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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1-chloro-2,4,6-trinitrobenzene
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Accession:CHEBI:53053 term browser browse the term
Definition:The C-nitro compound that is chlorobenzene with three nitro substituents in the 2-, 4- and 6-positions.
Synonyms:related_synonym: 2,4,6-Trinitro-1-chlorobenzene;   2,4,6-Trinitrochlorobenzene;   2-Chloro-1,3,5-trinitrobenzene;   Formula=C6H2ClN3O6;   InChI=1S/C6H2ClN3O6/c7-6-4(9(13)14)1-3(8(11)12)2-5(6)10(15)16/h1-2H;   InChIKey=HJRJRUMKQCMYDL-UHFFFAOYSA-N;   Picryl chloride;   SMILES=[O-][N+](=O)c1cc(c(Cl)c(c1)[N+]([O-])=O)[N+]([O-])=O;   Tncb;   Trinitrochlorobenzene
 xref: Beilstein:1588666;   CAS:88-88-0;   Gmelin:241377
 xref_mesh: MESH:D010853
 xref: PMID:11168631;   PMID:12631250;   PMID:12809997;   PMID:14112263;   PMID:15696100;   PMID:16675348;   PMID:19870667;   PMID:21664903;   PMID:21986191;   PMID:22289731;   PMID:22834538;   PMID:23106683;   PMID:23149290;   PMID:23661987;   PMID:3918942;   PMID:7843258;   PMID:9326394;   Reaxys:1588666;   Wikipedia:Picryl_chloride


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1-chloro-2,4,6-trinitrobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions ISO CASP1 protein promotes the reaction [Picryl Chloride results in increased cleavage of IL18 protein]; CASP1 protein promotes the reaction [Picryl Chloride results in increased cleavage of IL1B protein] CTD PMID:17429439 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
increases expression
ISO [Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IFNG protein; Cyclosporine promotes the reaction [Picryl Chloride results in increased expression of IFNG protein]; Particulate Matter analog promotes the reaction [Picryl Chloride results in increased expression of IFNG]; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IFNG protein]; Vehicle Emissions analog promotes the reaction [Picryl Chloride results in increased expression of IFNG]
Picryl Chloride results in decreased expression of IFNG
Picryl Chloride results in increased expression of IFNG mRNA; Picryl Chloride results in increased expression of IFNG protein
CTD PMID:12484431, PMID:16442096, PMID:17371993, PMID:21804303, PMID:23817207 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL10 protein; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL10 protein] CTD PMID:17371993 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression
ISO [Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL12B protein; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL12B protein]
Picryl Chloride results in increased expression of IL12B mRNA
CTD PMID:11708898, PMID:17371993 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 increases response to substance ISO IL12RB2 protein results in increased susceptibility to Picryl Chloride CTD PMID:18725520 NCBI chr 4:98,049,195...98,141,562
Ensembl chr 4:98,052,842...98,141,482
JBrowse link
G Il18 interleukin 18 multiple interactions
increases secretion
increases expression
increases cleavage
ISO CASP1 protein promotes the reaction [Picryl Chloride results in increased cleavage of IL18 protein]
Picryl Chloride results in increased secretion of IL18 protein
Picryl Chloride results in increased expression of IL18 mRNA; Picryl Chloride results in increased expression of IL18 protein
Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]; Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]; pyrazolanthrone inhibits the reaction [Picryl Chloride results in increased expression of IL18 mRNA]; pyrazolanthrone inhibits the reaction [Picryl Chloride results in increased secretion of IL18 protein]; Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]
CTD PMID:15734285, PMID:16442096, PMID:17429439, PMID:20381601 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases cleavage
ISO 4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein]; CASP1 protein promotes the reaction [Picryl Chloride results in increased cleavage of IL1B protein]
[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL1B protein; Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein]; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL1B protein]; Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein]; Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein]
CTD PMID:15734285, PMID:16442096, PMID:17371993, PMID:17429439, PMID:18854230 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
ISO 4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]
Picryl Chloride results in increased expression of IL4; Picryl Chloride results in increased expression of IL4 mRNA; Picryl Chloride results in increased expression of IL4 protein
[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL4 protein; bu-zhong-yi-qi-tang inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]; Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]; Dexamethasone inhibits the reaction [Picryl Chloride results in increased expression of IL4 mRNA]; Particulate Matter analog promotes the reaction [Picryl Chloride results in increased expression of IL4]; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL4 protein]; Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]; Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]; Vehicle Emissions analog promotes the reaction [Picryl Chloride results in increased expression of IL4]
CTD PMID:12188032, PMID:15734285, PMID:16442096, PMID:17371993, PMID:18854230, PMID:21804303, PMID:23817207 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL6 protein]; Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL6 protein] CTD PMID:15734285, PMID:16442096 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO Picryl Chloride results in increased phosphorylation of JUN protein CTD PMID:20381601 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Picryl Chloride results in increased phosphorylation of MAPK8 protein CTD PMID:20381601 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases secretion
ISO Glycyrrhizic Acid inhibits the reaction [Picryl Chloride results in increased secretion of MMP2 protein]; saikosaponin affects the reaction [Picryl Chloride results in increased secretion of MMP2 protein] CTD PMID:16945185 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
ISO Cyclosporine inhibits the reaction [Picryl Chloride results in increased activity of MPO protein]; Prednisolone inhibits the reaction [Picryl Chloride results in increased activity of MPO protein]; Rolipram inhibits the reaction [Picryl Chloride results in increased activity of MPO protein] CTD PMID:16442096 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Ngf nerve growth factor increases expression ISO Picryl Chloride results in increased expression of NGF mRNA CTD PMID:21804303 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IFNG protein]; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL10 protein]; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL12B protein]; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL1B protein]; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL4 protein]; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of TNF protein] CTD PMID:17371993 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO TLR2 protein affects the reaction [TLR4 protein results in increased susceptibility to Picryl Chloride] CTD PMID:18725520 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases response to substance
ISO TLR2 protein affects the reaction [TLR4 protein results in increased susceptibility to Picryl Chloride] CTD PMID:18725520 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Picryl Chloride co-treated with pirinixic acid] results in decreased expression of TNF protein; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of TNF protein] CTD PMID:17371993 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        epitope 6835
          1-chloro-2,4,6-trinitrobenzene 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                carbocyclic compound 18181
                                  benzenoid aromatic compound 17178
                                    benzenes 16920
                                      chlorobenzenes 12990
                                        monochlorobenzenes 8871
                                          1-chloro-2,4,6-trinitrobenzene 18
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