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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diphenylmethane-4,4'-diisocyanate
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Accession:CHEBI:53218 term browser browse the term
Definition:A diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions.
Synonyms:related_synonym: 1,1'-Methylenebis(4-isocyanatobenzene);   4,4'-Diisocyanatodiphenylmethane;   4,4'-Methylenebis(phenyl isocyanate);   4,4'-Methylenedi(phenyl isocyanate);   4,4'-Methylenedi-p-phenylene diisocyanate;   4,4'-Methylenediphenyl diisocyanate;   4,4'-Methylenediphenyl isocyanate;   4,4'-Methylenediphenylene diisocyanate;   4,4'-Methylenediphenylene isocyanate;   4,4'-methylene diphenyl diisocyanate;   4-4'-Diisocyanate de diphenylmethane;   Bis(1,4-isocyanatophenyl)methane;   Bis(4-isocyanatophenyl)methane;   Bis(p-isocyanatophenyl)methane;   Bis(para-isocyanatophenyl)methane;   Diphenyl methane diisocyanate;   Diphenylmethan-4,4'-diisocyanat;   Diphenylmethane diisocyanate;   Diphenylmethyl diisocyanate;   Formula=C15H10N2O2;   InChI=1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2;   InChIKey=UPMLOUAZCHDJJD-UHFFFAOYSA-N;   MDI;   MDR;   Methylbisphenyl isocyanate;   Methylene bisphenyl isocyanate;   Methylene di-p-phenylene isocyanate;   Methylene diphenyl diisocyanate;   Methylenebis(4-isocyanatobenzene);   Methylenebis(4-phenyl isocyanate);   Methylenebis(4-phenylene isocyanate);   Methylenebis(p-phenyl isocyanate);   Methylenebis(p-phenylene isocyanate);   Methylenebis(para-phenyl isocyanate);   Methylenebis(para-phenylene isocyanate);   Methylenebisphenyl diisocyanate;   Methylenedi-p-phenylene diisocyanate;   Methylenedi-para-phenylene diisocyanate;   SMILES=O=C=Nc1ccc(Cc2ccc(cc2)N=C=O)cc1;   p,p'-Diphenylmethane diisocyanate;   p,p'-Methylenebis(phenyl isocyanate);   para,para'-Diphenylmethane diisocyanate;   para,para'-Methylenebis(phenyl isocyanate)
 xref: Beilstein:797662;   CAS:101-68-8;   Gmelin:166464;   KEGG:C19453
 xref_mesh: MESH:C005969
 xref: PMID:11927838;   PMID:1447476;   PMID:14531868;   PMID:17042142;   PMID:17336832;   PMID:18352975;   PMID:18418755;   PMID:18484168;   PMID:18787742;   PMID:19014769;   PMID:19191163;   PMID:19732394;   PMID:19757291;   PMID:20165612;   PMID:20933064;   PMID:21414210;   PMID:21878336;   PMID:21987383;   PMID:24572447;   PMID:26337647;   PMID:26690039;   PMID:26954368;   PMID:6296214;   PMID:6821040;   PMID:8093967;   PMID:8711735;   PMID:8960156;   Patent:WO2010121997;   Reaxys:797662;   Wikipedia:Diphenylmethane_diisocyanate


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diphenylmethane-4,4'-diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding
EXP
ISO
[4,4'-diphenylmethane diisocyanate binds to ALB protein] which results in increased chemical synthesis of N6-(((4-(4-(acetylamino)benzyl)phenyl)amino)carbonyl)lysine; [4,4'-diphenylmethane diisocyanate binds to ALB protein] which results in increased chemical synthesis of N6-(((4-(4-aminobenzyl)phenyl)amino)carbonyl)lysine
[4,4'-diphenylmethane diisocyanate co-treated with Glutathione] binds to and results in increased metabolism of ALB protein
CTD PMID:19928878, PMID:23791970 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cd86 CD86 molecule increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance ISO GSTM1 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of ICAM1 protein CTD PMID:11698162 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL10 mRNA CTD PMID:16940033 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL13 mRNA CTD PMID:16940033 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il2 interleukin 2 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL2 protein CTD PMID:22381623 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 mRNA; 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 protein CTD PMID:11708898, PMID:16940033, PMID:22381623 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Mir206 microRNA 206 multiple interactions
decreases expression
ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA CTD PMID:31609387 NCBI chr 9:26,791,764...26,791,847
Ensembl chr 9:26,791,764...26,791,847
JBrowse link
G Mir381 microRNA 381 multiple interactions
decreases expression
ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA CTD PMID:31609387 NCBI chr 6:133,876,615...133,876,675
Ensembl chr 6:133,876,586...133,876,693
JBrowse link
G Nat1 N-acetyltransferase 1 increases response to substance ISO NAT1 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA; [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA
4,4'-diphenylmethane diisocyanate results in increased expression of NOS2 mRNA
CTD PMID:31609387 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression
multiple interactions
ISO 4,4'-diphenylmethane diisocyanate results in increased expression of PPP3CA mRNA
[[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA; [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA
CTD PMID:31609387 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        hapten 3014
          diphenylmethane-4,4'-diisocyanate 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic aromatic compound 19154
                                  diarylmethane 6657
                                    diphenylmethane 4005
                                      diphenylmethane-4,4'-diisocyanate 15
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