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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gemfibrozil
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Accession:CHEBI:5296 term browser browse the term
Definition:An aromatic ether that has formula C15H22O3.
Synonyms:exact_synonym: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
 related_synonym: 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure;   2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure;   2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid;   Formula=C15H22O3;   Gemfibrozilo;   InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17);   InChIKey=HEMJJKBWTPKOJG-UHFFFAOYSA-N;   Lopid;   SMILES=Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1;   gemfibrozilum
 xref: Beilstein:1881200;   CAS:25812-30-0;   DrugBank:DB01241;   Drug_Central:1285;   KEGG:D00334;   LINCS:LSM-2227
 xref_mesh: MESH:D015248
 xref: Patent:DE1925423;   Patent:US3674836;   Patent:US4126637;   Wikipedia:Gemfibrozil


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gemfibrozil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 increases expression ISO
EXP		 Gemfibrozil results in increased expression of ABCA1 mRNA; Gemfibrozil results in increased expression of ABCA1 protein CTD PMID:19201410 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 multiple interactions ISO Gemfibrozil inhibits the reaction [[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin] CTD PMID:22162766 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 affects expression ISO Gemfibrozil affects the expression of ACAA2 mRNA CTD PMID:12011481 PMID:27665778 NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279 		JBrowse link
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain affects expression ISO Gemfibrozil affects the expression of ACADVL mRNA CTD PMID:27665778 NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237 		JBrowse link
G Ace2 angiotensin converting enzyme 2 increases expression ISO Gemfibrozil results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO Gemfibrozil results in increased expression of ACOT1 mRNA CTD PMID:27665778 NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression ISO Gemfibrozil results in increased expression of ACOT2 mRNA CTD PMID:27665778 NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647 		JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression ISO Gemfibrozil results in increased expression of ACOT4 mRNA CTD PMID:27665778 NCBI chr12:84,084,028...84,091,497
Ensembl chr12:84,085,153...84,095,375 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl increases expression ISO Gemfibrozil results in increased expression of ACOX1 mRNA CTD PMID:18619722 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Ahr aryl-hydrocarbon receptor increases expression ISO Gemfibrozil results in increased expression of AHR mRNA CTD PMID:12011481 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 decreases activity ISO Gemfibrozil results in decreased activity of AKR1B10 protein mutant form CTD PMID:18325492 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
affects localization		 EXP Gemfibrozil results in increased phosphorylation of AKT1 protein
Gemfibrozil affects the localization of AKT1 protein		 CTD PMID:22685291 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO Gemfibrozil results in increased expression of ANGPTL4 mRNA CTD PMID:27665778 NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804 		JBrowse link
G Apoa1 apolipoprotein A-I increases expression
multiple interactions		 ISO
EXP		 Gemfibrozil results in increased expression of APOA1 protein
Gemfibrozil promotes the reaction [APOA1 protein results in increased secretion of Lipids]		 CTD PMID:11701466 PMID:19201410 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apob apolipoprotein B decreases expression ISO Gemfibrozil results in decreased expression of APOB protein CTD PMID:9006809 PMID:11701466 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835 		JBrowse link
G Apoc2 apolipoprotein C2 decreases expression
multiple interactions		 ISO Gemfibrozil results in decreased expression of APOC2 protein
[Gemfibrozil results in decreased expression of APOC2 protein] which results in decreased abundance of Triglycerides		 CTD PMID:8847480 NCBI chr 7:19,405,504...19,411,866
Ensembl chr 7:19,405,504...19,411,866 		JBrowse link
G Apoc3 apolipoprotein C-III decreases expression ISO Gemfibrozil results in decreased expression of APOC3 mRNA; Gemfibrozil results in decreased expression of APOC3 protein CTD PMID:8847480 NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934 		JBrowse link
G Apoe apolipoprotein E increases expression ISO Gemfibrozil results in increased expression of APOE protein CTD PMID:9006809 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Car9 carbonic anhydrase 9 multiple interactions ISO Gemfibrozil inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA] CTD PMID:34520103 NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729 		JBrowse link
G Cat catalase increases activity EXP
