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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gemfibrozil
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Accession:CHEBI:5296 term browser browse the term
Definition:An aromatic ether that has formula C15H22O3.
Synonyms:exact_synonym: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
 related_synonym: 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure;   2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure;   2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid;   Formula=C15H22O3;   Gemfibrozilo;   InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17);   InChIKey=HEMJJKBWTPKOJG-UHFFFAOYSA-N;   Lopid;   SMILES=Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1;   gemfibrozilum
 xref: Beilstein:1881200;   CAS:25812-30-0;   DrugBank:DB01241;   Drug_Central:1285;   KEGG:D00334;   LINCS:LSM-2227
 xref_mesh: MESH:D015248
 xref: Patent:DE1925423;   Patent:US3674836;   Patent:US4126637;   Wikipedia:Gemfibrozil



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gemfibrozil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Gemfibrozil results in increased expression of ABCA1 mRNA; Gemfibrozil results in increased expression of ABCA1 protein CTD PMID:19201410 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Gemfibrozil inhibits the reaction [[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin] CTD PMID:22162766 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 affects expression EXP Gemfibrozil affects the expression of ACAA2 mRNA CTD PMID:12011481 PMID:27665778 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain affects expression EXP Gemfibrozil affects the expression of ACADVL mRNA CTD PMID:27665778 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression ISO Gemfibrozil results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression EXP Gemfibrozil results in increased expression of ACOT1 mRNA CTD PMID:27665778 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP Gemfibrozil results in increased expression of ACOT2 mRNA CTD PMID:27665778 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression EXP Gemfibrozil results in increased expression of ACOT4 mRNA CTD PMID:27665778 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP Gemfibrozil results in increased expression of ACOX1 mRNA CTD PMID:18619722 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression EXP Gemfibrozil results in increased expression of AHR mRNA CTD PMID:12011481 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases activity ISO Gemfibrozil results in decreased activity of AKR1B10 protein mutant form CTD PMID:18325492 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 affects expression EXP Gemfibrozil affects the expression of AKR7A3 mRNA CTD PMID:12011481 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
affects localization
ISO Gemfibrozil results in increased phosphorylation of AKT1 protein
Gemfibrozil affects the localization of AKT1 protein
CTD PMID:22685291 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression EXP Gemfibrozil results in increased expression of ANGPTL4 mRNA CTD PMID:27665778 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Apoa1 apolipoprotein A1 increases expression
multiple interactions
ISO Gemfibrozil results in increased expression of APOA1 protein
Gemfibrozil promotes the reaction [APOA1 protein results in increased secretion of Lipids]
CTD PMID:11701466 PMID:19201410 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apob apolipoprotein B decreases expression ISO
EXP
Gemfibrozil results in decreased expression of APOB protein CTD PMID:9006809 PMID:11701466 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoc2 apolipoprotein C2 decreases expression
multiple interactions
EXP Gemfibrozil results in decreased expression of APOC2 protein
[Gemfibrozil results in decreased expression of APOC2 protein] which results in decreased abundance of Triglycerides
CTD PMID:8847480 NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476
JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP Gemfibrozil results in decreased expression of APOC3 mRNA; Gemfibrozil results in decreased expression of APOC3 protein CTD PMID:8847480 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
JBrowse link
G Apoe apolipoprotein E increases expression EXP Gemfibrozil results in increased expression of APOE protein CTD PMID:9006809 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Cat catalase increases activity ISO
EXP
Gemfibrozil results in increased activity of CAT protein CTD PMID:20953357 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Gemfibrozil results in decreased expression of CCL2 mRNA; Gemfibrozil results in decreased expression of CCL2 protein CTD PMID:25051504 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression EXP Gemfibrozil results in decreased expression of CCL5 protein CTD PMID:25051504 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased activity of CEBPB protein] CTD PMID:12244038 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Gemfibrozil results in increased expression of CES2 mRNA CTD PMID:12011481 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO Gemfibrozil results in decreased activity of CFTR protein CTD PMID:15289377 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Colq collagen like tail subunit of asymmetric acetylcholinesterase increases expression EXP Gemfibrozil results in increased expression of COLQ mRNA CTD PMID:27665778 NCBI chr16:6,731,850...6,824,973
