreased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

fibroblast growth factor 6

increases expression

EXP

Phenformin results in increased expression of MT1F mRNA

NCBI chr 4:159,854,913...159,863,447
Ensembl chr 4:161,541,089...161,553,521

G

flavin containing dimethylaniline monoxygenase 2

decreases expression

EXP

Phenformin results in decreased expression of FMO2 mRNA

NCBI chr13:75,221,149...75,244,377
Ensembl chr13:77,757,629...77,777,534

G

flavin containing dimethylaniline monoxygenase 5

increases expression

EXP

Phenformin results in increased expression of FMO5 mRNA

NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:187,910,964...187,938,464

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

Phenformin results in decreased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

forkhead box A1

decreases expression

EXP

Phenformin results in decreased expression of FOXA1 mRNA

NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:80,800,960...80,871,191

G

forkhead box A2

decreases expression

EXP

Phenformin results in decreased expression of FOXA2 mRNA

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:155,923,307...155,928,757

G

forkhead box O3

decreases expression

EXP

Phenformin results in decreased expression of FOXO3 mRNA

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

formyl peptide receptor 1

decreases expression

EXP

Phenformin results in decreased expression of FPR1 mRNA

NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:67,421,313...67,422,520

G

Fraser extracellular matrix complex subunit 1

decreases expression

EXP

Phenformin results in decreased expression of FRAS1 mRNA

NCBI chr14:12,791,407...13,200,862
Ensembl chr14:13,095,370...13,504,664

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

EXP

Phenformin results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,757,899...86,818,033

G

growth arrest and DNA-damage-inducible, gamma

decreases expression

EXP

Phenformin results in decreased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,528,610...13,530,369

G

1,4-alpha-glucan branching enzyme 1

decreases expression

EXP

Phenformin results in decreased expression of GBE1 mRNA

NCBI chr11:8,734,806...9,000,226
Ensembl chr11:22,181,103...22,446,638

G

guanylate binding protein 1

increases expression

EXP

Phenformin results in increased expression of GBP1 mRNA

NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:234,190,708...234,206,802
Ensembl chr 2:234,190,708...234,206,802

G

guanylate binding protein 1, pseudogene 1

increases expression

EXP

Phenformin results in increased expression of GBP1-PS1 mRNA

NCBI chr 2:231,517,485...231,525,865
Ensembl chr 2:234,190,708...234,206,802

G

glucokinase

decreases expression

EXP

Phenformin results in decreased expression of GCK mRNA

NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949

G

GIMAP family P-loop NTPase domain containing 1

decreases expression

EXP

Phenformin results in decreased expression of GIMD1 mRNA

NCBI chr 2:221,103,878...221,138,559
Ensembl chr 2:223,777,889...223,812,576

G

glycerol kinase

increases expression

EXP

Phenformin results in increased expression of GK mRNA

NCBI chr X:50,162,089...50,238,707
Ensembl chr X:54,112,214...54,196,701

G

glycine N-methyltransferase

increases expression

EXP

Phenformin results in increased expression of GNMT mRNA

NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:21,752,266...21,755,692

G

glutamic-oxaloacetic transaminase 1

increases expression

EXP

Phenformin results in increased expression of GOT1 mRNA

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glycoprotein V (platelet)

decreases expression

EXP

Phenformin results in decreased expression of GP5 mRNA

NCBI chr11:70,443,613...70,446,705
Ensembl chr11:83,948,507...83,952,367

G

glycoprotein A33

increases expression

EXP

Phenformin results in increased expression of GPA33 mRNA

NCBI chr13:78,381,141...78,414,765
Ensembl chr13:80,912,430...80,948,903

G

glycerol-3-phosphate acyltransferase, mitochondrial

increases expression

EXP

Phenformin results in increased expression of GPAM mRNA

NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:264,113,813...264,175,911

G

glycerol-3-phosphate acyltransferase 3

increases expression

EXP

Phenformin results in increased expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051

G

glycerol-3-phosphate dehydrogenase 2

increases expression

EXP

Phenformin results in increased expression of GPD2 mRNA

NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:62,210,814...62,346,593

G

glycoprotein nmb

increases expression

EXP

Phenformin results in increased expression of GPNMB mRNA

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:79,341,021...79,380,240

G

GPRIN family member 3

decreases expression

EXP

Phenformin results in decreased expression of GPRIN3 mRNA

NCBI chr 4:88,572,062...88,657,369
Ensembl chr 4:89,892,867...89,987,565

G

glutamic--pyruvic transaminase

increases expression

EXP

Phenformin results in increased expression of GPT mRNA

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 2, pseudogene 2

affects expression

EXP

Phenformin affects the expression of GPX2-PS2 mRNA

NCBI chr X:59,444,660...59,445,203

G

glutathione S-transferase mu 2

increases expression

EXP

Phenformin results in increased expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase mu 4

increases expression

EXP

Phenformin results in increased expression of GSTM4 mRNA

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:198,358,744...198,373,638

G

glutathione S-transferase, mu 7

increases expression

EXP

Phenformin results in increased expression of GSTM7 mRNA

NCBI chr 2:195,566,701...195,572,149
Ensembl chr 2:198,254,875...198,260,373

G

glutathione S-transferase zeta 1

increases expression

EXP

Phenformin results in increased expression of GSTZ1 mRNA

NCBI chr 6:112,525,576...112,536,228
Ensembl chr 6:112,525,377...112,536,233

G

glycophorin A

decreases expression

EXP

Phenformin results in decreased expression of GYPA mRNA

NCBI chr19:27,450,304...27,465,940
Ensembl chr19:44,354,706...44,370,291

G

H2A clustered histone 4

decreases expression

EXP

Phenformin results in decreased expression of H2AC4 mRNA

NCBI chr17:47,495,624...47,496,127
Ensembl chr17:47,495,546...47,496,173

G

H2A.X variant histone

decreases expression

EXP

Phenformin results in decreased expression of H2AX mRNA

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

hepcidin antimicrobial peptide

decreases expression

EXP

Phenformin results in decreased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

hemoglobin subunit beta

decreases expression

EXP

Phenformin results in decreased expression of HBB-B1 mRNA

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873

G

hemoglobin, beta adult s chain

decreases expression

EXP

Phenformin results in decreased expression of HBB-BS mRNA

NCBI chr 1:158,218,356...158,219,741

G

hematopoietically expressed homeobox

decreases expression

EXP

Phenformin results in decreased expression of HHEX mRNA

NCBI chr 1:244,602,945...244,608,532
Ensembl chr 1:244,602,825...244,608,604

G

hypoxia inducible factor 1 subunit alpha

increases expression

ISO

Phenformin results in increased expression of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

histone cluster 1 H2A family member F

decreases expression

EXP

Phenformin results in decreased expression of HIST1H2AF mRNA

NCBI chr17:41,379,404...41,379,796

G

histone cluster 1 H2a family member I like 1

decreases expression

EXP

Phenformin results in decreased expression of HIST1H2AIL1 mRNA

NCBI chr17:41,568,181...41,569,093
Ensembl chr17:47,493,820...47,494,861
Ensembl chr17:47,493,820...47,494,861

