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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chromium(3+) trichloride
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Accession:CHEBI:53351 term browser browse the term
Definition:A chromium chloride with the chromium cation in the +3 oxidation state.
Synonyms:related_synonym: Chromic chloride;   Chromium chloride;   Chromium trichloride;   Chromium(III) chloride;   CrCl3;   Formula=Cl3Cr;   InChI=1S/3ClH.Cr/h3*1H;/q;;;+3/p-3;   InChIKey=QSWDMMVNRMROPK-UHFFFAOYSA-K;   Puratronic chromium chloride;   SMILES=[Cl-].[Cl-].[Cl-].[Cr+3];   Trichlorochromium;   anhydrous chromium(III) chloride
 xref: CAS:10025-73-7;   CAS:39345-92-1;   Drug_Central:5118;   Gmelin:130477;   Gmelin:1890;   Gmelin:532690
 xref_mesh: MESH:C022990
 xref: PMID:1108802;   PMID:1254974;   PMID:16349963;   PMID:19013231;   PMID:20237381;   PMID:29079364;   PMID:5112173;   PMID:670731;   PMID:7351481;   Patent:CN101456852;   Patent:CN101473776;   Patent:CN101632832;   Patent:CN101863755;   Reaxys:3903065;   Wikipedia:Chromium(III)_chloride



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chromium(3+) trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
decreases expression
ISO [cobaltous chloride co-treated with chromic chloride] results in decreased expression of ALPL protein
chromic chloride results in decreased expression of ALPL protein
CTD PMID:25966675 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Aspm assembly factor for spindle microtubules increases expression ISO chromic chloride results in increased expression of ASPM mRNA CTD PMID:12128095 NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755
JBrowse link
G Bach2 BTB domain and CNC homolog 2 increases expression ISO chromic chloride results in increased expression of BACH2 mRNA CTD PMID:12128095 NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO chromic chloride results in increased expression of BAX protein CTD PMID:14741615 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO chromic chloride results in decreased expression of BCL2 protein CTD PMID:14741615 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO chromic chloride results in increased expression of BTG2 mRNA CTD PMID:12128095 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Casp3 caspase 3 multiple interactions ISO chromic chloride results in increased expression of and results in increased activity of CASP3 protein CTD PMID:14741615 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO chromic chloride results in increased expression of and results in increased activity of CASP8 protein CTD PMID:14741615 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase increases activity EXP chromic chloride results in increased activity of CAT protein CTD PMID:21888059 PMID:23413686 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO chromic chloride results in increased expression of CCL2 protein
chromic chloride inhibits the reaction [Glucose results in increased secretion of CCL2 protein]
[cobaltous chloride co-treated with chromic chloride] results in increased expression of CCL2 mRNA
CTD PMID:17665966 PMID:23629852 PMID:25966675 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO chromic chloride results in increased expression of CDC25A mRNA CTD PMID:12128095 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Eng endoglin increases expression ISO chromic chloride results in increased expression of ENG mRNA CTD PMID:12128095 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP chromic chloride results in increased activity of GSR protein CTD PMID:21888059 PMID:23413686 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO chromic chloride results in increased expression of ICAM1 protein CTD PMID:23629852 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression
EXP
ISO
chromic chloride promotes the reaction [INS1 protein results in increased expression of IGF1 mRNA]
chromic chloride results in increased expression of IGF1 mRNA
CTD PMID:12153762 PMID:20013160 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 decreases expression ISO chromic chloride results in decreased expression of IGFBP1 mRNA CTD PMID:12153762 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO chromic chloride inhibits the reaction [Glucose results in increased secretion of IL6 protein]; chromic chloride promotes the reaction [Estradiol inhibits the reaction [Glucose results in increased secretion of IL6 protein]]
chromic chloride results in increased expression of IL6 mRNA
[cobaltous chloride co-treated with chromic chloride] results in increased expression of IL6 mRNA
CTD PMID:15528032 PMID:17665966 PMID:25966675 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions
increases activity
ISO [chromic chloride results in increased activity of INS protein modified form] which results in increased import of Glucose; [chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; Mannose inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate]; Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate] CTD PMID:17965850 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insr insulin receptor increases expression EXP chromic chloride results in increased expression of INSR mRNA CTD PMID:19283340 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions ISO [cobaltous chloride co-treated with chromic chloride] affects the expression of LRP5 mRNA CTD PMID:25966675 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
JBrowse link
G Ly6d lymphocyte antigen 6 family member D decreases expression ISO chromic chloride results in decreased expression of LY6D mRNA CTD PMID:12128095 NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733
JBrowse link
G Mtf2 metal response element binding transcription factor 2 increases expression ISO chromic chloride results in increased expression of MTF2 mRNA CTD PMID:12128095 NCBI chr14:1,639,256...1,683,513
Ensembl chr14:1,640,746...1,683,524
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO [cobaltous chloride co-treated with chromic chloride] results in increased expression of NFATC1 mRNA CTD PMID:25966675 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Pon1 paraoxonase 1 increases expression ISO chromic chloride results in increased expression of PON1 mRNA CTD PMID:12128095 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO [cobaltous chloride co-treated with chromic chloride] affects the expression of RUNX2 mRNA CTD PMID:25966675 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sephs2 selenophosphate synthetase 2 increases expression ISO chromic chloride results in increased expression of SEPHS2 mRNA CTD PMID:12128095 NCBI chr 1:181,893,146...181,895,464
Ensembl chr 1:181,892,599...181,895,497
JBrowse link
G Serpina1 serpin family A member 1 decreases activity EXP
ISO
chromic chloride results in decreased activity of SERPINA1 protein CTD PMID:12122574 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 increases expression ISO chromic chloride results in increased expression of SGPL1 mRNA CTD PMID:12128095 NCBI chr20:29,047,793...29,094,209
Ensembl chr20:29,047,796...29,094,084
JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects localization ISO chromic chloride affects the localization of SLC2A4 protein CTD PMID:16339278 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions
decreases expression
ISO [cobaltous chloride co-treated with chromic chloride] results in decreased expression of SP7 mRNA
chromic chloride results in decreased expression of SP7 mRNA
CTD PMID:25966675 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chromic chloride inhibits the reaction [[Hydrogen Peroxide co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]
[cobaltous chloride co-treated with chromic chloride] results in increased expression of TNF mRNA
CTD PMID:11726202 PMID:25966675 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions
decreases expression
ISO [cobaltous chloride co-treated with chromic chloride] results in decreased expression of TNFRSF11B mRNA
chromic chloride results in decreased expression of TNFRSF11B mRNA
CTD PMID:25966675 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [cobaltous chloride co-treated with chromic chloride] results in increased expression of TNFSF11 mRNA CTD PMID:25966675 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Ubc ubiquitin C decreases expression
multiple interactions
EXP chromic chloride results in decreased expression of UBC mRNA
chromic chloride promotes the reaction [INS1 protein results in decreased expression of UBC mRNA]
CTD PMID:20013160 NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 20057
    role 20023
      biological role 20010
        aetiopathogenetic role 19293
          sensitiser 9837
            chromium(3+) trichloride 34
              chromium(3+) trichloride hexahydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  metal atom 17605
                    transition element atom 16993
                      d-block element atom 16984
                        chromium group element atom 7626
                          chromium atom 6422
                            chromium molecular entity 6391
                              chromium coordination entity 5593
                                chromium halide 34
                                  chromium chloride 34
                                    chromium(3+) trichloride 34
                                      chromium(3+) trichloride hexahydrate 0
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