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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diisocyanate
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Accession:CHEBI:53213 term browser browse the term
Definition:An isocyanate compound containing two isocyanate functional groups. Manufactured for reaction with polyols in the production of polyurethanes.
Synonyms:related_synonym: diisocyanates
 xref: PMID:17042142;   PMID:22774468;   PMID:23324746;   PMID:23343863;   PMID:23535363;   PMID:23558852;   PMID:23835991


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dicyclohexylmethane-4,4'-diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 increases expression ISO methylene bis(4-cyclohexylisocyanate) results in increased expression of IL10 mRNA CTD PMID:16940033 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 increases expression ISO methylene bis(4-cyclohexylisocyanate) results in increased expression of IL13 mRNA CTD PMID:16940033 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il4 interleukin 4 increases expression ISO methylene bis(4-cyclohexylisocyanate) results in increased expression of IL4 mRNA CTD PMID:16940033 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
diphenylmethane-4,4'-diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding
EXP
ISO
[4,4'-diphenylmethane diisocyanate binds to ALB protein] which results in increased chemical synthesis of N6-(((4-(4-(acetylamino)benzyl)phenyl)amino)carbonyl)lysine; [4,4'-diphenylmethane diisocyanate binds to ALB protein] which results in increased chemical synthesis of N6-(((4-(4-aminobenzyl)phenyl)amino)carbonyl)lysine
[4,4'-diphenylmethane diisocyanate co-treated with Glutathione] binds to and results in increased metabolism of ALB protein
CTD PMID:19928878 PMID:23791970 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cd86 CD86 molecule increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance ISO GSTM1 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of ICAM1 protein CTD PMID:11698162 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL10 mRNA CTD PMID:16940033 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL13 mRNA CTD PMID:16940033 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il2 interleukin 2 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL2 protein CTD PMID:22381623 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 mRNA; 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 protein CTD PMID:11708898 PMID:16940033 PMID:22381623 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Mir206 microRNA 206 multiple interactions
decreases expression
ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA CTD PMID:31609387 NCBI chr 9:26,791,764...26,791,847
Ensembl chr 9:26,791,764...26,791,847
JBrowse link
G Mir381 microRNA 381 multiple interactions
decreases expression
ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA CTD PMID:31609387 NCBI chr 6:133,876,615...133,876,675
Ensembl chr 6:133,876,586...133,876,693
JBrowse link
G Nat1 N-acetyltransferase 1 increases response to substance ISO NAT1 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA; [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA
4,4'-diphenylmethane diisocyanate results in increased expression of NOS2 mRNA
CTD PMID:31609387 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression
multiple interactions
ISO 4,4'-diphenylmethane diisocyanate results in increased expression of PPP3CA mRNA
[[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA; [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA
CTD PMID:31609387 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
hexamethylene diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of AMPD3 mRNA CTD PMID:24211530 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G Atox1 antioxidant 1 copper chaperone increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATOX1 promoter CTD PMID:25445006 NCBI chr10:40,790,850...40,805,886
Ensembl chr10:40,790,845...40,805,941
JBrowse link
G Atp8a2 ATPase phospholipid transporting 8A2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATP8A2 gene CTD PMID:25445006 NCBI chr15:39,955,689...40,488,737
Ensembl chr15:40,000,322...40,428,800
JBrowse link
G Atp9b ATPase phospholipid transporting 9B (putative) increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATP9B gene CTD PMID:25445006 NCBI chr18:77,343,551...77,535,608
Ensembl chr18:77,343,551...77,535,593
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of CACNA1H gene CTD PMID:25445006 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Dhx29 DExH-box helicase 29 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of DHX29 mRNA CTD PMID:19527780 NCBI chr 2:44,787,066...44,837,834
Ensembl chr 2:44,787,002...44,837,831
JBrowse link
G Dscaml1 DS cell adhesion molecule-like 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of DSCAML1 gene CTD PMID:25445006 NCBI chr 8:49,733,835...50,056,115
Ensembl chr 8:49,737,798...50,055,560
JBrowse link
G Ebag9 estrogen receptor binding site associated, antigen, 9 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of EBAG9 gene CTD PMID:25445006 NCBI chr 7:83,564,563...83,582,516
Ensembl chr 7:83,564,563...83,582,508
JBrowse link
G Fam210a family with sequence similarity 210, member A increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FAM210A promoter CTD PMID:25445006 NCBI chr18:64,045,023...64,084,594
Ensembl chr18:64,045,432...64,084,556
JBrowse link
G Farp1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FARP1 gene CTD PMID:25445006 NCBI chr15:106,375,298...106,625,837
Ensembl chr15:106,434,177...106,625,837
JBrowse link
G Fbxw4 F-box and WD repeat domain containing 4 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FBXW4 gene CTD PMID:25445006 NCBI chr 1:265,318,526...265,420,503
Ensembl chr 1:265,318,526...265,420,503
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of FTH1 mRNA CTD PMID:24211530 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of FTL mRNA CTD PMID:24211530 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of GCLM mRNA CTD PMID:24211530 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of GNRHR mRNA CTD PMID:19527780 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance ISO GSTM1 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gypc glycophorin C (Gerbich blood group) increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of GYPC gene CTD PMID:25445006 NCBI chr18:25,312,386...25,344,614
Ensembl chr18:25,312,387...25,344,614
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of HMOX1 mRNA CTD PMID:24211530 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of ICAM1 protein CTD PMID:11698162 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of IFNG protein CTD PMID:12884401 PMID:19422874 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of IL10 protein CTD PMID:12884401 PMID:19422874 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 increases secretion ISO 1,6-hexamethylene diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of IL22RA2 gene CTD PMID:25445006 NCBI chr 1:15,084,136...15,107,423
Ensembl chr 1:15,093,599...15,106,954
JBrowse link
G Il4 interleukin 4 increases expression
increases secretion
ISO 1,6-hexamethylene diisocyanate results in increased expression of IL4 protein
1,6-hexamethylene diisocyanate results in increased secretion of IL4 protein
CTD PMID:12884401 PMID:17693426 PMID:19422874 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 increases secretion ISO 1,6-hexamethylene diisocyanate results in increased secretion of IL5 protein CTD PMID:17693426 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ISG20 promoter CTD PMID:25445006 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
JBrowse link
G Islr2 immunoglobulin superfamily containing leucine-rich repeat 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ISLR2 gene CTD PMID:25445006 NCBI chr 8:62,983,333...62,991,401
Ensembl chr 8:62,984,552...62,987,182
JBrowse link
G Kitlg KIT ligand affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of KITLG mRNA CTD PMID:19110044 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Lca5l lebercilin LCA5 like increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of LCA5L gene CTD PMID:25445006 NCBI chr11:36,512,823...36,546,806
Ensembl chr11:36,512,974...36,533,073
JBrowse link
G Ldha lactate dehydrogenase A affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of LDHA mRNA CTD PMID:19110044 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G LOC686596 similar to aquaporin 10 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of AQP10 mRNA CTD PMID:19527780 NCBI chr 2:189,309,151...189,314,092 JBrowse link
G Lrrn4 leucine rich repeat neuronal 4 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of LRRN4 gene CTD PMID:25445006 NCBI chr 3:125,521,879...125,547,685
