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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-halophenol
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Accession:CHEBI:53291 term browser browse the term
Definition:A halophenol in which the halogen atom is bonded to the carbon atom adjacent to the C-OH group.
Synonyms:related_synonym: 2-halophenols;   Formula=C6H5OX;   SMILES=Oc1ccccc1*

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3,3',5,5'-tetraiodothyroacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 tetraiodothyroacetic acid inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK1 protein]		 CTD PMID:17174366 PMID:17984113 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 tetraiodothyroacetic acid inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK3 protein]		 CTD PMID:17174366 PMID:17984113 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO tetraiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]; tetraiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]] CTD PMID:22227104 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]] CTD PMID:22227104 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701 		JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO tetraiodothyroacetic acid binds to RXRA protein CTD PMID:31566444 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO tetraiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
affects binding
increases activity		 ISO tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; tetraiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein]
tetraiodothyroacetic acid binds to THRB protein
tetraiodothyroacetic acid results in increased activity of THRB protein		 CTD PMID:22227104 PMID:31077750 PMID:31566444 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of TP53 protein modified form] CTD PMID:17984113 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
3,3',5-triiodo-L-thyronine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Triiodothyronine results in increased expression of ABCA1 mRNA CTD PMID:25172293 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Triiodothyronine results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Triiodothyronine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases expression EXP Triiodothyronine results in increased expression of ABCC5 mRNA CTD PMID:29357290 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211 		JBrowse link
G Abcf3 ATP binding cassette subfamily F member 3 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ABCF3 mRNA CTD PMID:14761676 NCBI chr11:84,026,206...84,037,938
Ensembl chr11:84,026,207...84,037,938 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
increases expression
increases activity		 EXP Triiodothyronine inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]; Triiodothyronine inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]
Triiodothyronine results in increased expression of ACACA mRNA
Triiodothyronine results in increased activity of ACACA protein		 CTD PMID:1973097 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Acbd4 acyl-CoA binding domain containing 4 decreases expression ISO Triiodothyronine results in decreased expression of ACBD4 mRNA CTD PMID:23397585 NCBI chr10:91,186,131...91,200,081
Ensembl chr10:91,187,593...91,196,572 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP Triiodothyronine results in increased expression of and results in increased activity of ACE protein CTD PMID:1659346 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression
decreases expression		 EXP Triiodothyronine results in increased expression of ACOT1 mRNA
Triiodothyronine results in decreased expression of ACOT1 mRNA		 CTD PMID:15953391 PMID:28299817 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO Triiodothyronine results in increased expression of ACSL1 mRNA CTD PMID:30209975 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 increases expression EXP Triiodothyronine results in increased expression of ACSL5 mRNA CTD PMID:15953391 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008 		JBrowse link
G Acvrl1 activin A receptor like type 1 increases expression ISO Triiodothyronine results in increased expression of ACVRL1 mRNA CTD PMID:25172293 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335 		JBrowse link
G Adam11 ADAM metallopeptidase domain 11 increases expression ISO Triiodothyronine results in increased expression of ADAM11 mRNA CTD PMID:25172293 NCBI chr10:90,731,260...90,749,221
Ensembl chr10:90,731,148...90,749,217 		JBrowse link
G Adam12 ADAM metallopeptidase domain 12 increases expression ISO Triiodothyronine results in increased expression of ADAM12 mRNA CTD PMID:23397585 NCBI chr 1:205,951,840...206,286,294
Ensembl chr 1:205,956,342...206,282,575 		JBrowse link
G Adam15 ADAM metallopeptidase domain 15 decreases expression ISO Triiodothyronine results in decreased expression of ADAM15 mRNA CTD PMID:23397585 NCBI chr 2:188,661,831...188,672,337
Ensembl chr 2:188,661,699...188,672,247 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADAM19 mRNA CTD PMID:14761676 NCBI chr10:31,146,107...31,240,582
Ensembl chr10:31,146,107...31,240,582 		JBrowse link
G Add2 adducin 2 increases expression ISO Triiodothyronine results in increased expression of ADD2 mRNA CTD PMID:23397585 NCBI chr 4:117,691,294...117,887,556
Ensembl chr 4:117,743,710...117,882,464 		JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression EXP Triiodothyronine results in increased expression of ADRB1 mRNA; Triiodothyronine results in increased expression of ADRB1 protein CTD PMID:10217540 PMID:11090638 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases expression		 ISO bicalutamide inhibits the reaction [Triiodothyronine results in increased expression of ADRB2 protein]
Triiodothyronine results in increased expression of ADRB2 mRNA; Triiodothyronine results in increased expression of ADRB2 protein		 CTD PMID:18454446 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
increases expression
decreases expression		 EXP Amiodarone inhibits the reaction [Triiodothyronine results in decreased expression of ADRB3 protein]
Triiodothyronine results in increased expression of ADRB3 protein
Triiodothyronine results in decreased expression of ADRB3 mRNA; Triiodothyronine results in decreased expression of ADRB3 protein		 CTD PMID:8836703 PMID:10217540 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Triiodothyronine promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA] CTD PMID:28478156 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akap12 A-kinase anchoring protein 12 increases expression ISO Triiodothyronine results in increased expression of AKAP12 mRNA CTD PMID:23397585 NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581 		JBrowse link
G Akirin2 akirin 2 increases expression ISO Triiodothyronine results in increased expression of AKIRIN2 mRNA CTD PMID:23397585 NCBI chr 5:50,001,945...50,016,544
Ensembl chr 5:50,002,184...50,016,539 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Triiodothyronine results in increased expression of AKR1C2 mRNA CTD PMID:15507505 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO Triiodothyronine results in increased expression of AKR1C3 mRNA CTD PMID:15507505 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine results in increased phosphorylation of AKT1 protein]; AKT1 protein affects the reaction [Triiodothyronine affects the expression of TTN mRNA] CTD PMID:16021636 PMID:18096819 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alb albumin affects binding ISO Triiodothyronine binds to ALB protein CTD PMID:21517007 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH1A3 mRNA CTD PMID:14761676 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression EXP Triiodothyronine results in increased expression of ALDH3A2 mRNA CTD PMID:15953391 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345 		JBrowse link
G Amh anti-Mullerian hormone multiple interactions EXP Triiodothyronine affects the reaction [Propylthiouracil affects the expression of AMH mRNA] CTD PMID:7819453 NCBI chr 7:11,775,155...11,777,503
Ensembl chr 7:11,775,155...11,777,503 		JBrowse link
G Angptl8 angiopoietin-like 8 multiple interactions ISO [THRA protein co-treated with Triiodothyronine] promotes the reaction [ANGPTL8 protein binds to PLIN3 protein]; [THRA protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 mRNA; [THRA protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 protein; [THRB protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 mRNA; ANGPTL8 protein affects the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein] CTD PMID:24262987 NCBI chr 8:22,855,495...22,858,565
Ensembl chr 8:22,856,539...22,858,565 		JBrowse link
G Apoa1 apolipoprotein A1 increases expression EXP Triiodothyronine results in increased expression of APOA1 protein CTD PMID:6816881 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoa4 apolipoprotein A4 multiple interactions EXP Triiodothyronine results in increased expression of [APOE protein co-treated with APOA4 protein] CTD PMID:6816881 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376 		JBrowse link
G Apoe apolipoprotein E multiple interactions EXP Triiodothyronine results in increased expression of [APOE protein co-treated with APOA4 protein] CTD PMID:6816881 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G App amyloid beta precursor protein decreases expression
multiple interactions		 ISO Triiodothyronine results in decreased expression of APP mRNA; Triiodothyronine results in decreased expression of APP protein
Tretinoin promotes the reaction [Triiodothyronine results in decreased secretion of APP protein]		 CTD PMID:17199430 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Triiodothyronine results in increased expression of AQP1 mRNA CTD PMID:25172293 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360 		JBrowse link
G Aqp8 aquaporin 8 increases expression EXP Triiodothyronine results in increased expression of AQP8 mRNA CTD PMID:15953391 NCBI chr 1:193,424,818...193,430,665
Ensembl chr 1:193,424,812...193,430,676 		JBrowse link
G Arhgef25 Rho guanine nucleotide exchange factor 25 decreases expression ISO Triiodothyronine results in decreased expression of ARHGEF25 mRNA CTD PMID:23397585 NCBI chr 7:70,469,304...70,476,633
Ensembl chr 7:70,469,312...70,476,340 		JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D increases expression ISO Triiodothyronine results in increased expression of ARL4D mRNA CTD PMID:25172293 NCBI chr10:89,577,556...89,580,368
Ensembl chr10:89,578,212...89,580,368 		JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression EXP Triiodothyronine results in increased expression of ARRDC3 mRNA CTD PMID:28299817 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069 		JBrowse link
G Aspg asparaginase increases expression EXP Triiodothyronine results in increased expression of ASPG mRNA CTD PMID:29357290 NCBI chr 6:136,682,279...136,701,673
Ensembl chr 6:136,682,126...136,701,628 		JBrowse link
G Aspm assembly factor for spindle microtubules decreases expression ISO Triiodothyronine results in decreased expression of ASPM mRNA CTD PMID:23397585 NCBI chr13:56,546,021...56,591,793
Ensembl chr13:56,546,021...56,591,793 		JBrowse link
G Atg5 autophagy related 5 increases expression
affects response to substance		 ISO Triiodothyronine results in increased expression of ATG5 mRNA; Triiodothyronine results in increased expression of ATG5 protein
ATG5 protein affects the susceptibility to Triiodothyronine		 CTD PMID:30209975 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140 		JBrowse link
G Atg7 autophagy related 7 increases expression ISO Triiodothyronine results in increased expression of ATG7 mRNA CTD PMID:30209975 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 increases expression ISO Triiodothyronine results in increased expression of ATP1B2 mRNA CTD PMID:25172293 NCBI chr10:56,205,622...56,211,879
Ensembl chr10:56,205,625...56,211,891 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions
increases expression		 EXP THRB protein promotes the reaction [Triiodothyronine results in increased expression of ATP2A2 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA] CTD PMID:11577024 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326 		JBrowse link
G Avp arginine vasopressin multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; AVP protein inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA] CTD PMID:11742803 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression ISO
EXP		 Triiodothyronine results in decreased expression of BAD protein CTD PMID:16021636 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO
EXP		 Triiodothyronine results in decreased expression of BAX protein CTD PMID:16021636 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 Triiodothyronine promotes the reaction [tamibarotene results in decreased expression of BCL2 mRNA]
Triiodothyronine results in increased expression of BCL2 protein		 CTD PMID:11201846 PMID:16021636 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO Triiodothyronine promotes the reaction [tamibarotene results in increased expression of BCL2A1A mRNA] CTD PMID:11201846 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO
EXP		 Triiodothyronine results in increased expression of BCL2L1 protein CTD PMID:16021636 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression EXP Triiodothyronine results in increased expression of BCL3 mRNA CTD PMID:22015988 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BMP2 mRNA CTD PMID:14761676 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions
decreases expression		 ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA] CTD PMID:14761676 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820 		JBrowse link
G Capns1 calpain, small subunit 1 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of CAPNS1 mRNA CTD PMID:14761676 NCBI chr 1:91,058,528...91,064,880
Ensembl chr 1:88,652,446...88,657,845 		JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions		 EXP
ISO		 Triiodothyronine results in decreased expression of CASP3 protein
THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased cleavage of CASP3 protein]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased cleavage of CASP3 protein]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]		 CTD PMID:16021636 PMID:32223187 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 EXP [Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein; gadolinium chloride inhibits the reaction [[Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein]; Resveratrol inhibits the reaction [Triiodothyronine results in decreased activity of CAT protein] CTD PMID:12516873 PMID:23391542 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccdc71 coiled-coil domain containing 71 decreases expression ISO Triiodothyronine results in decreased expression of CCDC71 mRNA CTD PMID:23397585 NCBI chr 8:117,236,933...117,251,573
Ensembl chr 8:117,246,376...117,250,280 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression		 ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of CCL5 mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of CCL5 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of CCL5 mRNA] CTD PMID:14761676 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccna2 cyclin A2 increases expression ISO
EXP		 Triiodothyronine results in increased expression of CCNA2 protein CTD PMID:16021636 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions		 ISO
EXP		 Triiodothyronine results in increased expression of CCND1 protein
Triiodothyronine results in increased expression of CCND1 mRNA; Triiodothyronine results in increased expression of CCND1 protein
THRB protein promotes the reaction [Triiodothyronine results in increased expression of CCND1 protein]; U 0126 inhibits the reaction [Triiodothyronine results in increased expression of CCND1 mRNA]		 CTD PMID:16021636 PMID:20638743 PMID:28315333 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO
EXP		 Triiodothyronine results in increased expression of CCNE1 protein
Triiodothyronine results in increased expression of CCNE1 mRNA; Triiodothyronine results in increased expression of CCNE1 protein		 CTD PMID:16021636 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Cdc45 cell division cycle 45 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CDC45 mRNA CTD PMID:14761676 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDKN1A mRNA; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of CDKN1A mRNA]; Triiodothyronine analog inhibits the reaction [CDKN1A protein binds to PCNA protein]; Triiodothyronine inhibits the reaction [CDKN1A protein binds to PCNA protein] CTD PMID:14761676 PMID:22383522 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
