Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chloromethylisothiazolinone
go back to main search page
Accession:CHEBI:53621 term browser browse the term
Definition:A 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product Kathon(TM).
Synonyms:exact_synonym: 5-chloro-2-methyl-1,2-thiazol-3(2H)-one
 related_synonym: 2,3-dihydro-2-methyl-3-oxo-5-chloroisothiazole;   5-Chloro-2-methyl-4-isothiazolin-3-one;   5-chloro-2-methyl-2H-isothiazol-3-one;   CMIT;   Formula=C4H4ClNOS;   InChI=1S/C4H4ClNOS/c1-6-4(7)2-3(5)8-6/h2H,1H3;   InChIKey=DHNRXBZYEKSXIM-UHFFFAOYSA-N;   MCI;   SMILES=Cn1sc(Cl)cc1=O;   methylchloroisothiazolinone
 xref: CAS:26172-55-4
 xref_mesh: MESH:C011421
 xref: PMID:10416701;   PMID:20492831;   PMID:20566902;   PMID:21616561;   PMID:22994269;   PMID:23510348;   PMID:23510349;   Reaxys:1210149;   Wikipedia:Methylchloroisothiazolinone


show annotations for term's descendants           Sort by:
chloromethylisothiazolinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of ACTB protein CTD PMID:29267982 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased activity of AKR1C2 promoter CTD PMID:21195160 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Alb albumin increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of ALB protein CTD PMID:29267982 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of CCL4 protein CTD PMID:18353026 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 multiple interactions ISO [5-chloro-2-methyl-4-isothiazolin-3-one co-treated with 2-methyl-4-isothiazolin-3-one] results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839 		JBrowse link
G Dhx9 DExH-box helicase 9 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of DHX9 protein CTD PMID:29267982 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069 		JBrowse link
G Hbb hemoglobin subunit beta increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HBB protein CTD PMID:29267982 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hist1h4m histone cluster 1, H4m increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of H4C1 protein CTD PMID:29267982 NCBI chr17:42,698,016...42,698,420
Ensembl chr17:42,698,025...42,698,958 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of HMOX1 mRNA CTD PMID:20713136 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HNRNPK protein CTD PMID:29267982 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HSP90AA1 protein CTD PMID:29267982 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HSPA1A protein CTD PMID:29267982 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HSPA8 protein CTD PMID:29267982 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Il2 interleukin 2 increases secretion ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased secretion of IL2 protein CTD PMID:22245253 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 increases secretion ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lmna lamin A/C increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of LMNA protein CTD PMID:29267982 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Myh9 myosin, heavy chain 9 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of MYH9 protein CTD PMID:29267982 NCBI chr 7:111,224,291...111,304,963
Ensembl chr 7:109,343,706...109,424,457 		JBrowse link
G Notch3 notch receptor 3 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of NOTCH3 mRNA CTD PMID:20713136 NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of NQO1 mRNA CTD PMID:20491607 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pkm pyruvate kinase M1/2 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of PKM protein CTD PMID:29267982 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [5-chloro-2-methyl-4-isothiazolin-3-one co-treated with 2-methyl-4-isothiazolin-3-one] results in increased expression of VEGFA protein CTD PMID:25617811 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        antimicrobial agent 18276
          chloromethylisothiazolinone 22
            MCI/MI 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            organic molecule 19735
                              organic cyclic compound 19528
                                organic heterocyclic compound 18895
                                  heteroarene 17170
                                    monocyclic heteroarene 15017
                                      azole 14514
                                        thiazoles 1801
                                          1,2-thiazoles 681
                                            methylisothiazolinone 675
                                              chloromethylisothiazolinone 22
                                                MCI/MI 0
paths to the root