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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:copolymer macromolecule
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Accession:CHEBI:53310 term browser browse the term
Definition:A macromolecule derived from two or more species of monomer.
Synonyms:related_synonym: co-polymer;   co-polymers;   copolymer;   copolymers;   heteropolymer;   heteropolymers
 alt_id: CHEBI:53178

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alginic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acan aggrecan increases expression ISO alginic acid results in increased expression of ACAN mRNA CTD PMID:16371897 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441 		JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression ISO alginic acid results in increased expression of COL10A1 mRNA CTD PMID:16371897 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO alginic acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:12723939 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alginic acid inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]; alginic acid inhibits the reaction [TNF protein results in increased abundance of Nitric Oxide]; alginic acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:12723939 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
compound 48/80 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gusb glucuronidase, beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases activity EXP p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase affects response to substance ISO KIT protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610 		JBrowse link
G Kng2 kininogen 2 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity		 EXP atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein] CTD PMID:29402411 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein] CTD PMID:29402411 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 affects response to substance ISO MRGPRX2 protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr 1:103,743,746...103,760,945
Ensembl chr 1:103,741,503...103,760,913 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
pluronic P-123 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing decreases secretion
multiple interactions		 EXP Poloxamer results in decreased secretion of ADIPOQ protein
carvacrol inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]]; Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]		 CTD PMID:29071762 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 EXP Poloxamer results in increased expression of CASP3 protein
carvacrol inhibits the reaction [Poloxamer results in increased expression of CASP3 protein]; carvacrol inhibits the reaction [Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]]; Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]		 CTD PMID:29071762 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 EXP carvacrol inhibits the reaction [Poloxamer results in decreased activity of CAT protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]]; Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein] CTD PMID:29071762 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA] CTD PMID:32169474 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions
increases secretion		 EXP carvacrol inhibits the reaction [Poloxamer results in increased secretion of CKM protein] CTD PMID:29071762 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841 		JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA] CTD PMID:32169474 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300 		JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA] CTD PMID:32169474 NCBI chr14:1,462,292...1,467,264
Ensembl chr14:1,462,358...1,467,264 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [nickel monoxide co-treated with Poloxamer] results in increased expression of HMOX1 mRNA CTD PMID:25964212 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM1 mRNA] CTD PMID:32169474 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Icam2 intercellular adhesion molecule 2 multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM2 mRNA] CTD PMID:32169474 NCBI chr10:94,569,889...94,581,218
Ensembl chr10:94,569,890...94,576,512 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA] CTD PMID:32169474 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL6 mRNA] CTD PMID:32169474 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM mRNA] CTD PMID:32169474 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Lep leptin multiple interactions
increases secretion		 EXP carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein]; Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Mb myoglobin multiple interactions
increases secretion		 EXP carvacrol inhibits the reaction [Poloxamer results in increased secretion of MB protein]; Simvastatin inhibits the reaction [Poloxamer results in increased secretion of MB protein] CTD PMID:29071762 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864 		JBrowse link
G Pnlip pancreatic lipase decreases activity ISO Poloxamer results in decreased activity of PNLIP protein CTD PMID:16872557 NCBI chr 1:279,798,187...279,811,372
Ensembl chr 1:279,798,187...279,811,372 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Poloxamer inhibits the reaction [Nanotubes, Carbon inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]] CTD PMID:17709331 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA] CTD PMID:32169474 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      molecular entity 19768
        polyatomic entity 19686
          macromolecule 3480
            copolymer macromolecule 29
              alginic acid 4
              alpha-D-Kdo-4P-O(CH2)3S(CH2)2NH(polyacrylamide) macromolecule + 0
              alpha-D-Kdo-5P-O(CH2)3S(CH2)2NH(polyacrylamide) macromolecule + 0
              alternating copolymer + 9
              beta-D-arabinosyl-(1->2)-alpha-D-arabinosyl-(1->3)-[beta-D-arabinosyl-(1->2)-alpha-D-arabinosyl-(1->5)]-alpha-Darabinosyl-(1->5)-alpha-D-arabinoside--copovidone glycoconjugate 0
              beta-D-mannosyl-(1->2)-beta-D-mannosyl-(1->2)-alpha-D-mannoside--copovidone glycoconjugate 0
              beta-D-mannosyl-(1->2)-beta-D-mannosyl-(1->2)-beta-D-mannoside--copovidone glycoconjugate 0
              block copolymer + 18
              colestipol + 0
              copolymer + 0
              copovidone macromolecule + 0
              graft copolymer 0
              nafion macromolecule + 0
              periodic copolymer 0
              poly(2-hydroxyethyl methylacrylate-co-acrylic acid) 0
              poly(D,L-lactic acid-co-glycolic acid) 0
              poly(N,N'-methylenebisacrylamide-co-methacrylic acid) 0
              poly(amido amine) 0
              poly(fluorene-co-phenylene) + 0
              poly(m-phenylenevinylene-co-2,5-dioctyloxy-p-phenylenevinylene) 0
              poly(styrene-co-methacrylic acid) 0
              poly[dimethylsiloxane-co-[3-(2-(2-hydroxyethoxy)ethoxy)propyl]methylsiloxane] macromolecule + 0
              random copolymer + 0
              sodium alginate 0
              statistical copolymer 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  group 19687
                    polyatomic entity 19686
                      macromolecule 3480
                        copolymer macromolecule 29
                          alginic acid 4
                          alpha-D-Kdo-4P-O(CH2)3S(CH2)2NH(polyacrylamide) macromolecule + 0
                          alpha-D-Kdo-5P-O(CH2)3S(CH2)2NH(polyacrylamide) macromolecule + 0
                          alternating copolymer + 9
                          beta-D-arabinosyl-(1->2)-alpha-D-arabinosyl-(1->3)-[beta-D-arabinosyl-(1->2)-alpha-D-arabinosyl-(1->5)]-alpha-Darabinosyl-(1->5)-alpha-D-arabinoside--copovidone glycoconjugate 0
                          beta-D-mannosyl-(1->2)-beta-D-mannosyl-(1->2)-alpha-D-mannoside--copovidone glycoconjugate 0
                          beta-D-mannosyl-(1->2)-beta-D-mannosyl-(1->2)-beta-D-mannoside--copovidone glycoconjugate 0
                          block copolymer + 18
                          colestipol + 0
                          copolymer + 0
                          copovidone macromolecule + 0
                          graft copolymer 0
                          nafion macromolecule + 0
                          periodic copolymer 0
                          poly(2-hydroxyethyl methylacrylate-co-acrylic acid) 0
                          poly(D,L-lactic acid-co-glycolic acid) 0
                          poly(N,N'-methylenebisacrylamide-co-methacrylic acid) 0
                          poly(amido amine) 0
                          poly(fluorene-co-phenylene) + 0
                          poly(m-phenylenevinylene-co-2,5-dioctyloxy-p-phenylenevinylene) 0
                          poly(styrene-co-methacrylic acid) 0
                          poly[dimethylsiloxane-co-[3-(2-(2-hydroxyethoxy)ethoxy)propyl]methylsiloxane] macromolecule + 0
                          random copolymer + 0
                          sodium alginate 0
                          statistical copolymer 0
paths to the root