G

histone cluster 2 H3 family member C2

decreases expression

EXP

Phenformin results in decreased expression of HIST2H3C2 mRNA

NCBI chr 2:183,837,296...183,837,721
Ensembl chr 2:186,521,116...186,550,846

G

HLF transcription factor, PAR bZIP family member

decreases expression

EXP

Phenformin results in decreased expression of HLF mRNA

NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,654,534...75,708,619

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

EXP

Phenformin results in decreased expression of HMGCR mRNA

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

hyaluronan-mediated motility receptor

decreases expression

EXP

Phenformin results in decreased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,635,915...25,665,390

G

hydroxysteroid (17-beta) dehydrogenase 2

increases expression

EXP

Phenformin results in increased expression of HSD17B2 mRNA

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:62,662,098...62,733,943

G

heat shock protein 90 alpha family class A member 1

decreases expression

EXP

Phenformin results in decreased expression of HSP90AA1 mRNA

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein family A (Hsp70) member 4 like

decreases expression

EXP

Phenformin results in decreased expression of HSPA4L mRNA

NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:125,668,236...125,720,986

G

hydroxylysine kinase

increases expression

EXP

Phenformin results in increased expression of HYKK mRNA

NCBI chr 8:55,315,919...55,339,720
Ensembl chr 8:64,212,071...64,235,818

G

immediate early response 2

decreases expression

EXP

Phenformin results in decreased expression of IER2 mRNA

NCBI chr19:23,494,551...23,496,075
Ensembl chr19:40,398,160...40,402,708

G

interferon-gamma-inducible GTPase 4 like

increases expression

EXP

Phenformin results in increased expression of IFGGA4L mRNA

NCBI chr18:53,838,426...53,854,858
Ensembl chr18:56,108,872...56,125,302

G

interferon gamma inducible protein 47

increases expression

EXP

Phenformin results in increased expression of IFI47 mRNA

NCBI chr10:33,297,618...33,305,248
Ensembl chr10:33,776,399...33,806,372

G

interferon induced transmembrane protein 3

increases expression

EXP

Phenformin results in increased expression of IFITM3 mRNA

NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:205,481,168...205,547,920

G

insulin-like growth factor 2 mRNA binding protein 3

decreases expression

EXP

Phenformin results in decreased expression of IGF2BP3 mRNA

NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:79,393,067...79,525,730

G

insulin-like growth factor binding protein, acid labile subunit

decreases expression

EXP

Phenformin results in decreased expression of IGFALS mRNA

NCBI chr10:14,397,076...14,408,439
Ensembl chr10:14,403,399...14,407,138

G

insulin-like growth factor binding protein 2

increases expression

EXP

Phenformin results in increased expression of IGFBP2 mRNA

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

insulin-like growth factor binding protein 5

decreases expression

EXP

Phenformin results in decreased expression of IGFBP5 mRNA

NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:81,897,616...81,914,390

G

interleukin 1 receptor type 1

increases expression

EXP

Phenformin results in increased expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 33

increases expression

EXP

Phenformin results in increased expression of IL33 mRNA

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:237,115,572...237,150,901

G

inhibin subunit alpha

decreases expression

EXP

Phenformin results in decreased expression of INHA mRNA

NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:84,443,109...84,446,009

G

inhibin subunit beta A

decreases expression

EXP

Phenformin results in decreased expression of INHBA mRNA

NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508

G

inhibin subunit beta E

increases expression

EXP

Phenformin results in increased expression of INHBE mRNA

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:65,061,531...65,064,519

G

indolethylamine N-methyltransferase

increases expression

EXP

Phenformin results in increased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:85,648,459...85,652,755

G

insulin induced gene 1

decreases expression

EXP

Phenformin results in decreased expression of INSIG1 mRNA

NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778

G

insulin induced gene 2

increases expression

EXP

Phenformin results in increased expression of INSIG2 mRNA

NCBI chr13:32,472,390...32,500,139
Ensembl chr13:35,025,164...35,047,658

G

inositol hexakisphosphate kinase 2

decreases expression

EXP

Phenformin results in decreased expression of IP6K2 mRNA

NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:118,362,795...118,388,667

G

interferon regulatory factor 2 binding protein 2

decreases expression

EXP

Phenformin results in decreased expression of IRF2BP2 mRNA

NCBI chr19:54,559,417...54,565,096
Ensembl chr19:71,456,689...71,462,368

G

interferon regulatory factor 2 binding protein-like

decreases expression

EXP

Phenformin results in decreased expression of IRF2BPL mRNA

NCBI chr 6:106,527,179...106,531,294
Ensembl chr 6:112,258,188...112,263,280

G

insulin receptor substrate 2

decreases expression

EXP

Phenformin results in decreased expression of IRS2 mRNA

NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

Phenformin results in decreased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

Phenformin results in decreased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:40,073,541...40,085,218

G

potassium voltage-gated channel subfamily A member 2

increases expression

EXP

Phenformin results in increased expression of KCNA2 mRNA

NCBI chr 2:197,392,746...197,406,606
Ensembl chr 2:197,392,698...197,407,519

G

potassium inwardly-rectifying channel, subfamily J, member 5

increases expression

EXP

Phenformin results in increased expression of KCNJ5 mRNA

NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:38,983,034...39,011,101

G

kinesin family member 11

decreases expression

EXP

Phenformin results in decreased expression of KIF11 mRNA

NCBI chr 1:244,494,916...244,589,250
Ensembl chr 1:244,494,875...244,589,250

G

kinesin family member 20A

decreases expression

EXP

Phenformin results in decreased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,504,072...26,512,909

G

kinesin family member 20B

decreases expression

EXP

Phenformin results in decreased expression of KIF20B mRNA

NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:241,840,987...241,896,451

G

kinesin family member 23

decreases expression

EXP

Phenformin results in decreased expression of KIF23 mRNA

NCBI chr 8:71,293,439...71,321,911
Ensembl chr 8:71,293,482...71,320,856

G

kinetochore scaffold 1

decreases expression

EXP

Phenformin results in decreased expression of KNL1 mRNA

NCBI chr 3:126,483,498...126,545,774
Ensembl chr 3:126,483,544...126,545,774

G

keratin 18

increases expression

EXP

Phenformin results in increased expression of KRT18 mRNA

NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:135,035,982...135,039,848
Ensembl chr10:135,035,982...135,039,848

