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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chromium(3+) trichloride
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Accession:CHEBI:53351 term browser browse the term
Definition:A chromium chloride with the chromium cation in the +3 oxidation state.
Synonyms:related_synonym: Chromic chloride;   Chromium chloride;   Chromium trichloride;   Chromium(III) chloride;   CrCl3;   Formula=Cl3Cr;   InChI=1S/3ClH.Cr/h3*1H;/q;;;+3/p-3;   InChIKey=QSWDMMVNRMROPK-UHFFFAOYSA-K;   Puratronic chromium chloride;   SMILES=[Cl-].[Cl-].[Cl-].[Cr+3];   Trichlorochromium;   anhydrous chromium(III) chloride
 xref: CAS:10025-73-7;   CAS:39345-92-1;   Drug_Central:5118;   Gmelin:130477;   Gmelin:1890;   Gmelin:532690
 xref_mesh: MESH:C022990
 xref: PMID:1108802;   PMID:1254974;   PMID:16349963;   PMID:19013231;   PMID:20237381;   PMID:29079364;   PMID:5112173;   PMID:670731;   PMID:7351481;   Patent:CN101456852;   Patent:CN101473776;   Patent:CN101632832;   Patent:CN101863755;   Reaxys:3903065;   Wikipedia:Chromium(III)_chloride


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chromium(3+) trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
decreases expression
ISO [cobaltous chloride co-treated with chromic chloride] results in decreased expression of ALPL protein
chromic chloride results in decreased expression of ALPL protein
CTD PMID:25966675 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Aspm assembly factor for spindle microtubules increases expression ISO chromic chloride results in increased expression of ASPM mRNA CTD PMID:12128095 NCBI chr13:56,546,021...56,591,793
Ensembl chr13:56,546,021...56,591,793
JBrowse link
G Bach2 BTB domain and CNC homolog 2 increases expression ISO chromic chloride results in increased expression of BACH2 mRNA CTD PMID:12128095 NCBI chr 5:47,458,891...47,807,176
Ensembl chr 5:47,546,014...47,807,166
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO chromic chloride results in increased expression of BAX protein CTD PMID:14741615 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO chromic chloride results in decreased expression of BCL2 protein CTD PMID:14741615 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO chromic chloride results in increased expression of BTG2 mRNA CTD PMID:12128095 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Casp3 caspase 3 multiple interactions ISO chromic chloride results in increased expression of and results in increased activity of CASP3 protein CTD PMID:14741615 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO chromic chloride results in increased expression of and results in increased activity of CASP8 protein CTD PMID:14741615 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase increases activity EXP chromic chloride results in increased activity of CAT protein CTD PMID:21888059, PMID:23413686 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO chromic chloride results in increased expression of CCL2 protein
[cobaltous chloride co-treated with chromic chloride] results in increased expression of CCL2 mRNA
chromic chloride inhibits the reaction [Glucose results in increased secretion of CCL2 protein]
CTD PMID:17665966, PMID:23629852, PMID:25966675 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO chromic chloride results in increased expression of CDC25A mRNA CTD PMID:12128095 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Eng endoglin increases expression ISO chromic chloride results in increased expression of ENG mRNA CTD PMID:12128095 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP chromic chloride results in increased activity of GSR protein CTD PMID:21888059, PMID:23413686 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO chromic chloride results in increased expression of ICAM1 protein CTD PMID:23629852 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression
EXP
ISO
chromic chloride promotes the reaction [INS1 protein results in increased expression of IGF1 mRNA]
chromic chloride results in increased expression of IGF1 mRNA
CTD PMID:12153762, PMID:20013160 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 decreases expression ISO chromic chloride results in decreased expression of IGFBP1 mRNA CTD PMID:12153762 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO chromic chloride inhibits the reaction [Glucose results in increased secretion of IL6 protein]; chromic chloride promotes the reaction [Estradiol inhibits the reaction [Glucose results in increased secretion of IL6 protein]]
[cobaltous chloride co-treated with chromic chloride] results in increased expression of IL6 mRNA
chromic chloride results in increased expression of IL6 mRNA
CTD PMID:15528032, PMID:17665966, PMID:25966675 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions
increases activity