Ensembl chr16:6,731,858...6,787,107
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Gemfibrozil results in increased expression of CPT1A mRNA CTD PMID:27665778 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression EXP Gemfibrozil results in increased expression of CPT1B mRNA CTD PMID:12011481 PMID:32741897 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression EXP Gemfibrozil results in increased expression of CPT2 mRNA CTD PMID:27665778 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Crat carnitine O-acetyltransferase increases expression EXP Gemfibrozil results in increased expression of CRAT mRNA CTD PMID:27665778 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Gemfibrozil results in decreased expression of CXCL10 protein CTD PMID:25051504 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO [Gemfibrozil results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine CTD PMID:26599973 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Gemfibrozil results in decreased expression of CYP2C11 protein CTD PMID:9209713 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions
increases expression
decreases expression
decreases activity
ISO [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 protein; [Gemfibrozil results in decreased activity of CYP2C8 protein] which affects the chemical synthesis of Aconitine metabolite; [Gemfibrozil results in decreased activity of CYP2C8 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine; Gemfibrozil inhibits the reaction [CYP2C8 protein affects the metabolism of pioglitazone]
Gemfibrozil results in increased expression of CYP2C8 mRNA
Gemfibrozil results in decreased expression of CYP2C8 protein
Gemfibrozil metabolite results in decreased activity of CYP2C8 protein; Gemfibrozil results in decreased activity of CYP2C8 protein
CTD PMID:15771232 PMID:15900286 PMID:16042675 PMID:21277363 PMID:29960002
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 affects expression ISO Gemfibrozil affects the expression of CYP2J2 protein CTD PMID:29960002 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
increases expression
ISO Gemfibrozil results in increased activity of CYP3A4 protein
Gemfibrozil results in increased expression of CYP3A4 mRNA
CTD PMID:15771232 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP Gemfibrozil results in increased expression of CYP4A1 mRNA CTD PMID:27665778 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 increases expression EXP Gemfibrozil results in increased expression of CYP4A2 mRNA CTD PMID:10787435 NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP Gemfibrozil results in increased expression of CYP4A3 mRNA CTD PMID:27665778 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Gemfibrozil results in decreased expression of CYP7A1 mRNA CTD PMID:14685799 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Dact2 dishevelled-binding antagonist of beta-catenin 2 increases expression EXP Gemfibrozil results in increased expression of DACT2 mRNA CTD PMID:27665778 NCBI chr 1:55,181,023...55,191,026
Ensembl chr 1:55,181,024...55,191,096
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 increases expression EXP Gemfibrozil results in increased expression of DECR1 mRNA CTD PMID:27665778 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 increases expression EXP Gemfibrozil results in increased expression of DECR2 mRNA CTD PMID:27665778 NCBI chr10:15,104,907...15,113,281 JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Gemfibrozil results in increased expression of ECH1 mRNA CTD PMID:27665778 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 affects expression
increases expression
EXP Gemfibrozil affects the expression of ECI1 mRNA
Gemfibrozil results in increased expression of ECI1 mRNA
CTD PMID:12011481 PMID:27665778 NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression EXP Gemfibrozil results in increased expression of EHHADH mRNA CTD PMID:27665778 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression EXP Gemfibrozil results in increased expression of ELOVL6 mRNA CTD PMID:27665778 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
JBrowse link
