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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hexamethylene diisocyanate
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Accession:CHEBI:53578 term browser browse the term
Definition:A diisocyanate compound with the two isocyanates linked by a hexane-1,6-diyl group.
Synonyms:related_synonym: 1,6-Diisocyanatohexane;   1,6-Hexamethylene diisocyanate;   1,6-Hexanediol diisocyanate;   1,6-Hexylene diisocyanate;   Formula=C8H12N2O2;   HDI;   HMDI;   Hexane 1,6-diisocyanate;   InChI=1S/C8H12N2O2/c11-7-9-5-3-1-2-4-6-10-8-12/h1-6H2;   InChIKey=RRAMGCGOFNQTLD-UHFFFAOYSA-N;   SMILES=O=C=NCCCCCCN=C=O
 xref: Beilstein:956709;   CAS:822-06-0;   Gmelin:50636
 xref_mesh: MESH:C015262
 xref: PMID:11927838;   PMID:16731584;   PMID:17042142;   PMID:21878336;   PMID:22293954;   PMID:22419182;   PMID:22449630;   PMID:23178851;   PMID:23262421;   PMID:23421488;   PMID:24083673;   PMID:6296214;   Reaxys:956709;   Wikipedia:Hexamethylene_diisocyanate


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hexamethylene diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of AMPD3 mRNA CTD PMID:24211530 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G Atox1 antioxidant 1 copper chaperone increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATOX1 promoter CTD PMID:25445006 NCBI chr10:40,790,850...40,805,886
Ensembl chr10:40,790,845...40,805,941
JBrowse link
G Atp8a2 ATPase phospholipid transporting 8A2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATP8A2 gene CTD PMID:25445006 NCBI chr15:39,955,689...40,488,737
Ensembl chr15:40,000,322...40,428,800
JBrowse link
G Atp9b ATPase phospholipid transporting 9B (putative) increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATP9B gene CTD PMID:25445006 NCBI chr18:77,343,551...77,535,608
Ensembl chr18:77,343,551...77,535,593
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of CACNA1H gene CTD PMID:25445006 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Dhx29 DExH-box helicase 29 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of DHX29 mRNA CTD PMID:19527780 NCBI chr 2:44,787,066...44,837,834
Ensembl chr 2:44,787,002...44,837,831
JBrowse link
G Dscaml1 DS cell adhesion molecule-like 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of DSCAML1 gene CTD PMID:25445006 NCBI chr 8:49,733,835...50,056,115
Ensembl chr 8:49,737,798...50,055,560
JBrowse link
G Ebag9 estrogen receptor binding site associated, antigen, 9 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of EBAG9 gene CTD PMID:25445006 NCBI chr 7:83,564,563...83,582,516
Ensembl chr 7:83,564,563...83,582,508
JBrowse link
G Fam210a family with sequence similarity 210, member A increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FAM210A promoter CTD PMID:25445006 NCBI chr18:64,045,023...64,084,594
Ensembl chr18:64,045,432...64,084,556
JBrowse link
G Farp1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FARP1 gene CTD PMID:25445006 NCBI chr15:106,375,298...106,625,837
Ensembl chr15:106,434,177...106,625,837
JBrowse link
G Fbxw4 F-box and WD repeat domain containing 4 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FBXW4 gene CTD PMID:25445006 NCBI chr 1:265,318,526...265,420,503
Ensembl chr 1:265,318,526...265,420,503
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of FTH1 mRNA CTD PMID:24211530 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of FTL mRNA CTD PMID:24211530 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of GCLM mRNA CTD PMID:24211530 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of GNRHR mRNA CTD PMID:19527780 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance ISO GSTM1 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gypc glycophorin C (Gerbich blood group) increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of GYPC gene CTD PMID:25445006 NCBI chr18:25,312,386...25,344,614
Ensembl chr18:25,312,387...25,344,614
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of HMOX1 mRNA CTD PMID:24211530 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of ICAM1 protein CTD PMID:11698162 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of IFNG protein CTD PMID:12884401, PMID:19422874 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of IL10 protein CTD PMID:12884401, PMID:19422874 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 increases secretion ISO 1,6-hexamethylene diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of IL22RA2 gene CTD PMID:25445006 NCBI chr 1:15,084,136...15,107,423
Ensembl chr 1:15,093,599...15,106,954
JBrowse link
G Il4 interleukin 4 increases expression
increases secretion
ISO 1,6-hexamethylene diisocyanate results in increased expression of IL4 protein
1,6-hexamethylene diisocyanate results in increased secretion of IL4 protein
CTD PMID:12884401, PMID:17693426, PMID:19422874 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 increases secretion ISO 1,6-hexamethylene diisocyanate results in increased secretion of IL5 protein CTD PMID:17693426 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ISG20 promoter CTD PMID:25445006 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
JBrowse link
G Islr2 immunoglobulin superfamily containing leucine-rich repeat 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ISLR2 gene CTD PMID:25445006 NCBI chr 8:62,983,333...62,991,401
Ensembl chr 8:62,984,552...62,987,182
JBrowse link
G Kitlg KIT ligand affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of KITLG mRNA CTD PMID:19110044 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Lca5l lebercilin LCA5 like increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of LCA5L gene CTD PMID:25445006 NCBI chr11:36,512,823...36,546,806
Ensembl chr11:36,512,974...36,533,073
JBrowse link
G Ldha lactate dehydrogenase A affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of LDHA mRNA CTD PMID:19110044 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G LOC686596 similar to aquaporin 10 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of AQP10 mRNA CTD PMID:19527780 NCBI chr 2:189,309,151...189,314,092 JBrowse link