ISO [chromic chloride results in increased activity of INS protein modified form] which results in increased import of Glucose; [chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; Mannose inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate]; Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate] CTD PMID:17965850 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor increases expression EXP chromic chloride results in increased expression of INSR mRNA CTD PMID:19283340 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions ISO [cobaltous chloride co-treated with chromic chloride] affects the expression of LRP5 mRNA CTD PMID:25966675 NCBI chr 1:218,816,833...218,920,147
Ensembl chr 1:218,816,841...218,920,094
JBrowse link
G Ly6d lymphocyte antigen 6 family member D decreases expression ISO chromic chloride results in decreased expression of LY6D mRNA CTD PMID:12128095 NCBI chr 7:115,993,304...115,994,812
Ensembl chr 7:115,993,301...115,994,783
JBrowse link
G Mtf2 metal response element binding transcription factor 2 increases expression ISO chromic chloride results in increased expression of MTF2 mRNA CTD PMID:12128095 NCBI chr14:2,656,776...2,701,027
Ensembl chr14:2,658,267...2,700,977
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO [cobaltous chloride co-treated with chromic chloride] results in increased expression of NFATC1 mRNA CTD PMID:25966675 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Pon1 paraoxonase 1 increases expression ISO chromic chloride results in increased expression of PON1 mRNA CTD PMID:12128095 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO [cobaltous chloride co-treated with chromic chloride] affects the expression of RUNX2 mRNA CTD PMID:25966675 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sephs2 selenophosphate synthetase 2 increases expression ISO chromic chloride results in increased expression of SEPHS2 mRNA CTD PMID:12128095 NCBI chr 1:198,719,158...198,721,476
Ensembl chr 1:198,719,162...198,721,476
JBrowse link
G Serpina1 serpin family A member 1 decreases activity EXP
ISO
chromic chloride results in decreased activity of SERPINA1 protein CTD PMID:12122574 NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265
JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 increases expression ISO chromic chloride results in increased expression of SGPL1 mRNA CTD PMID:12128095 NCBI chr20:30,699,936...30,769,178
Ensembl chr20:30,699,872...30,749,940
JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects localization ISO chromic chloride affects the localization of SLC2A4 protein CTD PMID:16339278 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions
decreases expression
ISO [cobaltous chloride co-treated with chromic chloride] results in decreased expression of SP7 mRNA
chromic chloride results in decreased expression of SP7 mRNA
CTD PMID:25966675 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chromic chloride inhibits the reaction [[Hydrogen Peroxide co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]
[cobaltous chloride co-treated with chromic chloride] results in increased expression of TNF mRNA
CTD PMID:11726202, PMID:25966675 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions
decreases expression
ISO [cobaltous chloride co-treated with chromic chloride] results in decreased expression of TNFRSF11B mRNA
chromic chloride results in decreased expression of TNFRSF11B mRNA
CTD PMID:25966675 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [cobaltous chloride co-treated with chromic chloride] results in increased expression of TNFSF11 mRNA CTD PMID:25966675 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Ubc ubiquitin C decreases expression
multiple interactions
EXP chromic chloride results in decreased expression of UBC mRNA
chromic chloride promotes the reaction [INS1 protein results in decreased expression of UBC mRNA]
CTD PMID:20013160 NCBI chr12:36,638,457...36,642,734
Ensembl chr12:36,638,457...36,642,734
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        aetiopathogenetic role 18937
          sensitiser 9724
            chromium(3+) trichloride 34
              chromium(3+) trichloride hexahydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  metal atom 17263
                    transition element atom 16711
                      d-block element atom 16701
                        chromium group element atom 7447
                          chromium atom 6226
                            chromium molecular entity 6193
                              chromium coordination entity 5399
                                chromium halide 34
                                  chromium chloride 34
                                    chromium(3+) trichloride 34
                                      chromium(3+) trichloride hexahydrate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.