Ensembl chr 3:125,523,781...125,533,600
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 1,6-hexamethylene diisocyanate promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK1 protein
CTD PMID:27129696 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 1,6-hexamethylene diisocyanate promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK3 protein
CTD PMID:27129696 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO 1,6-hexamethylene diisocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK8 protein
CTD PMID:27129696 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO 1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK9 protein
1,6-hexamethylene diisocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]
CTD PMID:27129696 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mrpl58 mitochondrial ribosomal protein L58 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of MRPL58 gene CTD PMID:25445006 NCBI chr10:103,956,019...103,962,515
Ensembl chr10:103,956,019...103,962,515
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of MYC mRNA CTD PMID:24211530 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nab2 Ngfi-A binding protein 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of NAB2 gene CTD PMID:25445006 NCBI chr 7:70,963,580...70,971,471
Ensembl chr 7:70,961,575...70,969,905
JBrowse link
G Nat1 N-acetyltransferase 1 increases response to substance ISO NAT1 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nexn nexilin (F actin binding protein) affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of NEXN mRNA CTD PMID:19527780 NCBI chr 2:257,452,937...257,484,607
Ensembl chr 2:257,453,347...257,484,587
JBrowse link
G Nmbr neuromedin B receptor increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of NMBR gene CTD PMID:25445006 NCBI chr 1:8,933,744...8,945,850
Ensembl chr 1:8,933,831...8,944,987
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of NQO1 mRNA CTD PMID:24211530 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Olr1433 olfactory receptor 1433 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of OR2W3 mRNA CTD PMID:19527780 NCBI chr10:44,292,927...44,293,954
Ensembl chr10:44,292,927...44,293,954
JBrowse link
G Osbp2 oxysterol binding protein 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of OSBP2 mRNA CTD PMID:19527780 NCBI chr14:83,943,976...84,107,031
Ensembl chr14:83,943,977...84,106,997
JBrowse link
G Rnmt RNA (guanine-7-) methyltransferase increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of RNMT promoter CTD PMID:25445006 NCBI chr18:64,084,746...64,108,246
Ensembl chr18:64,084,795...64,108,246
JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SEL1L3 mRNA CTD PMID:24211530 NCBI chr14:60,122,968...60,229,565
Ensembl chr14:60,123,169...60,229,734
JBrowse link
G Slc16a4 solute carrier family 16, member 4 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of SLC16A4 mRNA CTD PMID:19110044 NCBI chr 2:210,045,122...210,161,017
Ensembl chr 2:210,045,161...210,068,502
JBrowse link
G Slc25a28 solute carrier family 25 member 28 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of SLC25A28 gene CTD PMID:25445006 NCBI chr 1:263,420,039...263,431,312
Ensembl chr 1:263,420,061...263,431,290
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SLC7A11 mRNA CTD PMID:24211530 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Socs3 suppressor of cytokine signaling 3 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of SOCS3 mRNA CTD PMID:19110044 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Specc1 sperm antigen with calponin homology and coiled-coil domains 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of SPECC1 gene CTD PMID:25445006 NCBI chr10:48,240,291...48,542,171
Ensembl chr10:48,240,127...48,542,292
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SQSTM1 mRNA CTD PMID:24211530 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stc1 stanniocalcin 1 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of STC1 mRNA CTD PMID:19527780 NCBI chr15:50,891,137...50,901,791
Ensembl chr15:50,891,127...50,903,162
JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 decreases expression ISO 1,6-hexamethylene diisocyanate results in decreased expression of SYNE2 mRNA CTD PMID:24211530 NCBI chr 6:98,884,269...99,153,551 JBrowse link
G Tlr2 toll-like receptor 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of TLR2 mRNA CTD PMID:19110044 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tmem253 transmembrane protein 253 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of TMEM253 promoter CTD PMID:25445006 NCBI chr15:28,413,414...28,416,039
Ensembl chr15:28,413,461...28,415,554
JBrowse link
G Tnnt2 troponin T2, cardiac type decreases expression ISO 1,6-hexamethylene diisocyanate results in decreased expression of TNNT2 mRNA CTD PMID:24211530 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of TXNRD1 mRNA CTD PMID:24211530 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of UBA2 mRNA CTD PMID:19527780 NCBI chr 1:90,010,681...90,035,522
Ensembl chr 1:90,011,306...90,035,522
JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of UBE2E1 promoter CTD PMID:25445006 NCBI chr15:8,124,869...8,178,252
Ensembl chr15:8,125,526...8,177,781
JBrowse link
G Zfp219 zinc finger protein 219 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ZNF219 promoter CTD PMID:25445006 NCBI chr15:28,402,412...28,417,379
Ensembl chr15:28,402,415...28,406,046
JBrowse link
isophorone diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 increases expression ISO isophorone diisocyanate results in increased expression of IL10 protein CTD PMID:19422874 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 increases secretion ISO isophorone diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO isophorone diisocyanate results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [isophorone diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 increases expression
increases secretion
ISO isophorone diisocyanate results in increased expression of IL4 protein
isophorone diisocyanate results in increased secretion of IL4 protein
CTD PMID:17693426 PMID:19422874 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 affects the susceptibility to isophorone diisocyanate CTD PMID:23564646 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
toluene 2,4-diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acyp1 acylphosphatase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ACYP1 mRNA CTD PMID:11379042 NCBI chr 6:109,097,065...109,110,266
Ensembl chr 6:109,097,065...109,104,050
JBrowse link
G Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ADAMTS15 mRNA CTD PMID:19647056 NCBI chr 8:31,977,001...32,000,378
Ensembl chr 8:31,977,001...32,000,378
JBrowse link
G Adcy6 adenylate cyclase 6 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ADCY6 mRNA CTD PMID:11379042 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
increases expression
ISO FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]
AGER protein affects the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]
CTD PMID:28329851 PMID:30261222 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of AKT1 protein] CTD PMID:26089345 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions
affects binding
ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of KRT14 mRNA; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of KRT19 mRNA; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; IL1B protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein] CTD PMID:9124697 PMID:14676436 PMID:15478392 PMID:16908450 PMID:17030242 PMID:17042142 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ankrd2 ankyrin repeat domain 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ANKRD2 mRNA CTD PMID:19647056 NCBI chr 1:261,281,859...261,291,307
Ensembl chr 1:261,281,543...261,291,394
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ASNS mRNA CTD PMID:18242016 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Axl Axl receptor tyrosine kinase decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of AXL mRNA CTD PMID:11379042 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Bpifa2 BPI fold containing family A, member 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of BPIFA2 mRNA CTD PMID:11379042 NCBI chr 3:149,492,612...149,501,614
Ensembl chr 3:149,493,655...149,501,613
JBrowse link
G Bspry B-box and SPRY domain containing increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of BSPRY mRNA CTD PMID:18242016 NCBI chr 5:78,334,284...78,356,462
Ensembl chr 5:78,334,284...78,356,460
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of BST2 mRNA CTD PMID:19647056 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of BUB1 mRNA CTD PMID:21404309 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of BUB1B mRNA CTD PMID:21404309 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CACNB3 mRNA CTD PMID:11379042 NCBI chr 7:140,311,120...140,324,902
