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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alexidine
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Accession:CHEBI:53661 term browser browse the term
Definition:An amphipathic bisbiguanide with a structure consisting of two (2-ethylhexyl)guanide units linked by a hexamethylene bridge.
Synonyms:exact_synonym: N,N''''-hexane-1,6-diylbis[N'-(2-ethylhexyl)(imidodicarbonimidic diamide)]
 related_synonym: 1,1'-Hexamethylenebis(5-(2-ethylhexyl)biguanide);   Formula=C26H56N10;   InChI=1S/C26H56N10/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36);   InChIKey=LFVVNPBBFUSSHL-UHFFFAOYSA-N;   N,N'-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide;   SMILES=CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC;   alexidina;   alexidinum;   bisguadine
 xref: Beilstein:2404807;   CAS:22573-93-9;   Drug_Central:113;   LINCS:LSM-4432
 xref_mesh: MESH:C001570
 xref: PMID:10848923;   PMID:22152633;   PMID:22495680;   PMID:23492900;   PMID:23970139;   PMID:24139264;   PMID:265389;   PMID:381628;   Patent:CN101624356;   Reaxys:2404807;   Wikipedia:Alexidine


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alexidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 increases expression
multiple interactions
ISO alexidine results in increased expression of ATF3 mRNA
MTF1 protein affects the reaction [alexidine results in increased expression of ATF3 mRNA]
CTD PMID:32661532 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO alexidine results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO alexidine results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO alexidine results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO alexidine results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO alexidine results in increased expression of HMOX1 mRNA CTD PMID:32661532 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO alexidine results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO alexidine results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mt2A metallothionein 2A increases expression ISO alexidine results in increased expression of MT2A mRNA CTD PMID:32661532 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO MTF1 protein affects the reaction [alexidine results in increased expression of ATF3 mRNA]; MTF1 protein affects the reaction [alexidine results in increased expression of MT1M mRNA] CTD PMID:32661532 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO alexidine results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          antibacterial agent 13571
            alexidine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            heteroorganic entity 19294
                              organonitrogen compound 18538
                                guanidines 2213
                                  biguanides 446
                                    alexidine 11
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