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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diphenylmethane-4,4'-diisocyanate
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Accession:CHEBI:53218 term browser browse the term
Definition:A diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions.
Synonyms:related_synonym: 1,1'-Methylenebis(4-isocyanatobenzene);   4,4'-Diisocyanatodiphenylmethane;   4,4'-Methylenebis(phenyl isocyanate);   4,4'-Methylenedi(phenyl isocyanate);   4,4'-Methylenedi-p-phenylene diisocyanate;   4,4'-Methylenediphenyl diisocyanate;   4,4'-Methylenediphenyl isocyanate;   4,4'-Methylenediphenylene diisocyanate;   4,4'-Methylenediphenylene isocyanate;   4,4'-methylene diphenyl diisocyanate;   4-4'-Diisocyanate de diphenylmethane;   Bis(1,4-isocyanatophenyl)methane;   Bis(4-isocyanatophenyl)methane;   Bis(p-isocyanatophenyl)methane;   Bis(para-isocyanatophenyl)methane;   Diphenyl methane diisocyanate;   Diphenylmethan-4,4'-diisocyanat;   Diphenylmethane diisocyanate;   Diphenylmethyl diisocyanate;   Formula=C15H10N2O2;   InChI=1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2;   InChIKey=UPMLOUAZCHDJJD-UHFFFAOYSA-N;   MDI;   MDR;   Methylbisphenyl isocyanate;   Methylene bisphenyl isocyanate;   Methylene di-p-phenylene isocyanate;   Methylene diphenyl diisocyanate;   Methylenebis(4-isocyanatobenzene);   Methylenebis(4-phenyl isocyanate);   Methylenebis(4-phenylene isocyanate);   Methylenebis(p-phenyl isocyanate);   Methylenebis(p-phenylene isocyanate);   Methylenebis(para-phenyl isocyanate);   Methylenebis(para-phenylene isocyanate);   Methylenebisphenyl diisocyanate;   Methylenedi-p-phenylene diisocyanate;   Methylenedi-para-phenylene diisocyanate;   SMILES=O=C=Nc1ccc(Cc2ccc(cc2)N=C=O)cc1;   p,p'-Diphenylmethane diisocyanate;   p,p'-Methylenebis(phenyl isocyanate);   para,para'-Diphenylmethane diisocyanate;   para,para'-Methylenebis(phenyl isocyanate)
 xref: Beilstein:797662;   CAS:101-68-8;   Gmelin:166464;   KEGG:C19453
 xref_mesh: MESH:C005969
 xref: PMID:11927838;   PMID:1447476;   PMID:14531868;   PMID:17042142;   PMID:17336832;   PMID:18352975;   PMID:18418755;   PMID:18484168;   PMID:18787742;   PMID:19014769;   PMID:19191163;   PMID:19732394;   PMID:19757291;   PMID:20165612;   PMID:20933064;   PMID:21414210;   PMID:21878336;   PMID:21987383;   PMID:24572447;   PMID:26337647;   PMID:26690039;   PMID:26954368;   PMID:6296214;   PMID:6821040;   PMID:8093967;   PMID:8711735;   PMID:8960156;   Patent:WO2010121997;   Reaxys:797662;   Wikipedia:Diphenylmethane_diisocyanate



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diphenylmethane-4,4'-diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding
EXP
ISO
[4,4'-diphenylmethane diisocyanate binds to ALB protein] which results in increased chemical synthesis of N6-(((4-(4-(acetylamino)benzyl)phenyl)amino)carbonyl)lysine; [4,4'-diphenylmethane diisocyanate binds to ALB protein] which results in increased chemical synthesis of N6-(((4-(4-aminobenzyl)phenyl)amino)carbonyl)lysine
[4,4'-diphenylmethane diisocyanate co-treated with Glutathione] binds to and results in increased metabolism of ALB protein
CTD PMID:19928878 PMID:23791970 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cd86 CD86 molecule increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance ISO GSTM1 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of ICAM1 protein CTD PMID:11698162 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10 interleukin 10 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL10 mRNA CTD PMID:16940033 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL13 mRNA CTD PMID:16940033 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il2 interleukin 2 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL2 protein CTD PMID:22381623 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 mRNA; 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 protein CTD PMID:11708898 PMID:16940033 PMID:22381623 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il4r interleukin 4 receptor increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Mir206 microRNA 206 multiple interactions
decreases expression
ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA CTD PMID:31609387 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Mir381 microRNA 381 multiple interactions
decreases expression
ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA CTD PMID:31609387 NCBI chr 6:128,740,976...128,741,036 JBrowse link
G Nat1 N-acetyltransferase 1 increases response to substance ISO NAT1 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA; [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA
4,4'-diphenylmethane diisocyanate results in increased expression of NOS2 mRNA
CTD PMID:31609387 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression
multiple interactions
ISO 4,4'-diphenylmethane diisocyanate results in increased expression of PPP3CA mRNA
[[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA; [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA
CTD PMID:31609387 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        hapten 3023
          diphenylmethane-4,4'-diisocyanate 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic aromatic compound 19189
                                  diarylmethane 6776
                                    diphenylmethane 4081
                                      diphenylmethane-4,4'-diisocyanate 15
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