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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:apo carotenoid
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Accession:CHEBI:53183 term browser browse the term
Definition:A compound arising from loss of part of the carotene skeleton (excluding retinoids)
Synonyms:related_synonym: apo carotenoids;   apocarotenoid;   apocarotenoids

show annotations for term's descendants           Sort by:
 
(+)-abscisic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion
multiple interactions		 ISO CCL2 protein results in increased secretion of Abscisic Acid
fluridone inhibits the reaction [CCL2 protein results in increased secretion of Abscisic Acid]		 CTD PMID:24211328 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
8'-apo-beta,psi-caroten-8'-al term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO apocarotenal results in increased expression of ACADM mRNA CTD PMID:17034753 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases expression ISO apocarotenal results in increased expression of ADH5 mRNA CTD PMID:17034753 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression ISO apocarotenal results in decreased expression of ALDH1B1 mRNA CTD PMID:17034753 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358 		JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 decreases expression ISO apocarotenal results in decreased expression of ALDH3B1 mRNA CTD PMID:17034753 NCBI chr 1:219,145,457...219,181,536
Ensembl chr 1:219,145,459...219,186,860 		JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 decreases expression ISO apocarotenal results in decreased expression of ALDH4A1 mRNA CTD PMID:17034753 NCBI chr 5:158,090,238...158,115,725
Ensembl chr 5:158,042,587...158,135,733 		JBrowse link
G Ank2 ankyrin 2 increases expression ISO apocarotenal results in increased expression of ANK2 mRNA CTD PMID:17034753 NCBI chr 2:231,224,643...231,522,655
Ensembl chr 2:231,226,949...231,648,122 		JBrowse link
G Ank3 ankyrin 3 increases expression ISO apocarotenal results in increased expression of ANK3 mRNA CTD PMID:17034753 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO apocarotenal results in increased expression of ASAH1 mRNA CTD PMID:17034753 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836 		JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO apocarotenal results in increased expression of ASB1 mRNA CTD PMID:17034753 NCBI chr 9:98,668,231...98,689,471
Ensembl chr 9:98,668,231...98,684,900 		JBrowse link
G Asb9 ankyrin repeat and SOCS box-containing 9 increases expression ISO apocarotenal results in increased expression of ASB9 mRNA CTD PMID:17034753 NCBI chr  X:31,700,637...31,745,790
Ensembl chr  X:31,700,633...31,780,425 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO apocarotenal results in decreased expression of BAX mRNA CTD PMID:17034753 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bco2 beta-carotene oxygenase 2 multiple interactions ISO [BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Cryptoxanthins] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite; [BCO2 protein results in increased metabolism of Zeaxanthins] which results in increased chemical synthesis of apocarotenal metabolite CTD PMID:21106934 NCBI chr 8:54,965,577...54,990,604
Ensembl chr 8:54,965,583...54,998,864 		JBrowse link
G Casp8ap2 caspase 8 associated protein 2 increases expression ISO apocarotenal results in increased expression of CASP8AP2 mRNA CTD PMID:17034753 NCBI chr 5:47,853,699...47,891,147
Ensembl chr 5:47,853,818...47,891,668 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO apocarotenal results in increased expression of CDH1 mRNA CTD PMID:17034753 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cldn10 claudin 10 increases expression ISO apocarotenal results in increased expression of CLDN10 mRNA CTD PMID:17034753 NCBI chr15:104,026,590...104,115,748
Ensembl chr15:104,026,601...104,115,748 		JBrowse link
G Cldn18 claudin 18 increases expression ISO apocarotenal results in increased expression of CLDN18 mRNA CTD PMID:17034753 NCBI chr 8:107,933,725...107,960,656
Ensembl chr 8:107,934,860...107,952,530 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO apocarotenal results in decreased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression ISO apocarotenal results in decreased expression of COL4A1 mRNA CTD PMID:17034753 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153 		JBrowse link