G Lrrn4 leucine rich repeat neuronal 4 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of LRRN4 gene CTD PMID:25445006 NCBI chr 3:125,521,879...125,547,685
Ensembl chr 3:125,523,781...125,533,600
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 1,6-hexamethylene diisocyanate promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK1 protein
CTD PMID:27129696 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 1,6-hexamethylene diisocyanate promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK3 protein
CTD PMID:27129696 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO 1,6-hexamethylene diisocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK8 protein
CTD PMID:27129696 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO 1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK9 protein
1,6-hexamethylene diisocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]
CTD PMID:27129696 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mrpl58 mitochondrial ribosomal protein L58 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of MRPL58 gene CTD PMID:25445006 NCBI chr10:103,956,019...103,962,515
Ensembl chr10:103,956,019...103,962,515
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of MYC mRNA CTD PMID:24211530 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nab2 Ngfi-A binding protein 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of NAB2 gene CTD PMID:25445006 NCBI chr 7:70,963,580...70,971,471
Ensembl chr 7:70,961,575...70,969,905
JBrowse link
G Nat1 N-acetyltransferase 1 increases response to substance ISO NAT1 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nexn nexilin (F actin binding protein) affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of NEXN mRNA CTD PMID:19527780 NCBI chr 2:257,452,937...257,484,607
Ensembl chr 2:257,453,347...257,484,587
JBrowse link
G Nmbr neuromedin B receptor increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of NMBR gene CTD PMID:25445006 NCBI chr 1:8,933,744...8,945,850
Ensembl chr 1:8,933,831...8,944,987
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of NQO1 mRNA CTD PMID:24211530 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Olr1433 olfactory receptor 1433 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of OR2W3 mRNA CTD PMID:19527780 NCBI chr10:44,292,927...44,293,954
Ensembl chr10:44,292,927...44,293,954
JBrowse link
G Osbp2 oxysterol binding protein 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of OSBP2 mRNA CTD PMID:19527780 NCBI chr14:83,943,976...84,107,031
Ensembl chr14:83,943,977...84,106,997
JBrowse link
G Rnmt RNA (guanine-7-) methyltransferase increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of RNMT promoter CTD PMID:25445006 NCBI chr18:64,084,746...64,108,246
Ensembl chr18:64,084,795...64,108,246
JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SEL1L3 mRNA CTD PMID:24211530 NCBI chr14:60,122,968...60,229,565
Ensembl chr14:60,123,169...60,229,734
JBrowse link
G Slc16a4 solute carrier family 16, member 4 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of SLC16A4 mRNA CTD PMID:19110044 NCBI chr 2:210,045,122...210,161,017
Ensembl chr 2:210,045,161...210,068,502
JBrowse link
G Slc25a28 solute carrier family 25 member 28 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of SLC25A28 gene CTD PMID:25445006 NCBI chr 1:263,420,039...263,431,312
Ensembl chr 1:263,420,061...263,431,290
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SLC7A11 mRNA CTD PMID:24211530 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Socs3 suppressor of cytokine signaling 3 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of SOCS3 mRNA CTD PMID:19110044 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Specc1 sperm antigen with calponin homology and coiled-coil domains 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of SPECC1 gene CTD PMID:25445006 NCBI chr10:48,240,291...48,542,171
Ensembl chr10:48,240,127...48,542,292
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SQSTM1 mRNA CTD PMID:24211530 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stc1 stanniocalcin 1 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of STC1 mRNA CTD PMID:19527780 NCBI chr15:50,891,137...50,901,791
Ensembl chr15:50,891,127...50,903,162
JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 decreases expression ISO 1,6-hexamethylene diisocyanate results in decreased expression of SYNE2 mRNA CTD PMID:24211530 NCBI chr 6:98,884,269...99,153,551 JBrowse link
G Tlr2 toll-like receptor 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of TLR2 mRNA CTD PMID:19110044 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tmem253 transmembrane protein 253 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of TMEM253 promoter CTD PMID:25445006 NCBI chr15:28,413,414...28,416,039
Ensembl chr15:28,413,461...28,415,554
JBrowse link
G Tnnt2 troponin T2, cardiac type decreases expression ISO 1,6-hexamethylene diisocyanate results in decreased expression of TNNT2 mRNA CTD PMID:24211530 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of TXNRD1 mRNA CTD PMID:24211530 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of UBA2 mRNA CTD PMID:19527780 NCBI chr 1:90,010,681...90,035,522
Ensembl chr 1:90,011,306...90,035,522
JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of UBE2E1 promoter CTD PMID:25445006 NCBI chr15:8,124,869...8,178,252
Ensembl chr15:8,125,526...8,177,781
JBrowse link
G Zfp219 zinc finger protein 219 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ZNF219 promoter CTD PMID:25445006 NCBI chr15:28,402,412...28,417,379
Ensembl chr15:28,402,415...28,406,046
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        hapten 3006
          hexamethylene diisocyanate 63
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      p-block molecular entity 19670
                        carbon group molecular entity 19572
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  isocyanates 338
                                    diisocyanate 304
                                      hexamethylene diisocyanate 63
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