ISO		 Gemfibrozil results in increased activity of CAT protein CTD PMID:20953357 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Gemfibrozil results in decreased expression of CCL2 mRNA; Gemfibrozil results in decreased expression of CCL2 protein CTD PMID:25051504 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Gemfibrozil results in decreased expression of CCL5 protein CTD PMID:25051504 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased activity of CEBPB protein] CTD PMID:12244038 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Ces2h carboxylesterase 2H increases expression ISO Gemfibrozil results in increased expression of CES2 mRNA CTD PMID:12011481 NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator decreases activity EXP Gemfibrozil results in decreased activity of CFTR protein CTD PMID:15289377 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Colq collagen like tail subunit of asymmetric acetylcholinesterase increases expression ISO Gemfibrozil results in increased expression of COLQ mRNA CTD PMID:27665778 NCBI chr14:31,245,039...31,299,820
Ensembl chr14:31,245,039...31,313,300 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver increases expression ISO Gemfibrozil results in increased expression of CPT1A mRNA CTD PMID:27665778 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle increases expression ISO Gemfibrozil results in increased expression of CPT1B mRNA CTD PMID:12011481 PMID:32741897 NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression ISO Gemfibrozil results in increased expression of CPT2 mRNA CTD PMID:27665778 NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807 		JBrowse link
G Crat carnitine acetyltransferase increases expression ISO Gemfibrozil results in increased expression of CRAT mRNA CTD PMID:27665778 NCBI chr 2:30,290,483...30,305,602
Ensembl chr 2:30,290,483...30,305,825 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression ISO Gemfibrozil results in decreased expression of CXCL10 protein CTD PMID:25051504 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
multiple interactions		 ISO Gemfibrozil results in decreased activity of CYP1A2 protein
[Gemfibrozil results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine		 CTD PMID:26599973 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 multiple interactions
decreases activity
decreases expression
increases expression		 ISO [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 protein; [Gemfibrozil results in decreased activity of CYP2C8 protein] which affects the chemical synthesis of Aconitine metabolite; [Gemfibrozil results in decreased activity of CYP2C8 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine; Gemfibrozil inhibits the reaction [CYP2C8 protein affects the metabolism of pioglitazone]
Gemfibrozil metabolite results in decreased activity of CYP2C8 protein; Gemfibrozil results in decreased activity of CYP2C8 protein
Gemfibrozil results in decreased expression of CYP2C8 protein
Gemfibrozil results in increased expression of CYP2C8 mRNA		 CTD PMID:15771232 PMID:15900286 PMID:16042675 PMID:21277363 PMID:29960002 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene decreases expression ISO Gemfibrozil results in decreased expression of CYP2C11 protein CTD PMID:9209713 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733 		JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 affects expression ISO Gemfibrozil affects the expression of CYP2J2 protein CTD PMID:29960002 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815 		JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B increases expression ISO Gemfibrozil results in increased expression of CYP4A1 mRNA CTD PMID:27665778 NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases expression ISO Gemfibrozil results in decreased expression of CYP7A1 mRNA CTD PMID:14685799 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Dact2 dishevelled-binding antagonist of beta-catenin 2 increases expression ISO Gemfibrozil results in increased expression of DACT2 mRNA CTD PMID:27665778 NCBI chr17:14,415,492...14,424,595
Ensembl chr17:14,415,314...14,424,566 		JBrowse link
G Decr1 2,4-dienoyl CoA reductase 1, mitochondrial increases expression ISO Gemfibrozil results in increased expression of DECR1 mRNA CTD PMID:27665778 NCBI chr 4:15,917,240...15,945,377
Ensembl chr 4:15,917,240...15,945,507 		JBrowse link
G Decr2 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal increases expression ISO Gemfibrozil results in increased expression of DECR2 mRNA CTD PMID:27665778 NCBI chr17:26,300,182...26,309,096
Ensembl chr17:26,300,182...26,309,311 		JBrowse link
G Ech1 enoyl coenzyme A hydratase 1, peroxisomal increases expression ISO Gemfibrozil results in increased expression of ECH1 mRNA CTD PMID:27665778 NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672 		JBrowse link
G Eci1 enoyl-Coenzyme A delta isomerase 1 affects expression
increases expression		 ISO Gemfibrozil affects the expression of ECI1 mRNA
Gemfibrozil results in increased expression of ECI1 mRNA		 CTD PMID:12011481 PMID:27665778 NCBI chr17:24,645,657...24,658,290
Ensembl chr17:24,645,615...24,658,322 		JBrowse link
G Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase increases expression ISO Gemfibrozil results in increased expression of EHHADH mRNA CTD PMID:27665778 NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression ISO Gemfibrozil results in increased expression of ELOVL6 mRNA CTD PMID:27665778 NCBI chr 3:129,326,035...129,432,144
Ensembl chr 3:129,326,004...129,432,144 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic affects expression ISO Gemfibrozil affects the expression of EPHX2 protein CTD PMID:29960002 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G Fads1 fatty acid desaturase 1 increases activity ISO Gemfibrozil results in increased activity of FADS1 protein CTD PMID:7606338 NCBI chr19:10,160,245...10,174,238
Ensembl chr19:10,160,252...10,174,241 		JBrowse link
G Fads2 fatty acid desaturase 2 increases activity ISO Gemfibrozil results in increased activity of FADS2 protein CTD PMID:7606338 NCBI chr19:10,040,129...10,078,867
