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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:donepezil
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Accession:CHEBI:53289 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
Synonyms:related_synonym: Formula=C24H29NO3;   InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3;   InChIKey=ADEBPBSSDYVVLD-UHFFFAOYSA-N;   SMILES=C1(=C(C=C2C(=C1)CC(C2=O)(CC3CCN(CC3)CC4=CC=CC=C4)[H])OC)OC;   donepezilo;   donepezilum
 xref: Beilstein:7081955;   CAS:120014-06-4;   DrugBank:DB00843;   Drug_Central:946;   KEGG:D07869;   LINCS:LSM-1598
 xref_mesh: MESH:D000077265
 xref: Reaxys:7081955;   Wikipedia:Donepezil
 cyclic_relationship: is_conjugate_base_of CHEBI:145498


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      chemical substance 12208
        mixture 11156
          racemate 10085
            donepezil 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      ketone 16216
                                        cyclic ketone 13930
                                          indanones 4
                                            2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one 0
                                              (S)-donepezil 0
                                                donepezil 0
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