Ensembl chr 7:140,315,368...140,324,902
JBrowse link
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CAD mRNA CTD PMID:21404309 NCBI chr 6:26,657,507...26,680,459
Ensembl chr 6:26,657,780...26,680,284
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
increases cleavage
ISO 1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CASP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased cleavage of CASP1 protein]; L 709049 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CASP1 protein]; MCC-950 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CASP1 protein] CTD PMID:25929181 PMID:31070765 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Cav1 caveolin 1 multiple interactions
increases phosphorylation
ISO AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate analog results in increased phosphorylation of CAV1 protein]; CAV1 protein mutant form inhibits the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; CAV1 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate analog results in increased phosphorylation of CAV1 protein]
FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of CAV1 protein]
CTD PMID:29940203 PMID:30261222 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions
increases expression
ISO
EXP
BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]
Toluene 2,4-Diisocyanate results in increased expression of CCL11 mRNA
CTD PMID:15823807 PMID:17015710 PMID:20219652 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCL12 mRNA CTD PMID:19647056 NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions
increases expression
ISO diflorasone promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein]
Toluene 2,4-Diisocyanate results in increased expression of CCL17 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein
CTD PMID:15491423 PMID:21404309 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of CCL2 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL2 protein
CCL2 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]
CTD PMID:19647056 PMID:20219652 PMID:21404309 PMID:26072274 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCL22 mRNA CTD PMID:21404309 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCL3 mRNA CTD PMID:19647056 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCL4 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL4 protein CTD PMID:19647056 PMID:20219652 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 affects response to substance
decreases expression
increases expression
multiple interactions
ISO
EXP
CCL5 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate
Toluene 2,4-Diisocyanate results in decreased expression of CCL5 mRNA
Toluene 2,4-Diisocyanate results in increased expression of CCL5 mRNA
Toluene 2,4-Diisocyanate results in increased expression of CCL5 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein
BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 mRNA]
[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]
CTD PMID:11467998 PMID:12356572 PMID:15491423 PMID:15823807 PMID:16908450 PMID:17015710 PMID:18447907 PMID:21404309 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCL6 mRNA CTD PMID:19647056 PMID:21404309 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCL7 mRNA CTD PMID:19647056 PMID:21404309 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCNA2 mRNA CTD PMID:21404309 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb2 cyclin B2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCNB2 mRNA CTD PMID:21404309 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccne1 cyclin E1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCNE1 mRNA CTD PMID:21404309 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccnf cyclin F increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCNF mRNA CTD PMID:18242016 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCR2 mRNA CTD PMID:19647056
G Ccr6 C-C motif chemokine receptor 6 increases expression
decreases expression
ISO Toluene 2,4-Diisocyanate results in increased expression of CCR6 protein
Toluene 2,4-Diisocyanate results in decreased expression of CCR6 mRNA
CTD PMID:21404309 PMID:27103660 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Cd24 CD24 molecule decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CD24A mRNA CTD PMID:21404309 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Cd36 CD36 molecule decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CD36 mRNA CTD PMID:21404309 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd4 Cd4 molecule multiple interactions ISO CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG mRNA]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA] CTD PMID:15590890 NCBI chr 4:157,381,862...157,408,357
Ensembl chr 4:157,383,052...157,408,176
JBrowse link
G Cd40 CD40 molecule increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CD40 mRNA CTD PMID:19647056 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd47 Cd47 molecule decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CD47 mRNA CTD PMID:11379042 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CD55 mRNA CTD PMID:21404309 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Cd8b CD8b molecule decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CD8B1 mRNA CTD PMID:21404309 NCBI chr 4:99,185,960...99,201,887
Ensembl chr 4:99,185,885...99,202,023
JBrowse link
G Cdc20 cell division cycle 20 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC20 mRNA CTD PMID:21404309 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC25A mRNA CTD PMID:21404309 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25b cell division cycle 25B increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC25B mRNA CTD PMID:21404309 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC25C mRNA CTD PMID:21404309 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc45 cell division cycle 45 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC45 mRNA CTD PMID:21404309 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdc6 cell division cycle 6 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC6 mRNA CTD PMID:21404309 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdc7 cell division cycle 7 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC7 mRNA CTD PMID:21404309 NCBI chr14:3,826,658...3,846,891
Ensembl chr14:3,826,659...3,846,891
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDCA2 mRNA CTD PMID:18242016 NCBI chr15:44,365,396...44,411,601
Ensembl chr15:44,365,405...44,411,004
JBrowse link
G Cdh1 cadherin 1 multiple interactions
affects localization
ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]; Toluene 2,4-Diisocyanate results in decreased expression of and affects the localization of CDH1 protein CTD PMID:26089345 PMID:30517707 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDK1 mRNA CTD PMID:21404309 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDK2 mRNA CTD PMID:21404309 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDKN1A mRNA CTD PMID:21404309 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CDKN1B mRNA CTD PMID:21404309 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CDKN1C mRNA CTD PMID:21404309 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cntf ciliary neurotrophic factor increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CNTF mRNA CTD PMID:21404309 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Commd3 COMM domain containing 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of COMMD3 mRNA CTD PMID:21404309 NCBI chr17:85,356,042...85,359,835
Ensembl chr17:85,356,042...85,359,833
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein] CTD PMID:16908450 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CSF2RB2 mRNA CTD PMID:19647056 NCBI chr 7:119,554,383...119,568,248
Ensembl chr 7:119,554,354...119,568,776
JBrowse link
G Csf3r colony stimulating factor 3 receptor increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CSF3R mRNA CTD PMID:19647056 NCBI chr 5:144,031,353...144,051,966
Ensembl chr 5:144,031,402...144,051,600
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CTLA4 protein CTD PMID:27103660 NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
affects localization
increases phosphorylation
ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased expression of and affects the localization of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of CTNNB1 protein]; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CTNNB1 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CTNNB1 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein]; Toluene 2,4-Diisocyanate results in decreased expression of and affects the localization of CTNNB1 protein; Toluene 2,4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein
Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein
AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; AGER protein affects the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; CAV1 protein mutant form inhibits the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]
CTD PMID:26089345 PMID:30261222 PMID:30517707 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CXCL10 mRNA CTD PMID:19647056 PMID:21404309 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CXCL12 mRNA CTD PMID:21404309 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CXCL13 mRNA CTD PMID:21404309 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CXCL16 mRNA CTD PMID:19647056 NCBI chr10:57,060,005...57,064,600
Ensembl chr10:57,060,007...57,064,600
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression
ISO AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]
Toluene 2,4-Diisocyanate results in increased expression of CXCL2 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein
CTD PMID:12956900 PMID:16963530 PMID:17014439 PMID:17980417 PMID:28826779 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CXCL1 mRNA CTD PMID:19647056 PMID:28826779 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CXCL5 mRNA CTD PMID:19647056 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression
increases expression
ISO Toluene 2,4-Diisocyanate results in decreased expression of CXCL9 mRNA
Toluene 2,4-Diisocyanate results in increased expression of CXCL9 mRNA
CTD PMID:11379042 PMID:19647056 PMID:21404309 PMID:28826779 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CXCR3 mRNA CTD PMID:21404309 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CXCR4 mRNA CTD PMID:11379042 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cxcr6 C-X-C motif chemokine receptor 6 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CXCR6 mRNA CTD PMID:21404309 NCBI chr 8:132,869,712...132,870,766
Ensembl chr 8:132,869,712...132,870,767
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects response to substance
increases expression
multiple interactions
ISO CYP1A1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate
Toluene 2,4-Diisocyanate results in increased expression of CYP1A1 mRNA
Toluene 2,4-Diisocyanate results in increased expression of and results in decreased activity of CYP1A1 protein
CTD PMID:12415424 PMID:18447907 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression
increases expression
EXP Toluene 2,4-Diisocyanate results in decreased expression of CYP2B1 mRNA; Toluene 2,4-Diisocyanate results in decreased expression of CYP2B1 protein
Toluene 2,4-Diisocyanate results in increased expression of CYP2B1
CTD PMID:11043495 PMID:12415424 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CYP2F2 mRNA CTD PMID:11379042 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of DACT1 mRNA CTD PMID:18242016 NCBI chr 6:93,740,440...93,751,003
Ensembl chr 6:93,740,586...93,749,809
JBrowse link
G Dbf4 DBF4 zinc finger increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of DBF4 mRNA CTD PMID:21404309 NCBI chr 4:22,898,527...22,914,091
Ensembl chr 4:22,898,527...22,914,177
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of DNAJB6 mRNA CTD PMID:11379042 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890
JBrowse link
G Dntt DNA nucleotidylexotransferase decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of DNTT mRNA CTD PMID:21404309 NCBI chr 1:260,289,626...260,321,174
Ensembl chr 1:260,289,589...260,321,320
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of DPYD mRNA CTD PMID:21404309 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Dtymk deoxythymidylate kinase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of DTYMK mRNA CTD PMID:21404309 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of DUSP4 mRNA CTD PMID:18242016 NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169
JBrowse link
G Dut deoxyuridine triphosphatase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of DUT mRNA CTD PMID:18242016 PMID:21404309 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of E2F1 mRNA CTD PMID:21404309 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f2 E2F transcription factor 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of E2F2 mRNA CTD PMID:21404309 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein] CTD PMID:16908450 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO 2',3'-dialdehyde ATP inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]; Acetylcysteine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; Adenosine Triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]; CAV1 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein]; CCL2 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; coomassie Brilliant Blue inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; KN 62 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; P2RX4 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein; Toluene 2,4-Diisocyanate results in increased secretion of and results in increased expression of ENPP2 protein CTD PMID:26072274 PMID:29940203 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Epor erythropoietin receptor decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of EPOR mRNA CTD PMID:21404309 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ERCC6L mRNA CTD PMID:18242016 NCBI chr  X:72,018,373...72,034,140
Ensembl chr  X:72,018,373...72,034,099
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of FABP1 mRNA CTD PMID:18242016 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fcer2 Fc fragment of IgE receptor II decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of FCER2A mRNA CTD PMID:21404309 NCBI chr12:2,233,772...2,245,324
Ensembl chr12:2,233,778...2,245,324
JBrowse link
G Ffar2 free fatty acid receptor 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of FFAR2 mRNA CTD PMID:18242016 NCBI chr 1:89,268,197...89,271,942
Ensembl chr 1:89,268,938...89,269,930
JBrowse link
G Fus FUS RNA binding protein decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of FUS mRNA CTD PMID:11379042 NCBI chr 1:199,412,805...199,426,705
Ensembl chr 1:199,412,834...199,426,702
JBrowse link
G Grap2 GRB2-related adaptor protein 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of GRAP2 mRNA CTD PMID:21404309 NCBI chr 7:121,791,330...121,864,835
Ensembl chr 7:121,841,855...121,864,679
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein] CTD PMID:26089345 PMID:30517707 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance
decreases expression
ISO GSTM1 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanate
Toluene 2,4-Diisocyanate results in decreased expression of GSTM1 mRNA; Toluene 2,4-Diisocyanate results in decreased expression of GSTM5 mRNA
CTD PMID:11927838 PMID:21404309 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of GSTM3 mRNA CTD PMID:21404309 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gsto2 glutathione S-transferase omega 2 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of GSTO2 mRNA CTD PMID:21404309 NCBI chr 1:267,617,517...267,640,455
Ensembl chr 1:271,229,036...271,243,517
Ensembl chr 1:271,229,036...271,243,517
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
affects response to substance
ISO GSTP1 gene polymorphism affects the metabolism of Toluene 2,4-Diisocyanate
GSTP1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate
CTD PMID:20032816 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of GSTT2 mRNA CTD PMID:21404309 NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475
JBrowse link
G Gzma granzyme A increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of GZMA mRNA CTD PMID:18242016 NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458
JBrowse link
G Gzmb granzyme B decreases expression
increases expression
ISO Toluene 2,4-Diisocyanate results in decreased expression of GZMB mRNA
Toluene 2,4-Diisocyanate results in increased expression of GZMB mRNA
CTD PMID:11379042 PMID:18652873 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Hdc histidine decarboxylase multiple interactions
increases expression
increases activity
EXP Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased activity of HDC protein]; Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HDC mRNA]; sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HDC mRNA] CTD PMID:15054596 PMID:18360087 PMID:19050374 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein] CTD PMID:25929181 PMID:28329851 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hnrnpll heterogeneous nuclear ribonucleoprotein L-like increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of HNRNPLL mRNA CTD PMID:21404309 NCBI chr 6:2,698,983...2,729,715
Ensembl chr 6:2,699,961...2,729,394