multiple interactions		 EXP
ISO		 Triiodothyronine results in decreased expression of CDKN1B mRNA; Triiodothyronine results in decreased expression of CDKN1B protein
THRB protein promotes the reaction [Triiodothyronine results in decreased expression of CDKN1B protein]		 CTD PMID:16021636 PMID:20638743 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Ces2c carboxylesterase 2C increases expression EXP Triiodothyronine results in increased expression of CES2C mRNA CTD PMID:28299817 NCBI chr 1:282,640,752...282,648,319
Ensembl chr 1:282,638,017...282,702,424 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions
decreases expression		 EXP Phenelzine inhibits the reaction [Triiodothyronine results in decreased expression of CGA mRNA]; Triiodothyronine inhibits the reaction [Phenelzine results in increased expression of CGA mRNA] CTD PMID:20148560 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367 		JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation ISO Triiodothyronine analog results in increased phosphorylation of CHEK1 protein CTD PMID:22383522 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882 		JBrowse link
G Chst1 carbohydrate sulfotransferase 1 increases expression ISO Triiodothyronine results in increased expression of CHST1 mRNA CTD PMID:25172293 NCBI chr 3:81,441,785...81,512,829
Ensembl chr 3:81,498,022...81,512,807 		JBrowse link
G Clu clusterin increases expression EXP Triiodothyronine results in increased expression of CLU mRNA CTD PMID:7531505 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857 		JBrowse link
G Col10a1 collagen type X alpha 1 chain multiple interactions
increases expression		 EXP ciglitazone inhibits the reaction [Triiodothyronine results in increased expression of COL10A1 mRNA]; troglitazone inhibits the reaction [Triiodothyronine results in increased expression of COL10A1 mRNA] CTD PMID:16023420 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 EXP Triiodothyronine promotes the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
Triiodothyronine results in increased expression of COL1A1 mRNA		 CTD PMID:18031379 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col6a3 collagen type VI alpha 3 chain increases expression ISO Triiodothyronine results in increased expression of COL6A3 mRNA CTD PMID:15507505 NCBI chr 9:97,926,784...98,004,643
Ensembl chr 9:97,926,787...98,004,546 		JBrowse link
G Coq10b coenzyme Q10B increases expression EXP Triiodothyronine results in increased expression of COQ10B mRNA CTD PMID:29357290 NCBI chr 9:61,655,963...61,675,880
Ensembl chr 9:61,655,963...61,675,873 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions
increases expression		 ISO Chloroquine promotes the reaction [Triiodothyronine results in increased expression of COX4I1 protein] CTD PMID:30209975 NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression
multiple interactions		 ISO
EXP		 Triiodothyronine results in increased expression of CPT1A mRNA
Triiodothyronine results in increased expression of CPT1A mRNA; Triiodothyronine results in increased expression of CPT1A protein
resveratrol promotes the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]
Resveratrol promotes the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A protein]; Triiodothyronine promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CPT1A mRNA]		 CTD PMID:23209300 PMID:25048947 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression ISO Triiodothyronine results in increased expression of CPT1B mRNA CTD PMID:30209975 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347 		JBrowse link
G Cracr2b calcium release activated channel regulator 2B decreases expression ISO Triiodothyronine results in decreased expression of CRACR2B mRNA CTD PMID:23397585 NCBI chr 1:214,439,810...214,445,876
Ensembl chr 1:214,440,503...214,445,874
Ensembl chr 1:214,440,503...214,445,874 		JBrowse link
G Crat carnitine O-acetyltransferase increases expression EXP Triiodothyronine results in increased expression of CRAT mRNA CTD PMID:15953391 NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362 		JBrowse link
G Csad cysteine sulfinic acid decarboxylase increases expression EXP Triiodothyronine results in increased expression of CSAD mRNA CTD PMID:15953391 NCBI chr 7:143,781,520...143,810,880
Ensembl chr 7:143,781,702...143,793,970 		JBrowse link
G Csk C-terminal Src kinase multiple interactions ISO CSK protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]] CTD PMID:9664232 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303 		JBrowse link
G Ctse cathepsin E increases expression EXP Triiodothyronine results in increased expression of CTSE mRNA CTD PMID:15953391 NCBI chr13:48,426,833...48,449,493
Ensembl chr13:48,426,820...48,449,490 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CYCS mRNA]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CYCS mRNA] CTD PMID:32223187 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]]; Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]; Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein] CTD PMID:21726595 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein]]; Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 mRNA]; Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP17A1 protein] CTD PMID:21726595 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO Triiodothyronine affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Triiodothyronine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Triiodothyronine results in increased expression of CYP1A1 mRNA		 CTD PMID:28478156 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO Triiodothyronine results in increased expression of CYP1A2 mRNA
Triiodothyronine affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; Triiodothyronine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 protein]		 CTD PMID:28478156 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO Triiodothyronine results in increased expression of CYP24A1 mRNA
(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of CYP24A1 mRNA]		 CTD PMID:21815645 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity
increases expression		 EXP Triiodothyronine results in increased activity of CYP2E1 protein
Triiodothyronine results in increased expression of CYP2E1 protein		 CTD PMID:14631868 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression
multiple interactions		 ISO Triiodothyronine results in increased expression of CYP3A4 mRNA
SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of CYP3A4 mRNA]		 CTD PMID:21815645 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP Triiodothyronine results in decreased expression of CYP8B1 mRNA CTD PMID:10393316 PMID:29357290 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression ISO Triiodothyronine results in increased expression of DBP mRNA CTD PMID:25172293 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846 		JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 increases expression EXP Triiodothyronine results in increased expression of DECR2 mRNA CTD PMID:15953391 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413 		JBrowse link
G Dio1 iodothyronine deiodinase 1 affects abundance
multiple interactions
increases expression
affects metabolic processing
increases chemical synthesis		 ISO
EXP		 DIO1 gene SNP affects the abundance of Triiodothyronine
2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Triiodothyronine results in increased expression of DIO1 mRNA]
[DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine; [DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine]
DIO1 protein affects the metabolism of Triiodothyronine
Arsenic affects the reaction [Triiodothyronine results in increased expression of DIO1 mRNA]; Pentachlorophenol inhibits the reaction [Triiodothyronine results in increased expression of DIO1 mRNA]
DIO1 protein results in increased chemical synthesis of Triiodothyronine		 CTD PMID:15254343 PMID:16131326 PMID:17105838 PMID:18288313 PMID:21565810 PMID:23397585 PMID:24001430 PMID:25646720 PMID:27420076 PMID:28167136 PMID:29357290 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520 		JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions
increases expression
increases chemical synthesis		 ISO
EXP		 2,2',4,4',5-brominated diphenyl ether inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4',5-brominated diphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; [DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine; [DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine; kaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine]
Triiodothyronine results in increased expression of DIO2 mRNA
DIO2 protein results in increased chemical synthesis of Triiodothyronine		 CTD PMID:17327447 PMID:17615150 PMID:23397585 PMID:25646720 PMID:26004626 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723 		JBrowse link
G Dio3 iodothyronine deiodinase 3 increases expression
multiple interactions		 ISO Triiodothyronine results in increased expression of DIO3 mRNA
[DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine		 CTD PMID:23397585 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138 		JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DMBT1 mRNA CTD PMID:14761676 NCBI chr 1:201,620,642...201,689,905
NCBI chr 1:203,149,414...203,228,705 		JBrowse link
G Dmpk DM1 protein kinase increases expression EXP Triiodothyronine results in increased expression of DMPK mRNA CTD PMID:15953391 NCBI chr 1:79,988,096...79,999,358
Ensembl chr 1:79,989,019...79,999,364 		JBrowse link
G Dmtn dematin actin binding protein increases expression ISO Triiodothyronine results in increased expression of DMTN mRNA CTD PMID:25172293 NCBI chr15:52,292,762...52,320,385
Ensembl chr15:52,292,765...52,320,385 		JBrowse link
G Dusp2 dual specificity phosphatase 2 multiple interactions
decreases expression		 ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DUSP2 mRNA; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in decreased expression of DUSP2 mRNA] CTD PMID:14761676 NCBI chr 3:119,776,925...119,779,110
Ensembl chr 3:119,776,925...119,779,099 		JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 increases expression ISO Triiodothyronine results in increased expression of DYNC1LI2 mRNA CTD PMID:23397585 NCBI chr19:740,007...762,897
Ensembl chr19:740,028...762,897 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Triiodothyronine results in increased expression of ECH1 mRNA CTD PMID:15953391 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005 		JBrowse link
G Efcab3 EF-hand calcium binding domain 3 decreases expression ISO Triiodothyronine results in decreased expression of EFCAB3 mRNA CTD PMID:23397585 NCBI chr10:93,304,559...93,332,849
Ensembl chr10:93,305,969...93,332,702 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP
ISO		 [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; AVP protein inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]
Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11742803 PMID:16150908 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO Triiodothyronine results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:30209975 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248 		JBrowse link
G Eml2 EMAP like 2 increases expression ISO Triiodothyronine results in increased expression of EML2 mRNA CTD PMID:23397585 NCBI chr 1:80,087,684...80,118,784
Ensembl chr 1:80,087,684...80,119,012 		JBrowse link
G Eno1 enolase 1 increases expression ISO Triiodothyronine results in increased expression of ENO1 mRNA CTD PMID:15507505 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609 		JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression ISO Triiodothyronine results in increased expression of EPAS1 mRNA CTD PMID:25172293 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265 		JBrowse link
G Epb41l3 erythrocyte membrane protein band 4.1-like 3 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of EPB41L3 mRNA CTD PMID:14761676 NCBI chr 9:117,314,935...117,666,408
Ensembl chr 9:117,538,009...117,666,410 		JBrowse link
G Ereg epiregulin increases expression ISO Triiodothyronine results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression		 ISO Tamoxifen inhibits the reaction [Triiodothyronine results in decreased expression of ESR1 mRNA] CTD PMID:19942988 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions EXP [Arsenic co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of ESR2 mRNA; [bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [bisphenol A results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in increased expression of ESR2 mRNA; [enzacamene co-treated with Estradiol co-treated with Triiodothyronine] affects the expression of ESR2 mRNA; [Estradiol co-treated with Triiodothyronine] inhibits the reaction [bisphenol A results in decreased expression of ESR2 mRNA]; [Estradiol co-treated with Triiodothyronine] promotes the reaction [Zearalenone results in decreased expression of ESR2 mRNA]; [Zearalenone co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [Zearalenone results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in decreased expression of ESR2 mRNA CTD PMID:27338438 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase increases expression EXP Triiodothyronine results in increased expression of ETHE1 mRNA CTD PMID:28299817 NCBI chr 1:81,457,008...81,472,061
Ensembl chr 1:81,456,984...81,472,097 		JBrowse link
G Eva1c eva-1 homolog C increases expression ISO Triiodothyronine results in increased expression of EVA1C mRNA CTD PMID:25172293 NCBI chr11:31,001,697...31,075,784
Ensembl chr11:31,002,451...31,075,809 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression EXP Triiodothyronine results in increased expression of FABP4 mRNA CTD PMID:15953391 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305 		JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression EXP Triiodothyronine results in increased expression of FABP5 mRNA CTD PMID:15953391 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378 		JBrowse link
G Fads2 fatty acid desaturase 2 increases expression EXP Triiodothyronine results in increased expression of FADS2 mRNA CTD PMID:15953391 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524 		JBrowse link
G Fam171b family with sequence similarity 171, member B decreases expression ISO Triiodothyronine results in decreased expression of FAM171B mRNA CTD PMID:23397585 NCBI chr 3:71,210,048...71,265,419
Ensembl chr 3:71,210,301...71,262,615 		JBrowse link
G Fam83h family with sequence similarity 83, member H increases expression ISO Triiodothyronine results in increased expression of FAM83H mRNA CTD PMID:23397585 NCBI chr 7:117,062,748...117,070,936
Ensembl chr 7:117,062,692...117,070,936 		JBrowse link
G Fasn fatty acid synthase increases expression EXP Triiodothyronine results in increased expression of FASN mRNA CTD PMID:15953391 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP Triiodothyronine results in increased expression of FDFT1 mRNA CTD PMID:15953391 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302 		JBrowse link
G Fdps farnesyl diphosphate synthase increases expression EXP Triiodothyronine results in increased expression of FDPS mRNA CTD PMID:15953391 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA] CTD PMID:11742803 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824 		JBrowse link
G Fgf18 fibroblast growth factor 18 multiple interactions ISO Triiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:16150908 NCBI chr10:18,047,109...18,082,290
Ensembl chr10:18,047,109...18,063,391 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO
EXP		 Triiodothyronine inhibits the reaction [FGF2 protein results in increased phosphorylation of STAT1 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; Triiodothyronine promotes the reaction [FGF2 protein promotes the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]]; Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:11742803 PMID:12805413 PMID:16150908 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Fgf7 fibroblast growth factor 7 decreases expression ISO Triiodothyronine results in decreased expression of FGF7 mRNA CTD PMID:15507505 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872 		JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions ISO Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:16150908 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression
multiple interactions		 ISO
EXP		 Triiodothyronine results in increased expression of FGFR1 mRNA
Triiodothyronine results in increased expression of FGFR1 mRNA; Triiodothyronine results in increased expression of FGFR1 protein
Cycloheximide inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]; Dactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]; Triiodothyronine promotes the reaction [FGF2 protein promotes the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]]		 CTD PMID:12805413 PMID:16150908 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO Triiodothyronine results in increased expression of FGFR2 mRNA CTD PMID:16150908 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases expression ISO Triiodothyronine results in increased expression of FGFR3 mRNA CTD PMID:16150908 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706 		JBrowse link
G Fkbp10 FKBP prolyl isomerase 10 decreases expression ISO Triiodothyronine results in decreased expression of FKBP10 mRNA CTD PMID:23397585 NCBI chr10:88,326,337...88,338,199
Ensembl chr10:88,326,080...88,338,207 		JBrowse link
G Flrt1 fibronectin leucine rich transmembrane protein 1 increases expression ISO Triiodothyronine results in increased expression of FLRT1 mRNA CTD PMID:25172293 NCBI chr 1:222,340,481...222,417,915
Ensembl chr 1:222,344,713...222,350,173 		JBrowse link
G Foxo6 forkhead box O6 increases expression ISO Triiodothyronine results in increased expression of FOXO6 mRNA CTD PMID:25172293 NCBI chr 5:139,208,153...139,227,288
Ensembl chr 5:139,208,046...139,227,196 		JBrowse link
G Fpgs folylpolyglutamate synthase increases expression EXP Triiodothyronine results in increased expression of FPGS mRNA CTD PMID:15953391 NCBI chr 3:11,717,667...11,729,694
Ensembl chr 3:11,717,667...11,723,327 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP FSHB protein promotes the reaction [Triiodothyronine results in increased expression of INHBB mRNA]; Triiodothyronine promotes the reaction [FSHB protein results in increased expression of INHBB mRNA] CTD PMID:7531505 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 increases expression EXP Triiodothyronine results in increased expression of FXYD2 mRNA CTD PMID:15953391 NCBI chr 8:49,710,334...49,717,492
Ensembl chr 8:49,710,477...49,716,955 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases expression		 ISO (4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of G6PC1 mRNA]; SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of G6PC1 mRNA] CTD PMID:21815645 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G Gap43 growth associated protein 43 increases expression EXP Triiodothyronine results in increased expression of GAP43 mRNA; Triiodothyronine results in increased expression of GAP43 protein CTD PMID:15708448 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914 		JBrowse link
G Gba glucosylceramidase beta increases activity EXP Triiodothyronine results in increased activity of GBA protein CTD PMID:9101438 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601 		JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression EXP Triiodothyronine results in increased expression of GCH1 mRNA CTD PMID:15953391 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011 		JBrowse link
G Gh1 growth hormone 1 multiple interactions
increases expression		 EXP
ISO		 Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Amiodarone inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; bisphenol A promotes the reaction [Triiodothyronine results in increased expression of and results in increased secretion of GH protein]; Butyric Acid inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Dexamethasone promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Edetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of and results in increased secretion of GH protein]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]; Pentetic Acid promotes the reaction [Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Polybrominated Biphenyls analog inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Polybrominated Biphenyls analog inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]; Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]; Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]; Triiodothyronine results in increased expression of and results in increased secretion of GH protein; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Tretinoin results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]
Triiodothyronine results in increased expression of GH mRNA; Triiodothyronine results in increased expression of GH1 mRNA; Triiodothyronine results in increased expression of GH1 protein		 CTD PMID:2211641 PMID:2910914 PMID:10720163 PMID:15240998 PMID:17090972 PMID:17928132 PMID:22201216 PMID:24001430 PMID:27420076 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180 		JBrowse link
G Ghrh growth hormone releasing hormone multiple interactions EXP Triiodothyronine promotes the reaction [Dexamethasone results in increased expression of GHRH mRNA] CTD PMID:17090972 NCBI chr 3:153,449,124...153,468,794
Ensembl chr 3:153,449,125...153,468,794 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Triiodothyronine results in increased expression of GJA1 protein CTD PMID:15685554 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 increases expression EXP Triiodothyronine results in increased expression of GPCPD1 mRNA CTD PMID:15953391 NCBI chr 3:125,169,131...125,213,598
Ensembl chr 3:125,169,135...125,213,607 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 increases expression EXP Triiodothyronine results in increased expression of GPD2 mRNA CTD PMID:29357290 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074 		JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 increases expression ISO Triiodothyronine results in increased expression of GRIK4 mRNA CTD PMID:23397585 NCBI chr 8:46,804,134...47,237,546
Ensembl chr 8:46,806,147...47,094,352 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions EXP Triiodothyronine inhibits the reaction [goitrin results in increased expression of GSTA2 protein] CTD PMID:7532609 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP Triiodothyronine inhibits the reaction [goitrin results in increased expression of GSTP1 protein] CTD PMID:7532609 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 decreases expression ISO Triiodothyronine results in decreased expression of GULP1 mRNA CTD PMID:23397585 NCBI chr 9:51,263,484...51,538,066
Ensembl chr 9:51,263,622...51,538,072 		JBrowse link
G H1f5 H1.5 linker histone, cluster member increases expression ISO Triiodothyronine results in increased expression of H1-5 mRNA CTD PMID:23397585 NCBI chr17:44,766,313...44,766,981
Ensembl chr17:44,766,313...44,766,981 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions		 ISO Triiodothyronine analog results in increased phosphorylation of H2AX protein
Triiodothyronine analog promotes the reaction [Cisplatin results in increased expression of H2AX protein]		 CTD PMID:22383522 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 increases expression EXP Triiodothyronine results in increased expression of HBA-A1 mRNA CTD PMID:15953391 NCBI chr10:15,602,794...15,603,649
Ensembl chr10:15,602,794...15,603,649 		JBrowse link
G Hbb hemoglobin subunit beta increases expression EXP Triiodothyronine results in increased expression of HBB mRNA CTD PMID:15953391 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725 		JBrowse link
G Hbg1 hemoglobin subunit gamma 1 increases expression EXP Triiodothyronine results in increased expression of HBG1 mRNA CTD PMID:15953391 NCBI chr 1:168,992,841...168,994,219
Ensembl chr 1:168,992,722...168,994,253 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 increases expression ISO Triiodothyronine results in increased expression of HCN2 mRNA CTD PMID:25172293 NCBI chr 7:12,851,730...12,870,087
Ensembl chr 7:12,851,739...12,874,215 		JBrowse link
G Hdc histidine decarboxylase decreases expression EXP Triiodothyronine results in decreased expression of HDC mRNA CTD PMID:29357290 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619 		JBrowse link
G Heg1 heart development protein with EGF-like domains 1 increases expression ISO Triiodothyronine results in increased expression of HEG1 mRNA CTD PMID:25172293 NCBI chr11:70,234,248...70,322,966
Ensembl chr11:70,236,888...70,322,690 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Triiodothyronine results in increased expression of HIF1A mRNA CTD PMID:15507505 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A increases expression EXP Triiodothyronine results in increased expression of HIGD1A mRNA CTD PMID:15953391 NCBI chr 8:130,482,492...130,491,888
Ensembl chr 8:130,482,493...130,491,998 		JBrowse link
G Hira histone cell cycle regulator increases expression ISO Triiodothyronine results in increased expression of HIRA mRNA CTD PMID:23397585 NCBI chr11:86,168,196...86,276,430
Ensembl chr11:86,168,196...86,276,430 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Triiodothyronine results in increased expression of HMGCS1 mRNA CTD PMID:15953391 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression ISO Triiodothyronine results in increased expression of HMGCS2 mRNA CTD PMID:23397585 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423 		JBrowse link
G Hnrnph3 heterogeneous nuclear ribonucleoprotein H3 increases expression ISO Triiodothyronine results in increased expression of HNRNPH3 mRNA CTD PMID:23397585 NCBI chr20:27,167,926...27,178,172
Ensembl chr20:27,169,267...27,216,941 		JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor increases expression ISO Triiodothyronine results in increased expression of HR mRNA CTD PMID:25172293 PMID:26096596 NCBI chr15:52,241,801...52,261,276
Ensembl chr15:52,241,801...52,261,276 		JBrowse link
G Hscb HscB mitochondrial iron-sulfur cluster co-chaperone decreases expression ISO Triiodothyronine results in decreased expression of HSCB mRNA CTD PMID:23397585 NCBI chr12:51,878,267...51,888,645
Ensembl chr12:51,878,153...51,888,669 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; Triiodothyronine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B1 mRNA]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]; Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA] CTD PMID:21726595
G Hunk hormonally upregulated Neu-associated kinase increases expression ISO Triiodothyronine results in increased expression of HUNK mRNA CTD PMID:25172293 NCBI chr11:30,550,141...30,663,465
Ensembl chr11:30,550,141...30,663,465 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 increases expression EXP Triiodothyronine results in increased expression of IDH1 mRNA CTD PMID:15953391 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression
increases secretion		 EXP Estradiol inhibits the reaction [Triiodothyronine results in increased expression of IGF1 mRNA]; Estradiol inhibits the reaction [Triiodothyronine results in increased secretion of IGF1 protein] CTD PMID:7684602 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP Triiodothyronine results in increased expression of IGFBP2 mRNA CTD PMID:15953391 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789 		JBrowse link
G Iglon5 IgLON family member 5 increases expression ISO Triiodothyronine results in increased expression of IGLON5 mRNA CTD PMID:25172293 NCBI chr 1:98,440,186...98,457,942
Ensembl chr 1:98,440,186...98,455,920 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Triiodothyronine results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL1B mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL1B protein]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL1B mRNA]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL1B protein]
Triiodothyronine results in increased expression of IL1B mRNA		 CTD PMID:32223187 PMID:32816093 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il24 interleukin 24 increases expression ISO Triiodothyronine results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL6 protein]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL6 protein] CTD PMID:32223187 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Inhbb inhibin subunit beta B multiple interactions
increases expression		 EXP FSHB protein promotes the reaction [Triiodothyronine results in increased expression of INHBB mRNA]; Triiodothyronine promotes the reaction [FSHB protein results in increased expression of INHBB mRNA] CTD PMID:7531505 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with Rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with Rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 protein; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with Rosiglitazone co-treated with Triiodothyronine] results in increased expression of SLC2A4 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with Rosiglitazone co-treated with Triiodothyronine] results in increased expression of SLC2A4 protein CTD PMID:27605626 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Insig1 insulin induced gene 1 increases expression EXP Triiodothyronine results in increased expression of INSIG1 mRNA CTD PMID:15953391 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of IRF1 mRNA CTD PMID:14761676 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Triiodothyronine promotes the reaction [tamibarotene results in increased expression of ITGAM protein] CTD PMID:11201846 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]] CTD PMID:22227104 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410 		JBrowse link
G Itgb5 integrin subunit beta 5 increases expression
decreases expression		 ISO Triiodothyronine results in increased expression of ITGB5 mRNA
Triiodothyronine results in decreased expression of ITGB5 mRNA		 CTD PMID:23397585 NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372 		JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase increases expression ISO Triiodothyronine results in increased expression of ITPK1 mRNA CTD PMID:25172293 NCBI chr 6:126,448,920...126,582,188
Ensembl chr 6:126,450,139...126,582,134 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP Triiodothyronine results in increased expression of ITPR1 mRNA CTD PMID:15953391 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748 		JBrowse link
G Kantr KDM5C adjacent transcript increases expression ISO Triiodothyronine results in increased expression of KANTR mRNA CTD PMID:25172293 NCBI chr  X:22,369,521...22,399,881
Ensembl chr  X:22,369,521...22,399,901 		JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 increases expression ISO Triiodothyronine results in increased expression of KCNA1 mRNA CTD PMID:25172293 NCBI chr 4:159,190,781...159,192,526
Ensembl chr 4:159,190,804...159,192,526 		JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 decreases expression ISO Triiodothyronine results in decreased expression of KCNA4 mRNA CTD PMID:25172293 NCBI chr 3:98,293,295...98,300,763
Ensembl chr 3:98,297,554...98,300,680 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions ISO [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 protein CTD PMID:27605626 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956 		JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO Triiodothyronine results in decreased expression of KCTD12 mRNA CTD PMID:25172293 NCBI chr15:87,384,632...87,390,627 JBrowse link
G Kif1b kinesin family member 1B increases expression EXP Triiodothyronine results in increased expression of KIF1B mRNA CTD PMID:15953391 NCBI chr 5:165,994,803...166,133,497
Ensembl chr 5:165,938,576...166,133,491 		JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression
increases expression		 ISO Triiodothyronine results in decreased expression of KLF9 mRNA
Triiodothyronine results in increased expression of KLF9 mRNA		 CTD PMID:15507505 PMID:23397585 PMID:26096596 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198 		JBrowse link
G Krt13 keratin 13 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KRT13 mRNA CTD PMID:14761676 NCBI chr10:88,032,130...88,036,040
Ensembl chr10:88,032,130...88,036,040 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression		 ISO
EXP		 Amiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]; desethylamiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]