G Ephx2 epoxide hydrolase 2 affects expression ISO Gemfibrozil affects the expression of EPHX2 protein CTD PMID:29960002 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Fads1 fatty acid desaturase 1 increases activity EXP Gemfibrozil results in increased activity of FADS1 protein CTD PMID:7606338 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Fads2 fatty acid desaturase 2 increases activity EXP Gemfibrozil results in increased activity of FADS2 protein CTD PMID:7606338 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Gata3 GATA binding protein 3 decreases expression EXP Gemfibrozil results in decreased expression of GATA3 mRNA CTD PMID:20006695 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of GPT protein CTD PMID:30853469 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 affects expression EXP Gemfibrozil affects the expression of HMGCS2 mRNA CTD PMID:27665778 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression EXP Gemfibrozil results in increased expression of HSD17B4 mRNA; Gemfibrozil results in increased expression of HSD17B4 protein CTD PMID:9209713 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Ifng interferon gamma multiple interactions ISO Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased activity of PPARA protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased activity of CEBPB protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:12244038 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 affects expression
decreases expression
EXP Gemfibrozil affects the expression of IL10 protein
Gemfibrozil results in decreased expression of IL10 protein
CTD PMID:25051504 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Gemfibrozil inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15968640 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects expression
ISO
EXP
Gemfibrozil inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Gemfibrozil affects the expression of IL1B mRNA
Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased activity of PPARA protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased activity of CEBPB protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD PMID:12244038 PMID:15968640 PMID:25051504 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression EXP Gemfibrozil results in decreased expression of IL6 protein CTD PMID:25051504 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
affects response to substance
increases phosphorylation
affects localization
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil affects the localization of KLF4 protein]; KLF4 mRNA affects the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]
KLF4 mRNA affects the susceptibility to Gemfibrozil
Gemfibrozil results in increased phosphorylation of KLF4 protein
CTD PMID:22685291 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of LCN2 mRNA CTD PMID:30853469 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lep leptin decreases expression
increases expression
EXP Gemfibrozil results in decreased expression of LEP protein
Gemfibrozil results in increased expression of LEP protein
CTD PMID:25051504 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lpl lipoprotein lipase increases activity
multiple interactions
ISO
EXP
Gemfibrozil results in increased activity of LPL protein
[Gemfibrozil results in increased activity of LPL protein] which results in decreased abundance of Triglycerides
CTD PMID:8593127 PMID:9006809 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Mgll monoglyceride lipase increases expression EXP Gemfibrozil results in increased expression of MGLL mRNA CTD PMID:27665778 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR133B mRNA CTD PMID:30853469 NCBI chr 9:23,098,134...23,098,217
Ensembl chr 9:23,098,134...23,098,217
JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR206 mRNA CTD PMID:30853469 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases methylation ISO Gemfibrozil results in decreased methylation of MYC promoter CTD PMID:11857776 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 increases expression EXP Gemfibrozil results in increased expression of NCEH1 mRNA CTD PMID:27665778 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:12244038 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 increases expression ISO Gemfibrozil results in increased expression of NR1H2 mRNA CTD PMID:19201410 NCBI chr 1:95,041,967...95,047,377
Ensembl chr 1:95,041,967...95,047,377
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression
affects response to substance
multiple interactions
EXP
ISO
Gemfibrozil results in increased expression of NR1H3 protein
Gemfibrozil results in increased expression of NR1H3 mRNA
NR1H3 protein affects the susceptibility to Gemfibrozil
NR1H3 protein affects the reaction [Gemfibrozil results in increased expression of PPARA mRNA]
CTD PMID:15998575 PMID:19201410 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization ISO Gemfibrozil affects the localization of NR1I3 protein CTD PMID:17962186 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP Gemfibrozil results in increased expression of PCNA protein CTD PMID:9007043 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP Gemfibrozil results in decreased expression of PDK4 mRNA CTD PMID:27665778 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha increases expression EXP Gemfibrozil results in increased expression of PEX11A mRNA CTD PMID:27665778 NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172
JBrowse link