G Col4a2 collagen type IV alpha 2 chain decreases expression ISO apocarotenal results in decreased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr16:83,386,388...83,522,169
Ensembl chr16:83,387,364...83,438,561 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 decreases expression ISO apocarotenal results in decreased expression of CRABP2 mRNA CTD PMID:17034753 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505 		JBrowse link
G Ctsb cathepsin B decreases expression ISO apocarotenal results in decreased expression of CTSB mRNA CTD PMID:17034753 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO apocarotenal results in increased expression of CXCL12 mRNA CTD PMID:17034753 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO apocarotenal results in increased expression of CXCL6 mRNA CTD PMID:17034753 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO apocarotenal results in increased expression of CXCL9 mRNA CTD PMID:17034753 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO apocarotenal results in increased expression of CXCR4 mRNA CTD PMID:17034753 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression ISO apocarotenal results in increased expression of CYP2C9 mRNA CTD PMID:17034753 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Dlx2 distal-less homeobox 2 increases expression ISO apocarotenal results in increased expression of DLX2 mRNA CTD PMID:17034753 NCBI chr 3:58,180,088...58,181,971
Ensembl chr 3:58,180,088...58,181,971 		JBrowse link
G Dlx4 distal-less homeobox 4 increases expression ISO apocarotenal results in increased expression of DLX4 mRNA CTD PMID:17034753 NCBI chr10:82,958,525...82,963,919
Ensembl chr10:82,958,525...82,963,919 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO apocarotenal results in decreased expression of ERCC2 mRNA CTD PMID:17034753 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression ISO apocarotenal results in decreased expression of ETS1 mRNA CTD PMID:17034753 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO apocarotenal results in increased expression of FAS mRNA CTD PMID:17034753 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO apocarotenal results in decreased expression of FASN mRNA CTD PMID:17034753 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO apocarotenal results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338 		JBrowse link
G Gbp1 guanylate binding protein 1 increases expression ISO apocarotenal results in increased expression of GBP1 mRNA CTD PMID:17034753 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO apocarotenal results in decreased expression of GSTK1 mRNA CTD PMID:17034753 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression ISO apocarotenal results in decreased expression of GSTM2 mRNA CTD PMID:17034753 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856 		JBrowse link
G Gstm3l glutathione S-transferase mu 3-like increases expression ISO apocarotenal results in increased expression of GSTM5 mRNA CTD PMID:17034753 NCBI chr 2:210,761,729...210,766,501
Ensembl chr 2:210,761,729...210,766,501 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 decreases expression ISO apocarotenal results in decreased expression of GSTM4 mRNA CTD PMID:17034753 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 decreases expression ISO apocarotenal results in decreased expression of GSTZ1 mRNA CTD PMID:17034753 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244 		JBrowse link
G Hoxa7 homeobox A7 increases expression ISO apocarotenal results in increased expression of HOXA7 mRNA CTD PMID:17034753 NCBI chr 4:82,184,299...82,187,890
Ensembl chr 4:82,183,196...82,186,190 		JBrowse link
G Hoxb6 homeo box B6 increases expression ISO apocarotenal results in increased expression of HOXB6 mRNA CTD PMID:17034753 NCBI chr10:84,147,331...84,150,238
Ensembl chr10:84,147,836...84,149,600 		JBrowse link
G Hoxc10 homeo box C10 increases expression ISO apocarotenal results in increased expression of HOXC10 mRNA CTD PMID:17034753 NCBI chr 7:144,577,578...144,582,802
Ensembl chr 7:144,577,465...144,582,622 		JBrowse link
G Ifna1 interferon, alpha 1 increases expression ISO apocarotenal results in increased expression of IFNA14 mRNA CTD PMID:17034753 NCBI chr 5:106,951,822...106,952,908
Ensembl chr 5:106,952,082...106,952,792 		JBrowse link