Triiodothyronine inhibits the reaction [Amiodarone results in decreased expression of LDLR protein]		 CTD PMID:9071962 PMID:9712728 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lgi4 leucine-rich repeat LGI family, member 4 increases expression ISO Triiodothyronine results in increased expression of LGI4 mRNA CTD PMID:25172293 NCBI chr 1:89,491,588...89,502,939
Ensembl chr 1:89,491,654...89,502,974 		JBrowse link
G Lhx3 LIM homeobox 3 decreases expression ISO Triiodothyronine results in decreased expression of LHX3 mRNA CTD PMID:23397585 NCBI chr 3:3,653,861...3,662,509
Ensembl chr 3:3,654,755...3,661,810 		JBrowse link
G Linc00176 long intergenic non-protein coding RNA 176 decreases expression ISO Triiodothyronine results in decreased expression of C20ORF204 mRNA CTD PMID:23397585 NCBI chr 3:177,163,038...177,166,874
Ensembl chr 3:177,164,359...177,166,737 		JBrowse link
G Lipe lipase E, hormone sensitive type increases expression ISO Triiodothyronine results in increased expression of LIPE mRNA CTD PMID:30209975 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 decreases expression ISO Triiodothyronine results in decreased expression of LMCD1 mRNA CTD PMID:25172293 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551 		JBrowse link
G Lpin3 lipin 3 increases expression ISO Triiodothyronine results in increased expression of LPIN3 mRNA CTD PMID:25172293 NCBI chr 3:156,874,805...156,899,601
Ensembl chr 3:156,886,454...156,899,436 		JBrowse link
G Lpl lipoprotein lipase increases expression EXP Triiodothyronine results in increased expression of LPL mRNA CTD PMID:15953391 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496 		JBrowse link
G Lss lanosterol synthase increases expression EXP Triiodothyronine results in increased expression of LSS mRNA CTD PMID:15953391 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497 		JBrowse link
G Ltb4r leukotriene B4 receptor multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LTB4R mRNA CTD PMID:14761676 NCBI chr15:34,449,299...34,453,352
Ensembl chr15:34,452,116...34,453,171 		JBrowse link
G Lyrm9 LYR motif containing 9 decreases expression ISO Triiodothyronine results in decreased expression of LYRM9 mRNA CTD PMID:23397585 NCBI chr10:66,099,478...66,113,559
Ensembl chr10:66,099,531...66,113,559 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases lipidation
increases expression
multiple interactions		 ISO Triiodothyronine results in increased lipidation of MAP1LC3B protein
Triiodothyronine results in increased expression of MAP1LC3B mRNA
bafilomycin A1 promotes the reaction [Triiodothyronine results in increased lipidation of MAP1LC3B protein]; Triiodothyronine promotes the reaction [bafilomycin A1 results in increased lipidation of MAP1LC3B protein]		 CTD PMID:30209975 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression		 ISO
EXP		 tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK1 protein
Triiodothyronine results in increased expression of MAPK1 mRNA
Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Triiodothyronine results in increased expression of MAPK1 mRNA]		 CTD PMID:12805413 PMID:16150908 PMID:17174366 PMID:28315333 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases expression		 ISO
EXP		 tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Triiodothyronine results in increased phosphorylation of and results in increased activity of MAPK3 protein
Triiodothyronine results in increased expression of MAPK3 mRNA
Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Triiodothyronine promotes the reaction [FGF18 protein results in increased phosphorylation of MAPK3 protein]; Triiodothyronine promotes the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Triiodothyronine results in increased expression of MAPK3 mRNA]		 CTD PMID:12805413 PMID:16150908 PMID:17174366 PMID:28315333 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mbp myelin basic protein increases expression ISO Triiodothyronine results in increased expression of MBP protein alternative form CTD PMID:15345905 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310 		JBrowse link
G Me1 malic enzyme 1 increases expression EXP Triiodothyronine results in increased expression of ME1 mRNA CTD PMID:15953391 PMID:29357290 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834 		JBrowse link
G Meioc meiosis specific with coiled-coil domain decreases expression ISO Triiodothyronine results in decreased expression of MEIOC mRNA CTD PMID:23397585 NCBI chr10:90,622,954...90,641,883
Ensembl chr10:90,622,992...90,642,151 		JBrowse link
G Mfsd2a major facilitator superfamily domain containing 2A increases expression ISO Triiodothyronine results in increased expression of MFSD2A mRNA CTD PMID:25172293 NCBI chr 5:140,642,865...140,657,759
Ensembl chr 5:140,642,885...140,657,745 		JBrowse link
G Mier3 MIER family member 3 decreases expression ISO Triiodothyronine results in decreased expression of MIER3 mRNA CTD PMID:23397585 NCBI chr 2:43,266,301...43,295,175
Ensembl chr 2:43,266,739...43,294,889 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression
multiple interactions		 ISO Triiodothyronine results in increased expression of MKI67 mRNA
U 0126 inhibits the reaction [Triiodothyronine results in increased expression of MKI67 mRNA]		 CTD PMID:28315333 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Mmd2 monocyte to macrophage differentiation-associated 2 increases expression EXP Triiodothyronine results in increased expression of MMD2 mRNA CTD PMID:29357290 NCBI chr12:14,021,724...14,078,121
Ensembl chr12:14,021,727...14,078,134 		JBrowse link
G Mmp11 matrix metallopeptidase 11 multiple interactions
increases expression		 ISO (4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of MMP11 mRNA]; SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of MMP11 mRNA] CTD PMID:21815645 NCBI chr20:13,670,051...13,678,834
Ensembl chr20:13,670,066...13,678,089 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Triiodothyronine inhibits the reaction [TGFB1 protein results in increased secretion of MMP2 protein] CTD PMID:18031379 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased activity of MPO protein CTD PMID:7503757 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Triiodothyronine results in decreased phosphorylation of MTOR protein CTD PMID:30209975 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions
increases expression		 EXP S100A6 protein inhibits the reaction [Triiodothyronine results in increased expression of MYH6 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA] CTD PMID:11577024 PMID:15578571 PMID:15652358 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions
decreases expression		 EXP Triiodothyronine inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
Triiodothyronine results in decreased expression of MYH7 mRNA		 CTD PMID:11577024 PMID:15578571 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089 		JBrowse link
G Naglt1 Na+ dependent glucose transporter 1 increases expression EXP Triiodothyronine results in increased expression of NAGLT1 mRNA CTD PMID:15953391 NCBI chr20:45,095,232...45,107,532
Ensembl chr20:45,094,791...45,107,555 		JBrowse link
G Ncapg2 non-SMC condensin II complex, subunit G2 decreases expression ISO Triiodothyronine results in decreased expression of NCAPG2 mRNA CTD PMID:23397585 NCBI chr 6:144,291,313...144,362,454
Ensembl chr 6:144,291,974...144,363,947 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO [Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein; bisphenol A inhibits the reaction [[Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein] CTD PMID:22227104 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Triiodothyronine promotes the reaction [NCOA2 protein binds to THRA protein]; Triiodothyronine promotes the reaction [NCOA2 protein binds to THRB protein]; Triiodothyronine promotes the reaction [THRA protein binds to NCOA2 protein]; Triiodothyronine promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:29146198 PMID:31566444 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]; Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein] CTD PMID:22227104 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein] CTD PMID:22227104 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701 		JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression EXP Triiodothyronine results in increased expression of NDUFA5 mRNA CTD PMID:15953391 NCBI chr 4:51,590,413...51,598,771
Ensembl chr 4:51,590,413...51,598,771 		JBrowse link
G Nefl neurofilament light decreases expression ISO Triiodothyronine results in decreased expression of NEFL mRNA CTD PMID:25172293 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574 		JBrowse link
G Nefm neurofilament medium decreases expression ISO Triiodothyronine results in decreased expression of NEFM mRNA CTD PMID:25172293 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity
multiple interactions		 EXP Triiodothyronine results in increased activity of NFKB1 protein
Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of NFKB1 protein]		 CTD PMID:15019085 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nnat neuronatin decreases expression EXP Triiodothyronine results in decreased expression of NNAT mRNA CTD PMID:29357290 NCBI chr 3:154,043,873...154,046,334
Ensembl chr 3:154,043,873...154,046,330 		JBrowse link
G Npnt nephronectin increases expression ISO Triiodothyronine results in increased expression of NPNT mRNA CTD PMID:25172293 NCBI chr 2:238,001,767...238,068,886
Ensembl chr 2:238,002,990...238,068,694 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression EXP Triiodothyronine results in increased expression of NR0B2 mRNA CTD PMID:29357290 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]; Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA] CTD PMID:21726595 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Nrgn neurogranin increases expression EXP Triiodothyronine results in increased expression of NRGN mRNA; Triiodothyronine results in increased expression of NRGN protein CTD PMID:15708448 NCBI chr 8:40,015,049...40,023,193
Ensembl chr 8:40,015,049...40,023,193 		JBrowse link
G Nrp1 neuropilin 1 increases expression EXP Triiodothyronine results in increased expression of NRP1 mRNA CTD PMID:15953391 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP Triiodothyronine results in increased expression of NSDHL mRNA CTD PMID:15953391 NCBI chr  X:152,933,118...152,964,399
Ensembl chr  X:152,933,069...152,964,390 		JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor increases expression EXP Triiodothyronine results in increased expression of NSMF mRNA CTD PMID:15953391 NCBI chr 3:2,262,173...2,270,996
Ensembl chr 3:2,262,253...2,270,995 		JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression
increases activity		 EXP Triiodothyronine results in increased expression of NT5E mRNA
Triiodothyronine results in increased activity of NT5E protein		 CTD PMID:15543949 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696 		JBrowse link
G Nudt7 nudix hydrolase 7 increases expression EXP Triiodothyronine results in increased expression of NUDT7 mRNA CTD PMID:15953391 NCBI chr19:46,455,745...46,470,070
Ensembl chr19:46,455,761...46,482,050 		JBrowse link
G Nup214 nucleoporin 214 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NUP214 mRNA CTD PMID:14761676 NCBI chr 3:9,227,869...9,236,878
NCBI chr 3:10,993,584...11,070,638
Ensembl chr 3:9,227,823...9,236,736
Ensembl chr 3:9,227,823...9,236,736 		JBrowse link
G Ocln occludin increases expression EXP Triiodothyronine results in increased expression of OCLN mRNA CTD PMID:15953391 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218 		JBrowse link
G Olr59 olfactory receptor 59 increases expression EXP Triiodothyronine results in increased expression of OLR59 mRNA CTD PMID:28299817 NCBI chr 1:167,906,030...167,940,688
Ensembl chr 1:167,906,061...167,911,961 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO Triiodothyronine results in increased expression of OSGIN1 mRNA CTD PMID:25172293 NCBI chr19:52,056,808...52,085,491
Ensembl chr19:52,077,109...52,085,496 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
affects binding		 EXP 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine binds to P4HB protein]; bisphenol A inhibits the reaction [Triiodothyronine binds to P4HB protein]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of and results in increased secretion of GH protein]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]; Polychlorinated Biphenyls metabolite inhibits the reaction [Triiodothyronine binds to P4HB protein] CTD PMID:17928132 PMID:18515855 PMID:19374345 PMID:22201216 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987 		JBrowse link
G Padi4 peptidyl arginine deiminase 4 increases expression EXP Triiodothyronine results in increased expression of PADI4 mRNA CTD PMID:15953391 NCBI chr 5:159,260,675...159,293,906
Ensembl chr 5:159,260,675...159,293,673 		JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 decreases expression ISO Triiodothyronine results in decreased expression of PARP4 mRNA CTD PMID:23397585 NCBI chr15:36,809,362...36,911,167 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
increases expression		 EXP
ISO		 SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PCK1 mRNA]
(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of PCK1 mRNA]; SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of PCK1 mRNA]		 CTD PMID:21815645 PMID:23209300 PMID:30209975 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions
affects binding		 ISO Triiodothyronine results in increased expression of PCNA protein
THRB protein promotes the reaction [Triiodothyronine results in increased expression of PCNA protein]
Triiodothyronine analog inhibits the reaction [CDKN1A protein binds to PCNA protein]; Triiodothyronine analog inhibits the reaction [POLD3 protein binds to PCNA protein]; Triiodothyronine inhibits the reaction [CDKN1A protein binds to PCNA protein]
Triiodothyronine analog binds to PCNA protein; Triiodothyronine binds to PCNA protein		 CTD PMID:17174366 PMID:20638743 PMID:22383522 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 decreases expression ISO Triiodothyronine results in decreased expression of PCSK1 mRNA CTD PMID:15291740 NCBI chr 2:91,450,162...91,497,091
Ensembl chr 2:91,450,162...91,497,091 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 decreases expression ISO Triiodothyronine results in decreased expression of PCSK2 mRNA CTD PMID:15585599 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions
increases expression		 ISO
EXP		 resveratrol promotes the reaction [Triiodothyronine results in increased expression of PDK4 mRNA]
resveratrol promotes the reaction [Triiodothyronine results in increased expression of PDK4 mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PDK4 mRNA]		 CTD PMID:23209300 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814 		JBrowse link
G Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 increases expression EXP Triiodothyronine results in increased expression of PDP2 mRNA CTD PMID:29357290 NCBI chr19:597,427...601,556
Ensembl chr19:597,427...601,469 		JBrowse link
G Peg10 paternally expressed 10 increases expression ISO Triiodothyronine results in increased expression of PEG10 mRNA CTD PMID:23397585 NCBI chr 4:29,795,524...29,804,517 JBrowse link
G Pex5 peroxisomal biogenesis factor 5 increases expression ISO Triiodothyronine results in increased expression of PEX5 mRNA CTD PMID:23397585 NCBI chr 4:156,983,914...157,009,675
Ensembl chr 4:156,983,915...157,009,674
Ensembl chr 4:156,983,915...157,009,674 		JBrowse link
G Pfkp phosphofructokinase, platelet increases expression ISO Triiodothyronine results in increased expression of PFKP mRNA CTD PMID:15507505 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471 		JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 increases expression ISO Triiodothyronine results in increased expression of PHOSPHO1 mRNA CTD PMID:25172293 NCBI chr10:83,635,557...83,643,862
Ensembl chr10:83,636,518...83,643,859 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta increases expression ISO Triiodothyronine results in increased expression of PIK3CD mRNA CTD PMID:25172293 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028 		JBrowse link
G Pla2g6 phospholipase A2 group VI increases expression EXP Triiodothyronine results in increased expression of PLA2G6 mRNA CTD PMID:15953391 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347 		JBrowse link
G Pld5 phospholipase D family, member 5 increases expression ISO Triiodothyronine results in increased expression of PLD5 mRNA CTD PMID:23397585 NCBI chr13:94,025,696...94,355,219
Ensembl chr13:94,025,369...94,355,219 		JBrowse link