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
increases expression
EXP Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; Olopatadine Hydrochloride inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; Quercetin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; Toluene 2,4-Diisocyanate promotes the reaction [Pyrilamine binds to HRH1 protein]
Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA; Toluene 2,4-Diisocyanate results in increased expression of HRH1 protein
CTD PMID:15054595 PMID:15513549 PMID:18360087 PMID:19050374 PMID:19075512 PMID:23333628 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of HSP90AB1 mRNA CTD PMID:11379042 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of HSPA4 mRNA CTD PMID:11379042 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein
Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA; Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein
4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]
CTD PMID:11698162 PMID:12789230 PMID:16210060 PMID:17014439 PMID:17015710 PMID:17641053 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Icos inducible T-cell co-stimulator increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ICOS protein CTD PMID:27103660 NCBI chr 9:67,748,157...67,786,808
Ensembl chr 9:67,763,897...67,785,580
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IFI27 mRNA CTD PMID:18242016 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Ifi44l interferon-induced protein 44-like increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IFI44L mRNA CTD PMID:18242016 NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
JBrowse link
G Ifnb1 interferon beta 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IFNB1 mRNA CTD PMID:11379042 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma multiple interactions
increases secretion
increases expression
affects secretion
decreases expression
ISO CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG mRNA]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]
Toluene 2,4-Diisocyanate results in increased expression of IFNG mRNA; Toluene 2,4-Diisocyanate results in increased expression of IFNG protein
Toluene 2,4-Diisocyanate affects the secretion of IFNG protein
Toluene 2,4-Diisocyanate results in decreased expression of IFNG mRNA; Toluene 2,4-Diisocyanate results in decreased expression of IFNG protein
CTD PMID:10637130 PMID:11243917 PMID:12356572 PMID:12884401 PMID:15588918 PMID:15590890 PMID:16271432 PMID:17014439 PMID:17641053 PMID:17980417 PMID:18242016 PMID:18652873 PMID:19042193 PMID:19150644 PMID:19422874 PMID:19428947 PMID:20219652 PMID:21404309 PMID:28329851 PMID:28826779 PMID:31577921 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr2 interferon gamma receptor 2 increases expression
decreases expression
ISO Toluene 2,4-Diisocyanate results in increased expression of IFNGR2 mRNA
Toluene 2,4-Diisocyanate results in decreased expression of IFNGR2 mRNA
CTD PMID:19647056 PMID:21404309 NCBI chr11:31,694,339...31,712,611
Ensembl chr11:31,694,339...31,712,611
JBrowse link
G Il10 interleukin 10 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL10 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL10 protein CTD PMID:11243917 PMID:12884401 PMID:16940033 PMID:19422874 PMID:19428947 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of IL11RA1 mRNA CTD PMID:21404309 NCBI chr 5:58,149,150...58,159,072
Ensembl chr 5:58,151,985...58,159,072
JBrowse link
G Il12b interleukin 12B increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL12B mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL12B protein CTD PMID:11379042 PMID:18652873 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL12RB1 mRNA CTD PMID:18242016 PMID:21404309 NCBI chr16:20,370,722...20,383,576
Ensembl chr16:20,371,338...20,383,337
JBrowse link
G Il13 interleukin 13 multiple interactions
increases secretion
increases expression
ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]
Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL13 protein
CTD PMID:11243917 PMID:15590890 PMID:16940033 PMID:17015710 PMID:17641053 PMID:17693426 PMID:19428947 PMID:20219652 PMID:28329851 PMID:30017638 PMID:30261222 PMID:30517707 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il15 interleukin 15 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL15 mRNA CTD PMID:11243917 PMID:11379042 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il17a interleukin 17A multiple interactions
increases secretion
decreases expression
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL17A protein]; Wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]
Toluene 2,4-Diisocyanate results in decreased expression of IL17A protein
Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL17A protein
CTD PMID:17982072 PMID:28826779 PMID:31577921 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression
increases secretion
ISO 1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL18 protein]; 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein]; L 709049 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL18 protein]; MCC-950 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL18 protein] CTD PMID:30517707 PMID:31070765 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il19 interleukin 19 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL19 mRNA CTD PMID:19647056 NCBI chr13:47,663,592...47,677,869
Ensembl chr13:47,664,080...47,670,407
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases secretion
ISO IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]
Toluene 2,4-Diisocyanate results in increased secretion of IL1A protein
CTD PMID:1699434 PMID:16210060 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
increases expression
ISO [Tetradecanoylphorbol Acetate co-treated with Toluene 2,4-Diisocyanate] results in increased expression of and results in increased secretion of IL1B protein; IL1B protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein
Toluene 2,4-Diisocyanate results in increased secretion of IL1B protein
Toluene 2,4-Diisocyanate results in increased expression of IL1B mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL1B protein
1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]; L 709049 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; MCC-950 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein
CTD PMID:1699434 PMID:11379042 PMID:12098602 PMID:12789230 PMID:14676436 PMID:16210060 PMID:17641053 PMID:18652873 PMID:19647056 PMID:21404309 PMID:24964617 PMID:25929181 PMID:29846729 PMID:29940203 PMID:31070765 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of IL1RL1 mRNA CTD PMID:11379042 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il2 interleukin 2 decreases expression
increases expression
ISO Toluene 2,4-Diisocyanate results in decreased expression of IL2 mRNA
Toluene 2,4-Diisocyanate results in increased expression of IL2 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL2 protein
CTD PMID:11379042 PMID:18652873 PMID:22381623 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il24 interleukin 24 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL24 mRNA CTD PMID:19647056 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL2RA mRNA CTD PMID:21404309 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il2rb interleukin 2 receptor subunit beta increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL2RB mRNA CTD PMID:19647056 PMID:21404309 NCBI chr 7:119,701,338...119,716,238
Ensembl chr 7:119,701,251...119,716,238
JBrowse link
G Il3 interleukin 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL3 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL3 protein CTD PMID:11379042 PMID:16271432 PMID:18652873 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il33 interleukin 33 increases expression
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of IL33 protein
4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL33 protein]; [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol co-treated with Toluene 2,4-Diisocyanate] results in increased expression of IL33 protein; [diarylpropionitrile co-treated with Toluene 2,4-Diisocyanate] results in increased expression of IL33 protein; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL33 protein]; diarylpropionitrile inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL33 protein]; Estradiol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL33 protein]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL33 protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL33 protein
CTD PMID:29846729 PMID:30017638 PMID:30445053 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
increases secretion
affects secretion
ISO
EXP
