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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cobalt(2+) sulfate
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Accession:CHEBI:53470 term browser browse the term
Definition:A compound of cobalt and sulfate in which the ratio of cobalt (+2 oxidation state) to sulfate is 1:1.
Synonyms:related_synonym: CoSO4;   Cobalt Brown;   Cobalt monosulfate;   Cobalt sulfate;   Cobalt(II) sulfate;   Cobaltous sulfate;   Formula=CoO4S;   InChI=1S/Co.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2;   InChIKey=KTVIXTQDYHMGHF-UHFFFAOYSA-L;   SMILES=[Co++].[O-]S([O-])(=O)=O
 xref: CAS:10026-24-1;   CAS:10124-43-3;   Gmelin:268815;   Gmelin:270126;   Gmelin:270959;   Gmelin:8292;   KEGG:C17383;   KEGG:C19215
 xref_mesh: MESH:C026305
 xref: PMID:2415590


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cobalt(2+) sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ak1 adenylate kinase 1 decreases expression ISO cobalt sulfate results in decreased expression of AK1 mRNA CTD PMID:19502547 NCBI chr 3:11,652,143...11,659,135 JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO cobalt sulfate results in increased expression of ALDOA mRNA CTD PMID:19502547 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression ISO cobalt sulfate results in increased expression of ANKRD37 mRNA CTD PMID:19502547 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP cobalt sulfate results in decreased expression of BAX protein CTD PMID:25310813 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Ca9 carbonic anhydrase 9 increases expression ISO cobalt sulfate results in increased expression of CA9 mRNA CTD PMID:19502547 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
JBrowse link
G Casp3 caspase 3 decreases expression EXP cobalt sulfate results in decreased expression of CASP3 protein CTD PMID:25310813 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion
increases expression
ISO cobalt sulfate results in increased secretion of CCL4 protein
cobalt sulfate results in increased expression of CCL4 mRNA
CTD PMID:16314067 PMID:20713136 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO cobalt sulfate results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO cobalt sulfate results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases expression ISO cobalt sulfate results in increased expression of EGLN1 mRNA CTD PMID:19502547 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 decreases expression ISO cobalt sulfate results in decreased expression of EGLN2 mRNA CTD PMID:19502547 NCBI chr 1:83,969,456...83,977,665
Ensembl chr 1:83,969,457...83,977,236
JBrowse link
G Eno1 enolase 1 increases expression ISO cobalt sulfate results in increased expression of ENO1 mRNA CTD PMID:19502547 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Eno2 enolase 2 increases expression ISO cobalt sulfate results in increased expression of ENO2 mRNA CTD PMID:19502547 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO cobalt sulfate results in increased expression of FOS mRNA CTD PMID:10362023 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO cobalt sulfate results in increased expression of GAPDH mRNA CTD PMID:19502547 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity
ISO HIF1A protein promotes the reaction [cobalt sulfate results in increased expression of VEGFA protein]
cobalt sulfate results in increased activity of HIF1A protein
CTD PMID:19502547 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha decreases expression ISO cobalt sulfate results in decreased expression of HIF3A mRNA CTD PMID:19502547 NCBI chr 1:78,976,318...78,997,869
Ensembl chr 1:78,976,318...78,997,869
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated increases expression ISO cobalt sulfate results in increased expression of HILPDA mRNA CTD PMID:19502547 NCBI chr 4:56,547,600...56,550,584
Ensembl chr 4:56,549,739...56,549,993
JBrowse link
G Hk2 hexokinase 2 increases expression ISO cobalt sulfate results in increased expression of HK2 mRNA CTD PMID:19502547 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO cobalt sulfate results in increased expression of HMOX1 mRNA CTD PMID:20713136 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Igf1 insulin-like growth factor 1 increases secretion EXP cobalt sulfate results in increased secretion of IGF1 protein CTD PMID:25310813 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il1b interleukin 1 beta increases expression ISO cobalt sulfate results in increased expression of IL1B mRNA CTD PMID:20713136 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il7r interleukin 7 receptor increases expression ISO cobalt sulfate results in increased expression of IL7R mRNA CTD PMID:20713136
G Ldha lactate dehydrogenase A increases expression ISO cobalt sulfate results in increased expression of LDHA mRNA CTD PMID:19502547 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO cobalt sulfate results in increased expression of MIF mRNA CTD PMID:19502547 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mt2A metallothionein 2A increases expression ISO cobalt sulfate results in increased expression of MT2A mRNA CTD PMID:10362023 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nppb natriuretic peptide B increases expression ISO cobalt sulfate results in increased expression of NPPB mRNA CTD PMID:19502547 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression ISO cobalt sulfate results in increased expression of PDK1 mRNA CTD PMID:19502547 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression ISO cobalt sulfate results in increased expression of PGK1 mRNA CTD PMID:19502547 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO cobalt sulfate results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta decreases expression ISO cobalt sulfate results in decreased expression of PPP2R1B mRNA CTD PMID:19502547 NCBI chr 8:55,279,278...55,311,768
Ensembl chr 8:55,279,373...55,301,320
JBrowse link
G Tfrc transferrin receptor increases expression ISO cobalt sulfate results in increased expression of TFRC mRNA CTD PMID:19502547 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO cobalt sulfate results in increased expression of TNFAIP3 mRNA CTD PMID:20713136 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO cobalt sulfate results in increased expression of TNFAIP6 mRNA CTD PMID:20713136 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
increases expression
ISO cobalt sulfate results in decreased expression of VEGFA mRNA
HIF1A protein promotes the reaction [cobalt sulfate results in increased expression of VEGFA protein]
CTD PMID:19502547 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      biological role 19804
        biochemical role 19339
          cofactor 15554
            cobalt(2+) 4261
              cobalt(2+) sulfate 35
                cobalt(2+) sulfate heptahydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      chalcogen 19438
                        oxygen atom 19400
                          oxygen molecular entity 19400
                            hydroxides 19123
                              oxoacid 18256
                                chalcogen oxoacid 11493
                                  sulfur oxoacid 11097
                                    sulfuric acid 8017
                                      sulfuric acid derivative 8017
                                        sulfates 8014
                                          sulfate salt 7063
                                            inorganic sulfate salt 7005
                                              metal sulfate 7004
                                                cobalt(2+) sulfate 35
                                                  cobalt(2+) sulfate heptahydrate 0
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