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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chloromethylisothiazolinone
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Accession:CHEBI:53621 term browser browse the term
Definition:A 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product Kathon(TM).
Synonyms:exact_synonym: 5-chloro-2-methyl-1,2-thiazol-3(2H)-one
 related_synonym: 2,3-dihydro-2-methyl-3-oxo-5-chloroisothiazole;   5-Chloro-2-methyl-4-isothiazolin-3-one;   5-chloro-2-methyl-2H-isothiazol-3-one;   CMIT;   Formula=C4H4ClNOS;   InChI=1S/C4H4ClNOS/c1-6-4(7)2-3(5)8-6/h2H,1H3;   InChIKey=DHNRXBZYEKSXIM-UHFFFAOYSA-N;   MCI;   SMILES=Cn1sc(Cl)cc1=O;   methylchloroisothiazolinone
 xref: Beilstein:1210149;   CAS:26172-55-4
 xref_mesh: MESH:C011421
 xref: PMID:10416701;   PMID:20492831;   PMID:20566902;   PMID:21616561;   PMID:22994269;   PMID:23510348;   PMID:23510349;   Reaxys:1210149;   Wikipedia:Methylchloroisothiazolinone


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chloromethylisothiazolinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of ACTB protein CTD PMID:29267982 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased activity of AKR1C2 promoter CTD PMID:21195160 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Alb albumin increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of ALB protein CTD PMID:29267982 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of CCL4 protein CTD PMID:18353026 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 multiple interactions ISO [5-chloro-2-methyl-4-isothiazolin-3-one co-treated with 2-methyl-4-isothiazolin-3-one] results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr17:8,317,933...8,325,956
Ensembl chr17:8,317,933...8,324,839
JBrowse link
G Dhx9 DExH-box helicase 9 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of DHX9 protein CTD PMID:29267982 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
JBrowse link
G Hbb hemoglobin subunit beta increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HBB protein CTD PMID:29267982 NCBI chr 1:158,250,421...158,251,832 JBrowse link
G Hist1h4m histone cluster 1, H4m increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of H4C1 protein CTD PMID:29267982 NCBI chr17:42,698,054...42,698,365
Ensembl chr17:42,698,025...42,698,958
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of HMOX1 mRNA CTD PMID:20713136 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HNRNPK protein CTD PMID:29267982 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HSP90AA1 protein CTD PMID:29267982 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HSPA1A protein CTD PMID:29267982
G Hspa8 heat shock protein family A (Hsp70) member 8 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HSPA8 protein CTD PMID:29267982 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Il2 interleukin 2 increases secretion ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased secretion of IL2 protein CTD PMID:22245253 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 increases secretion ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lmna lamin A/C increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of LMNA protein CTD PMID:29267982 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Myh9 myosin, heavy chain 9 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of MYH9 protein CTD PMID:29267982 NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457
JBrowse link
G Notch3 notch receptor 3 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of NOTCH3 mRNA CTD PMID:20713136 NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of NQO1 mRNA CTD PMID:20491607 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pkm pyruvate kinase M1/2 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of PKM protein CTD PMID:29267982 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [5-chloro-2-methyl-4-isothiazolin-3-one co-treated with 2-methyl-4-isothiazolin-3-one] results in increased expression of VEGFA protein CTD PMID:25617811 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          chloromethylisothiazolinone 22
            MCI/MI 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  heteroarene 16534
                                    monocyclic heteroarene 13436
                                      azole 12624
                                        thiazoles 1714
                                          1,2-thiazoles 659
                                            methylisothiazolinone 653
                                              chloromethylisothiazolinone 22
                                                MCI/MI 0
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