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; [Toluene 2,4-Diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 protein; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL4 protein]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; Estradiol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL4 protein; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]
Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Olopatadine Hydrochloride inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Quercetin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]
Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL4 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]
Toluene 2,4-Diisocyanate affects the secretion of IL4 protein
CTD PMID:10637130 PMID:11243917 PMID:11467998 PMID:11708898 PMID:11758997 PMID:12356572 PMID:12789230 PMID:12884401 PMID:12956900 PMID:15588918 PMID:15590890 PMID:15950818 PMID:16210060 PMID:16271432 PMID:16940033 PMID:17014439 PMID:17015710 PMID:17257216 PMID:17641053 PMID:17693426 PMID:17980417 PMID:18652873 PMID:19042193 PMID:19050374 PMID:19075512 PMID:19150644 PMID:19422874 PMID:19428947 PMID:20219652 PMID:20371970 PMID:22381623 PMID:23333628 PMID:25929181 PMID:28329851 PMID:28826779 PMID:29846729 PMID:30017638 PMID:30261222 PMID:30517707 PMID:31577921 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL4RA mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL4RA protein CTD PMID:19647056 PMID:22381623 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il5 interleukin 5 multiple interactions
increases secretion
increases expression
ISO
EXP
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]
sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA]
Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL5 protein
CTD PMID:15590890 PMID:16271432 PMID:16516891 PMID:17014439 PMID:17015710 PMID:17641053 PMID:17693426 PMID:19050374 PMID:20219652 PMID:28329851 PMID:30017638 PMID:30261222 PMID:30517707 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
increases expression
ISO
EXP
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]; AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]
[Tetradecanoylphorbol Acetate co-treated with Toluene 2,4-Diisocyanate] results in increased expression of and results in increased secretion of IL6 protein
Toluene 2,4-Diisocyanate results in increased expression of IL6 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL6 protein
CTD PMID:1699434 PMID:11758997 PMID:12956900 PMID:18652873 PMID:19647056 PMID:20219652 PMID:24964617 PMID:30517707 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il7 interleukin 7 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of IL7 mRNA CTD PMID:18242016 PMID:21404309 NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977
JBrowse link
G Il7r interleukin 7 receptor decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of IL7R mRNA CTD PMID:21404309
G Il9 interleukin 9 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL9 mRNA CTD PMID:11243917 NCBI chr17:8,558,827...8,561,950
Ensembl chr17:8,558,827...8,561,950
JBrowse link
G Inhba inhibin subunit beta A increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of INHBA mRNA CTD PMID:19647056 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of ISG15 mRNA CTD PMID:11379042 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Itgae integrin subunit alpha E increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ITGAE protein CTD PMID:27103660 NCBI chr10:59,652,324...59,711,885
Ensembl chr10:59,539,405...59,711,874
JBrowse link
G Kitlg KIT ligand decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of KITL mRNA CTD PMID:21404309 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Krt14 keratin 14 multiple interactions ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of KRT14 mRNA CTD PMID:15478392 NCBI chr10:88,118,029...88,122,233
Ensembl chr10:88,055,823...88,122,233
JBrowse link
G Krt19 keratin 19 multiple interactions ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of KRT19 mRNA CTD PMID:15478392 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Lig1 DNA ligase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of LIG1 mRNA CTD PMID:21404309 NCBI chr 1:75,356,212...75,394,757
Ensembl chr 1:75,356,220...75,394,758
JBrowse link
G LOC103694381 lymphotoxin-beta multiple interactions
increases expression
ISO TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTB mRNA] CTD PMID:11467998 PMID:12356572 PMID:19647056 NCBI chr20:4,861,343...4,863,513
Ensembl chr20:4,861,335...4,863,198
JBrowse link
G Lta lymphotoxin alpha multiple interactions
increases expression
ISO TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTA mRNA] CTD PMID:12356572 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of MAP3K7 mRNA CTD PMID:11379042 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein]
Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK1 protein]
CTD PMID:16908450 PMID:26089345 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein]
Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK3 protein]
CTD PMID:16908450 PMID:26089345 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MCM2 mRNA CTD PMID:21404309 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MCM3 mRNA CTD PMID:21404309 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MCM4 mRNA CTD PMID:21404309 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MCM5 mRNA CTD PMID:21404309 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MCM6 mRNA CTD PMID:21404309 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MCM7 mRNA CTD PMID:21404309 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of MGST1 mRNA CTD PMID:21404309 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of MGST2 mRNA CTD PMID:21404309 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
increases expression
increases activity
multiple interactions
ISO Toluene 2,4-Diisocyanate results in decreased expression of MMP9 protein
Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA; Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein
Toluene 2,4-Diisocyanate results in increased activity of MMP9 protein
4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of MMP9 protein]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of MMP9 protein
CTD PMID:11742282 PMID:12534559 PMID:12789230 PMID:14987308 PMID:15131573 PMID:16516891 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtcp1 mature T-cell proliferation 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MTCP1 mRNA CTD PMID:11379042 NCBI chr18:411,159...411,934
Ensembl chr18:411,455...411,849
JBrowse link
G Mx2 MX dynamin like GTPase 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MX2 mRNA CTD PMID:19647056 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Nat1 N-acetyltransferase 1 affects response to substance
increases response to substance
ISO NAT1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate
NAT1 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanate
CTD PMID:11927838 PMID:18447907 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanate CTD PMID:11927838 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Ndp norrin cystine knot growth factor NDP increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of NDP mRNA CTD PMID:11379042 NCBI chr  X:6,791,090...6,815,586
Ensembl chr  X:6,791,136...6,815,583
Ensembl chr  X:6,791,136...6,815,583
JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
EXP NGF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TAC1 protein]
Toluene 2,4-Diisocyanate results in increased expression of NGF protein
CTD PMID:14672914 PMID:16020193 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO MCC-950 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased activity of NLRP3 protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of NLRP3 protein CTD PMID:31070765 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of NOS2 protein CTD PMID:12974195 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of NOS3 protein CTD PMID:12974195 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nrp1 neuropilin 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of NRP1 protein CTD PMID:27103660 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ODC1 mRNA CTD PMID:21404309 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ORC1 mRNA CTD PMID:21404309 NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
JBrowse link
G Orc6 origin recognition complex, subunit 6 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ORC6 mRNA CTD PMID:21404309 NCBI chr19:27,457,541...27,464,804
Ensembl chr19:27,457,474...27,464,805
JBrowse link
G Osm oncostatin M increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of OSM mRNA CTD PMID:19647056 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions ISO P2RX4 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein] CTD PMID:26072274 NCBI chr12:39,308,022...39,325,673