Ensembl chr19:10,040,129...10,079,110 		JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO Gemfibrozil results in decreased expression of GATA3 mRNA CTD PMID:20006695 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of GPT protein CTD PMID:30853469 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 affects expression ISO Gemfibrozil affects the expression of HMGCS2 mRNA CTD PMID:27665778 NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO Gemfibrozil results in increased expression of HSD17B4 mRNA; Gemfibrozil results in increased expression of HSD17B4 protein CTD PMID:9209713 NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased activity of PPARA protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased activity of CEBPB protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:12244038 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il10 interleukin 10 affects expression
decreases expression		 ISO Gemfibrozil affects the expression of IL10 protein
Gemfibrozil results in decreased expression of IL10 protein		 CTD PMID:25051504 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il12b interleukin 12b multiple interactions EXP Gemfibrozil inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15968640 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects expression		 EXP
ISO		 Gemfibrozil inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased activity of PPARA protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased activity of CEBPB protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
Gemfibrozil affects the expression of IL1B mRNA		 CTD PMID:12244038 PMID:15968640 PMID:25051504 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 decreases expression ISO Gemfibrozil results in decreased expression of IL6 protein CTD PMID:25051504 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Klf4 Kruppel-like transcription factor 4 (gut) multiple interactions
affects localization
increases phosphorylation
affects response to substance		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil affects the localization of KLF4 protein]; KLF4 mRNA affects the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]
Gemfibrozil results in increased phosphorylation of KLF4 protein
KLF4 mRNA affects the susceptibility to Gemfibrozil		 CTD PMID:22685291 NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of LCN2 mRNA CTD PMID:30853469 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Lep leptin decreases expression
increases expression		 ISO Gemfibrozil results in decreased expression of LEP protein
Gemfibrozil results in increased expression of LEP protein		 CTD PMID:25051504 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lpl lipoprotein lipase increases activity
multiple interactions		 ISO Gemfibrozil results in increased activity of LPL protein
[Gemfibrozil results in increased activity of LPL protein] which results in decreased abundance of Triglycerides		 CTD PMID:8593127 PMID:9006809 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Mgll monoglyceride lipase increases expression ISO Gemfibrozil results in increased expression of MGLL mRNA CTD PMID:27665778 NCBI chr 6:88,701,397...88,805,342
Ensembl chr 6:88,701,394...88,805,342 		JBrowse link
G Mir133b microRNA 133b multiple interactions EXP [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR133B mRNA CTD PMID:30853469 NCBI chr 1:20,752,993...20,753,111
Ensembl chr 1:20,752,993...20,753,111 		JBrowse link
G Mir206 microRNA 206 multiple interactions EXP [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR206 mRNA CTD PMID:30853469 NCBI chr 1:20,749,234...20,749,306
Ensembl chr 1:20,749,234...20,749,306 		JBrowse link
G Myc myelocytomatosis oncogene decreases methylation EXP Gemfibrozil results in decreased methylation of MYC promoter CTD PMID:11857776 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 increases expression ISO Gemfibrozil results in increased expression of NCEH1 mRNA CTD PMID:27665778 NCBI chr 3:27,237,153...27,299,112
Ensembl chr 3:27,237,114...27,338,757 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:12244038 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 increases expression ISO Gemfibrozil results in increased expression of NR1H2 mRNA CTD PMID:19201410 NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression
multiple interactions
affects response to substance		 ISO
EXP		 Gemfibrozil results in increased expression of NR1H3 protein
NR1H3 protein affects the reaction [Gemfibrozil results in increased expression of PPARA mRNA]
Gemfibrozil results in increased expression of NR1H3 mRNA
NR1H3 protein affects the susceptibility to Gemfibrozil		 CTD PMID:15998575 PMID:19201410 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization EXP Gemfibrozil affects the localization of NR1I3 protein CTD PMID:17962186 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Gemfibrozil results in increased expression of PCNA protein CTD PMID:9007043 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 decreases expression ISO Gemfibrozil results in decreased expression of PDK4 mRNA CTD PMID:27665778 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309 		JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha increases expression ISO Gemfibrozil results in increased expression of PEX11A mRNA CTD PMID:27665778 NCBI chr 7:79,385,705...79,392,879
Ensembl chr 7:79,385,705...79,392,879 		JBrowse link
G Plin2 perilipin 2 increases expression ISO Gemfibrozil results in increased expression of PLIN2 mRNA CTD PMID:27665778 NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297 		JBrowse link