G Plin2 perilipin 2 increases expression EXP Triiodothyronine results in increased expression of PLIN2 mRNA CTD PMID:15953391 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857 		JBrowse link
G Plin3 perilipin 3 multiple interactions ISO [THRA protein co-treated with Triiodothyronine] promotes the reaction [ANGPTL8 protein binds to PLIN3 protein] CTD PMID:24262987 NCBI chr 9:10,769,739...10,781,659
Ensembl chr 9:10,773,901...10,781,109 		JBrowse link
G Plxnc1 plexin C1 increases expression ISO Triiodothyronine results in increased expression of PLXNC1 mRNA CTD PMID:23397585 NCBI chr 7:35,848,083...36,000,969
Ensembl chr 7:35,850,398...36,000,906 		JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression ISO Triiodothyronine results in increased expression of PMP22 mRNA CTD PMID:29901742 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression
decreases phosphorylation		 ISO Triiodothyronine results in increased expression of PNPLA2 mRNA
Triiodothyronine results in decreased phosphorylation of PNPLA2 protein		 CTD PMID:30209975 NCBI chr 1:214,434,638...214,439,720
Ensembl chr 1:214,434,626...214,439,720
Ensembl chr 1:214,434,626...214,439,720 		JBrowse link
G Podxl podocalyxin-like increases expression EXP Triiodothyronine results in increased expression of PODXL mRNA CTD PMID:15953391 NCBI chr 4:58,829,049...58,893,353
Ensembl chr 4:58,829,060...58,893,170 		JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit multiple interactions ISO Triiodothyronine analog inhibits the reaction [POLD3 protein binds to PCNA protein] CTD PMID:22383522 NCBI chr 1:165,085,142...165,122,385
Ensembl chr 1:165,083,622...165,123,455 		JBrowse link
G Polg DNA polymerase gamma, catalytic subunit multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of POLG mRNA CTD PMID:14761676 NCBI chr 1:141,172,117...141,188,893
Ensembl chr 1:141,172,531...141,188,031 		JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 increases expression EXP Triiodothyronine results in increased expression of POMT1 mRNA CTD PMID:15953391 NCBI chr 3:11,253,424...11,271,873
Ensembl chr 3:11,254,026...11,271,872 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [GW 7647 results in increased activity of PPARA protein] promotes the reaction [Phenobarbital results in increased degradation of Triiodothyronine]; [pirinixic acid results in increased activity of PPARA protein] promotes the reaction [Phenobarbital results in increased degradation of Triiodothyronine]; [Triiodothyronine co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA CTD PMID:19631232 PMID:25048947 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP Triiodothyronine inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of PPARG mRNA] CTD PMID:25048947 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP
ISO		 Triiodothyronine results in increased expression of PPARGC1A mRNA CTD PMID:23209300 PMID:30209975 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Prdm16 PR/SET domain 16 increases expression ISO Triiodothyronine results in increased expression of PRDM16 mRNA CTD PMID:30209975 NCBI chr 5:171,662,277...171,711,561
Ensembl chr 5:171,662,277...171,710,316 		JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein decreases expression ISO Triiodothyronine results in decreased expression of PRELP mRNA CTD PMID:25172293 NCBI chr13:50,749,526...50,773,934
Ensembl chr13:50,749,514...50,761,355 		JBrowse link
G Prickle2 prickle planar cell polarity protein 2 decreases expression ISO Triiodothyronine results in decreased expression of PRICKLE2 mRNA CTD PMID:25172293 NCBI chr 4:124,238,167...124,584,176
Ensembl chr 4:124,238,167...124,338,176 		JBrowse link
G Prl prolactin decreases expression
increases secretion
multiple interactions		 EXP Triiodothyronine results in decreased expression of PRL mRNA; Triiodothyronine results in decreased expression of PRL protein
Triiodothyronine results in increased secretion of PRL protein
bisphenol A inhibits the reaction [Triiodothyronine results in increased secretion of PRL protein]; Chlorodiphenyl (54% Chlorine) promotes the reaction [Triiodothyronine results in increased secretion of PRL protein]		 CTD PMID:3734668 PMID:17615682 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Prokr1 prokineticin receptor 1 increases expression ISO Triiodothyronine results in increased expression of PROKR1 mRNA CTD PMID:25172293 NCBI chr 4:119,375,790...119,386,551
Ensembl chr 4:119,375,778...119,386,590 		JBrowse link
G Psca prostate stem cell antigen multiple interactions
increases expression		 ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of PSCA mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of PSCA mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of PSCA mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of PSCA protein]
Triiodothyronine results in increased expression of PSCA mRNA; Triiodothyronine results in increased expression of PSCA protein		 CTD PMID:14761676 NCBI chr 7:116,090,189...116,091,955
Ensembl chr 7:116,090,189...116,091,955 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Triiodothyronine results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rab23 RAB23, member RAS oncogene family decreases expression ISO Triiodothyronine results in decreased expression of RAB23 mRNA CTD PMID:23397585 NCBI chr 9:38,469,784...38,496,185
Ensembl chr 9:38,470,298...38,495,176 		JBrowse link
G Rab3b RAB3B, member RAS oncogene family increases expression ISO Triiodothyronine results in increased expression of RAB3B mRNA CTD PMID:15507505 NCBI chr 5:128,501,789...128,568,170
Ensembl chr 5:128,501,847...128,568,188 		JBrowse link
G Rarb retinoic acid receptor, beta increases expression EXP Triiodothyronine results in increased expression of RARB mRNA CTD PMID:15708448 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity		 EXP Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of RELA protein] CTD PMID:15019085 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Retsat retinol saturase increases expression EXP Triiodothyronine results in increased expression of RETSAT mRNA CTD PMID:15953391 NCBI chr 4:100,465,365...100,474,128
Ensembl chr 4:100,465,170...100,474,301 		JBrowse link
G RGD1306063 similar to HT021 increases expression EXP Triiodothyronine results in increased expression of RGD1306063 mRNA CTD PMID:15953391 NCBI chr15:12,869,217...12,889,144
Ensembl chr15:12,872,408...12,889,108 		JBrowse link
G RGD1307603 similar to hypothetical protein MGC37914 decreases expression EXP Triiodothyronine results in decreased expression of RGD1307603 mRNA CTD PMID:29357290 NCBI chr 1:219,309,593...219,312,240
Ensembl chr 1:219,309,592...219,312,240 		JBrowse link
G RGD1564801 similar to hepatic multiple inositol polyphosphate phosphatase increases expression EXP Triiodothyronine results in increased expression of RGD1564801 mRNA CTD PMID:15953391 NCBI chr 1:75,151,956...75,154,325
Ensembl chr 1:75,152,883...75,154,325 		JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase increases expression ISO Triiodothyronine results in increased expression of AKR1C1 mRNA CTD PMID:15507505 NCBI chr17:69,468,427...69,497,132
Ensembl chr17:69,468,427...69,497,132 		JBrowse link
G Rhov ras homolog family member V increases expression ISO Triiodothyronine results in increased expression of RHOV mRNA CTD PMID:23397585 NCBI chr 3:111,078,642...111,087,347
Ensembl chr 3:111,078,619...111,087,347 		JBrowse link
G Rpa2 replication protein A2 increases phosphorylation ISO Triiodothyronine analog results in increased phosphorylation of RPA2 protein CTD PMID:22383522 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation		 ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Triiodothyronine results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:30209975 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Rxrb retinoid X receptor beta increases expression EXP Triiodothyronine results in increased expression of RXRB mRNA CTD PMID:15708448 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140 		JBrowse link
G Rxrg retinoid X receptor gamma increases expression EXP Triiodothyronine results in increased expression of RXRG mRNA CTD PMID:15708448 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552 		JBrowse link
G S100a6 S100 calcium binding protein A6 multiple interactions EXP S100A6 protein inhibits the reaction [Triiodothyronine results in increased expression of MYH6 mRNA] CTD PMID:15652358 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP Triiodothyronine results in increased expression of SC5D mRNA CTD PMID:15953391 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP Triiodothyronine results in increased expression of SCD1 mRNA CTD PMID:15953391 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Serpina6 serpin family A member 6 increases expression EXP Triiodothyronine results in increased expression of SERPINA6 mRNA CTD PMID:29357290 NCBI chr 6:127,523,948...127,534,178
Ensembl chr 6:127,523,906...127,534,247 		JBrowse link
G Serpina7 serpin family A member 7 affects binding ISO Triiodothyronine binds to SERPINA7 protein CTD PMID:20804816 PMID:21517007 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179 		JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 increases expression EXP Triiodothyronine results in increased expression of SIGMAR1 mRNA CTD PMID:15953391 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
affects response to substance		 EXP SIRT1 protein affects the reaction [Triiodothyronine results in decreased activity of SREBF1 protein]; SIRT1 protein affects the reaction [Triiodothyronine results in decreased expression of SREBF1 mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A protein]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PCK1 mRNA]; SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PDK4 mRNA]
Triiodothyronine results in increased expression of SIRT1 mRNA
SIRT1 protein affects the susceptibility to Triiodothyronine		 CTD PMID:23209300 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression EXP Triiodothyronine results in increased expression of SLC10A2 mRNA CTD PMID:28299817 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions
decreases expression		 ISO resveratrol inhibits the reaction [Triiodothyronine results in decreased expression of SLC15A1 mRNA]; resveratrol inhibits the reaction [Triiodothyronine results in decreased expression of SLC15A1 protein]
Triiodothyronine results in decreased expression of SLC15A1 mRNA; Triiodothyronine results in decreased expression of SLC15A1 protein		 CTD PMID:26394120 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426 		JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions
increases uptake		 ISO bisphenol A inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; bosutinib inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Dasatinib inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Desipramine inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Genistein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Imatinib Mesylate inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Indocyanine Green inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Meclofenamic Acid inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Phloretin inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]; Sulfobromophthalein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214 		JBrowse link
G Slc16a3 solute carrier family 16 member 3 increases expression ISO Triiodothyronine results in increased expression of SLC16A3 mRNA CTD PMID:15507505 NCBI chr10:110,138,519...110,148,360
Ensembl chr10:110,138,586...110,148,358 		JBrowse link
G Slc16a6 solute carrier family 16, member 6 increases expression
multiple interactions		 ISO Triiodothyronine results in increased expression of SLC16A6 mRNA
(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of SLC16A6 mRNA]		 CTD PMID:21815645 NCBI chr10:97,733,701...97,758,723
Ensembl chr10:97,735,548...97,756,521 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression ISO Triiodothyronine results in increased expression of SLC1A2 mRNA CTD PMID:25172293 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644 		JBrowse link
G Slc25a25 solute carrier family 25 member 25 increases expression EXP Triiodothyronine results in increased expression of SLC25A25 mRNA CTD PMID:29357290 NCBI chr 3:11,442,396...11,476,186
Ensembl chr 3:11,442,397...11,452,529 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Triiodothyronine results in increased expression of SLC2A1 mRNA CTD PMID:15507505 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of SLC2A4 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of SLC2A4 protein CTD PMID:27605626 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Slc2a5 solute carrier family 2 member 5 multiple interactions EXP [Triiodothyronine co-treated with Fructose] results in increased expression of SLC2A5 mRNA CTD PMID:17485832 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 increases expression EXP Triiodothyronine results in increased expression of SLC38A2 mRNA CTD PMID:29357290 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841 		JBrowse link
G Slc43a2 solute carrier family 43 member 2 increases expression ISO Triiodothyronine results in increased expression of SLC43A2 mRNA CTD PMID:25172293 NCBI chr10:63,676,317...63,719,283
Ensembl chr10:63,677,396...63,719,283 		JBrowse link
G Slc51b solute carrier family 51 subunit beta increases expression
multiple interactions		 ISO Triiodothyronine results in increased expression of SLC51B mRNA
(4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of SLC51B mRNA]		 CTD PMID:21815645 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Triiodothyronine results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Triiodothyronine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433 		JBrowse link
G Sned1 sushi, nidogen and EGF-like domains 1 increases expression ISO Triiodothyronine results in increased expression of SNED1 mRNA CTD PMID:25172293 NCBI chr 9:100,380,487...100,439,125
Ensembl chr 9:100,380,515...100,437,056 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression		 ISO Triiodothyronine inhibits the reaction [Paraquat results in decreased expression of SOD1 mRNA]; Triiodothyronine inhibits the reaction [THRA protein results in increased expression of SOD1 mRNA]; Triiodothyronine inhibits the reaction [THRB protein results in increased expression of SOD1 mRNA]
Triiodothyronine results in decreased expression of SOD1 mRNA		 CTD PMID:16738222 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Spen spen family transcriptional repressor increases expression ISO Triiodothyronine results in increased expression of SPEN mRNA CTD PMID:23397585 NCBI chr 5:160,015,573...160,070,915
Ensembl chr 5:160,015,454...160,070,965 		JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 increases expression ISO Triiodothyronine results in increased expression of SPTLC2 mRNA CTD PMID:23397585 NCBI chr 6:111,334,408...111,417,960
Ensembl chr 6:111,339,136...111,417,954 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression		 ISO [THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein; Ammonium Chloride inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; ANGPTL8 protein affects the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]
Triiodothyronine results in increased expression of SQSTM1 mRNA		 CTD PMID:24262987 PMID:30209975 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]] CTD PMID:22227104 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
decreases activity		 EXP SIRT1 protein affects the reaction [Triiodothyronine results in decreased activity of SREBF1 protein]; SIRT1 protein affects the reaction [Triiodothyronine results in decreased expression of SREBF1 mRNA] CTD PMID:23209300 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 decreases expression ISO Triiodothyronine results in decreased expression of SFRS3 mRNA CTD PMID:23397585 NCBI chr20:6,288,285...6,298,218
Ensembl chr20:6,288,267...6,298,213 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]]; Triiodothyronine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA] CTD PMID:21726595 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Stard8 StAR-related lipid transfer domain containing 8 increases expression ISO Triiodothyronine results in increased expression of STARD8 mRNA CTD PMID:25172293 NCBI chr  X:68,713,157...68,785,046