Ensembl chr12:39,308,025...39,325,673
JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions
affects response to substance
ISO P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]
P2RX7 gene SNP affects the susceptibility to Toluene 2,4-Diisocyanate
CTD PMID:26072274 PMID:29940203 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PCNA mRNA CTD PMID:21404309 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pf4 platelet factor 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PF4 mRNA CTD PMID:19647056 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Phf11 PHD finger protein 11 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PHF11 mRNA CTD PMID:19647056 NCBI chr15:38,692,817...39,683,417
Ensembl chr15:38,647,779...38,709,984
JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PKMYT1 mRNA CTD PMID:21404309 NCBI chr10:13,061,077...13,072,277
Ensembl chr10:13,061,170...13,073,283
JBrowse link
G Plk1 polo-like kinase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PLK1 mRNA CTD PMID:21404309 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of POLA1 mRNA CTD PMID:21404309 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of POLA2 mRNA CTD PMID:21404309 NCBI chr 1:221,297,417...221,321,601
Ensembl chr 1:221,273,538...221,321,570
JBrowse link
G Pold1 DNA polymerase delta 1, catalytic subunit increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of POLD1 mRNA CTD PMID:21404309 NCBI chr 1:100,538,066...100,554,105
Ensembl chr 1:100,537,900...100,554,488
JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of POLD3 mRNA CTD PMID:21404309 NCBI chr 1:165,085,142...165,122,385
Ensembl chr 1:165,083,622...165,123,455
JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of POLE mRNA CTD PMID:21404309 NCBI chr12:52,403,533...52,452,075
Ensembl chr12:52,403,529...52,452,040
JBrowse link
G Polr1b RNA polymerase I subunit B increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of POLR1B mRNA CTD PMID:21404309 NCBI chr 3:121,632,043...121,656,506
Ensembl chr 3:121,632,043...121,656,506
JBrowse link
G Ppa1 inorganic pyrophosphatase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PPA1 mRNA CTD PMID:18242016 NCBI chr20:31,265,519...31,292,451
Ensembl chr20:31,265,483...31,310,674
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases localization
ISO pioglitazone promotes the reaction [Toluene 2,4-Diisocyanate results in increased localization of PPARG protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; rosiglitazone promotes the reaction [Toluene 2,4-Diisocyanate results in increased localization of PPARG protein] CTD PMID:17015710 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppbp pro-platelet basic protein increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PPBP mRNA CTD PMID:19647056 NCBI chr14:18,852,433...18,853,237
Ensembl chr14:18,851,954...18,853,315
JBrowse link
G Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PPP2R3A mRNA CTD PMID:11379042 NCBI chr 8:109,481,352...109,621,462
Ensembl chr 8:109,482,614...109,621,408
JBrowse link
G Prim1 DNA primase subunit 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PRIM1 mRNA CTD PMID:21404309 NCBI chr 7:2,435,524...2,451,169
Ensembl chr 7:2,435,553...2,451,165
JBrowse link
G Psme4 proteasome activator subunit 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PSME4 mRNA CTD PMID:21404309 NCBI chr14:115,166,165...115,269,041
Ensembl chr14:115,166,416...115,269,056
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; Toluene 2,4-Diisocyanate results in decreased expression of and results in decreased activity of PTEN protein CTD PMID:17982072 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PTTG1 mRNA CTD PMID:21404309 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RBL1 mRNA CTD PMID:11379042 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
JBrowse link
G Rcc1 regulator of chromosome condensation 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RCC1 mRNA CTD PMID:18242016 NCBI chr 5:150,508,840...150,531,062
Ensembl chr 5:150,509,040...150,525,254
JBrowse link
G Rcn1 reticulocalbin 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of RCN1 mRNA CTD PMID:11379042 NCBI chr 3:95,404,863...95,419,110
Ensembl chr 3:95,406,284...95,418,679
JBrowse link
G Recql4 RecQ like helicase 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RECQL4 mRNA CTD PMID:18242016 NCBI chr 7:117,765,892...117,773,128
Ensembl chr 7:117,763,783...117,773,134
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
increases localization
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; Wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein] CTD PMID:17015710 PMID:17982072 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rfc3 replication factor C subunit 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RFC3 mRNA CTD PMID:21404309 NCBI chr12:1,460,581...1,471,344
Ensembl chr12:1,460,538...1,471,357
JBrowse link
G Rfc4 replication factor C subunit 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RFC4 mRNA CTD PMID:21404309 NCBI chr11:81,358,592...81,373,044
Ensembl chr11:81,358,592...81,373,043
JBrowse link
G Rfc5 replication factor C subunit 5 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RFC5 mRNA CTD PMID:21404309 NCBI chr12:44,931,494...44,941,051
Ensembl chr12:44,931,494...44,941,324
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of RHOA mRNA CTD PMID:11379042 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rnase2 ribonuclease A family member 2 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of RNASE2A mRNA CTD PMID:18242016 NCBI chr15:28,154,482...28,155,291
Ensembl chr15:28,154,482...28,155,291
JBrowse link
G Rnaseh2b ribonuclease H2, subunit B increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RNASEH2B mRNA CTD PMID:21404309 NCBI chr15:45,422,010...45,472,792
Ensembl chr15:45,422,010...45,464,892
JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of RORC mRNA alternative form
TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of RORC mRNA alternative form]
CTD PMID:31577921 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RRM1 mRNA CTD PMID:21404309 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RRM2 mRNA CTD PMID:21404309 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of RRM2B mRNA CTD PMID:21404309 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817
JBrowse link
G RT1-Ba RT1 class II, locus Ba decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of H2-AA mRNA CTD PMID:21404309 NCBI chr20:4,066,133...4,070,726
Ensembl chr20:4,066,132...4,070,721
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects response to substance ISO HLA-DQB1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate CTD PMID:18447907 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G Rtp4 receptor (chemosensory) transporter protein 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RTP4 mRNA CTD PMID:18242016 PMID:19647056 NCBI chr11:80,638,945...80,650,802
Ensembl chr11:80,638,945...80,650,802
JBrowse link
G Sftpd surfactant protein D increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of SFTPD mRNA CTD PMID:11379042 NCBI chr16:18,753,535...18,766,100
Ensembl chr16:18,745,458...18,766,174
JBrowse link
G Skp2 S-phase kinase associated protein 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of SKP2 mRNA CTD PMID:21404309 NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211
JBrowse link
G Smad1 SMAD family member 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of SMAD1 mRNA CTD PMID:11379042 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
G Sqle squalene epoxidase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of SQLE mRNA CTD PMID:18242016 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation
multiple interactions
ISO Toluene 2,4-Diisocyanate analog results in increased phosphorylation of SRC protein
Toluene 2,4-Diisocyanate results in increased phosphorylation of SRC protein
AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate analog results in increased phosphorylation of SRC protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate analog results in increased phosphorylation of SRC protein]
FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of SRC protein]
CTD PMID:30261222 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of SRSF7 mRNA CTD PMID:11379042 NCBI chr 6:2,879,312...2,886,505
Ensembl chr 6:2,880,518...2,886,465
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5A protein; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5A protein] CTD PMID:28329851 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5B protein; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5B protein] CTD PMID:28329851 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects response to substance ISO SULT1A1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate CTD PMID:18447907 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
