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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chloromethylisothiazolinone
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Accession:CHEBI:53621 term browser browse the term
Definition:A 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product Kathon(TM).
Synonyms:exact_synonym: 5-chloro-2-methyl-1,2-thiazol-3(2H)-one
 related_synonym: 2,3-dihydro-2-methyl-3-oxo-5-chloroisothiazole;   5-Chloro-2-methyl-4-isothiazolin-3-one;   5-chloro-2-methyl-2H-isothiazol-3-one;   CMIT;   Formula=C4H4ClNOS;   InChI=1S/C4H4ClNOS/c1-6-4(7)2-3(5)8-6/h2H,1H3;   InChIKey=DHNRXBZYEKSXIM-UHFFFAOYSA-N;   MCI;   SMILES=Cn1sc(Cl)cc1=O;   methylchloroisothiazolinone
 xref: Beilstein:1210149;   CAS:26172-55-4
 xref_mesh: MESH:C011421
 xref: PMID:10416701;   PMID:20492831;   PMID:20566902;   PMID:21616561;   PMID:22994269;   PMID:23510348;   PMID:23510349;   Reaxys:1210149;   Wikipedia:Methylchloroisothiazolinone


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chloromethylisothiazolinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of ACTB protein CTD PMID:29267982 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased activity of AKR1C2 promoter CTD PMID:21195160 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Alb albumin increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of ALB protein CTD PMID:29267982 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of CCL4 protein CTD PMID:18353026 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 multiple interactions ISO [5-chloro-2-methyl-4-isothiazolin-3-one co-treated with 2-methyl-4-isothiazolin-3-one] results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Dhx9 DExH-box helicase 9 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of DHX9 protein CTD PMID:29267982 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Hbb hemoglobin subunit beta increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HBB protein CTD PMID:29267982 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hist1h4m histone cluster 1, H4m increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of H4C1 protein CTD PMID:29267982 Ensembl chr17:44,815,684...44,815,995 JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of HMOX1 mRNA CTD PMID:20713136 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HNRNPK protein CTD PMID:29267982 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HSP90AA1 protein CTD PMID:29267982 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HSPA1A protein CTD PMID:29267982 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HSPA8 protein CTD PMID:29267982 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Il2 interleukin 2 increases secretion ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased secretion of IL2 protein CTD PMID:22245253 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 increases secretion ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lmna lamin A/C increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of LMNA protein CTD PMID:29267982 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Myh9 myosin, heavy chain 9 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of MYH9 protein CTD PMID:29267982 NCBI chr 7:118,740,005...118,792,507
Ensembl chr 7:118,741,110...118,792,625
JBrowse link
G Notch3 notch receptor 3 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of NOTCH3 mRNA CTD PMID:20713136 NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of NQO1 mRNA CTD PMID:20491607 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pkm pyruvate kinase M1/2 increases metabolic processing ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of PKM protein CTD PMID:29267982 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO 5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [5-chloro-2-methyl-4-isothiazolin-3-one co-treated with 2-methyl-4-isothiazolin-3-one] results in increased expression of VEGFA protein CTD PMID:25617811 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          chloromethylisothiazolinone 22
            MCI/MI 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  heteroarene 16447
                                    monocyclic heteroarene 13303
                                      azole 12471
                                        thiazoles 1241
                                          1,2-thiazoles 655
                                            methylisothiazolinone 652
                                              chloromethylisothiazolinone 22
                                                MCI/MI 0
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