G

lipopolysaccharide binding protein

increases expression

EXP

Phenformin results in increased expression of LBP mRNA

NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:167,373,924...167,401,518

G

leptin receptor

increases response to substance

EXP

LEPR gene mutant form results in increased susceptibility to Phenformin

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215

G

galectin 5

decreases expression

EXP

Phenformin results in decreased expression of LGALS5 mRNA

NCBI chr10:63,853,949...63,857,198
Ensembl chr10:64,351,964...64,355,180

G

lengsin, lens protein with glutamine synthetase domain

decreases expression

EXP

Phenformin results in decreased expression of LGSN mRNA

NCBI chr 9:33,416,362...33,447,919
Ensembl chr 9:40,916,520...40,943,943

G

lipase, member O1

decreases expression

EXP

Phenformin results in decreased expression of LIPO1 mRNA

NCBI chr 1:231,311,828...231,328,805
Ensembl chr 1:240,725,581...240,737,160

G

lysyl oxidase-like 4

increases expression

EXP

Phenformin results in increased expression of LOXL4 mRNA

NCBI chr 1:241,396,183...241,416,385
Ensembl chr 1:251,347,238...251,365,577

G

lysophosphatidic acid receptor 6

increases expression

EXP

Phenformin results in increased expression of LPAR6 mRNA

NCBI chr15:48,416,548...48,418,357
Ensembl chr15:54,823,717...54,978,783

G

lipin 1

decreases expression

EXP

Phenformin results in decreased expression of LPIN1 mRNA

NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991

G

lumican

decreases expression

EXP

Phenformin results in decreased expression of LUM mRNA

NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:34,245,360...34,252,508

G

leucine rich adaptor protein 1-like

decreases expression

EXP

Phenformin results in decreased expression of LURAP1L mRNA

NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:100,407,483...100,455,478

G

Ly6-C antigen

increases expression

EXP

Phenformin results in increased expression of LY6C mRNA

NCBI chr 7:106,959,508...106,963,329
Ensembl chr 7:108,840,263...108,878,007

G

Ly6/neurotoxin 1

decreases expression

EXP

Phenformin results in decreased expression of LYNX1 mRNA

NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:108,521,780...108,527,130

G

microtubule associated serine/threonine kinase-like

decreases expression

EXP

Phenformin results in decreased expression of MASTL mRNA

NCBI chr17:90,158,592...90,195,550
Ensembl chr17:90,160,068...90,195,564

G

muscleblind-like splicing regulator 3

increases expression

EXP

Phenformin results in increased expression of MBNL3 mRNA

NCBI chr X:130,641,942...130,737,179
Ensembl chr X:135,532,494...135,621,976

G

mesoderm specific transcript

decreases expression

EXP

Phenformin results in decreased expression of MEST mRNA

NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:60,316,102...60,333,509

G

microfibril associated protein 4

decreases expression

EXP

Phenformin results in decreased expression of MFAP4 mRNA

NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,655,722...46,669,740

G

MFSD2 lysolipid transporter A, lysophospholipid

decreases expression

EXP

Phenformin results in decreased expression of MFSD2A mRNA

NCBI chr 5:140,510,933...140,525,828
Ensembl chr 5:140,510,953...140,525,916

G

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

decreases expression

EXP

Phenformin results in decreased expression of MGAT4B mRNA

NCBI chr10:34,548,918...34,559,229
Ensembl chr10:35,050,512...35,060,309

G

matrix Gla protein

decreases expression

EXP

Phenformin results in decreased expression of MGP mRNA

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:171,497,471...171,500,859

G

microRNA 15b

increases expression

EXP

Phenformin results in increased expression of MIR15B mRNA

NCBI chr 2:155,555,178...155,555,275
Ensembl chr 2:155,555,178...155,555,275

G

microRNA 29b-2

increases expression

EXP

Phenformin results in increased expression of MIR29B2 mRNA

NCBI chr13:106,570,371...106,570,451
Ensembl chr13:109,098,827...109,098,916

G

microRNA 325

increases expression

EXP

Phenformin results in increased expression of MIR325 mRNA

NCBI chr X:70,457,918...70,458,015

G

microRNA 505

increases expression

EXP

Phenformin results in increased expression of MIR505 mRNA

NCBI chr X:138,742,487...138,742,553

G

microRNA let-7c-1

increases expression

EXP

Phenformin results in increased expression of MIRLET7C-1 mRNA

NCBI chr11:16,201,163...16,201,256
Ensembl chr11:29,688,107...29,688,214

G

marker of proliferation Ki-67

decreases expression

EXP

Phenformin results in decreased expression of MKI67 mRNA

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

MAPK interacting serine/threonine kinase 2

decreases expression

EXP

Phenformin results in decreased expression of MKNK2 mRNA

NCBI chr 7:9,690,385...9,701,527
Ensembl chr 7:9,690,421...9,701,529

G

MLX interacting protein-like

decreases expression

EXP

Phenformin results in decreased expression of MLXIPL mRNA

NCBI chr12:27,178,158...27,213,675
Ensembl chr12:27,178,158...27,213,660

G

macrophage stimulating 1 receptor

decreases expression

EXP

Phenformin results in decreased expression of MST1R mRNA

NCBI chr 8:117,471,928...117,491,059
Ensembl chr 8:117,475,968...117,490,515

G

metallothionein 1, pseudogene 3

increases expression

EXP

Phenformin results in increased expression of MT1M mRNA

NCBI chr17:74,786,652...74,787,040
Ensembl chr17:79,695,809...79,696,200

G

metallothionein 1A

increases expression

EXP

Phenformin results in increased expression of MT1A mRNA

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metallothionein 2

increases expression

EXP

Phenformin results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,837,927...10,838,709