Ensembl chr  X:68,713,123...68,785,052 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Triiodothyronine inhibits the reaction [FGF2 protein results in increased phosphorylation of STAT1 protein] CTD PMID:16150908 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A increases expression ISO Triiodothyronine results in increased expression of STAT5A mRNA CTD PMID:25172293 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases expression EXP Triiodothyronine results in increased expression of STAT5B mRNA CTD PMID:15953391 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829 		JBrowse link
G Stk19 serine/threonine kinase 19 increases expression ISO Triiodothyronine results in increased expression of STK19 mRNA CTD PMID:23397585 NCBI chr20:4,317,440...4,517,128 JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation
multiple interactions
affects sulfation		 ISO SULT1A1 protein results in increased sulfation of Triiodothyronine
Triiodothyronine inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]
SULT1A1 gene polymorphism affects the sulfation of Triiodothyronine		 CTD PMID:11739018 PMID:15531517 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP Triiodothyronine results in increased expression of SULT2A1 mRNA CTD PMID:15953391 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230 		JBrowse link
G Sult4a1 sulfotransferase family 4A, member 1 increases metabolic processing ISO SULT4A1 protein results in increased metabolism of Triiodothyronine CTD PMID:12039030 NCBI chr 7:124,958,546...124,982,602
Ensembl chr 7:124,958,546...124,982,566 		JBrowse link
G Taf5l TATA-box binding protein associated factor 5 like increases expression ISO Triiodothyronine results in increased expression of TAF5L mRNA CTD PMID:23397585 NCBI chr19:56,781,854...56,801,005
Ensembl chr19:56,781,859...56,799,445 		JBrowse link
G Tcim transcriptional and immune response regulator multiple interactions
increases expression		 ISO SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of TCIM mRNA] CTD PMID:21815645 NCBI chr16:72,401,526...72,403,180
Ensembl chr16:72,401,887...72,403,179
Ensembl chr16:72,401,887...72,403,179 		JBrowse link
G Tex264 testis expressed 264 increases expression EXP Triiodothyronine results in increased expression of TEX264 mRNA CTD PMID:29357290 NCBI chr 8:115,360,706...115,388,299
Ensembl chr 8:115,360,713...115,388,266 		JBrowse link
G Tfeb transcription factor EB increases expression ISO Triiodothyronine results in increased expression of TFEB mRNA CTD PMID:25172293 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Triiodothyronine inhibits the reaction [TGFB1 protein results in increased secretion of MMP2 protein]; Triiodothyronine promotes the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:18031379 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tgoln2 trans-golgi network protein 2 decreases expression
increases expression		 ISO Triiodothyronine results in decreased expression of TGOLN2 mRNA
Triiodothyronine results in increased expression of TGOLN2 mRNA		 CTD PMID:23397585 NCBI chr 4:100,475,415...100,483,229
Ensembl chr 4:100,475,416...100,483,168 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions
affects binding
increases expression
increases activity
decreases expression		 ISO
EXP		 (4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of THRA mRNA]; 2,2',4,4'-tetrabromodiphenyl ether analog affects the reaction [Triiodothyronine binds to THRA protein]; [THRA protein co-treated with Triiodothyronine] promotes the reaction [ANGPTL8 protein binds to PLIN3 protein]; [THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein; [THRA protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 mRNA; [THRA protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 protein; Ammonium Chloride inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; ANGPTL8 protein affects the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [Triiodothyronine binds to THRA protein]; bisphenol A inhibits the reaction [Triiodothyronine binds to THRA protein]; bisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; bisphenol F inhibits the reaction [Triiodothyronine binds to THRA protein]; Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; daidzein promotes the reaction [Triiodothyronine results in increased activity of THRA protein]; Genistein promotes the reaction [Triiodothyronine results in increased activity of THRA protein]; KB 130015 inhibits the reaction [Triiodothyronine binds to and results in increased activity of THRA protein]; pentabromodiphenyl ether analog inhibits the reaction [Triiodothyronine binds to THRA protein]; Polybrominated Biphenyls metabolite inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine binds to THRA protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; tetrachlorodian inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased cleavage of CASP3 protein]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of CYCS mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL1B mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of IL6 mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of TNF mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL1B protein]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of IL6 protein]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of TNF protein]]; tribromodiphenyl ether 28 analog affects the reaction [Triiodothyronine binds to THRA protein]; Triiodothyronine binds to and results in increased activity of THRA protein; Triiodothyronine inhibits the reaction [THRA protein results in increased expression of SOD1 mRNA]; Triiodothyronine promotes the reaction [NCOA2 protein binds to THRA protein]; Triiodothyronine promotes the reaction [THRA protein binds to NCOA2 protein]
2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]]; 2,2',4,4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine results in increased expression of THRA mRNA]; CSK protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine binds to THRA protein]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]; Triiodothyronine inhibits the reaction [[NR4A1 co-treated with THRA] results in increased expression of STAR mRNA]; Triiodothyronine promotes the reaction [[NR4A1 co-treated with THRA] results in increased expression of HSD3B1 mRNA]
[bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of THRA mRNA; [bisphenol A co-treated with Triiodothyronine] results in increased expression of THRA mRNA; Polybrominated Biphenyls inhibits the reaction [Triiodothyronine results in increased activity of THRA protein]; Polybrominated Biphenyls metabolite inhibits the reaction [Triiodothyronine binds to THRA protein]; THRA protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]; Triiodothyronine binds to and results in increased activity of THRA protein
Triiodothyronine results in decreased expression of THRA mRNA
Triiodothyronine results in increased expression of THRA mRNA; Triiodothyronine results in increased expression of THRA protein		 CTD PMID:7684602 PMID:9664232 PMID:11806713 PMID:12109914 PMID:12414890 PMID:12588052 PMID:15680168 PMID:15708448 PMID:16021636 PMID:16023420 PMID:16738222 PMID:19672399 PMID:21396401 PMID:21726595 PMID:22015988 PMID:22086976 PMID:23112079 PMID:23402801 PMID:24076165 PMID:24262987 PMID:24819616 PMID:25646720 PMID:27993100 PMID:28167136 PMID:29146198 PMID:29688519 PMID:31566444 PMID:32223187 PMID:33095664 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
decreases expression
affects binding
increases response to substance
increases activity
increases expression		 ISO
EXP		 (4-(4-hydroxy-3-isopropyl-5-(4-nitrophenylethynyl)benzyl)-3,5-dimethylphenoxy)acetic acid inhibits the reaction [Triiodothyronine results in increased expression of THRB mRNA]; 2,2',4,4'-tetrabromodiphenyl ether analog affects the reaction [Triiodothyronine binds to THRB protein]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [Triiodothyronine binds to THRB protein]; 2,3,4,7,8-pentachlorodibenzofuran inhibits the reaction [Triiodothyronine results in increased expression of THRB mRNA]; 2,4,6-tribromophenol inhibits the reaction [Triiodothyronine binds to THRB protein]; 2,4,6-trichlorophenol inhibits the reaction [Triiodothyronine binds to THRB protein]; 2,4,6-triiodophenol inhibits the reaction [Triiodothyronine binds to THRB protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Triiodothyronine binds to THRB protein]; 4-nonylphenol inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of THRB mRNA]; 6-OH-BDE-47 inhibits the reaction [Triiodothyronine binds to THRB protein]; [THRB protein co-treated with Triiodothyronine] results in increased expression of ANGPTL8 mRNA; [Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein; AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Amiodarone inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; bis(4-hydroxyphenyl)sulfone analog inhibits the reaction [Triiodothyronine binds to THRB protein]; bis(4-hydroxyphenyl)sulfone analog inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [Triiodothyronine binds to THRB protein]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; bisphenol A analog inhibits the reaction [Triiodothyronine binds to THRB protein]; bisphenol A inhibits the reaction [[Triiodothyronine co-treated with NCOA1 protein] results in increased activity of THRB protein]; bisphenol A inhibits the reaction [Triiodothyronine binds to THRB protein]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; bisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; bisphenol F inhibits the reaction [Triiodothyronine binds to THRB protein]; cyhalothrin inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; daidzein promotes the reaction [Triiodothyronine results in increased activity of THRB protein]; deoxynivalenol inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; desethylamiodarone inhibits the reaction [Triiodothyronine binds to THRB protein alternative form]; Genistein promotes the reaction [Triiodothyronine results in increased activity of THRB protein]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; KB 130015 inhibits the reaction [Triiodothyronine binds to and results in increased activity of THRB protein]; methoxyacetic acid promotes the reaction [Triiodothyronine results in increased activity of THRB protein]; pentabromodiphenyl ether analog inhibits the reaction [Triiodothyronine binds to THRB protein]; pentabromophenol inhibits the reaction [Triiodothyronine binds to THRB protein]; Polybrominated Biphenyls metabolite inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; systhane inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; T-2 Toxin inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine binds to THRB protein]; tetrabromobisphenol A inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; tetrachlorodian analog inhibits the reaction [Triiodothyronine binds to THRB protein]; tetrachlorodian inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Thyroxine inhibits the reaction [Triiodothyronine binds to THRB protein]; Tretinoin inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; tribromodiphenyl ether 28 analog affects the reaction [Triiodothyronine binds to THRB protein]; Triclosan inhibits the reaction [Triiodothyronine binds to THRB protein]; Triiodothyronine binds to and results in increased activity of THRB protein; Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]; Triiodothyronine inhibits the reaction [THRB protein binds to NCOR1 protein]; Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]; Triiodothyronine inhibits the reaction [THRB protein results in increased expression of SOD1 mRNA]; Triiodothyronine promotes the reaction [NCOA2 protein binds to THRB protein]; Triiodothyronine promotes the reaction [THRB protein binds to NCOA2 protein]; Zearalenone inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]
Triiodothyronine results in decreased expression of THRB mRNA
THRB protein results in increased susceptibility to Triiodothyronine
THRB protein promotes the reaction [Triiodothyronine results in decreased expression of CDKN1B protein]; THRB protein promotes the reaction [Triiodothyronine results in increased expression of CCND1 protein]; THRB protein promotes the reaction [Triiodothyronine results in increased expression of PCNA protein]
Triiodothyronine results in increased expression of THRB mRNA; Triiodothyronine results in increased expression of THRB protein
[bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of THRB mRNA; [bisphenol A co-treated with Triiodothyronine] results in increased expression of THRB mRNA; Butyric Acid inhibits the reaction [Triiodothyronine results in increased expression of THRB mRNA]; desethylamiodarone inhibits the reaction [Triiodothyronine binds to THRB protein]; Polybrominated Biphenyls inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]; THRB protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]; THRB protein promotes the reaction [Triiodothyronine results in increased expression of ATP2A2 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB protein]		 CTD PMID:2211641 PMID:8137729 PMID:11577024 PMID:11806713 PMID:12109914 PMID:12414890 PMID:12538616 PMID:12588052 PMID:15103026 PMID:15598685 PMID:15680168 PMID:15708448 PMID:16021636 PMID:16738222 PMID:18486176 PMID:18584933 PMID:18795168 PMID:19457453 PMID:19672399 PMID:20638743 PMID:20737425 PMID:21396401 PMID:22015988 PMID:22227104 PMID:23112079 PMID:23402801 PMID:24262987 PMID:25646720 PMID:27410513 PMID:27420076 PMID:27993100 PMID:28167136 PMID:28531659 PMID:28973306 PMID:29146198 PMID:29409039 PMID:29688519 PMID:29763311 PMID:31077750 PMID:31476497 PMID:31566444 PMID:33095664 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
G Thrsp thyroid hormone responsive multiple interactions
increases expression		 EXP
ISO		 Triiodothyronine inhibits the reaction [Amiodarone results in increased expression of THRSP mRNA]
Triiodothyronine results in increased expression of THRSP mRNA		 CTD PMID:2721112 PMID:10357836 PMID:15953391 PMID:28478156 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575 		JBrowse link
G Tmem184b transmembrane protein 184B multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of TMEM184B mRNA CTD PMID:14761676 NCBI chr 7:120,593,336...120,636,592
Ensembl chr 7:120,593,336...120,636,592 		JBrowse link
G Tmem44 transmembrane protein 44 increases expression ISO Triiodothyronine results in increased expression of TMEM44 mRNA CTD PMID:23397585 NCBI chr11:73,737,323...73,774,149
Ensembl chr11:73,738,433...73,774,190 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF mRNA; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF protein; Hexachlorocyclohexane inhibits the reaction [Triiodothyronine results in increased expression of TNF protein]
THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of TNF mRNA]]; THRA protein affects the reaction [Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of TNF protein]]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased expression of TNF mRNA]; Triiodothyronine inhibits the reaction [Silicon Dioxide results in increased secretion of TNF protein]		 CTD PMID:15019085 PMID:32223187 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 multiple interactions
increases expression		 ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of TNFRSF9 mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of TNFRSF9 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TNFRSF9 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TNFRSF9 protein]
Triiodothyronine results in increased expression of TNFRSF9 mRNA; Triiodothyronine results in increased expression of TNFRSF9 protein		 CTD PMID:14761676 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 increases expression
multiple interactions		 ISO Triiodothyronine results in increased expression of TOMM20 protein
Chloroquine promotes the reaction [Triiodothyronine results in increased expression of TOMM20 protein]; Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of TOMM20 protein]		 CTD PMID:30209975 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411 		JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions
increases expression		 ISO 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]; Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 protein]
Triiodothyronine results in increased expression of TRAF1 mRNA; Triiodothyronine results in increased expression of TRAF1 protein		 CTD PMID:14761676 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672 		JBrowse link
G Trim46 tripartite motif-containing 46 increases expression ISO Triiodothyronine results in increased expression of TRIM46 mRNA CTD PMID:23397585 NCBI chr 2:188,548,608...188,561,617