G Por cytochrome p450 oxidoreductase increases activity ISO Gemfibrozil results in increased activity of POR protein CTD PMID:7606338 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
multiple interactions
increases activity
affects response to substance		 ISO
EXP		 Gemfibrozil results in increased expression of PPARA protein
Gemfibrozil binds to and results in increased activity of PPARA protein; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased activity of PPARA protein]; NR1H3 protein affects the reaction [Gemfibrozil results in increased expression of PPARA mRNA]
Gemfibrozil results in increased activity of PPARA protein
Gemfibrozil binds to and results in increased activity of PPARA protein; PPARA gene mutant form inhibits the reaction [Gemfibrozil results in increased abundance of tauromuricholic acid]
PPARA protein affects the susceptibility to Gemfibrozil		 CTD PMID:12244038 PMID:15968640 PMID:15998575 PMID:19201410 PMID:20953357 More... NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ppard peroxisome proliferator activator receptor delta increases expression EXP
ISO		 Gemfibrozil results in increased expression of PPARD mRNA CTD PMID:19201410 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression ISO
EXP		 Gemfibrozil results in increased expression of PPARG mRNA CTD PMID:19201410 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase increases expression ISO Gemfibrozil results in increased expression of PPCS mRNA CTD PMID:27665778 NCBI chr 4:119,275,724...119,279,673
Ensembl chr 4:119,275,727...119,279,617 		JBrowse link
G Qpct glutaminyl-peptide cyclotransferase (glutaminyl cyclase) increases expression ISO Gemfibrozil results in increased expression of QPCT mRNA CTD PMID:27665778 NCBI chr17:79,359,335...79,397,807
Ensembl chr17:79,359,335...79,397,807 		JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) multiple interactions EXP [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A8 mRNA CTD PMID:30853469 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342 		JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) multiple interactions EXP [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A9 mRNA CTD PMID:30853469 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028 		JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 increases expression
increases activity		 EXP
ISO		 Gemfibrozil results in increased expression of SCD1 mRNA
Gemfibrozil results in increased activity of SCD protein
Gemfibrozil results in increased expression of SCD mRNA		 CTD PMID:7606338 PMID:8790349 PMID:27665778 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 decreases secretion
increases activity
decreases expression		 ISO Gemfibrozil results in decreased secretion of SERPINE1 protein
Gemfibrozil results in increased activity of SERPINE1 protein
Gemfibrozil results in decreased expression of SERPINE1 mRNA		 CTD PMID:9678787 PMID:10364093 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 increases expression ISO Gemfibrozil results in increased expression of SLC22A5 mRNA CTD PMID:27665778 NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486 		JBrowse link
G Slc26a5 solute carrier family 26, member 5 decreases expression ISO Gemfibrozil results in decreased expression of SLC26A5 mRNA CTD PMID:20006695 NCBI chr 5:22,013,999...22,070,602
Ensembl chr 5:22,015,653...22,070,602 		JBrowse link
G Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 affects expression ISO Gemfibrozil affects the expression of SLC27A2 mRNA CTD PMID:27665778 NCBI chr 2:126,394,944...126,430,163
Ensembl chr 2:126,394,327...126,430,163 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions
increases expression		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]; KLF4 mRNA affects the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; Wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; Wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]
Gemfibrozil results in increased expression of SOCS3 mRNA; Gemfibrozil results in increased expression of SOCS3 protein		 CTD PMID:22685291 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873 		JBrowse link
G Stmn1 stathmin 1 affects expression ISO Gemfibrozil affects the expression of STMN1 mRNA CTD PMID:12011481 NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP
ISO		 Gemfibrozil inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Gemfibrozil results in decreased expression of TNF protein		 CTD PMID:15968640 PMID:25051504 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases expression ISO Gemfibrozil results in increased expression of UGT1A1 mRNA CTD PMID:15771232 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO Gemfibrozil results in decreased expression of VCAM1 protein CTD PMID:25051504 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vnn1 vanin 1 increases expression ISO Gemfibrozil results in increased expression of VNN1 mRNA CTD PMID:27665778 NCBI chr10:23,770,586...23,781,242
Ensembl chr10:23,770,586...23,781,241 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        pharmaceutical 21187
          drug 21159
            antilipemic drug 9551
              gemfibrozil 92
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      monocarboxylic acid 18952
                                        fatty acid 17131
                                          saturated fatty acid 16833
                                            straight-chain saturated fatty acid 16259
                                              valeric acid 14821
                                                gemfibrozil 92
paths to the root