G Irf8 interferon regulatory factor 8 increases expression ISO apocarotenal results in increased expression of IRF8 mRNA CTD PMID:17034753 NCBI chr19:54,314,859...54,336,643
Ensembl chr19:54,314,865...54,336,640 		JBrowse link
G Irx4 iroquois homeobox 4 decreases expression ISO apocarotenal results in decreased expression of IRX4 mRNA CTD PMID:17034753 NCBI chr 1:32,634,774...32,645,151
Ensembl chr 1:32,634,796...32,643,771 		JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO apocarotenal results in decreased expression of ITGB4 mRNA CTD PMID:17034753 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078 		JBrowse link
G Ivl involucrin increases expression ISO apocarotenal results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577 		JBrowse link
G Krt17 keratin 17 decreases expression ISO apocarotenal results in decreased expression of KRT17 mRNA CTD PMID:17034753 NCBI chr10:88,158,993...88,163,712
Ensembl chr10:88,118,001...88,163,723 		JBrowse link
G Krt2 keratin 2 increases expression ISO apocarotenal results in increased expression of KRT2 mRNA CTD PMID:17034753 NCBI chr 7:143,412,858...143,420,463
Ensembl chr 7:143,412,858...143,420,027 		JBrowse link
G Krt7 keratin 7 affects expression ISO apocarotenal affects the expression of KRT7 mRNA CTD PMID:17034753 NCBI chr 7:143,059,731...143,075,907
Ensembl chr 7:143,059,764...143,075,907 		JBrowse link
G Lhx3 LIM homeobox 3 increases expression ISO apocarotenal results in increased expression of LHX3 mRNA CTD PMID:17034753 NCBI chr 3:3,653,861...3,662,509
Ensembl chr 3:3,654,755...3,661,810 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression ISO apocarotenal affects the expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO apocarotenal results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589 		JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO apocarotenal results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491 		JBrowse link
G Mnx1 motor neuron and pancreas homeobox 1 increases expression ISO apocarotenal results in increased expression of MNX1 mRNA CTD PMID:17034753 NCBI chr 4:2,376,350...2,381,308
Ensembl chr 4:2,376,958...2,381,271 		JBrowse link
G Msh5 mutS homolog 5 increases expression ISO apocarotenal results in increased expression of MSH5 mRNA CTD PMID:17034753 NCBI chr20:5,020,690...5,037,125
Ensembl chr20:5,020,667...5,037,088 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO apocarotenal results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nos1 nitric oxide synthase 1 increases expression ISO apocarotenal results in increased expression of NOS1 mRNA CTD PMID:17034753 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO apocarotenal results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958 		JBrowse link
G Pcdhgc3 protocadherin gamma subfamily C, 3 increases expression ISO apocarotenal results in increased expression of PCDHGC3 mRNA CTD PMID:17034753 NCBI chr18:30,954,552...30,971,113
Ensembl chr18:30,913,842...30,969,361 		JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression ISO apocarotenal results in increased expression of PLSCR1 mRNA CTD PMID:17034753 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217 		JBrowse link
G Plscr3 phospholipid scramblase 3 increases expression ISO apocarotenal results in increased expression of PLSCR3 mRNA CTD PMID:17034753 NCBI chr10:56,452,632...56,458,390
Ensembl chr10:56,453,877...56,458,390 		JBrowse link
G Plscr4 phospholipid scramblase 4 increases expression ISO apocarotenal results in increased expression of PLSCR4 mRNA CTD PMID:17034753 NCBI chr 8:99,880,073...99,917,733
Ensembl chr 8:99,880,073...99,918,825 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO apocarotenal results in increased expression of RAD51AP1 mRNA CTD PMID:17034753 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869 		JBrowse link
G Rad51d RAD51 paralog D increases expression ISO apocarotenal results in increased expression of RAD51D mRNA CTD PMID:17034753 NCBI chr10:70,222,703...70,241,352
Ensembl chr10:70,227,163...70,241,254 		JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO apocarotenal results in decreased expression of RARA mRNA CTD PMID:17034753 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210 		JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO apocarotenal results in increased expression of RARB mRNA CTD PMID:17034753 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599 		JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO apocarotenal results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 2:164,650,722...164,684,982