increases expression
EXP [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 mRNA; [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 protein; NGF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TAC1 protein]; staurosporine aglycone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TAC1 protein] CTD PMID:10673198 PMID:14672914 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tfdp1 transcription factor Dp-1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TFDP1 mRNA CTD PMID:18242016 PMID:21404309 NCBI chr16:81,088,642...81,127,244
Ensembl chr16:81,089,292...81,127,257
JBrowse link
G Tfec transcription factor EC increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TFEC mRNA CTD PMID:19647056 NCBI chr 4:44,063,533...44,136,815
Ensembl chr 4:44,065,045...44,136,815
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
ISO BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein] CTD PMID:17015710 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of TGFBR2 mRNA CTD PMID:21404309 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression
ISO Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of TIMP1 protein
Toluene 2,4-Diisocyanate results in increased expression of TIMP1 mRNA; Toluene 2,4-Diisocyanate results in increased expression of TIMP1 protein
CTD PMID:12534559 PMID:14987308 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tk1 thymidine kinase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TK1 mRNA CTD PMID:21404309 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of TNF protein]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTA mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTB mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of XCL1 mRNA]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of TNF protein
[Tetradecanoylphorbol Acetate co-treated with Toluene 2,4-Diisocyanate] results in increased expression of and results in increased secretion of TNF protein
Toluene 2,4-Diisocyanate results in increased expression of TNF mRNA; Toluene 2,4-Diisocyanate results in increased expression of TNF protein
CTD PMID:11467998 PMID:12356572 PMID:12789230 PMID:16516891 PMID:17014439 PMID:17641053 PMID:18652873 PMID:20219652 PMID:20371970 PMID:24964617 PMID:28826779 PMID:29846729 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TNFRSF12A mRNA CTD PMID:19647056 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TNFRSF19 mRNA CTD PMID:21404309 NCBI chr15:41,249,820...41,316,203
Ensembl chr15:41,246,308...41,338,284
JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TNFRSF4 mRNA CTD PMID:21404309 NCBI chr 5:173,447,784...173,450,474
Ensembl chr 5:173,447,784...173,450,474
JBrowse link
G Tnfsf13 TNF superfamily member 13 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of TNFSF13 mRNA CTD PMID:21404309 NCBI chr10:56,286,964...56,290,680
Ensembl chr10:56,286,887...56,289,952
JBrowse link
G Tnfsf13b TNF superfamily member 13b decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of TNFSF13B mRNA CTD PMID:21404309 NCBI chr16:85,275,690...85,306,419
Ensembl chr16:85,275,678...85,306,366
JBrowse link
G Tnfsf14 TNF superfamily member 14 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TNFSF14 mRNA CTD PMID:19647056 NCBI chr 9:9,761,363...9,765,461
Ensembl chr 9:9,761,536...9,765,186
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 increases expression
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of TRPV4 protein
GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TRPV4 protein]
CTD PMID:30517707 NCBI chr12:47,698,915...47,737,902
Ensembl chr12:47,698,947...47,737,902
JBrowse link
G Tslp thymic stromal lymphopoietin increases expression
increases secretion
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of TSLP mRNA; Toluene 2,4-Diisocyanate results in increased expression of TSLP protein
Toluene 2,4-Diisocyanate results in increased secretion of TSLP protein
bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of TSLP protein]; Estradiol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of TSLP protein]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of TSLP protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of TSLP protein; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of RORC mRNA alternative form]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL17A protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5A protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5B protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TSLP protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]
CTD PMID:19647056 PMID:28329851 PMID:29846729 PMID:30017638 PMID:31577921 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TXN1 mRNA CTD PMID:19647056 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Tyms thymidylate synthetase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TYMS mRNA CTD PMID:21404309 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Uck2 uridine-cytidine kinase 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of UCK2 mRNA CTD PMID:21404309 NCBI chr13:85,376,716...85,443,976
Ensembl chr13:85,376,716...85,443,976
JBrowse link
G Upb1 beta-ureidopropionase 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of UPB1 mRNA CTD PMID:21404309 NCBI chr20:14,167,383...14,193,724
Ensembl chr20:14,167,586...14,193,690
JBrowse link
G Usp18 ubiquitin specific peptidase 18 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of USP18 mRNA CTD PMID:19647056 NCBI chr 4:153,812,312...153,834,374
Ensembl chr 4:153,805,993...153,834,430
JBrowse link
G Usp8 ubiquitin specific peptidase 8 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of USP8 mRNA CTD PMID:11379042 NCBI chr 3:119,173,818...119,222,499
Ensembl chr 3:119,173,818...119,222,484
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression
ISO
EXP
4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]
Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA; Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein
CTD PMID:12789230 PMID:15823807 PMID:16210060 PMID:17015710 PMID:17641053 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of VEGFA mRNA alternative form
Toluene 2,4-Diisocyanate results in increased expression of VEGFA protein
CTD PMID:11907124 PMID:18250044 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 multiple interactions
increases expression
ISO TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of XCL1 mRNA] CTD PMID:11467998 PMID:12356572 NCBI chr13:83,199,402...83,202,845
Ensembl chr13:83,199,264...83,202,864
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of YWHAQ mRNA CTD PMID:11379042 NCBI chr 6:43,463,294...43,493,816
Ensembl chr 6:43,463,294...43,493,816
JBrowse link
G Zbp1 Z-DNA binding protein 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ZBP1 mRNA CTD PMID:18242016 PMID:19647056 NCBI chr 3:171,276,062...171,292,062
Ensembl chr 3:171,276,062...171,286,537
JBrowse link
toluene 2,6-diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO 2,6-diisocyanatotoluene binds to ALB protein CTD PMID:9124697 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression
multiple interactions
ISO 2,6-diisocyanatotoluene results in increased expression of ENPP2 mRNA; 2,6-diisocyanatotoluene results in increased expression of ENPP2 protein
KN 62 inhibits the reaction [2,6-diisocyanatotoluene results in increased expression of ENPP2 mRNA]
CTD PMID:22952646 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 mRNA; [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 protein CTD PMID:10673198 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        aetiopathogenetic role 18951
          allergen 16937
            diisocyanate 307
              1,3-bis(6-isocyanatohexyl)-1,3-diazetidine-2,4-dione 0
              dicyclohexylmethane-4,4'-diisocyanate 3
              diphenylmethane-4,4'-diisocyanate 15
              hexamethylene diisocyanate 63
              isophorone diisocyanate 6
              toluene meta-diisocyanate + 251
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            heteroorganic entity 19175
                              organochalcogen compound 18886
                                organooxygen compound 18809
                                  isocyanates 341
                                    diisocyanate 307
                                      1,3-bis(6-isocyanatohexyl)-1,3-diazetidine-2,4-dione 0
                                      dicyclohexylmethane-4,4'-diisocyanate 3
                                      diphenylmethane-4,4'-diisocyanate 15
                                      hexamethylene diisocyanate 63
                                      isophorone diisocyanate 6
                                      toluene meta-diisocyanate + 251
paths to the root