G

MTSS I-BAR domain containing 1

decreases expression

EXP

Phenformin results in decreased expression of MTSS1 mRNA

NCBI chr 7:92,378,228...92,517,444
Ensembl chr 7:92,378,238...92,517,303

G

MX dynamin like GTPase 2

increases expression

EXP

Phenformin results in increased expression of MX2 mRNA

NCBI chr11:50,375,101...50,399,373
Ensembl chr11:50,375,191...50,402,478

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

EXP

Phenformin results in decreased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

myosin heavy chain 7

increases expression

EXP

Phenformin results in increased expression of MYH7 mRNA

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194

G

myocilin

increases expression

EXP

Phenformin results in increased expression of MYOC mRNA

NCBI chr13:77,509,963...77,520,361
Ensembl chr13:77,509,963...77,520,361

G

myomesin 2

increases expression

EXP

Phenformin results in increased expression of MYOM2 mRNA

NCBI chr16:74,520,148...74,592,658
Ensembl chr16:81,221,938...81,295,162

G

non-SMC condensin I complex, subunit G

decreases expression

EXP

Phenformin results in decreased expression of NCAPG mRNA

NCBI chr14:69,616,473...69,645,445
Ensembl chr14:69,616,473...69,645,445

G

neutrophil cytosolic factor 1

increases expression

EXP

Phenformin results in increased expression of NCF1 mRNA

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079

G

NDC80 kinetochore complex component

decreases expression

EXP

Phenformin results in decreased expression of NDC80 mRNA

NCBI chr 9:118,853,806...118,887,582
Ensembl chr 9:118,853,806...118,887,568

G

NFE2 like bZIP transcription factor 2

increases activity

ISO

Phenformin results in increased activity of NFE2L2 protein

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

decreases expression

EXP

Phenformin results in decreased expression of NFKBIA mRNA

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

neuronal guanine nucleotide exchange factor

decreases expression

EXP

Phenformin results in decreased expression of NGEF mRNA

NCBI chr 9:95,594,823...95,692,381
Ensembl chr 9:95,594,823...95,692,251

G

nocturnin

decreases expression

EXP

Phenformin results in decreased expression of NOCT mRNA

NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:137,422,074...137,442,282

G

natriuretic peptide A

increases expression

EXP

Phenformin results in increased expression of NPPA mRNA

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide receptor 3

increases expression

EXP

Phenformin results in increased expression of NPR3 mRNA

NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:62,597,668...62,660,066

G

neuropeptide Y

affects expression

EXP

Phenformin affects the expression of NPY mRNA

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

NAD(P)H quinone dehydrogenase 1

increases expression

EXP

Phenformin results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group D, member 1

increases expression

EXP

Phenformin results in increased expression of NR1D1 mRNA

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:84,224,540...84,231,812

G

nuclear receptor subfamily 1, group D, member 2

increases expression

EXP

Phenformin results in increased expression of NR1D2 mRNA

NCBI chr15:7,524,257...7,550,553
Ensembl chr15:9,954,906...9,981,330

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

EXP

Phenformin results in decreased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:134,247,192...134,268,041

G

nuclear receptor subfamily 4, group A, member 2

decreases expression

EXP

Phenformin results in decreased expression of NR4A2 mRNA

NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769

G

nuclear receptor subfamily 4, group A, member 3

decreases expression

EXP

Phenformin results in decreased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