Ensembl chr 2:164,650,722...164,684,985 		JBrowse link
G Six6 SIX homeobox 6 increases expression ISO apocarotenal results in increased expression of SIX6 mRNA CTD PMID:17034753 NCBI chr 6:95,816,749...95,821,729
Ensembl chr 6:95,816,749...95,821,729 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO apocarotenal results in decreased expression of SOD1 mRNA CTD PMID:17034753 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 affects expression ISO apocarotenal affects the expression of SPTLC2 mRNA CTD PMID:17034753 NCBI chr 6:111,334,408...111,417,960
Ensembl chr 6:111,339,136...111,417,954 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO apocarotenal results in increased expression of SREBF1 mRNA CTD PMID:17034753 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Tgm4 transglutaminase 4 increases expression ISO apocarotenal results in increased expression of TGM4 mRNA CTD PMID:17034753 NCBI chr 8:132,117,279...132,157,485
Ensembl chr 8:132,120,452...132,157,485 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression ISO apocarotenal results in increased expression of TNFRSF9 mRNA CTD PMID:17034753 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO apocarotenal results in increased expression of TNFSF10 mRNA CTD PMID:17034753 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899 		JBrowse link
G Txndc9 thioredoxin domain containing 9 increases expression ISO apocarotenal results in increased expression of TXNDC9 mRNA CTD PMID:17034753 NCBI chr 9:44,647,707...44,657,779
Ensembl chr 9:44,647,707...44,657,779 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 increases expression ISO apocarotenal results in increased expression of XRCC3 mRNA CTD PMID:17034753 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348 		JBrowse link
alpha-ionone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gna15 G protein subunit alpha 15 increases response to substance
multiple interactions		 ISO GNA15 protein results in increased susceptibility to alpha-ionone
[GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OLFR43 protein		 CTD PMID:15598656 NCBI chr 7:11,054,249...11,075,152
Ensembl chr 7:11,054,333...11,077,251 		JBrowse link
G Olr1513 olfactory receptor 1513 multiple interactions ISO [GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OLFR43 protein CTD PMID:15598656 NCBI chr10:61,033,113...61,034,051
Ensembl chr10:61,033,113...61,034,051 		JBrowse link
G Olr59 olfactory receptor 59 decreases activity ISO alpha-ionone results in decreased activity of OR51E2 protein CTD PMID:27226631 NCBI chr 1:167,906,030...167,940,688
Ensembl chr 1:167,906,061...167,911,961 		JBrowse link
beta-damascenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calml5 calmodulin-like 5 increases expression ISO beta-damascenone results in increased expression of CALM4 mRNA CTD PMID:22982537 NCBI chr17:70,044,956...70,045,886 JBrowse link
G Casp14 caspase 14 increases expression
affects localization		 ISO beta-damascenone results in increased expression of CASP14 mRNA
beta-damascenone affects the localization of CASP14 protein		 CTD PMID:22982537 NCBI chr 7:13,938,376...13,944,286
Ensembl chr 7:13,938,302...13,945,130 		JBrowse link
G Ces3a carboxylesterase 3a increases expression ISO beta-damascenone results in increased expression of CES3 mRNA CTD PMID:22982537 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Clca1 chloride channel accessory 1 increases expression ISO beta-damascenone results in increased expression of CLCA1 mRNA CTD PMID:22982537 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744 		JBrowse link
G Clca2 chloride channel accessory 2 increases expression ISO beta-damascenone results in increased expression of CLCA2 mRNA CTD PMID:22982537 NCBI chr 2:250,954,423...250,981,544
Ensembl chr 2:250,954,397...250,981,623 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO beta-damascenone results in increased expression of CYP17A1 mRNA CTD PMID:22982537 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Fcgbp Fc fragment of IgG binding protein increases expression ISO beta-damascenone results in increased expression of FCGBP mRNA CTD PMID:22982537 NCBI chr 1:85,003,280...85,046,840
Ensembl chr 1:85,003,280...85,046,840 		JBrowse link
