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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Gentiopicrin
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Accession:CHEBI:5321 term browser browse the term
Definition:A glycoside that has formula C16H20O9.
Synonyms:related_synonym: Formula=C16H20O9;   Gentiopicroside;   InChI=1S/C16H20O9/c1-2-7-8-3-4-22-14(21)9(8)6-23-15(7)25-16-13(20)12(19)11(18)10(5-17)24-16/h2-3,6-7,10-13,15-20H,1,4-5H2/t7-,10-,11-,12+,13-,15+,16+/m1/s1;   InChIKey=DUAGQYUORDTXOR-GPQRQXLASA-N;   SMILES=OC[C@H]1O[C@@H](O[C@@H]2OC=C3C(=O)OCC=C3[C@H]2C=C)[C@H](O)[C@@H](O)[C@@H]1O
 xref: CAS:20831-76-9;   KEGG:C09782;   KNApSAcK:C00003082
 xref_mesh: MESH:C012997


show annotations for term's descendants           Sort by:
Gentiopicrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions EXP Gentiopicrin reverses the interaction [1-naphthyl isothiocyanate decreases expression of MRP4 mRNA in rat liver] RGD PMID:30223280 RGD:15045612 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		ISO gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of BAX protein]
gentiopicroside results in increased expression of BAX protein 		CTD PMID:20558151 PMID:38852899 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		ISO gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of BCL2 protein]
gentiopicroside results in decreased expression of BCL2 protein 		CTD PMID:20558151 PMID:38852899 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage 		ISO gentiopicroside inhibits the reaction [[[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP3 protein] which results in increased cleavage of PARP1 protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP3 protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP3 protein modified form]
gentiopicroside results in increased cleavage of CASP3 protein 		CTD PMID:20558151 PMID:38852899 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP8 protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form] CTD PMID:20558151 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP9 protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP9 protein modified form] CTD PMID:20558151 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO gentiopicroside analog inhibits the reaction [Galactose results in increased expression of CDK5R1 protein] CTD PMID:36878094 NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO gentiopicroside analog inhibits the reaction [Galactose results in decreased expression of CTNNB1 protein] CTD PMID:36878094 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased localization of CYCS protein] CTD PMID:20558151 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP Gentiopicrin decreases expression of Cyp7a1 mRNA in rat ANIT induced cholestatic liver RGD PMID:30223280 RGD:15045612 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO gentiopicroside analog inhibits the reaction [Galactose results in increased expression of and results in decreased phosphorylation of GSK3B protein] CTD PMID:36878094 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Lrp6 LDL receptor related protein 6 multiple interactions ISO [Galactose co-treated with gentiopicroside analog] results in increased expression of LRP6 protein CTD PMID:36878094 NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:169,000,968...169,131,716 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		ISO gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of MAPK1 protein modified form]
gentiopicroside results in increased phosphorylation of MAPK1 protein 		CTD PMID:20558151 PMID:38852899 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		ISO gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of MAPK3 protein modified form]
gentiopicroside results in increased phosphorylation of MAPK3 protein 		CTD PMID:20558151 PMID:38852899 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO gentiopicroside analog inhibits the reaction [Galactose results in increased expression of MAPT protein] CTD PMID:36878094 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase increases phosphorylation ISO gentiopicroside results in increased phosphorylation of MLKL protein CTD PMID:38852899 NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP Gentiopicrin reverses the reaction [1-naphthyl isothiocyanate decreases expression of Nr1h4 mRNA in rat liver] RGD PMID:30223280 RGD:15045612 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression ISO gentiopicroside results in increased expression of OGG1 mRNA CTD PMID:38852899 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression 		ISO gentiopicroside inhibits the reaction [[[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP3 protein] which results in increased cleavage of PARP1 protein]
gentiopicroside results in increased expression of PARP1 mRNA
gentiopicroside results in increased expression of and results in increased cleavage of PARP1 protein 		CTD PMID:20558151 PMID:38852899 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Psenen presenilin enhancer gamma secretase subunit multiple interactions ISO gentiopicroside analog inhibits the reaction [Galactose results in increased expression of PSENEN protein] CTD PMID:36878094 NCBI chr 1:94,942,348...94,943,545
Ensembl chr 1:94,942,225...94,943,752 		JBrowse link
G Rest RE1-silencing transcription factor multiple interactions ISO gentiopicroside analog inhibits the reaction [Galactose results in decreased expression of REST protein] CTD PMID:36878094 NCBI chr14:31,213,415...31,233,451
Ensembl chr14:31,213,415...31,248,662 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of TNF protein] CTD PMID:20558151 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 increases expression ISO gentiopicroside results in increased expression of XRCC1 mRNA CTD PMID:38852899 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    chemical entity 20839
      atom 20839
        nonmetal atom 20747
          oxygen atom 20439
            oxygen molecular entity 20439
              organooxygen compound 19791
                carbohydrates and carbohydrate derivatives 15420
                  carbohydrate derivative 14439
                    glycosyl compound 13147
                      glycoside 11918
                        Gentiopicrin 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    p-block element atom 20786
                      carbon group element atom 20695
                        carbon atom 20690
                          organic molecular entity 20690
                            heteroorganic entity 20202
                              organochalcogen compound 19889
                                organooxygen compound 19791
                                  carbohydrates and carbohydrate derivatives 15420
                                    carbohydrate 15420
                                      carbohydrate derivative 14439
                                        glycosyl compound 13147
                                          glycoside 11918
                                            Gentiopicrin 23
paths to the root