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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hexamethylene diisocyanate
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Accession:CHEBI:53578 term browser browse the term
Definition:A diisocyanate compound with the two isocyanates linked by a hexane-1,6-diyl group.
Synonyms:related_synonym: 1,6-Diisocyanatohexane;   1,6-Hexamethylene diisocyanate;   1,6-Hexanediol diisocyanate;   1,6-Hexylene diisocyanate;   Formula=C8H12N2O2;   HDI;   HMDI;   Hexane 1,6-diisocyanate;   InChI=1S/C8H12N2O2/c11-7-9-5-3-1-2-4-6-10-8-12/h1-6H2;   InChIKey=RRAMGCGOFNQTLD-UHFFFAOYSA-N;   SMILES=O=C=NCCCCCCN=C=O
 xref: Beilstein:956709;   CAS:822-06-0;   Gmelin:50636
 xref_mesh: MESH:C015262
 xref: PMID:11927838;   PMID:16731584;   PMID:17042142;   PMID:21878336;   PMID:22293954;   PMID:22419182;   PMID:22449630;   PMID:23178851;   PMID:23262421;   PMID:23421488;   PMID:24083673;   PMID:6296214;   Reaxys:956709;   Wikipedia:Hexamethylene_diisocyanate


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hexamethylene diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of AMPD3 mRNA CTD PMID:24211530 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
JBrowse link
G Atox1 antioxidant 1 copper chaperone increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATOX1 promoter CTD PMID:25445006 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950
JBrowse link
G Atp8a2 ATPase phospholipid transporting 8A2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATP8A2 gene CTD PMID:25445006 NCBI chr15:33,817,309...34,350,193
Ensembl chr15:33,819,755...34,350,223
JBrowse link
G Atp9b ATPase phospholipid transporting 9B (putative) increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATP9B gene CTD PMID:25445006 NCBI chr18:74,176,863...74,368,993
Ensembl chr18:74,176,863...74,368,953
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of CACNA1H gene CTD PMID:25445006 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Dhx29 DExH-box helicase 29 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of DHX29 mRNA CTD PMID:19527780 NCBI chr 2:44,560,653...44,611,450
Ensembl chr 2:44,560,714...44,611,445
JBrowse link
G Dscaml1 DS cell adhesion molecule-like 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of DSCAML1 gene CTD PMID:25445006 NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:45,740,298...46,057,320
JBrowse link
G Ebag9 estrogen receptor binding site associated, antigen, 9 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of EBAG9 gene CTD PMID:25445006 NCBI chr 7:75,810,950...75,828,902
Ensembl chr 7:75,810,594...75,861,248
JBrowse link
G Fam210a family with sequence similarity 210, member A increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FAM210A promoter CTD PMID:25445006 NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171
JBrowse link
G Farp1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FARP1 gene CTD PMID:25445006 NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299
JBrowse link
G Fbxw4 F-box and WD repeat domain containing 4 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FBXW4 gene CTD PMID:25445006 NCBI chr 1:244,426,892...244,514,188
Ensembl chr 1:244,426,896...244,514,163
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of FTH1 mRNA CTD PMID:24211530 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of FTL mRNA CTD PMID:24211530 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of GCLM mRNA CTD PMID:24211530 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of GNRHR mRNA CTD PMID:19527780 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance ISO GSTM1 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gypc glycophorin C (Gerbich blood group) increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of GYPC gene CTD PMID:25445006 NCBI chr18:24,160,738...24,193,408
Ensembl chr18:24,160,739...24,193,204
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of HMOX1 mRNA CTD PMID:24211530 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of ICAM1 protein CTD PMID:11698162 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of IFNG protein CTD PMID:12884401 PMID:19422874 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of IL10 protein CTD PMID:12884401 PMID:19422874 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 increases secretion ISO 1,6-hexamethylene diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of IL22RA2 gene CTD PMID:25445006 NCBI chr 1:14,353,736...14,377,844
Ensembl chr 1:14,364,489...14,377,844
JBrowse link
G Il4 interleukin 4 increases expression
increases secretion
ISO 1,6-hexamethylene diisocyanate results in increased expression of IL4 protein
1,6-hexamethylene diisocyanate results in increased secretion of IL4 protein
CTD PMID:12884401 PMID:17693426 PMID:19422874 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 increases secretion ISO 1,6-hexamethylene diisocyanate results in increased secretion of IL5 protein CTD PMID:17693426 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ISG20 promoter CTD PMID:25445006 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Islr2 immunoglobulin superfamily containing leucine-rich repeat 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ISLR2 gene CTD PMID:25445006 NCBI chr 8:58,608,165...58,616,246
Ensembl chr 8:58,608,709...58,614,650
JBrowse link
G Kitlg KIT ligand affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of KITLG mRNA CTD PMID:19110044 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Lca5l lebercilin LCA5 like increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of LCA5L gene CTD PMID:25445006 NCBI chr11:35,460,648...35,495,133
Ensembl chr11:35,461,118...35,495,047
JBrowse link
G Ldha lactate dehydrogenase A affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of LDHA mRNA CTD PMID:19110044 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of HSPA6 mRNA CTD PMID:19110044 NCBI chr13:83,271,340...83,275,267 JBrowse link
G LOC686596 similar to aquaporin 10 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of AQP10 mRNA CTD PMID:19527780 NCBI chr 2:175,402,609...175,407,677
Ensembl chr 2:175,403,263...175,406,815
JBrowse link
