CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: polyethylene macromolecule
Accession: CHEBI:53226
browse the term
Definition: A macromolecule composed of ethane or substituted ethane units.
Synonyms: related_synonym: poly(ethene)s; poly(ethylene)s; polyethenes; polyethylene; polyethylenes
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Crp
C-reactive protein
decreases expression
ISO
Colesevelam Hydrochloride results in decreased expression of CRP protein
CTD
PMID:16616026
NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions increases expression
ISO
Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA] Colesevelam Hydrochloride results in increased expression of HMGCR mRNA
CTD
PMID:22120639
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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Ldlr
low density lipoprotein receptor
increases expression
ISO
Colesevelam Hydrochloride results in increased expression of LDLR mRNA
CTD
PMID:22120639
NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
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Acp5
acid phosphatase 5, tartrate resistant
decreases expression
ISO
Polyethylene results in decreased expression of ACP5 mRNA
CTD
PMID:15585240
NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
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Ascl1
achaete-scute family bHLH transcription factor 1
decreases expression
ISO
Polyethylene results in decreased expression of ASCL1 mRNA
CTD
PMID:23203475
NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
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Bglap
bone gamma-carboxyglutamate protein
decreases expression
ISO
Polyethylene results in decreased expression of BGLAP protein
CTD
PMID:10225790
NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
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Col1a1
collagen type I alpha 1 chain
decreases expression
ISO
Polyethylene results in decreased expression of COL1A1 mRNA
CTD
PMID:11216681
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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Csf2
colony stimulating factor 2
affects secretion
ISO
Polyethylene affects the secretion of CSF2 protein
CTD
PMID:15046894
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
Polyethylene results in decreased expression of FOS mRNA
CTD
PMID:15585240
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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Foxg1
forkhead box G1
decreases expression
ISO
Polyethylene results in decreased expression of FOXG1 mRNA
CTD
PMID:23203475
NCBI chr 6:69,971,227...69,974,037
Ensembl chr 6:69,971,227...69,974,037
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Hes5
hes family bHLH transcription factor 5
decreases expression
ISO
Polyethylene results in decreased expression of HES5 mRNA
CTD
PMID:23203475
NCBI chr 5:172,364,421...172,365,188
Ensembl chr 5:172,364,421...172,365,188
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Il1b
interleukin 1 beta
multiple interactions
ISO
Polyethylene analog promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD
PMID:10602080
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il6
interleukin 6
increases expression multiple interactions
ISO
Polyethylene results in increased expression of IL6 mRNA; Polyethylene results in increased expression of IL6 protein Polyethylene analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD
PMID:10602080 PMID:11771709
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Litaf
lipopolysaccharide-induced TNF factor
increases expression
ISO
Polyethylene results in increased expression of LITAF mRNA
CTD
PMID:17408380
NCBI chr10:4,753,546...4,763,272
Ensembl chr10:4,719,713...4,763,510
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Neurod1
neuronal differentiation 1
decreases expression
ISO
Polyethylene results in decreased expression of NEUROD1 mRNA
CTD
PMID:23203475
NCBI chr 3:66,414,314...66,417,617
Ensembl chr 3:66,414,308...66,417,741
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Notch1
notch receptor 1
decreases expression
ISO
Polyethylene results in decreased expression of NOTCH1 mRNA
CTD
PMID:23203475
NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
increases expression
ISO
Polyethylene results in increased expression of SRC mRNA
CTD
PMID:15585240
NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
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Tnf
tumor necrosis factor
increases expression multiple interactions affects secretion
ISO
Polyethylene results in increased expression of TNF mRNA Polyethylene analog inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Polyethylene affects the secretion of TNF protein Etidronic Acid inhibits the reaction [Polyethylene affects the secretion of TNF protein]; ibandronic acid inhibits the reaction [Polyethylene affects the secretion of TNF protein]
CTD
PMID:10413987 PMID:10602080 PMID:17408380
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tnfrsf11b
TNF receptor superfamily member 11B
decreases expression decreases secretion
ISO
Polyethylene results in decreased expression of TNFRSF11B protein Polyethylene results in decreased secretion of TNFRSF11B protein
CTD
PMID:15046894 PMID:15585240
NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
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Tnfsf11
TNF superfamily member 11
affects secretion increases secretion
ISO
Polyethylene affects the secretion of TNFSF11 protein Polyethylene results in increased secretion of TNFSF11 protein
CTD
PMID:15046894 PMID:15585240
NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
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C3
complement C3
increases expression
ISO
styrofoam analog results in increased expression of C3 protein
CTD
PMID:19428933
NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
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C5
complement C5
increases expression
ISO
styrofoam analog results in increased expression of C5 protein
CTD
PMID:19428933
NCBI chr 3:14,049,993...14,113,931 NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions affects activity
ISO
styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP1A2 protein] styrofoam analog affects the activity of CYP1A2 protein
CTD
