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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gemfibrozil
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Accession:CHEBI:5296 term browser browse the term
Definition:An aromatic ether that has formula C15H22O3.
Synonyms:exact_synonym: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
 related_synonym: 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure;   2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure;   2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid;   Formula=C15H22O3;   Gemfibrozilo;   InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17);   InChIKey=HEMJJKBWTPKOJG-UHFFFAOYSA-N;   Lopid;   SMILES=Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1;   gemfibrozilum
 xref: Beilstein:1881200;   CAS:25812-30-0;   DrugBank:DB01241;   Drug_Central:1285;   KEGG:D00334;   LINCS:LSM-2227
 xref_mesh: MESH:D015248
 xref: Patent:DE1925423;   Patent:US3674836;   Patent:US4126637;   Wikipedia:Gemfibrozil


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gemfibrozil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Gemfibrozil results in increased expression of ABCA1 mRNA; Gemfibrozil results in increased expression of ABCA1 protein CTD PMID:19201410 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Gemfibrozil inhibits the reaction [[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin] CTD PMID:22162766 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 affects expression EXP Gemfibrozil affects the expression of ACAA2 mRNA CTD PMID:12011481, PMID:27665778 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain affects expression EXP Gemfibrozil affects the expression of ACADVL mRNA CTD PMID:27665778 NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression EXP Gemfibrozil results in increased expression of ACOT1 mRNA CTD PMID:27665778 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP Gemfibrozil results in increased expression of ACOT2 mRNA CTD PMID:27665778 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression EXP Gemfibrozil results in increased expression of ACOT4 mRNA CTD PMID:27665778 NCBI chr 6:107,517,668...107,522,952
Ensembl chr 6:107,517,668...107,522,952
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP Gemfibrozil results in increased expression of ACOX1 mRNA CTD PMID:18619722 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression EXP Gemfibrozil results in increased expression of AHR mRNA CTD PMID:12011481 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases activity ISO Gemfibrozil results in decreased activity of AKR1B10 protein mutant form CTD PMID:18325492 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 affects expression EXP Gemfibrozil affects the expression of AKR7A3 mRNA CTD PMID:12011481 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
affects localization
ISO Gemfibrozil results in increased phosphorylation of AKT1 protein
Gemfibrozil affects the localization of AKT1 protein
CTD PMID:22685291 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression EXP Gemfibrozil results in increased expression of ANGPTL4 mRNA CTD PMID:27665778 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Apoa1 apolipoprotein A1 increases expression
multiple interactions
ISO Gemfibrozil results in increased expression of APOA1 protein
Gemfibrozil promotes the reaction [APOA1 protein results in increased secretion of Lipids]
CTD PMID:11701466, PMID:19201410 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apob apolipoprotein B decreases expression ISO
EXP
Gemfibrozil results in decreased expression of APOB protein CTD PMID:9006809, PMID:11701466 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Apoc2 apolipoprotein C2 decreases expression
multiple interactions
EXP Gemfibrozil results in decreased expression of APOC2 protein
[Gemfibrozil results in decreased expression of APOC2 protein] which results in decreased abundance of Triglycerides
CTD PMID:8847480 NCBI chr 1:80,589,023...80,593,991
Ensembl chr 1:80,589,023...80,594,136
JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP Gemfibrozil results in decreased expression of APOC3 mRNA; Gemfibrozil results in decreased expression of APOC3 protein CTD PMID:8847480 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Apoe apolipoprotein E increases expression EXP Gemfibrozil results in increased expression of APOE protein CTD PMID:9006809 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Cat catalase increases activity ISO
EXP
Gemfibrozil results in increased activity of CAT protein CTD PMID:20953357 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Gemfibrozil results in decreased expression of CCL2 mRNA; Gemfibrozil results in decreased expression of CCL2 protein CTD PMID:25051504 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression EXP Gemfibrozil results in decreased expression of CCL5 protein CTD PMID:25051504 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased activity of CEBPB protein] CTD PMID:12244038 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Gemfibrozil results in increased expression of CES2 mRNA CTD PMID:12011481 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO Gemfibrozil results in decreased activity of CFTR protein CTD PMID:15289377 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Colq collagen like tail subunit of asymmetric acetylcholinesterase increases expression EXP Gemfibrozil results in increased expression of COLQ mRNA CTD PMID:27665778 NCBI chr16:7,626,380...7,681,621
Ensembl chr16:7,627,603...7,681,576
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Gemfibrozil results in increased expression of CPT1A mRNA CTD PMID:27665778 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression EXP Gemfibrozil results in increased expression of CPT1B mRNA CTD PMID:12011481 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression EXP Gemfibrozil results in increased expression of CPT2 mRNA CTD PMID:27665778 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Crat carnitine O-acetyltransferase increases expression EXP Gemfibrozil results in increased expression of CRAT mRNA CTD PMID:27665778 NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Gemfibrozil results in decreased expression of CXCL10 protein CTD PMID:25051504 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO [Gemfibrozil results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine CTD PMID:26599973 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Gemfibrozil results in decreased expression of CYP2C11 protein CTD PMID:9209713 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions
increases expression
decreases expression