NUF2 component of NDC80 kinetochore complex

decreases expression

EXP

Phenformin results in decreased expression of NUF2 mRNA

NCBI chr13:84,226,448...84,290,957
Ensembl chr13:84,226,509...84,255,598

G

nucleolar and spindle associated protein 1

decreases expression

EXP

Phenformin results in decreased expression of NUSAP1 mRNA

NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:127,057,265...127,087,237

G

out at first homolog

increases expression

EXP

Phenformin results in increased expression of OAF mRNA

NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:52,491,315...52,509,285

G

ornithine aminotransferase

increases expression

EXP

Phenformin results in increased expression of OAT mRNA

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:196,777,975...196,797,754

G

olfactory receptor 906

increases expression

EXP

Phenformin results in increased expression of OLR906 mRNA

NCBI chr 7:1,821,264...1,822,202
Ensembl chr 7:2,431,055...2,431,993

G

osteomodulin

decreases expression

EXP

Phenformin results in decreased expression of OMD mRNA

NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,266,646...15,274,870

G

opioid binding protein/cell adhesion molecule-like

decreases expression

EXP

Phenformin results in decreased expression of OPCML mRNA

NCBI chr 8:26,788,988...27,304,551
Ensembl chr 8:34,451,500...35,558,966

G

oxysterol binding protein-like 3

decreases expression

EXP

Phenformin results in decreased expression of OSBPL3 mRNA

NCBI chr 4:79,346,583...79,523,523
Ensembl chr 4:80,677,390...80,854,169

G

oxidative stress induced growth inhibitor 1

decreases expression

EXP

Phenformin results in decreased expression of OSGIN1 mRNA

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:64,401,173...64,409,162

G

OTU deubiquitinase 1

decreases expression

EXP

Phenformin results in decreased expression of OTUD1 mRNA

NCBI chr17:82,259,920...82,262,770
Ensembl chr17:87,149,175...87,330,706

G

purinergic receptor P2X 7

increases expression

EXP

Phenformin results in increased expression of P2RX7 mRNA

NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193

G

purinergic receptor P2Y2

increases expression

EXP

Phenformin results in increased expression of P2RY2 mRNA

NCBI chr 1:164,764,119...164,779,578
Ensembl chr 1:164,759,213...164,781,852

G

progestin and adipoQ receptor family member 9

decreases expression

EXP

Phenformin results in decreased expression of PAQR9 mRNA

NCBI chr 8:96,114,249...96,116,546
Ensembl chr 8:104,993,827...104,998,285

G

PDZ binding kinase

decreases expression

EXP

Phenformin results in decreased expression of PBK mRNA

NCBI chr15:40,022,873...40,034,014
Ensembl chr15:44,198,544...44,209,570

G

phenazine biosynthesis-like protein domain containing 1

increases expression

EXP

Phenformin results in increased expression of PBLD1 mRNA

NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,549,974...25,565,226

G

phenazine biosynthesis-like protein domain containing 2

increases expression

EXP

Phenformin results in increased expression of PBLD2 mRNA

NCBI chr20:25,568,242...25,603,092
Ensembl chr20:25,567,078...25,615,889

G

probasin

increases expression

EXP

Phenformin results in increased expression of PBSN mRNA

NCBI chr X:41,914,346...41,929,591
Ensembl chr X:45,792,738...45,807,983

G

PCNA clamp associated factor

decreases expression

EXP

Phenformin results in decreased expression of PCLAF mRNA

NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:75,315,707...75,328,106

G

phosphodiesterase 4B

increases expression

EXP

Phenformin results in increased expression of PDE4B mRNA

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:122,135,174...122,598,267

G

pyruvate dehydrogenase kinase 4

increases expression

EXP

Phenformin results in increased expression of PDK4 mRNA

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:34,556,330...34,568,381

G

PDZ and LIM domain 1

decreases expression

EXP

Phenformin results in decreased expression of PDLIM1 mRNA

NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:248,991,818...249,047,379

G

PDZ and LIM domain 3

decreases expression

EXP

Phenformin results in decreased expression of PDLIM3 mRNA

NCBI chr16:46,352,460...46,383,680
Ensembl chr16:53,085,020...53,116,217

G

PDZ domain containing RING finger 3

increases expression

EXP

Phenformin results in increased expression of PDZRN3 mRNA

NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:135,327,082...135,553,294

G

proenkephalin

increases expression

EXP

Phenformin results in increased expression of PENK mRNA

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:21,981,382...21,986,705

G

period circadian regulator 1

decreases expression

EXP

Phenformin results in decreased expression of PER1 mRNA

NCBI chr10:53,800,126...53,814,963
Ensembl chr10:54,302,641...54,314,211

G

period circadian regulator 2

decreases expression

EXP

Phenformin results in decreased expression of PER2 mRNA

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:99,454,830...99,496,993

G

peroxisomal biogenesis factor 11 alpha

increases expression

EXP

Phenformin results in increased expression of PEX11A mRNA

NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:143,089,410...143,096,645

G

peroxisomal biogenesis factor 16

increases expression

EXP

Phenformin results in increased expression of PEX16 mRNA

NCBI chr 3:78,347,212...78,352,603
Ensembl chr 3:98,798,654...98,808,630

G

platelet factor 4

decreases expression

EXP

Phenformin results in decreased expression of PF4 mRNA

NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

decreases expression

EXP

Phenformin results in decreased expression of PFKFB1 mRNA

NCBI chr X:19,508,522...19,562,165
Ensembl chr X:22,937,494...22,989,704

G

putative homeodomain transcription factor 1

decreases expression

EXP

Phenformin results in decreased expression of PHTF1 mRNA

NCBI chr 2:191,470,849...191,537,399
Ensembl chr 2:194,161,000...194,219,530

G

peptidase inhibitor 15

decreases expression

EXP

Phenformin results in decreased expression of PI15 mRNA

NCBI chr 5:1,395,094...1,423,213
Ensembl chr 5:6,174,963...6,247,841

G

phosphoinositide-3-kinase regulatory subunit 1

decreases expression

EXP

Phenformin results in decreased expression of PIK3R1 mRNA

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

pyruvate kinase L/R

decreases expression

EXP

Phenformin results in decreased expression of PKLR mRNA

NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644

G

phospholipase A2, group XIIA

increases expression

EXP

Phenformin results in increased expression of PLA2G12A mRNA

NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:221,110,685...221,126,964

G

phospholipase C, gamma 1

increases phosphorylation

ISO

Phenformin results in increased phosphorylation of PLCG1 protein

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:169,804,846...169,836,050

G

perilipin 2

decreases expression

EXP

Phenformin results in decreased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:106,202,634...106,258,878

G

polo-like kinase 1

decreases expression

EXP

Phenformin results in decreased expression of PLK1 mRNA

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:186,147,658...186,157,637

G

phospholipid phosphatase related 1

decreases expression

EXP

Phenformin results in decreased expression of PLPPR1 mRNA

NCBI chr 5:63,437,457...63,725,286
Ensembl chr 5:68,232,963...68,592,444

G

patatin-like phospholipase domain containing 3

decreases expression

EXP

Phenformin results in decreased expression of PNPLA3 mRNA

NCBI chr 7:117,173,485...117,194,065
Ensembl chr 7:117,173,516...117,194,594

G

cytochrome p450 oxidoreductase

decreases expression

EXP

Phenformin results in decreased expression of POR mRNA

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

POTE ankyrin domain family, member F, pseudogene 1

decreases expression

EXP

Phenformin results in decreased expression of POTEF mRNA

NCBI chr18:23,626,518...23,629,132

G

peroxisome proliferator-activated receptor delta

decreases expression

EXP

Phenformin results in decreased expression of PPARD mRNA

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

phosphopantothenoylcysteine synthetase

increases expression

EXP

Phenformin results in increased expression of PPCS mRNA

NCBI chr 5:133,023,077...133,026,899
Ensembl chr 5:138,308,397...138,312,012

G

protein phosphatase, Mg2+/Mn2+ dependent, 1K

increases expression

EXP

Phenformin results in increased expression of PPM1K mRNA

NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:88,942,386...88,969,136

G

protein phosphatase 1, regulatory subunit 15A

decreases expression

EXP

Phenformin results in decreased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:105,136,525...105,139,774