G Flg filaggrin increases expression ISO beta-damascenone results in increased expression of FLG mRNA; beta-damascenone results in increased expression of FLG protein CTD PMID:22982537 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Hrnr hornerin increases expression ISO beta-damascenone results in increased expression of HRNR mRNA CTD PMID:22982537 NCBI chr 2:193,626,283...193,639,848
Ensembl chr 2:193,627,243...193,634,181 		JBrowse link
G Il20ra interleukin 20 receptor subunit alpha increases expression ISO beta-damascenone results in increased expression of IL20RA mRNA CTD PMID:22982537 NCBI chr 1:15,180,328...15,222,785
Ensembl chr 1:15,180,328...15,222,785 		JBrowse link
G Krt1 keratin 1 increases expression ISO beta-damascenone results in increased expression of KRT1 mRNA CTD PMID:22982537 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544 		JBrowse link
G Krt10 keratin 10 increases expression ISO beta-damascenone results in increased expression of KRT10 mRNA CTD PMID:22982537 NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736 		JBrowse link
G Lce1c late cornified envelope 1C increases expression ISO beta-damascenone results in increased expression of LCE1C mRNA CTD PMID:22982537
G Lce1d late cornified envelope 1D increases expression ISO beta-damascenone results in increased expression of LCE1D mRNA CTD PMID:22982537
G Lce1f late cornified envelope 1F increases expression ISO beta-damascenone results in increased expression of LCE1F mRNA CTD PMID:22982537 NCBI chr 2:192,990,607...192,992,193
Ensembl chr 2:192,990,831...192,991,199 		JBrowse link
G Lce1l late cornified envelope 1L increases expression ISO beta-damascenone results in increased expression of LCE1B mRNA CTD PMID:22982537 NCBI chr 2:193,164,403...193,165,736
Ensembl chr 2:193,164,403...193,165,736 		JBrowse link
G Lipm lipase, family member M increases expression ISO beta-damascenone results in increased expression of LIPM mRNA CTD PMID:22982537 NCBI chr 1:252,409,232...252,428,567
Ensembl chr 1:252,409,268...252,428,774 		JBrowse link
G LOC100909600 PI-PLC X domain-containing protein 1-like increases expression ISO beta-damascenone results in increased expression of PLCXD1 mRNA CTD PMID:22982537 NCBI chr12:52,674,837...52,678,047 JBrowse link
G Loricrin loricrin cornified envelope precursor protein increases expression ISO beta-damascenone results in increased expression of LOR mRNA CTD PMID:22982537 NCBI chr 2:191,984,455...191,990,713
Ensembl chr 2:191,984,773...191,986,170 		JBrowse link
G Otop3 otopetrin 3 increases expression ISO beta-damascenone results in increased expression of OTOP3 mRNA CTD PMID:22982537 NCBI chr10:103,887,045...103,898,331
Ensembl chr10:103,891,369...103,898,331 		JBrowse link
G Pla2g4f phospholipase A2, group IVF increases expression ISO beta-damascenone results in increased expression of PLA2G4F mRNA CTD PMID:22982537 NCBI chr 3:112,068,617...112,083,978
Ensembl chr 3:112,072,330...112,084,144 		JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 increases expression ISO beta-damascenone results in increased expression of SDR16C5 mRNA CTD PMID:22982537 NCBI chr 5:16,904,926...16,930,111
Ensembl chr 5:16,904,926...16,930,075 		JBrowse link
G Susd2 sushi domain containing 2 increases expression ISO beta-damascenone results in increased expression of SUSD2 mRNA CTD PMID:22982537 NCBI chr20:13,965,098...13,972,547
Ensembl chr20:13,965,121...13,972,547 		JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression ISO beta-damascenone results in increased expression of TMPRSS4 mRNA CTD PMID:22982537 NCBI chr 8:49,469,804...49,503,304
Ensembl chr 8:49,469,503...49,502,647 		JBrowse link
beta-ionone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO beta-ionone results in increased expression of BAX protein CTD PMID:31506784 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO beta-ionone results in decreased expression of BCL2 protein CTD PMID:23100158 PMID:31506784 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression		 ISO [alpha-Tocopherol co-treated with beta-ionone] results in increased activity of CASP3 protein
beta-ionone results in increased cleavage of CASP3 protein
beta-ionone results in increased expression of CASP3 protein modified form		 CTD PMID:17618090 PMID:23100158 PMID:31506784 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO beta-ionone results in decreased expression of CCND1 protein CTD PMID:15450939 PMID:31506784 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO beta-ionone results in decreased expression of CDK2 protein CTD PMID:15450939 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO beta-ionone results in decreased expression of CDK4 protein CTD PMID:15450939 PMID:31506784 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cryz crystallin zeta increases activity ISO beta-ionone results in increased activity of CRYZ protein CTD PMID:31506784 NCBI chr 2:260,884,315...260,911,827
