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ONTOLOGY REPORT - ANNOTATIONS


Term:gemfibrozil
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Accession:CHEBI:5296 term browser browse the term
Definition:An aromatic ether that has formula C15H22O3.
Synonyms:exact_synonym: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
 related_synonym: 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure;   2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure;   2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid;   Formula=C15H22O3;   Gemfibrozilo;   InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17);   InChIKey=HEMJJKBWTPKOJG-UHFFFAOYSA-N;   Lopid;   SMILES=Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1;   gemfibrozilum
 xref: Beilstein:1881200 "Beilstein";   CAS:25812-30-0 "ChemIDplus";   CAS:25812-30-0 "KEGG DRUG";   DrugBank:DB01241;   Drug_Central:1285 "DrugCentral";   KEGG:D00334;   LINCS:LSM-2227
 xref_mesh: MESH:D015248
 xref: Patent:DE1925423;   Patent:US3674836;   Patent:US4126637;   Wikipedia:Gemfibrozil


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gemfibrozil term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:6480464
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Acaa2 acetyl-CoA acyltransferase 2 JBrowse link 18 70,733,872 70,762,395 RGD:6480464
G Acadvl acyl-CoA dehydrogenase, very long chain JBrowse link 10 56,619,321 56,624,468 RGD:6480464
G Acot1 acyl-CoA thioesterase 1 JBrowse link 6 107,485,088 107,493,082 RGD:6480464
G Acot2 acyl-CoA thioesterase 2 JBrowse link 6 107,460,596 107,468,324 RGD:6480464
G Acot4 acyl-CoA thioesterase 4 JBrowse link 6 107,517,668 107,522,952 RGD:6480464
G Acox1 acyl-CoA oxidase 1 JBrowse link 10 104,724,534 104,748,003 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Akr1b10 aldo-keto reductase family 1 member B10 JBrowse link 4 61,813,265 61,830,371 RGD:6480464
G Akr7a3 aldo-keto reductase family 7 member A3 JBrowse link 5 157,801,120 157,813,756 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Angptl4 angiopoietin-like 4 JBrowse link 7 18,627,814 18,634,043 RGD:6480464
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:6480464
G Apob apolipoprotein B JBrowse link 6 33,176,826 33,216,381 RGD:6480464
G Apoc2 apolipoprotein C2 JBrowse link 1 80,589,023 80,593,991 RGD:6480464
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:6480464
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Ces2h carboxylesterase 2H JBrowse link 19 37,052,555 37,067,176 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Colq collagen like tail subunit of asymmetric acetylcholinesterase JBrowse link 16 7,626,380 7,681,621 RGD:6480464
G Cpt1a carnitine palmitoyltransferase 1A JBrowse link 1 218,568,157 218,629,679 RGD:6480464
G Cpt1b carnitine palmitoyltransferase 1B JBrowse link 7 130,395,211 130,404,731 RGD:6480464
G Cpt2 carnitine palmitoyltransferase 2 JBrowse link 5 127,505,646 127,523,016 RGD:6480464
G Crat carnitine O-acetyltransferase JBrowse link 3 8,967,984 8,981,959 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 JBrowse link 1 257,676,172 258,004,428 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:6480464
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 JBrowse link 5 134,492,734 134,507,158 RGD:6480464
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 JBrowse link 5 134,196,910 134,207,888 RGD:6480464
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 JBrowse link 5 134,468,666 134,484,851 RGD:6480464
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 5 19,358,734 19,368,431 RGD:6480464
G Dact2 dishevelled-binding antagonist of beta-catenin 2 JBrowse link 1 56,159,435 56,169,443 RGD:6480464
G Decr1 2,4-dienoyl-CoA reductase 1 JBrowse link 5 29,573,893 29,601,731 RGD:6480464
G Decr2 2,4-dienoyl-CoA reductase 2 JBrowse link 10 15,451,850 15,460,227 RGD:6480464
G Ech1 enoyl-CoA hydratase 1 JBrowse link 1 87,009,798 87,015,996 RGD:6480464
G Eci1 enoyl-CoA delta isomerase 1 JBrowse link 10 13,797,573 13,810,918 RGD:6480464
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase JBrowse link 11 82,945,104 82,978,364 RGD:6480464
G Elovl6 ELOVL fatty acid elongase 6 JBrowse link 2 234,187,490 234,296,124 RGD:6480464
G Ephx2 epoxide hydrolase 2 JBrowse link 15 42,757,241 42,794,211 RGD:6480464
G Fads1 fatty acid desaturase 1 JBrowse link 1 226,234,034 226,249,118 RGD:6480464
G Fads2 fatty acid desaturase 2 JBrowse link 1 225,906,582 226,152,568 RGD:6480464
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 JBrowse link 2 200,452,623 200,480,785 RGD:6480464
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 JBrowse link 18 44,810,462 44,897,677 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:6480464
G Lcn2 lipocalin 2 JBrowse link 3 11,414,189 11,417,534 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:6480464
G Mgll monoglyceride lipase JBrowse link 4 120,671,436 120,773,458 RGD:6480464
G Mir133b microRNA 133b JBrowse link 9 26,795,649 26,795,732 RGD:6480464
G Mir206 microRNA 206 JBrowse link 9 26,791,764 26,791,847 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Nceh1 neutral cholesterol ester hydrolase 1 JBrowse link 2 112,868,834 112,932,622 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 JBrowse link 1 100,554,577 100,559,896 RGD:6480464
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 JBrowse link 3 80,004,130 80,014,197 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Pdk4 pyruvate dehydrogenase kinase 4 JBrowse link 4 30,546,772 30,556,774 RGD:6480464
G Pex11a peroxisomal biogenesis factor 11 alpha JBrowse link 1 141,474,189 141,481,270 RGD:6480464
G Plin2 perilipin 2 JBrowse link 5 104,984,413 105,010,863 RGD:6480464
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Ppard peroxisome proliferator-activated receptor delta JBrowse link 20 7,818,289 7,883,482 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ppcs phosphopantothenoylcysteine synthetase JBrowse link 5 138,466,298 138,470,108 RGD:6480464
G Qpct glutaminyl-peptide cyclotransferase JBrowse link 6 1,657,110 1,689,575 RGD:6480464
G S100a8 S100 calcium binding protein A8 JBrowse link 2 190,073,239 190,074,333 RGD:6480464
G S100a9 S100 calcium binding protein A9 JBrowse link 2 190,097,436 190,100,209 RGD:6480464
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Slc22a5 solute carrier family 22 member 5 JBrowse link 10 39,201,101 39,228,090 RGD:6480464
G Slc26a5 solute carrier family 26 member 5 JBrowse link 4 9,795,811 9,860,904 RGD:6480464
G Slc27a2 solute carrier family 27 member 2 JBrowse link 3 119,014,620 119,052,531 RGD:6480464
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6480464
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464
G Vnn1 vanin 1 JBrowse link 1 22,614,832 22,625,134 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      application 19225
        pharmaceutical 19089
          drug 19089
            antilipemic drug 6370
              gemfibrozil 93
Path 2
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  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        monocarboxylic acid 17254
                                          fatty acid 15818
                                            saturated fatty acid 15785
                                              straight-chain saturated fatty acid 15181
                                                valeric acid 14347
                                                  gemfibrozil 93
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.