G

protein phosphatase 1, regulatory subunit 3B

decreases expression

EXP

Phenformin results in decreased expression of PPP1R3B mRNA

NCBI chr16:56,830,011...56,842,395
Ensembl chr16:63,532,842...63,549,997

G

protein regulator of cytokinesis 1

decreases expression

EXP

Phenformin results in decreased expression of PRC1 mRNA

NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:143,659,481...143,681,012

G

DNA primase subunit 1

decreases expression

EXP

Phenformin results in decreased expression of PRIM1 mRNA

NCBI chr 7:446,342...462,526

G

protein kinase AMP-activated catalytic subunit alpha 1

increases phosphorylation

ISO

Phenformin results in increased phosphorylation of PRKAA1 protein

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

prospero homeobox 1

increases expression

EXP

Phenformin results in increased expression of PROX1 mRNA

NCBI chr13:104,196,615...104,251,007
Ensembl chr13:104,200,378...104,250,975

G

proline rich and Gla domain 4

decreases expression

EXP

Phenformin results in decreased expression of PRRG4 mRNA

NCBI chr 3:91,214,646...91,243,347
Ensembl chr 3:111,673,582...111,698,205

G

proteasome 20S subunit beta 8

increases expression

EXP

Phenformin results in increased expression of PSMB8 mRNA

NCBI chr20:4,654,068...4,657,049
Ensembl chr20:4,654,068...4,657,031

G

protein tyrosine kinase 6

decreases expression

EXP

Phenformin results in decreased expression of PTK6 mRNA

NCBI chr 3:188,684,633...188,693,224
Ensembl chr 3:188,684,633...188,693,224

G

protein tyrosine phosphatase, non-receptor type 3

increases expression

EXP

Phenformin results in increased expression of PTPN3 mRNA

NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:76,703,687...76,860,470

G

pumilio RNA-binding family member 3, pseudogene 3

increases expression

EXP

Phenformin results in increased expression of PUM3-PS3 mRNA

NCBI chr12:16,357,131...16,359,221

G

RAB30, member RAS oncogene family

increases expression

EXP

Phenformin results in increased expression of RAB30 mRNA

NCBI chr 1:146,803,719...146,898,369
Ensembl chr 1:156,216,137...156,310,778

G

Rap guanine nucleotide exchange factor 5

decreases expression

EXP

Phenformin results in decreased expression of RAPGEF5 mRNA

NCBI chr 6:138,445,184...138,679,943
Ensembl chr 6:144,580,976...144,822,908

G

regulator of calcineurin 1

decreases expression

EXP

Phenformin results in decreased expression of RCAN1 mRNA

NCBI chr11:31,622,208...31,702,150
Ensembl chr11:45,108,124...45,118,236

G

retinol dehydrogenase 5

decreases expression

EXP

Phenformin results in decreased expression of RDH5 mRNA

NCBI chr 7:1,341,172...1,346,863
Ensembl chr 7:1,925,335...1,936,049

G

regenerating family member 3 gamma

increases expression

EXP

Phenformin results in increased expression of REG3G mRNA

NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:112,482,183...112,484,738

G

similar to interferon-inducible GTPase

increases expression

EXP

Phenformin results in increased expression of RGD1309362 mRNA

Ensembl chr18:55,943,264...55,994,435

G

regulator of G-protein signaling 2

decreases expression

EXP

Phenformin results in decreased expression of RGS2 mRNA

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697

G

RP1, axonemal microtubule associated

decreases expression

EXP

Phenformin results in decreased expression of RP1 mRNA

NCBI chr 5:19,918,728...20,380,811
Ensembl chr 5:19,918,799...20,377,580

G

ribonucleotide reductase regulatory subunit M2

decreases expression

EXP

Phenformin results in decreased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:47,067,690...47,075,370

G

RT1 class I, locus A

decreases expression

EXP

Phenformin results in decreased expression of RT1-A mRNA

G

SH3 domain binding kinase 1

increases expression

EXP

Phenformin results in increased expression of SBK1 mRNA

NCBI chr 1:180,807,092...180,851,910
Ensembl chr 1:190,273,642...190,282,473

G

small Cajal body-specific RNA 15

decreases expression

EXP

Phenformin results in decreased expression of SCARNA15 mRNA

NCBI chr 1:135,484,620...135,484,683
Ensembl chr 1:144,893,795...144,893,921

G

stearoyl-CoA desaturase

decreases expression

EXP

Phenformin results in decreased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:253,218,970...253,231,785

G

syndecan 4

decreases expression

EXP

Phenformin results in decreased expression of SDC4 mRNA

NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:173,574,239...173,593,670

G

short chain dehydrogenase/reductase family 42E, member 1

increases expression

EXP

Phenformin results in increased expression of SDR42E1 mRNA

NCBI chr19:45,715,366...45,727,901
Ensembl chr19:62,624,150...62,636,756

G

serine dehydratase

increases expression

EXP

Phenformin results in increased expression of SDS mRNA

NCBI chr12:36,083,226...36,090,540
Ensembl chr12:41,743,799...41,748,773

G

serpin family A member 7

increases expression

EXP

Phenformin results in increased expression of SERPINA7 mRNA

NCBI chr X:107,452,044...107,510,958
Ensembl chr X:107,452,044...107,457,681

G

serpin family C member 1

increases activity

ISO

Phenformin results in increased activity of SERPINC1 protein

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:75,790,546...75,817,643

G

serpin family E member 1

decreases expression

EXP

Phenformin results in decreased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:25,237,952...25,248,357

G

salt-inducible kinase 1

decreases expression

EXP

Phenformin results in decreased expression of SIK1 mRNA

NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,105...9,958,698

G

sirtuin 1

decreases expression

ISO

Phenformin results in decreased expression of SIRT1 protein

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 10 member 2

decreases expression

EXP

Phenformin results in decreased expression of SLC10A2 mRNA

NCBI chr16:84,386,528...84,409,475
Ensembl chr16:91,076,423...91,111,025

G

solute carrier family 10, member 5

decreases expression

EXP

Phenformin results in decreased expression of SLC10A5 mRNA

NCBI chr 2:91,457,540...91,458,844
Ensembl chr 2:93,360,766...93,368,978

G

solute carrier family 13 member 2

decreases expression

EXP

Phenformin results in decreased expression of SLC13A2 mRNA

NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,789,876...63,817,184

G

solute carrier family 13 member 3

increases expression

EXP

Phenformin results in increased expression of SLC13A3 mRNA

NCBI chr 3:174,561,174...174,623,893
Ensembl chr 3:174,561,168...174,623,895

G

solute carrier family 16 member 10

increases expression

EXP

Phenformin results in increased expression of SLC16A10 mRNA

NCBI chr20:45,014,229...45,122,392
Ensembl chr20:45,014,235...45,122,358

G

solute carrier family 17 member 9

decreases expression

EXP

Phenformin results in decreased expression of SLC17A9 mRNA

NCBI chr 3:167,839,246...167,857,462
Ensembl chr 3:188,216,944...188,233,551

G

solute carrier family 19 member 3

multiple interactions

ISO

Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]

NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:91,724,718...91,754,991

G

solute carrier family 1 member 2

increases expression

EXP

Phenformin results in increased expression of SLC1A2 mRNA

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

solute carrier family 1 member 4

increases expression

EXP

Phenformin results in increased expression of SLC1A4 mRNA

NCBI chr14:94,530,801...94,560,190
Ensembl chr14:98,730,450...98,761,790

G

solute carrier family 22 member 2

multiple interactions

ISO

Phenformin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22, member 23

decreases expression

EXP

Phenformin results in decreased expression of SLC22A23 mRNA

NCBI chr17:30,544,106...30,709,790
Ensembl chr17:30,749,445...30,915,139

G

solute carrier family 22 member 4

increases response to substance
affects uptake

ISO

SLC22A4 protein results in increased susceptibility to Phenformin
SLC22A4 protein affects the uptake of Phenformin

NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,634,098...38,679,920

G

solute carrier family 22 member 5

increases expression

EXP

Phenformin results in increased expression of SLC22A5 mRNA

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 25 member 23

decreases expression

EXP

Phenformin results in decreased expression of SLC25A23 mRNA

NCBI chr 9:1,882,636...1,898,369
Ensembl chr 9:1,969,357...1,985,365

G

solute carrier family 25, member 47

increases expression

EXP

Phenformin results in increased expression of SLC25A47 mRNA

NCBI chr 6:127,767,365...127,773,000
Ensembl chr 6:133,531,728...133,537,877

G

solute carrier family 27 member 1

increases expression

EXP

Phenformin results in increased expression of SLC27A1 mRNA

NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,313,015...18,330,045

G

solute carrier family 2 member 12

increases expression

EXP

Phenformin results in increased expression of SLC2A12 mRNA

NCBI chr 1:22,803,068...22,862,204
Ensembl chr 1:24,589,707...24,694,290

G

solute carrier family 2 member 5

decreases expression

EXP

Phenformin results in decreased expression of SLC2A5 mRNA

NCBI chr 5:165,857,412...165,892,928
Ensembl chr 5:165,866,172...165,894,038

G

solute carrier family 34 member 2

decreases expression

EXP

Phenformin results in decreased expression of SLC34A2 mRNA

NCBI chr14:57,910,931...57,930,236
Ensembl chr14:62,123,316...62,143,360

G

solute carrier family 35 member C2

decreases expression

EXP

Phenformin results in decreased expression of SLC35C2 mRNA

NCBI chr 3:154,012,262...154,023,549
Ensembl chr 3:174,431,718...174,442,792

G

solute carrier family 38, member 2

decreases expression

EXP

Phenformin results in decreased expression of SLC38A2 mRNA

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619

G

solute carrier family 47 member 1

multiple interactions

ISO

Phenformin inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Phenformin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:46,489,831...46,533,425

G

solute carrier family 4 member 1 (Diego blood group)

decreases expression

EXP

Phenformin results in decreased expression of SLC4A1 mRNA

NCBI chr10:87,807,010...87,823,274
Ensembl chr10:87,807,013...87,823,258

G

solute carrier family 4 member 4

increases expression

EXP

Phenformin results in increased expression of SLC4A4 mRNA

NCBI chr14:19,125,394...19,577,379
Ensembl chr14:19,129,264...19,577,435

G

solute carrier family 6 member 6

increases expression

EXP

Phenformin results in increased expression of SLC6A6 mRNA

NCBI chr 4:125,752,340...125,826,033
Ensembl chr 4:125,752,372...125,826,032

G

single-pass membrane protein with coiled-coil domains 1

increases expression

EXP

Phenformin results in increased expression of SMCO1 mRNA

NCBI chr11:68,512,113...68,514,999
Ensembl chr11:82,014,179...82,020,030

G

snail family transcriptional repressor 2

increases expression

EXP

Phenformin results in increased expression of SNAI2 mRNA

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349

G

syntrophin, beta 1

increases expression

EXP

Phenformin results in increased expression of SNTB1 mRNA

NCBI chr 7:87,060,926...87,329,315
Ensembl chr 7:88,950,642...89,219,017

G

suppressor of cytokine signaling 2

decreases expression

EXP

Phenformin results in decreased expression of SOCS2 mRNA

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:31,874,463...31,930,423

G

serine peptidase inhibitor, Kazal type 1

increases expression

EXP

Phenformin results in increased expression of SPINK1 mRNA

NCBI chr18:36,121,626...36,133,596
Ensembl chr18:36,076,399...36,133,545

G

sterol regulatory element binding transcription factor 1

decreases expression

EXP

Phenformin results in decreased expression of SREBF1 mRNA

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

SH3 and cysteine rich domain 3

decreases expression

EXP

Phenformin results in decreased expression of STAC3 mRNA

NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:65,228,352...65,235,878

G

signal transducer and activator of transcription 3

increases expression

EXP

Phenformin results in increased expression of STAT3 mRNA

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

signal transducer and activator of transcription 5B

decreases activity

ISO

Phenformin results in decreased activity of STAT5B protein

NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990

G

stathmin 1

decreases expression

EXP

Phenformin results in decreased expression of STMN1 mRNA

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842

G

syntaxin binding protein 6

increases expression

EXP

Phenformin results in increased expression of STXBP6 mRNA

NCBI chr 6:67,647,721...67,884,369
Ensembl chr 6:67,650,556...67,884,725

G

T-box transcription factor 3

increases expression

EXP

Phenformin results in increased expression of TBX3 mRNA

NCBI chr12:42,540,378...42,555,490
Ensembl chr12:42,540,378...42,554,171

G

titin-cap

increases expression

EXP

Phenformin results in increased expression of TCAP mRNA

NCBI chr10:83,381,719...83,382,887
Ensembl chr10:83,876,939...83,879,483

G

testis expressed 36

increases expression

EXP

Phenformin results in increased expression of TEX36 mRNA

NCBI chr 1:188,390,062...188,404,448
Ensembl chr 1:197,820,068...197,834,380

G

thrombospondin 1

increases expression

EXP

Phenformin results in increased expression of THBS1 mRNA

NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402

G

thyroid hormone responsive

decreases expression

EXP

Phenformin results in decreased expression of THRSP mRNA

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:161,133,453...161,139,827

G

thymidine kinase 1

decreases expression

EXP

Phenformin results in decreased expression of TK1 mRNA

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,533,449...103,556,228

G

triokinase and FMN cyclase

decreases expression

EXP

Phenformin results in decreased expression of TKFC mRNA

NCBI chr 1:216,664,446...216,677,815
Ensembl chr 1:216,661,477...216,677,928

G

transmembrane 7 superfamily member 2

increases expression

EXP

Phenformin results in increased expression of TM7SF2 mRNA

NCBI chr 1:212,785,217...212,789,572
Ensembl chr 1:212,785,217...212,789,557

G

transmembrane protein 30B

increases expression

EXP

Phenformin results in increased expression of TMEM30B mRNA

NCBI chr 6:92,251,626...92,254,702
Ensembl chr 6:97,987,130...97,991,170

G

transmembrane protein 37

decreases expression

EXP

Phenformin results in decreased expression of TMEM37 mRNA

NCBI chr13:31,184,322...31,191,477
Ensembl chr13:33,736,308...33,743,747

G

tropomodulin 4

increases expression

EXP

Phenformin results in increased expression of TMOD4 mRNA

NCBI chr 2:185,384,547...185,389,549
Ensembl chr 2:185,384,795...185,389,992

G

TNF alpha induced protein 2

increases expression

EXP

Phenformin results in increased expression of TNFAIP2 mRNA

NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:136,298,082...136,311,106

G

TNF alpha induced protein 3

decreases expression

EXP

Phenformin results in decreased expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF superfamily member 13