G Plin2 perilipin 2 increases expression EXP Gemfibrozil results in increased expression of PLIN2 mRNA CTD PMID:27665778 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Por cytochrome p450 oxidoreductase increases activity EXP Gemfibrozil results in increased activity of POR protein CTD PMID:7606338 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
affects response to substance
multiple interactions
increases activity
EXP
ISO
Gemfibrozil results in increased expression of PPARA protein
PPARA protein affects the susceptibility to Gemfibrozil
Gemfibrozil binds to and results in increased activity of PPARA protein
Gemfibrozil binds to and results in increased activity of PPARA protein; PPARA gene mutant form inhibits the reaction [Gemfibrozil results in increased abundance of tauromuricholic acid]
Gemfibrozil results in increased activity of PPARA protein
Gemfibrozil results in increased expression of PPARA mRNA
Gemfibrozil binds to and results in increased activity of PPARA protein; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased activity of PPARA protein]; NR1H3 protein affects the reaction [Gemfibrozil results in increased expression of PPARA mRNA]
CTD PMID:12244038 PMID:15968640 PMID:15998575 PMID:19201410 PMID:20953357 More... NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO Gemfibrozil results in increased expression of PPARD mRNA CTD PMID:19201410 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Gemfibrozil results in increased expression of PPARG mRNA CTD PMID:19201410 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase increases expression EXP Gemfibrozil results in increased expression of PPCS mRNA CTD PMID:27665778 NCBI chr 5:133,023,077...133,026,899
Ensembl chr 5:133,023,121...133,026,933
JBrowse link
G Qpct glutaminyl-peptide cyclotransferase increases expression EXP Gemfibrozil results in increased expression of QPCT mRNA CTD PMID:27665778 NCBI chr 6:15,964,656...15,996,925
Ensembl chr 6:15,964,657...15,996,711
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A8 mRNA CTD PMID:30853469 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A9 mRNA CTD PMID:30853469 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Scd stearoyl-CoA desaturase increases expression
increases activity
ISO
EXP
Gemfibrozil results in increased expression of SCD1 mRNA
Gemfibrozil results in increased expression of SCD mRNA
Gemfibrozil results in increased activity of SCD protein
CTD PMID:7606338 PMID:8790349 PMID:27665778 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Serpine1 serpin family E member 1 decreases secretion
decreases expression
increases activity
ISO Gemfibrozil results in decreased secretion of SERPINE1 protein
Gemfibrozil results in decreased expression of SERPINE1 mRNA
Gemfibrozil results in increased activity of SERPINE1 protein
CTD PMID:9678787 PMID:10364093 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression EXP Gemfibrozil results in increased expression of SLC22A5 mRNA CTD PMID:27665778 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc26a5 solute carrier family 26 member 5 decreases expression EXP Gemfibrozil results in decreased expression of SLC26A5 mRNA CTD PMID:20006695 NCBI chr 4:13,210,260...13,249,289
Ensembl chr 4:13,210,260...13,249,289
JBrowse link
G Slc27a2 solute carrier family 27 member 2 affects expression EXP Gemfibrozil affects the expression of SLC27A2 mRNA CTD PMID:27665778 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]; KLF4 mRNA affects the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]
Gemfibrozil results in increased expression of SOCS3 mRNA; Gemfibrozil results in increased expression of SOCS3 protein
CTD PMID:22685291 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Stmn1 stathmin 1 affects expression EXP Gemfibrozil affects the expression of STMN1 mRNA CTD PMID:12011481 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO Gemfibrozil results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Gemfibrozil inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Gemfibrozil results in decreased expression of TNF protein
CTD PMID:15968640 PMID:25051504 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Gemfibrozil results in increased expression of UGT1A1 mRNA CTD PMID:15771232 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP Gemfibrozil results in decreased expression of VCAM1 protein CTD PMID:25051504 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vnn1 vanin 1 increases expression EXP Gemfibrozil results in increased expression of VNN1 mRNA CTD PMID:27665778 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      application 19467
        pharmaceutical 19315
          drug 19315
            antilipemic drug 6452
              gemfibrozil 96
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      carboxylic acid 18361
                                        monocarboxylic acid 17631
                                          fatty acid 16010
                                            saturated fatty acid 15984
                                              straight-chain saturated fatty acid 15441
                                                valeric acid 14349
                                                  gemfibrozil 96
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