Ensembl chr 2:188,548,644...188,561,360 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta decreases expression
multiple interactions
increases secretion		 ISO
EXP		 Triiodothyronine results in decreased expression of TSHB mRNA
[Triiodothyronine co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in decreased expression of TSHB mRNA alternative form
TSHB protein results in increased secretion of Triiodothyronine		 CTD PMID:7827627 PMID:9092800 PMID:11288978 PMID:27420076 PMID:28167136 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681 		JBrowse link
G Ttbk1 tau tubulin kinase 1 increases expression ISO Triiodothyronine results in increased expression of TTBK1 mRNA CTD PMID:25172293 NCBI chr 9:16,862,305...16,899,399
Ensembl chr 9:16,862,248...16,902,199 		JBrowse link
G Ttn titin multiple interactions
affects expression		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine affects the expression of TTN mRNA]; AKT1 protein affects the reaction [Triiodothyronine affects the expression of TTN mRNA] CTD PMID:18096819 NCBI chr 3:63,565,160...63,837,815 JBrowse link
G Ttr transthyretin affects binding ISO Triiodothyronine binds to TTR protein CTD PMID:20804816 PMID:21517007 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions
increases expression		 ISO
EXP		 (+)-JQ1 compound inhibits the reaction [[Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA]; [Triiodothyronine co-treated with rosiglitazone co-treated with INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of UCP1 mRNA
Triiodothyronine results in increased expression of UCP1 mRNA; Triiodothyronine results in increased expression of UCP1 protein
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [Triiodothyronine co-treated with Norepinephrine] results in increased expression of UCP1 mRNA; AVP protein inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; AVP protein inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]; Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]; Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]		 CTD PMID:11742803 PMID:26972250 PMID:30209975 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP THRA protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]; THRB protein alternative form affects the reaction [Triiodothyronine promotes the reaction [Thiazolidinediones results in increased expression of UCP2]]; Triiodothyronine promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of UCP2 mRNA]; Triiodothyronine promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of UCP2 protein]; Triiodothyronine promotes the reaction [Bezafibrate results in increased expression of UCP2 mRNA]; Triiodothyronine promotes the reaction [carboprostacyclin results in increased expression of UCP2 mRNA]; Triiodothyronine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA] CTD PMID:12588052 PMID:25048947 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744 		JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases activity EXP Triiodothyronine results in increased activity of UGCG protein CTD PMID:9101438 NCBI chr 5:76,376,722...76,419,564
Ensembl chr 5:76,386,836...76,419,560 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases expression
multiple interactions		 EXP Triiodothyronine results in decreased expression of UGT1A1 mRNA
Vitamin A inhibits the reaction [Triiodothyronine results in decreased expression of UGT1A1 mRNA]		 CTD PMID:11299074 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression
multiple interactions		 EXP Triiodothyronine results in increased expression of UGT1A6 mRNA
Vitamin A inhibits the reaction [Triiodothyronine results in increased expression of UGT1A6 mRNA]		 CTD PMID:11299074 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Utp20 UTP20 small subunit processome component multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of UTP20 mRNA CTD PMID:14761676 NCBI chr 7:29,296,360...29,378,105
Ensembl chr 7:29,296,963...29,378,080 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression
multiple interactions		 ISO Triiodothyronine results in increased expression of VDAC1 protein
Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of VDAC1 protein]		 CTD PMID:30209975 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826 		JBrowse link
G Wls Wnt ligand secretion mediator increases expression ISO Triiodothyronine results in increased expression of WLS mRNA CTD PMID:23397585 NCBI chr 2:266,315,036...266,431,220
Ensembl chr 2:266,315,036...266,432,558 		JBrowse link
G Zc3h7b zinc finger CCCH-type containing 7B decreases expression ISO Triiodothyronine results in decreased expression of ZC3H7B mRNA CTD PMID:23397585 NCBI chr 7:122,978,999...123,027,166
Ensembl chr 7:122,979,021...123,027,150 		JBrowse link
G Zfp113 zinc finger protein 3 multiple interactions ISO [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ZNF3 mRNA CTD PMID:14761676 NCBI chr12:19,287,541...19,298,172
Ensembl chr12:19,288,403...19,294,888 		JBrowse link
G Zfp664 zinc finger protein 664 increases expression ISO Triiodothyronine results in increased expression of ZNF664 mRNA CTD PMID:23397585 NCBI chr12:36,201,327...36,203,396 JBrowse link
G Zmiz1 zinc finger, MIZ-type containing 1 increases expression ISO Triiodothyronine results in increased expression of ZMIZ1 mRNA CTD PMID:23397585 NCBI chr16:1,749,191...1,954,633
Ensembl chr16:1,749,191...1,954,614 		JBrowse link
thyroxine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 decreases abundance EXP ABCC2 results in decreased abundance of Thyroxine CTD PMID:19211616 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR affects the reaction [2,4,6-triphenyl-1-hexene results in increased abundance of Thyroxine] CTD PMID:18560529 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO Thyroxine binds to ALB protein
2,2',4,5'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to ALB protein]; Flame Retardants analog inhibits the reaction [Thyroxine binds to ALB protein]		 CTD PMID:20039755 PMID:21517007 PMID:29283575 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Amh anti-Mullerian hormone multiple interactions EXP Thyroxine affects the reaction [Propylthiouracil affects the expression of AMH mRNA] CTD PMID:7819453 NCBI chr 7:11,775,155...11,777,503
Ensembl chr 7:11,775,155...11,777,503 		JBrowse link
G App amyloid beta precursor protein decreases cleavage
decreases expression		 ISO Thyroxine results in decreased cleavage of APP protein
Thyroxine results in decreased expression of APP mRNA; Thyroxine results in decreased expression of APP protein		 CTD PMID:17199430 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases expression		 ISO [nano-diamino-tetrac co-treated with Resveratrol] inhibits the reaction [Thyroxine results in decreased expression of BAD mRNA]; Resveratrol inhibits the reaction [Thyroxine results in decreased expression of BAD mRNA]; Thyroxine inhibits the reaction [Resveratrol results in increased expression of BAD mRNA] CTD PMID:31336132 PMID:31883986 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Cat catalase multiple interactions
decreases expression
decreases activity		 EXP [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; arotinolol promotes the reaction [Thyroxine results in decreased expression of CAT protein]; Atenolol promotes the reaction [Thyroxine results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of CAT protein]
Thyroxine results in decreased expression of CAT mRNA; Thyroxine results in decreased expression of CAT protein		 CTD PMID:2575990 PMID:18723006 PMID:19914224 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions		 ISO Thyroxine results in increased expression of CCND1 mRNA
[Resveratrol co-treated with nano-diamino-tetrac] inhibits the reaction [Thyroxine results in increased expression of CCND1 mRNA]; nano-diamino-tetrac inhibits the reaction [Thyroxine results in increased expression of CCND1 mRNA]; Resveratrol inhibits the reaction [Thyroxine results in increased expression of CCND1 mRNA]		 CTD PMID:31336132 PMID:31883986 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cd274 CD274 molecule increases expression
multiple interactions		 ISO Thyroxine results in increased expression of CD274 mRNA; Thyroxine results in increased expression of CD274 protein; Thyroxine results in increased expression of PDL1 mRNA; Thyroxine results in increased expression of PDL1 protein
[Resveratrol co-treated with nano-diamino-tetrac] inhibits the reaction [Thyroxine results in increased expression of PDL1 mRNA]; nano-diamino-tetrac inhibits the reaction [Thyroxine results in increased expression of CD274 mRNA]; nano-diamino-tetrac inhibits the reaction [Thyroxine results in increased expression of CD274 protein]; nano-diamino-tetrac inhibits the reaction [Thyroxine results in increased expression of PDL1 mRNA]; NSC 74859 inhibits the reaction [Thyroxine results in increased expression of PDL1 protein]; Resveratrol inhibits the reaction [Thyroxine results in increased expression of PDL1 mRNA]; Resveratrol inhibits the reaction [Thyroxine results in increased expression of PDL1 protein]		 CTD PMID:29960019 PMID:31336132 PMID:31883986 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Thyroxine inhibits the reaction [resveratrol results in increased expression of CDKN1A mRNA] CTD PMID:17174366 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Thyroxine results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [Thyroxine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP Thyroxine results in decreased expression of CYP8B1 mRNA CTD PMID:10393316 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388 		JBrowse link
G Dcn decorin decreases expression ISO Thyroxine results in decreased expression of DCN mRNA CTD PMID:23935926 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323 		JBrowse link
G Dio1 iodothyronine deiodinase 1 affects abundance
multiple interactions
increases expression
affects metabolic processing
increases metabolic processing		 ISO
EXP		 DIO1 gene SNP affects the abundance of Thyroxine
2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine results in increased expression of DIO1 mRNA]
DIO1 protein affects the metabolism of Thyroxine
[DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine]		 CTD PMID:15254343 PMID:17105838 PMID:21565810 PMID:27420076 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520 		JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions
decreases expression
decreases activity
increases metabolic processing
affects metabolic processing		 ISO
EXP		 2,2',4,4',5-brominated diphenyl ether inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4',5-brominated diphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; [DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]; lactacystin inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]; Thyroxine results in decreased expression of and results in decreased activity of DIO2 protein
2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine results in decreased expression of DIO2 mRNA]
DIO2 protein mutant form affects the metabolism of Thyroxine		 CTD PMID:11108274 PMID:11425850 PMID:16728495 PMID:17615150 PMID:26004626 PMID:27420076 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723 		JBrowse link
G Dio3 iodothyronine deiodinase 3 increases activity
multiple interactions		 EXP Thyroxine results in increased activity of DIO3 protein
Hydrogen Peroxide promotes the reaction [Thyroxine results in increased activity of DIO3 protein]		 CTD PMID:18420745 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138 		JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 increases expression ISO Thyroxine results in increased expression of DMP1 mRNA CTD PMID:23935926 NCBI chr14:6,889,851...6,923,961
Ensembl chr14:6,889,856...6,900,733 		JBrowse link
G Duox1 dual oxidase 1 decreases expression ISO Thyroxine results in decreased expression of DUOX1 protein CTD PMID:17332529 NCBI chr 3:114,251,794...114,286,827
Ensembl chr 3:114,253,637...114,286,802 		JBrowse link
G Duox2 dual oxidase 2 decreases expression ISO Thyroxine results in decreased expression of DUOX2 protein CTD PMID:17332529 NCBI chr 3:114,218,187...114,237,808
Ensembl chr 3:114,218,193...114,235,933 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO Thyroxine results in increased expression of FGF1 mRNA CTD PMID:23935926 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Thyroxine results in increased expression of FGF2 mRNA CTD PMID:23935926 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thyroxine inhibits the reaction [resveratrol results in increased expression of FOS mRNA] CTD PMID:17174366 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gap43 growth associated protein 43 increases expression
multiple interactions		 EXP Thyroxine results in increased expression of GAP43 mRNA
Thyroxine inhibits the reaction [Ethanol results in decreased expression of GAP43 mRNA]		 CTD PMID:15940294 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914 		JBrowse link
G Gh1 growth hormone 1 decreases abundance
multiple interactions		 ISO GH1 protein results in decreased abundance of Thyroxine
[2,2',4,4'-tetrabromodiphenyl ether co-treated with Thyroxine] results in increased expression of GH mRNA		 CTD PMID:17311540 PMID:17324600 PMID:27420076 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions EXP Ipodate inhibits the reaction [Thyroxine results in increased activity of GPD2 protein]; Propylthiouracil inhibits the reaction [Thyroxine results in increased activity of GPD2 protein] CTD PMID:6723573 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases activity
decreases activity
increases expression
decreases expression		 EXP [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]
Thyroxine results in increased activity of GPX1 protein
Thyroxine results in decreased activity of GPX1 protein		 CTD PMID:19914224 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
decreases expression		 EXP [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]
Thyroxine results in decreased activity of GSR protein
Thyroxine results in decreased expression of GSR mRNA; Thyroxine results in decreased expression of GSR protein		 CTD PMID:19914224 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions EXP [Propylthiouracil results in increased abundance of Thyroxine] which results in increased expression of HES1 mRNA CTD PMID:15862623 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248 		JBrowse link
G Hes5 hes family bHLH transcription factor 5 multiple interactions EXP [Propylthiouracil results in increased abundance of Thyroxine] which results in increased expression of HES5 mRNA CTD PMID:15862623 NCBI chr 5:172,364,421...172,365,188
Ensembl chr 5:172,364,421...172,365,188 		JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor increases expression EXP Thyroxine results in increased expression of HR mRNA CTD PMID:29901742 NCBI chr15:52,241,801...52,261,276
Ensembl chr15:52,241,801...52,261,276 		JBrowse link
G Htra1 HtrA serine peptidase 1 increases expression ISO Thyroxine results in increased expression of HTRA1 mRNA CTD PMID:23935926 NCBI chr 1:201,499,067...201,548,508
Ensembl chr 1:201,499,028...201,548,513 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Thyroxine results in increased expression of IGF1 mRNA CTD PMID:23935926 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases expression		 EXP Vitamin E inhibits the reaction [Thyroxine results in increased expression of IGF1R protein] CTD PMID:17447016 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO NSC 74859 inhibits the reaction [Thyroxine results in increased expression of IL1B mRNA] CTD PMID:31336132 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]] CTD PMID:22227104 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thyroxine inhibits the reaction [resveratrol results in increased expression of JUN mRNA] CTD PMID:17174366 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
affects localization		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; NSC 74859 inhibits the reaction [Thyroxine results in increased phosphorylation of MAPK1 protein]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Thyroxine results in increased phosphorylation of and results in increased activity of MAPK1 protein
Thyroxine affects the localization of MAPK1 protein
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK1 protein]		 CTD PMID:17174366 PMID:17984113 PMID:31336132 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
