1,4-bis(2-ethylhexyl) sulfosuccinate - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	1,4-bis(2-ethylhexyl) sulfosuccinate	go back to main search page
Accession:	CHEBI:534	browse the term
Definition:	A succinate ester that has formula C20H38O7S.
Synonyms:	related_synonym:	1,4-bis(2-ethylhexoxy)-1,4-bis(oxidanylidene)butane-2-sulfonic acid; 1,4-bis(2-ethylhexoxy)-1,4-diketo-butane-2-sulfonic acid; 1,4-bis(2-ethylhexoxy)-1,4-dioxo-2-butanesulfonic acid; 1,4-bis(2-ethylhexoxy)-1,4-dioxo-butane-2-sulfonic acid; 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonic acid; 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonic acid; 1-(2-Methylphenyl)ethanone; 1-(2-Tolyl)ethanone; 1-(Methylphenyl)-Ethanone; 1-(Methylphenyl)ethan-1-one; 2'-Methyl-Acetophenone; 2'-Methylacetophenone; 2'-Methylacetylphenone; 2-Acetyltoluene; Acetophenone, 2'-methyl- (8CI); Docusate hydrogen; Ethanone, 1-(2-methylphenyl)- (9CI); Formula=C20H38O7S; InChI=1S/C20H38O7S/c1-5-9-11-16(7-3)14-26-19(21)13-18(28(23,24)25)20(22)27-15-17(8-4)12-10-6-2/h16-18H,5-15H2,1-4H3,(H,23,24,25); InChIKey=HNSDLXPSAYFUHK-UHFFFAOYSA-N; Methyl O-tolyl ketone; O-Acetyltoluene; O-Methyl acetophenone; O-Methylacetophenone; SMILES=CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S(O)(=O)=O; dioctyl disodium sulfosuccinate; dioctyl sulfosuccinate; dioctyl sulfosuccinic acid; docusate; docusate calcium
	xref:	CAS:10041-19-7; CAS:577-16-2; Drug_Central:941; HMDB:HMDB0032386; KEGG:C07874
	xref_mesh:	MESH:D004143
	xref:	PMID:19167006

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Genes (6)

1,4-bis(2-ethylhexyl) sulfosuccinate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

delta like non-canonical Notch ligand 1

decreases expression

Dioctyl Sulfosuccinic Acid results in decreased expression of DLK1 mRNA

NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522

G

fatty acid binding protein 4

increases expression

Dioctyl Sulfosuccinic Acid results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578

G

iodotyrosine deiodinase

multiple interactions

Dioctyl Sulfosuccinic Acid inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]

NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319

G

peroxisome proliferator activated receptor alpha

increases activity

Dioctyl Sulfosuccinic Acid results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

increases activity

Dioctyl Sulfosuccinic Acid results in increased activity of PPARD protein

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases activity

Dioctyl Sulfosuccinic Acid binds to and results in increased activity of PPARG protein
Dioctyl Sulfosuccinic Acid results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19800
chemical entity	19800
group	19722
inorganic group	19247
sulfo group	5774
organosulfonic acid	5774
1,4-bis(2-ethylhexyl) sulfosuccinate	6
Path 2
Term	Annotations
CHEBI ontology	19800
subatomic particle	19799
composite particle	19799
hadron	19799
baryon	19799
nucleon	19799
atomic nucleus	19799
atom	19799
main group element atom	19698
p-block element atom	19698
chalcogen	19450
oxygen atom	19423
oxygen molecular entity	19423
hydroxides	19158
oxoacid	18472
chalcogen oxoacid	11498
sulfur oxoacid	11106
sulfonic acid	7371
sulfo group	5774
organosulfonic acid	5774
1,4-bis(2-ethylhexyl) sulfosuccinate	6

paths to the root