Ensembl chr 2:260,884,337...260,911,792 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA] CTD PMID:20435455 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Lmnb1 lamin B1 decreases farnesylation ISO beta-ionone results in decreased farnesylation of LMNB1 protein CTD PMID:10203554 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO beta-ionone results in increased phosphorylation of MAPK1 protein
beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]		 CTD PMID:23268108 PMID:27226631 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein modified form]
beta-ionone results in increased phosphorylation of MAPK3 protein		 CTD PMID:23268108 PMID:27226631 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:23268108 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:23268108 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Olr59 olfactory receptor 59 multiple interactions ISO beta-ionone binds to and results in increased activity of OR51E2 protein CTD PMID:27226631 NCBI chr 1:167,906,030...167,940,688
Ensembl chr 1:167,906,061...167,911,961 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
beta-ionone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]		 CTD PMID:23268108 PMID:31506784 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:23268108 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:23268108 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tyr tyrosinase increases expression ISO beta-ionone results in increased expression of TYR mRNA; beta-ionone results in increased expression of TYR protein CTD PMID:27226631 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      atom 19851
        nonmetal atom 19733
          carbon atom 19639
            organic molecular entity 19639
              isoprenoid 10277
                apo carotenoid 121
                  10'-apo-beta-carotenal 0
                  13-apo-beta-carotenone 0
                  2,6-dimethyldeca-2,4,6,8-tetraenedial 0
                  4,4'-diapolycopenedial 0
                  4,9-dimethyldodeca-2,4,6,8,10-pentaenedial 0
                  4-methylocta-2,4,6-trienedial 0
                  6'-apo-beta-carotenal 0
                  9-cis-10'-apo-beta-carotenal 0
                  apo carotenoid C25 terpenoid + 0
                  apo carotenoid C35 terpenoid + 0
                  apo carotenoid diterpenoid + 0
                  apo carotenoid monoterpenoid + 44
                  apo carotenoid sesquiterpenoid + 1
                  apo carotenoid triterpenoid + 77
                  bixin dialdehyde 0
                  citranaxanthin 0
                  rosafluine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    main group molecular entity 19744
                      p-block molecular entity 19744
                        carbon group molecular entity 19650
                          organic molecular entity 19639
                            lipid 17214
                              isoprenoid 10277
                                apo carotenoid 121
                                  10'-apo-beta-carotenal 0
                                  13-apo-beta-carotenone 0
                                  2,6-dimethyldeca-2,4,6,8-tetraenedial 0
                                  4,4'-diapolycopenedial 0
                                  4,9-dimethyldodeca-2,4,6,8,10-pentaenedial 0
                                  4-methylocta-2,4,6-trienedial 0
                                  6'-apo-beta-carotenal 0
                                  9-cis-10'-apo-beta-carotenal 0
                                  apo carotenoid C25 terpenoid + 0
                                  apo carotenoid C35 terpenoid + 0
                                  apo carotenoid diterpenoid + 0
                                  apo carotenoid monoterpenoid + 44
                                  apo carotenoid sesquiterpenoid + 1
                                  apo carotenoid triterpenoid + 77
                                  bixin dialdehyde 0
                                  citranaxanthin 0
                                  rosafluine 0
paths to the root