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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Ginkgolide A
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Accession:CHEBI:5355 term browser browse the term
Definition:A diterpene lactone that has formula C20H24O9.
Synonyms:related_synonym: Formula=C20H24O9;   InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17?,18?,19-,20-/m1/s1;   InChIKey=FPUXKXIZEIDQKW-TVPHMGRTSA-N;   SMILES=C[C@@H]1C(=O)O[C@H]2CC34[C@H]5C[C@@H](C(C)(C)C)C33C(O)C(=O)O[C@H]3O[C@@]4(C(=O)O5)[C@@]12O
 xref: CAS:15291-75-5;   KEGG:C07601;   KNApSAcK:C00003429
 xref_mesh: MESH:C477042

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Ginkgolide A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO ginkgolide A results in increased expression of ABCB1 mRNA CTD PMID:19034627 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO ginkgolide A results in increased expression of ABCC2 mRNA CTD PMID:19034627 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:31697926 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Alb albumin multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein] CTD PMID:31697926 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of CALCA protein] CTD PMID:31697926 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression		 EXP ginkgolide A results in increased activity of CYP1A2 protein
ginkgolide A results in increased expression of CYP1A2 mRNA		 CTD PMID:18421621 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO ginkgolide A results in increased expression of CYP2B6 mRNA CTD PMID:19034627 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression EXP ginkgolide A results in increased expression of CYP3A18 mRNA CTD PMID:16258077 NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP ginkgolide A results in increased expression of CYP3A2 mRNA CTD PMID:16258077 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases activity
increases expression		 EXP ginkgolide A results in increased activity of CYP3A23-3A1 protein
ginkgolide A results in increased expression of CYP3A23-3A1 mRNA		 CTD PMID:16258077 PMID:17045319 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression ISO ginkgolide A results in increased expression of CYP3A4 mRNA CTD PMID:19034627 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:31697926 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Ifng interferon gamma multiple interactions ISO ginkgolide A affects the reaction [Carbon Tetrachloride results in increased expression of IFNG protein] CTD PMID:31697926 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein] CTD PMID:31697926 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Lbp lipopolysaccharide binding protein multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of LBP protein] CTD PMID:31697926 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 protein] CTD PMID:31697926 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO ginkgolide A results in increased activity of NR1I2 protein
ginkgolide A inhibits the reaction [Carbon Tetrachloride results in decreased expression of and affects the localization of NR1I2 protein]		 CTD PMID:19034627 PMID:31697926 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Ocln occludin multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in decreased expression of OCLN protein] CTD PMID:31697926 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein] CTD PMID:31697926 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in decreased expression of TJP1 protein] CTD PMID:31697926 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein] CTD PMID:31697926 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ginkgolide A inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] CTD PMID:31697926 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO ginkgolide A results in increased expression of UGT1A1 mRNA CTD PMID:19034627 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      atom 19873
        nonmetal atom 19751
          carbon atom 19657
            organic molecular entity 19657
              isoprenoid 10291
                terpenoid 9619
                  diterpenoid 8458
                    diterpene lactone 227
                      Ginkgolide A 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      carboxylic ester 14383
                                        lactone 6001
                                          terpene lactone 1773
                                            diterpene lactone 227
                                              Ginkgolide A 24
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