decreases expression

EXP

Phenformin results in decreased expression of TNFSF13 mRNA

NCBI chr10:54,898,805...54,901,815
Ensembl chr10:54,898,805...54,901,815

G

transducer of ERBB2, 2

decreases expression

EXP

Phenformin results in decreased expression of TOB2 mRNA

NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:115,239,895...115,258,155

G

DNA topoisomerase II alpha

decreases expression

EXP

Phenformin results in decreased expression of TOP2A mRNA

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366

G

tumor protein p53 inducible nuclear protein 1

decreases expression

EXP

Phenformin results in decreased expression of TP53INP1 mRNA

NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:29,051,264...29,069,484

G

tubulin polymerization promoting protein

decreases expression

EXP

Phenformin results in decreased expression of TPPP mRNA

NCBI chr 1:31,085,680...31,109,703
Ensembl chr 1:31,089,824...31,109,654

G

TPX2, microtubule nucleation factor

decreases expression

EXP

Phenformin results in decreased expression of TPX2 mRNA

NCBI chr 3:161,778,709...161,820,941
Ensembl chr 3:161,778,742...161,820,724

G

tripartite motif-containing 24

increases expression

EXP

Phenformin results in increased expression of TRIM24 mRNA

NCBI chr 4:66,567,342...66,692,029
Ensembl chr 4:67,534,335...67,684,226

G

tripartite motif-containing 50

increases expression

EXP

Phenformin results in increased expression of TRIM50 mRNA

NCBI chr12:21,300,784...21,317,668
Ensembl chr12:26,937,349...26,954,270

G

TSC22 domain family, member 3

decreases expression

EXP

Phenformin results in decreased expression of TSC22D3 mRNA

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:109,006,420...109,015,519

G

tsukushi, small leucine rich proteoglycan

decreases expression

EXP

Phenformin results in decreased expression of TSKU mRNA

NCBI chr 1:162,071,459...162,082,972
Ensembl chr 1:162,064,126...162,089,272

G

tetraspanin 4

decreases expression

EXP

Phenformin results in decreased expression of TSPAN4 mRNA

NCBI chr 1:196,571,307...196,593,842
Ensembl chr 1:206,001,731...206,021,413

G

Ttk protein kinase

decreases expression

EXP

Phenformin results in decreased expression of TTK mRNA

NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:93,634,319...93,672,664

G

tubulin, beta 1 class VI

decreases expression

EXP

Phenformin results in decreased expression of TUBB1 mRNA

NCBI chr 3:183,666,189...183,675,656
Ensembl chr 3:183,666,242...183,674,795

G

tubulin, beta 2A class IIa

decreases expression

EXP

Phenformin results in decreased expression of TUBB2A mRNA

NCBI chr17:31,002,186...31,006,057
Ensembl chr17:30,983,387...31,006,838

G

thioredoxin interacting protein

increases expression

EXP

Phenformin results in increased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

ubiquitin-conjugating enzyme E2C

decreases expression

EXP

Phenformin results in decreased expression of UBE2C mRNA

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678

G

uncoupling protein 3

increases expression

EXP

Phenformin results in increased expression of UCP3 mRNA

NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:164,227,882...164,241,210

G

UDP-glucose 6-dehydrogenase

decreases expression

EXP

Phenformin results in decreased expression of UGDH protein

NCBI chr14:43,202,480...43,226,002
Ensembl chr14:43,202,356...43,226,629

G

UDP glucuronosyltransferase family 2 member A3

increases expression

EXP

Phenformin results in increased expression of UGT2A3 mRNA

NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,851,969...20,869,973

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases expression

EXP

Phenformin results in increased expression of UGT2B1 mRNA

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,378,853...21,392,331

G

UDP glucuronosyltransferase 2 family, polypeptide B34 like 1

increases expression

EXP

Phenformin results in increased expression of UGT2B34L1 mRNA

NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,501,091...21,522,265

G

uridine phosphorylase 2

increases expression

EXP

Phenformin results in increased expression of UPP2 mRNA

NCBI chr 3:43,273,048...43,317,417
Ensembl chr 3:63,681,826...63,726,191

G

ubiquitin specific peptidase 18

increases expression

EXP

Phenformin results in increased expression of USP18 mRNA

NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:156,143,815...156,171,292

G

ubiquitin specific peptidase 2

decreases expression

EXP

Phenformin results in decreased expression of USP2 mRNA

NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:53,308,303...53,336,794

G

vestigial-like family member 4

decreases expression

EXP

Phenformin results in decreased expression of VGLL4 mRNA

NCBI chr 4:147,925,630...148,038,519
Ensembl chr 4:149,598,891...149,660,594

G

vanin 1

increases expression

EXP

Phenformin results in increased expression of VNN1 mRNA

NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:23,356,330...23,366,629

G

WEE1 G2 checkpoint kinase

decreases expression

EXP

Phenformin results in decreased expression of WEE1 mRNA

NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:173,608,949...173,632,449

G

X-linked inhibitor of apoptosis

increases expression

EXP

Phenformin results in increased expression of XIAP mRNA

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978

G

yippee-like 2

decreases expression

EXP

Phenformin results in decreased expression of YPEL2 mRNA

NCBI chr10:71,746,308...71,803,843
Ensembl chr10:72,243,591...72,301,124

G

zinc finger and BTB domain containing 16

decreases expression

EXP

Phenformin results in decreased expression of ZBTB16 mRNA

NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:57,891,081...58,073,507

G

zinc finger protein 354A

decreases expression

EXP

Phenformin results in decreased expression of ZFP354A mRNA

NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,897,228...35,909,510

G

zinc finger protein 36

decreases expression

EXP

Phenformin results in decreased expression of ZFP36 mRNA

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:92,796,628...92,799,108

G

zinc finger protein 750

increases expression

EXP

Phenformin results in increased expression of ZNF750 mRNA

NCBI chr10:106,772,162...106,781,186
Ensembl chr10:107,270,763...107,279,300

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases metabolic processing
decreases activity

ISO

CYP2C19 protein results in increased metabolism of Proguanil
Proguanil results in decreased activity of CYP2C19 protein

PMID:11124226 PMID:12464242

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

ISO

Proguanil results in decreased activity of CYP2D6 protein

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

Proguanil results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

solute carrier family 47 member 1

multiple interactions

ISO

Proguanil inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Proguanil inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:46,489,831...46,533,425

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
role	20820
application	20621
pharmaceutical	20416
drug	20416
hypoglycemic agent	4252
biguanides	456
N-(diaminomethylidene)-4-morpholinecarboximidamide	0
alexidine	11
buformin	0
chlorhexidine +	5
m-Chlorophenylbiguanide	2
phenformin	433
proguanil	5
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
main group element atom	20781
main group molecular entity	20781
p-block molecular entity	20781
carbon group molecular entity	20715
organic molecular entity	20710
heteroorganic entity	20219
organonitrogen compound	19403
guanidines	2373
biguanides	456
N-(diaminomethylidene)-4-morpholinecarboximidamide	0
alexidine	11
buformin	0
chlorhexidine +	5
m-Chlorophenylbiguanide	2
phenformin	433
proguanil	5

paths to the root