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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
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Accession:CHEBI:53238 term browser browse the term
Definition:An organic cation that is tetrazolium substituted with a dimethylthiazolyl group and two phenyl groups. The cation exists in two resonance forms.
Synonyms:related_synonym: 2-(4,5-dimethyl-1,3-thiazol-2-yl)-3,5-diphenyl-2H-tetrazol-3-ium;   Formula=C18H16N5S;   InChI=1S/C18H16N5S/c1-13-14(2)24-18(19-13)23-21-17(15-9-5-3-6-10-15)20-22(23)16-11-7-4-8-12-16/h3-12H,1-2H3/q+1;   InChIKey=FTZIQBGFCYJWKA-UHFFFAOYSA-N;   SMILES=Cc1nc(sc1C)-[n+]1nc(nn1-c1ccccc1)-c1ccccc1;   thiazolyl blue tetrazolium
 xref: Beilstein:3700797;   CAS:13146-93-5;   PMID:7994925


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3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO thiazolyl blue results in decreased activity of ABCB1 protein CTD PMID:15451006 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Aco2 aconitase 2 multiple interactions ISO [Calcium results in increased activity of ACO2 protein] which results in increased reduction of thiazolyl blue; [Potassium deficiency results in decreased activity of ACO2 protein] which results in decreased reduction of thiazolyl blue CTD PMID:12548706 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Casp3 caspase 3 increases activity ISO thiazolyl blue results in increased activity of CASP3 protein CTD PMID:22401948 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO thiazolyl blue results in increased activity of CASP8 protein CTD PMID:22401948 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 increases reduction
multiple interactions
ISO NQO2 protein results in increased reduction of thiazolyl blue
resveratrol inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]
CTD PMID:29281794 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      molecular entity 19771
        ion 15935
          organic ion 8447
            organic cation 7303
              3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium 5
                3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                organic heterocyclic compound 18519
                                  heteroarene 16515
                                    monocyclic heteroarene 13362
                                      azole 12537
                                        tetrazoles 344
                                          3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium 5
                                            3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 5
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