G Lrrn4 leucine rich repeat neuronal 4 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of LRRN4 gene CTD PMID:25445006 NCBI chr 3:120,138,093...120,150,877
Ensembl chr 3:120,139,410...120,150,831
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 1,6-hexamethylene diisocyanate promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK1 protein
CTD PMID:27129696 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 1,6-hexamethylene diisocyanate promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK3 protein
CTD PMID:27129696 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO 1,6-hexamethylene diisocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK8 protein
CTD PMID:27129696 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO 1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK9 protein
1,6-hexamethylene diisocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]
CTD PMID:27129696 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mrpl58 mitochondrial ribosomal protein L58 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of MRPL58 gene CTD PMID:25445006 NCBI chr10:100,646,374...100,652,871
Ensembl chr10:100,646,216...100,652,871
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of MYC mRNA CTD PMID:24211530 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nab2 Ngfi-A binding protein 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of NAB2 gene CTD PMID:25445006 NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989
JBrowse link
G Nat1 N-acetyltransferase 1 increases response to substance ISO NAT1 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nexn nexilin (F actin binding protein) affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of NEXN mRNA CTD PMID:19527780 NCBI chr 2:241,186,783...241,218,315
Ensembl chr 2:241,186,790...241,218,342
JBrowse link
G Nmbr neuromedin B receptor increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of NMBR gene CTD PMID:25445006 NCBI chr 1:9,115,033...9,146,081
Ensembl chr 1:9,134,889...9,145,462
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of NQO1 mRNA CTD PMID:24211530 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Olr1433 olfactory receptor 1433 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of OR2W3 mRNA CTD PMID:19527780 NCBI chr10:43,042,427...43,046,293
Ensembl chr10:43,037,857...43,046,701
JBrowse link
G Osbp2 oxysterol binding protein 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of OSBP2 mRNA CTD PMID:19527780 NCBI chr14:78,585,088...78,746,785
Ensembl chr14:78,585,089...78,746,786
JBrowse link
G Rnmt RNA (guanine-7-) methyltransferase increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of RNMT promoter CTD PMID:25445006 NCBI chr18:61,886,230...61,909,775
Ensembl chr18:61,886,292...61,909,775
JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SEL1L3 mRNA CTD PMID:24211530 NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644
JBrowse link
G Slc16a4 solute carrier family 16, member 4 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of SLC16A4 mRNA CTD PMID:19110044 NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117
JBrowse link
G Slc25a28 solute carrier family 25 member 28 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of SLC25A28 gene CTD PMID:25445006 NCBI chr 1:242,530,877...242,542,140
Ensembl chr 1:242,530,899...242,542,115
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SLC7A11 mRNA CTD PMID:24211530 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Socs3 suppressor of cytokine signaling 3 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of SOCS3 mRNA CTD PMID:19110044 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Specc1 sperm antigen with calponin homology and coiled-coil domains 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of SPECC1 gene CTD PMID:25445006 NCBI chr10:46,638,947...46,912,989
Ensembl chr10:46,638,809...46,912,802
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SQSTM1 mRNA CTD PMID:24211530 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Stc1 stanniocalcin 1 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of STC1 mRNA CTD PMID:19527780 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 decreases expression ISO 1,6-hexamethylene diisocyanate results in decreased expression of SYNE2 mRNA CTD PMID:24211530 NCBI chr 6:94,537,088...94,848,085 JBrowse link
G Tlr2 toll-like receptor 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of TLR2 mRNA CTD PMID:19110044 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tmem253 transmembrane protein 253 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of TMEM253 promoter CTD PMID:25445006 NCBI chr15:24,706,517...24,709,107
Ensembl chr15:24,706,529...24,708,625
JBrowse link
G Tnnt2 troponin T2, cardiac type decreases expression ISO 1,6-hexamethylene diisocyanate results in decreased expression of TNNT2 mRNA CTD PMID:24211530 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of TXNRD1 mRNA CTD PMID:24211530 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of UBA2 mRNA CTD PMID:19527780 NCBI chr 1:86,775,239...86,802,685
Ensembl chr 1:86,775,244...86,802,682
JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of UBE2E1 promoter CTD PMID:25445006 NCBI chr15:7,439,502...7,493,410
Ensembl chr15:7,439,759...7,493,400
JBrowse link
G Zfp219 zinc finger protein 219 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ZNF219 promoter CTD PMID:25445006 NCBI chr15:24,695,831...24,710,039
Ensembl chr15:24,695,837...24,710,030
JBrowse link

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  CHEBI ontology 19821
    role 19769
      biological role 19769
        hapten 3021
          hexamethylene diisocyanate 64
Path 2
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      p-block molecular entity 19716
                        carbon group molecular entity 19640
                          organic molecular entity 19630
                            heteroorganic entity 19294
                              organochalcogen compound 19064
                                organooxygen compound 19014
                                  isocyanates 345
                                    diisocyanate 309
                                      hexamethylene diisocyanate 64
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