affects localization		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; NSC 74859 inhibits the reaction [Thyroxine results in increased phosphorylation of MAPK3 protein]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Thyroxine results in increased phosphorylation of and results in increased activity of MAPK3 protein
Thyroxine affects the localization of MAPK3 protein
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK3 protein]		 CTD PMID:17174366 PMID:17984113 PMID:31336132 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Thyroxine results in increased expression of MMP9 mRNA CTD PMID:23935926 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Thyroxine promotes the reaction [THRA protein binds to NCOA2 protein]; Thyroxine promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]; Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein] CTD PMID:22227104 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein] CTD PMID:22227104 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Thyroxine results in increased activity of NR1I2 protein
[Thyroxine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects metabolic processing ISO NR1I3 protein affects the metabolism of Thyroxine CTD PMID:15004031 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases expression		 EXP Thyroxine inhibits the reaction [Ethanol results in decreased expression of NR3C1 mRNA]
Thyroxine results in increased expression of NR3C1 mRNA		 CTD PMID:15940294 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions EXP Ipodate inhibits the reaction [Thyroxine results in increased activity of ODC1 protein]; Propylthiouracil inhibits the reaction [Thyroxine results in increased activity of ODC1 protein] CTD PMID:6723573 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine results in increased expression of PCNA protein] CTD PMID:17174366 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 decreases expression EXP Thyroxine results in decreased expression of PCSK2 mRNA CTD PMID:15585599 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605 		JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO Thyroxine results in increased expression of PHEX mRNA CTD PMID:23935926 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982 		JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression ISO
EXP		 Thyroxine results in increased expression of PMP22 mRNA CTD PMID:29901742 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583 		JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO Thyroxine results in increased expression of POR mRNA CTD PMID:23935926 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Thyroxine inhibits the reaction [Triclosan results in decreased expression of PPARG protein] CTD PMID:28973666 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 EXP
ISO		 Thyroxine inhibits the reaction [resveratrol affects the localization of PTGS2 protein]
Thyroxine results in decreased expression of PTGS2 mRNA
[Resveratrol co-treated with nano-diamino-tetrac] promotes the reaction [Thyroxine results in decreased expression of PTGS2 mRNA]; nano-diamino-tetrac promotes the reaction [Thyroxine results in decreased expression of PTGS2 mRNA]; Resveratrol inhibits the reaction [Thyroxine results in decreased expression of PTGS2 mRNA]; Thyroxine inhibits the reaction [Resveratrol affects the localization of PTGS2 protein]; Thyroxine inhibits the reaction [Resveratrol results in increased expression of PTGS2 mRNA]		 CTD PMID:17984113 PMID:31336132 PMID:31883986 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO Thyroxine binds to RXRA protein CTD PMID:31566444 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908 		JBrowse link
G Sema7a semaphorin 7A (John Milton Hagen blood group) increases expression EXP Thyroxine results in increased expression of SEMA7A mRNA CTD PMID:29901742 NCBI chr 8:62,723,788...62,746,530
Ensembl chr 8:62,723,788...62,745,868 		JBrowse link
G Serpina7 serpin family A member 7 multiple interactions
affects binding		 ISO 3,5-dichlorobiphenyl metabolite inhibits the reaction [Thyroxine binds to SERPINA7 protein]; bisphenol A inhibits the reaction [Thyroxine binds to SERPINA7 protein]; tetrabromobisphenol A inhibits the reaction [Thyroxine binds to SERPINA7 protein]; tetrachlorodian inhibits the reaction [Thyroxine binds to SERPINA7 protein] CTD PMID:16478101 PMID:20804816 PMID:21517007 PMID:27528273 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179 		JBrowse link
G Shh sonic hedgehog signaling molecule increases expression EXP Thyroxine results in increased expression of SHH mRNA CTD PMID:29901742 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691 		JBrowse link
G Sirt1 sirtuin 1 increases expression ISO Thyroxine results in increased expression of SIRT1 protein CTD PMID:18204789 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Thyroxine inhibits the reaction [Triclosan results in decreased expression of SLC2A4 protein] CTD PMID:28973666 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Slc30a10 solute carrier family 30, member 10 decreases chemical synthesis ISO SLC30A10 gene mutant form results in decreased chemical synthesis of Thyroxine CTD PMID:28860195 NCBI chr13:103,396,295...103,406,759
Ensembl chr13:103,396,314...103,410,363 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 decreases expression ISO Thyroxine results in decreased expression of SLC5A5 protein CTD PMID:17332529 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
increases activity
decreases activity
decreases expression		 EXP [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; [Curcumin co-treated with Vitamin E] promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]; Atenolol promotes the reaction [Thyroxine results in decreased expression of SOD1 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; Curcumin promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]; Thyroxine inhibits the reaction [Zinc deficiency results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of SOD1 protein]; Vitamin E inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Thyroxine results in increased expression of SOD1 protein]; Vitamin E promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]
Thyroxine results in decreased expression of SOD1 mRNA; Thyroxine results in decreased expression of SOD1 protein		 CTD PMID:2575990 PMID:10381190 PMID:17447016 PMID:19914224 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases activity
decreases expression
increases expression		 EXP [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Atenolol inhibits the reaction [Thyroxine results in increased expression of SOD2 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased activity of SOD2 protein]; Curcumin promotes the reaction [Thyroxine results in increased expression of SOD2 protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Vitamin E promotes the reaction [Thyroxine results in increased expression of SOD2 protein] CTD PMID:2575990 PMID:19914224 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]] CTD PMID:22227104 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation		 ISO NSC 74859 inhibits the reaction [Thyroxine results in increased phosphorylation of STAT3 protein] CTD PMID:31336132 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects sulfation
multiple interactions
increases sulfation		 ISO SULT1A1 gene polymorphism affects the sulfation of Thyroxine
Thyroxine inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]
SULT1A1 protein results in increased sulfation of Thyroxine		 CTD PMID:11739018 PMID:15531517 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Sult4a1 sulfotransferase family 4A, member 1 increases metabolic processing ISO SULT4A1 protein results in increased metabolism of Thyroxine CTD PMID:12039030 NCBI chr 7:124,958,546...124,982,602
Ensembl chr 7:124,958,546...124,982,566 		JBrowse link
G Syn1 synapsin I multiple interactions ISO Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYN1 mRNA] CTD PMID:27413119 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198 		JBrowse link
G Syp synaptophysin multiple interactions ISO Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYP mRNA] CTD PMID:27413119 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 ISO NSC 74859 inhibits the reaction [Thyroxine results in increased expression of TGFB1 mRNA]; Resveratrol inhibits the reaction [Thyroxine results in increased expression of TGFB1 mRNA] CTD PMID:31336132 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Thra thyroid hormone receptor alpha affects binding
multiple interactions
increases expression		 ISO
EXP		 Thyroxine binds to THRA protein
Thyroxine promotes the reaction [THRA protein binds to NCOA2 protein]
Thyroxine results in increased expression of THRA mRNA
[bisphenol A co-treated with Estradiol co-treated with Thyroxine] results in increased expression of THRA mRNA; [bisphenol A co-treated with Thyroxine] results in increased expression of THRA mRNA		 CTD PMID:23112079 PMID:23402801 PMID:27993100 PMID:31566444 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
decreases expression
increases expression
increases activity
affects binding		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]; Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]; Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]; Thyroxine inhibits the reaction [Triiodothyronine binds to THRB protein]; Thyroxine promotes the reaction [THRB protein binds to NCOA2 protein]
Thyroxine results in decreased expression of THRB mRNA
Thyroxine results in increased expression of THRB mRNA
[bisphenol A co-treated with Estradiol co-treated with Thyroxine] results in increased expression of THRB mRNA; [bisphenol A co-treated with Thyroxine] results in increased expression of THRB mRNA
Thyroxine results in increased activity of THRB protein
Thyroxine binds to THRB protein		 CTD PMID:18584933 PMID:19457453 PMID:22227104 PMID:23112079 PMID:23402801 PMID:27420076 PMID:27993100 PMID:29409039 PMID:31077750 PMID:31566444 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Thyroxine results in increased expression of TNF mRNA CTD PMID:23935926 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects localization		 ISO
EXP		 Thyroxine inhibits the reaction [resveratrol results in increased activity of TP53 protein]
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of TP53 protein modified form]		 CTD PMID:17174366 PMID:17984113 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tpo thyroid peroxidase multiple interactions EXP [Propylthiouracil results in decreased activity of TPO protein] which results in decreased chemical synthesis of and results in decreased abundance of Thyroxine CTD PMID:28973696 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855 		JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 decreases abundance ISO TRPM7 gene mutant form results in decreased abundance of Thyroxine CTD PMID:30770447 NCBI chr 3:119,258,189...119,347,084
Ensembl chr 3:119,259,467...119,330,345 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions
decreases expression		 EXP
ISO		 Clofibrate inhibits the reaction [Thyroxine results in decreased expression of TSHB protein]; Thyroxine inhibits the reaction [lead acetate results in decreased expression of TSHB protein]
Thyroxine results in decreased expression of TSHB mRNA		 CTD PMID:18219302 PMID:21871911 PMID:27420076 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681 		JBrowse link
G Tshr-ps1 thyroid stimulating hormone receptor, pseudogene 1 decreases activity ISO Thyroxine results in decreased activity of TSHR protein CTD PMID:17332529 NCBI chr 4:93,447,412...93,448,194 JBrowse link
G Ttr transthyretin multiple interactions
affects binding		 ISO
EXP		 2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',3,3',4,4',5-heptachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,4'-tetrabromodiphenyl ether analog inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,5'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to TTR protein]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]; 3,5-dichlorobiphenyl metabolite inhibits the reaction [Thyroxine binds to TTR protein]; 4-nonylphenol inhibits the reaction [Thyroxine binds to TTR protein]; bisphenol A inhibits the reaction [Thyroxine binds to TTR protein]; Diethylstilbestrol inhibits the reaction [Thyroxine binds to TTR protein]; Flame Retardants analog inhibits the reaction [Thyroxine binds to TTR protein]; Flame Retardants inhibits the reaction [Thyroxine binds to TTR protein]; Halogenated Diphenyl Ethers analog inhibits the reaction [Thyroxine binds to TTR protein]; PCB 180 inhibits the reaction [Thyroxine binds to TTR protein]; pentabromophenol inhibits the reaction [Thyroxine binds to TTR protein]; Pentachlorophenol inhibits the reaction [Thyroxine binds to TTR protein]; perfluorobutanesulfonic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorobutyric acid affects the reaction [Thyroxine binds to TTR protein]; perfluorodecanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorododecanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluoroheptanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorohexanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorononanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorooctane sulfonic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorooctane sulfonic acid inhibits the reaction [Thyroxine binds to TTR protein]; perfluorooctanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorooctanoic acid inhibits the reaction [Thyroxine binds to TTR protein]; perfluoroundecanoic acid affects the reaction [Thyroxine binds to TTR protein]; Polychlorinated Biphenyls analog inhibits the reaction [Thyroxine binds to TTR protein]; T-2 Toxin inhibits the reaction [Thyroxine binds to TTR protein]; tetrabromobisphenol A inhibits the reaction [Thyroxine binds to TTR protein]; tetrachlorodian inhibits the reaction [Thyroxine binds to TTR protein]; Thyroxine inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; Waste Water inhibits the reaction [Thyroxine binds to TTR protein]
2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to TTR protein]		 CTD PMID:10631123 PMID:10869457 PMID:16478101 PMID:16601080 PMID:18161906 PMID:20039755 PMID:20804816 PMID:21357386 PMID:21517007 PMID:23584369 PMID:27528273 PMID:29283575 PMID:31077750 PMID:33095664 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP Thyroxine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA] CTD PMID:12588052 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Thyroxine results in increased expression of UGT1A1 mRNA CTD PMID:17884940 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 increases expression EXP Thyroxine results in increased expression of UGT1A5 mRNA CTD PMID:17884940 NCBI chr 9:95,274,707...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases expression EXP Thyroxine results in increased expression of UGT1A7 mRNA CTD PMID:17884940 NCBI chr 9:95,233,957...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions EXP [Clofibrate co-treated with Thyroxine] results in increased activity of UGT1A9 protein CTD PMID:18219302 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19817
    chemical entity 19817
      molecular entity 19814
        polyatomic entity 19727
          heteroatomic molecular entity 19653
            halide 18093
              organohalogen compound 17845
                halophenol 1802
                  2-halophenol 402
                    2-chlorophenol 0
                    2-iodophenol 0
                    3,3',5,5'-tetraiodothyroacetic acid 9
                    3,3',5-triiodo-L-thyronine + 364
                    L-thyroxine + 0
                    thyroxine + 85
Path 2
Term Annotations click to browse term
  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    p-block element atom 19705
                      carbon group element atom 19614
                        carbon atom 19603
                          organic molecular entity 19603
                            organic molecule 19532
                              organic cyclic compound 19348
                                organic aromatic compound 19180
                                  phenols 18160
                                    halophenol 1802
                                      2-halophenol 402
                                        2-chlorophenol 0
                                        2-iodophenol 0
                                        3,3',5,5'-tetraiodothyroacetic acid 9
                                        3,3',5-triiodo-L-thyronine + 364
                                        L-thyroxine + 0
                                        thyroxine + 85
paths to the root