PMID:19909766
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
multiple interactions decreases activity
ISO
styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2C9 protein] styrofoam analog results in decreased activity of CYP2C9 protein
CTD
PMID:19909766
NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity multiple interactions
ISO
styrofoam analog results in decreased activity of CYP2D6 protein styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein]
CTD
PMID:19909766
NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
decreases activity multiple interactions
ISO
styrofoam analog results in decreased activity of CYP3A4 protein styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP3A4 protein]
CTD
PMID:19909766
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Itgam
integrin subunit alpha M
increases expression
ISO
styrofoam analog results in increased expression of ITGAM protein
CTD
PMID:19428933
NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
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Pf4
platelet factor 4
increases secretion
ISO
styrofoam analog results in increased secretion of PF4 protein
CTD
PMID:19428933
NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
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Ppbp
pro-platelet basic protein
increases secretion
ISO
styrofoam analog results in increased secretion of PPBP protein
CTD
PMID:19428933
NCBI chr14:18,852,433...18,853,237
Ensembl chr14:18,851,954...18,853,315
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Selp
selectin P
increases expression
ISO
styrofoam results in increased expression of SELP protein
CTD
PMID:21123846
NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
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Angpt1
angiopoietin 1
decreases expression
ISO
Polyvinyl Chloride results in decreased expression of ANGPT1 mRNA
CTD
PMID:12809767
NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
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Atp5mc2
ATP synthase membrane subunit c locus 2
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of ATP5MC2 mRNA
CTD
PMID:25194297
NCBI chr 7:144,264,207...144,272,578
Ensembl chr 7:144,264,199...144,272,578
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Bola3
bolA family member 3
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of BOLA3 mRNA
CTD
PMID:25194297
NCBI chr 4:115,046,693...115,056,140
Ensembl chr 4:115,046,693...115,056,140
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Casp3
caspase 3
multiple interactions
ISO
[Silver co-treated with Povidone] affects the expression of CASP3 protein; [Silver co-treated with Povidone] results in decreased expression of CASP3 mRNA
CTD
PMID:27387714
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
ISO
[Silver co-treated with Povidone] results in decreased expression of CDKN1A mRNA; [Silver co-treated with Povidone] results in decreased expression of CDKN1A protein
CTD
PMID:27387714
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Col8a1
collagen type VIII alpha 1 chain
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of COL8A1 mRNA
CTD
PMID:25194297
NCBI chr11:44,877,690...45,006,203
Ensembl chr11:44,877,859...45,007,891
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Cox17
cytochrome c oxidase copper chaperone COX17
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of COX17 mRNA
CTD
PMID:25194297
NCBI chr11:64,962,663...64,968,437
Ensembl chr11:64,962,666...64,968,437
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of CYP1A1 mRNA
CTD
PMID:25194297
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Dad1
defender against cell death 1
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of DAD1 mRNA
CTD
PMID:25194297
NCBI chr15:32,868,136...32,887,933
Ensembl chr15:32,868,087...32,888,095
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Gbp2
guanylate binding protein 2
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of GBP2 mRNA
CTD
PMID:25194297
NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
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H2ax
H2A.X variant histone
multiple interactions
ISO
[Silver co-treated with Povidone] results in increased expression of H2AX protein modified form
CTD
PMID:27387714
NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
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Hmox1
heme oxygenase 1
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of HMOX1 mRNA
CTD
PMID:25194297
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Ifit3
interferon-induced protein with tetratricopeptide repeats 3
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of IFIT3 mRNA
CTD
PMID:25194297
NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
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Lims1
LIM zinc finger domain containing 1
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of LIMS1 mRNA
CTD
PMID:25194297
NCBI chr20:27,895,981...28,004,767
Ensembl chr20:27,954,433...28,002,082
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Lmnb2
lamin B2
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of LMNB2 mRNA
CTD
PMID:25194297
NCBI chr 7:11,657,870...11,676,936
Ensembl chr 7:11,660,934...11,675,472
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
[Silver Compounds co-treated with Povidone] results in increased activity of MAPK1 protein
CTD
PMID:21729742
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
[Silver Compounds co-treated with Povidone] results in increased activity of MAPK3 protein
CTD
PMID:21729742
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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Mdm2
MDM2 proto-oncogene
multiple interactions
ISO
[Silver co-treated with Povidone] affects the expression of MDM2 protein; [Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA
CTD
PMID:27387714
NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
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Mt1
metallothionein 1
multiple interactions
EXP
[Silver analog co-treated with Povidone] affects the expression of MT1A mRNA
CTD
PMID:25194297
NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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Nfix
nuclear factor I X
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of NFIX mRNA
CTD
PMID:25194297
NCBI chr19:25,818,640...25,914,777
Ensembl chr19:25,821,780...25,914,696
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of NQO1 mRNA
CTD
PMID:25194297
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Nrm
nurim
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of NRM mRNA
CTD
PMID:25194297
NCBI chr20:3,397,834...3,402,264
Ensembl chr20:3,397,834...3,401,315
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Nuak2
NUAK family kinase 2
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of NUAK2 mRNA
CTD
PMID:25194297
NCBI chr13:49,092,306...49,109,055
Ensembl chr13:49,092,306...49,109,050
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Ocln
occludin
affects expression
ISO
Povidone affects the expression of OCLN mRNA
CTD
PMID:19729060
NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
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Prpf38b
pre-mRNA processing factor 38B
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of PRPF38B mRNA
CTD
PMID:25194297
NCBI chr 2:211,706,245...211,715,271
Ensembl chr 2:211,706,228...211,715,311
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Prr13
proline rich 13
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of PRR13 mRNA
CTD
PMID:25194297
NCBI chr 7:144,064,931...144,068,235
Ensembl chr 7:144,064,931...144,098,101
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Psenen
presenilin enhancer gamma secretase subunit
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of PSENEN mRNA
CTD
PMID:25194297
NCBI chr 1:89,016,093...89,017,449
Ensembl chr 1:89,016,096...89,017,290
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of PTGS2 mRNA
CTD
PMID:25194297
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Ptk2
protein tyrosine kinase 2
multiple interactions
ISO
[Silver Compounds co-treated with Povidone] results in increased activity of PTK2 protein
CTD
PMID:21729742
NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
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Rab14
RAB14, member RAS oncogene family
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of RAB14 mRNA
CTD
PMID:25194297
NCBI chr 3:14,373,270...14,395,357
Ensembl chr 3:14,373,275...14,395,362
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Rbm25l1
RNA binding motif protein 25-like 1
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of RBM25L1 mRNA
CTD
PMID:25194297
NCBI chr10:10,457,316...10,460,540
Ensembl chr10:10,457,320...10,460,756
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Samd9
sterile alpha motif domain containing 9
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of SAMD9L mRNA
CTD
PMID:25194297
NCBI chr 4:28,304,967...28,324,637
Ensembl chr 4:28,305,002...28,310,178
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Selenow
selenoprotein W
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of SELENOW mRNA
CTD
PMID:25194297
NCBI chr 1:77,530,692...77,535,765
Ensembl chr 1:77,533,148...77,535,681 Ensembl chr 1:77,533,148...77,535,681
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Slc5a3
solute carrier family 5 member 3
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of SLC5A3 mRNA
CTD
PMID:25194297
NCBI chr11:32,229,366...32,231,812
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Sod2
superoxide dismutase 2
multiple interactions
ISO
[Silver co-treated with Povidone] results in increased expression of SOD2 mRNA; [Silver co-treated with Povidone] results in increased expression of SOD2 protein
CTD
PMID:27387714
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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Sparc
secreted protein acidic and cysteine rich
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of SPARC mRNA
CTD
PMID:25194297
NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
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Stat2
signal transducer and activator of transcription 2
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of STAT2 mRNA
CTD
PMID:25194297
NCBI chr 7:2,691,064...2,707,530
Ensembl chr 7:2,691,369...2,707,741
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Sv2b
synaptic vesicle glycoprotein 2b
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of SV2B mRNA
CTD
PMID:25194297
NCBI chr 1:136,664,199...136,842,247
Ensembl chr 1:136,664,204...136,842,247
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Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of TIPARP mRNA
CTD
PMID:25194297
NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469
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Tmtc3
transmembrane O-mannosyltransferase targeting cadherins 3
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of TMTC3 mRNA
CTD
PMID:25194297
NCBI chr 7:40,171,957...40,217,056
Ensembl chr 7:40,171,963...40,217,056
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Tp53
tumor protein p53
multiple interactions
ISO
[Silver co-treated with Povidone] affects the phosphorylation of TP53 protein; [Silver co-treated with Povidone] results in decreased expression of TP53 mRNA; [Silver co-treated with Povidone] results in decreased expression of TP53 protein
CTD
PMID:27387714
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Trappc1
trafficking protein particle complex 1
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in decreased expression of TRAPPC1 mRNA
CTD
PMID:25194297
NCBI chr10:55,924,996...55,926,582
Ensembl chr10:55,924,938...55,926,783
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Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
[Silver Compounds co-treated with Povidone] results in increased expression of VEGFA protein
CTD
PMID:21729742
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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Wdfy1
WD repeat and FYVE domain containing 1
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of WDFY1 mRNA
CTD
PMID:25194297
NCBI chr 9:85,477,070...85,528,885
Ensembl chr 9:85,475,841...85,528,869
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Zfhx3
zinc finger homeobox 3
multiple interactions
EXP
[Silver analog co-treated with Povidone] results in increased expression of ZFHX3 mRNA
CTD
PMID:25194297
NCBI chr19:42,753,983...42,925,794
Ensembl chr19:42,758,127...42,920,344
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