decreases activity
ISO [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 protein; [Gemfibrozil results in decreased activity of CYP2C8 protein] which affects the chemical synthesis of Aconitine metabolite; [Gemfibrozil results in decreased activity of CYP2C8 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine; Gemfibrozil inhibits the reaction [CYP2C8 protein affects the metabolism of pioglitazone]
Gemfibrozil results in increased expression of CYP2C8 mRNA
Gemfibrozil results in decreased expression of CYP2C8 protein
Gemfibrozil metabolite results in decreased activity of CYP2C8 protein; Gemfibrozil results in decreased activity of CYP2C8 protein
CTD PMID:15771232, PMID:15900286, PMID:16042675, PMID:21277363, PMID:29960002 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 affects expression ISO Gemfibrozil affects the expression of CYP2J2 protein CTD PMID:29960002 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP Gemfibrozil results in increased expression of CYP4A1 mRNA CTD PMID:27665778 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 increases expression EXP Gemfibrozil results in increased expression of CYP4A2 mRNA CTD PMID:10787435 NCBI chr 5:134,196,910...134,207,888
Ensembl chr 5:134,196,912...134,207,863
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP Gemfibrozil results in increased expression of CYP4A3 mRNA CTD PMID:27665778 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Gemfibrozil results in decreased expression of CYP7A1 mRNA CTD PMID:14685799 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Dact2 dishevelled-binding antagonist of beta-catenin 2 increases expression EXP Gemfibrozil results in increased expression of DACT2 mRNA CTD PMID:27665778 NCBI chr 1:56,159,435...56,169,443
Ensembl chr 1:56,159,426...56,168,351
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 increases expression EXP Gemfibrozil results in increased expression of DECR1 mRNA CTD PMID:27665778 NCBI chr 5:29,573,893...29,601,731
Ensembl chr 5:29,573,898...29,601,748
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 increases expression EXP Gemfibrozil results in increased expression of DECR2 mRNA CTD PMID:27665778 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Gemfibrozil results in increased expression of ECH1 mRNA CTD PMID:27665778 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 affects expression
increases expression
EXP Gemfibrozil affects the expression of ECI1 mRNA
Gemfibrozil results in increased expression of ECI1 mRNA
CTD PMID:12011481, PMID:27665778 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression EXP Gemfibrozil results in increased expression of EHHADH mRNA CTD PMID:27665778 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression EXP Gemfibrozil results in increased expression of ELOVL6 mRNA CTD PMID:27665778 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145
JBrowse link
G Ephx2 epoxide hydrolase 2 affects expression ISO Gemfibrozil affects the expression of EPHX2 protein CTD PMID:29960002 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Fads1 fatty acid desaturase 1 increases activity EXP Gemfibrozil results in increased activity of FADS1 protein CTD PMID:7606338 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fads2 fatty acid desaturase 2 increases activity EXP Gemfibrozil results in increased activity of FADS2 protein CTD PMID:7606338 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
JBrowse link
G Gata3 GATA binding protein 3 decreases expression EXP Gemfibrozil results in decreased expression of GATA3 mRNA CTD PMID:20006695 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of GPT protein CTD PMID:30853469 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 affects expression EXP Gemfibrozil affects the expression of HMGCS2 mRNA CTD PMID:27665778 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression EXP Gemfibrozil results in increased expression of HSD17B4 mRNA; Gemfibrozil results in increased expression of HSD17B4 protein CTD PMID:9209713 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Ifng interferon gamma multiple interactions ISO Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased activity of PPARA protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased activity of CEBPB protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:12244038 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 affects expression
decreases expression
EXP Gemfibrozil affects the expression of IL10 protein
Gemfibrozil results in decreased expression of IL10 protein
CTD PMID:25051504 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Gemfibrozil inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15968640 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects expression
ISO
EXP
Gemfibrozil inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Gemfibrozil affects the expression of IL1B mRNA
Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased activity of PPARA protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased activity of CEBPB protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD PMID:12244038, PMID:15968640, PMID:25051504 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression EXP Gemfibrozil results in decreased expression of IL6 protein CTD PMID:25051504 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
affects response to substance
increases phosphorylation
affects localization
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil affects the localization of KLF4 protein]; KLF4 mRNA affects the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]
KLF4 mRNA affects the susceptibility to Gemfibrozil
Gemfibrozil results in increased phosphorylation of KLF4 protein
CTD PMID:22685291 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of LCN2 mRNA CTD PMID:30853469 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Lep leptin decreases expression
increases expression
EXP Gemfibrozil results in decreased expression of LEP protein
Gemfibrozil results in increased expression of LEP protein
CTD PMID:25051504 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lpl lipoprotein lipase increases activity
multiple interactions
ISO
EXP
Gemfibrozil results in increased activity of LPL protein
[Gemfibrozil results in increased activity of LPL protein] which results in decreased abundance of Triglycerides
CTD PMID:8593127, PMID:9006809 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mgll monoglyceride lipase increases expression EXP Gemfibrozil results in increased expression of MGLL mRNA CTD PMID:27665778 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR133B mRNA CTD PMID:30853469 NCBI chr 9:26,795,649...26,795,732
Ensembl chr 9:26,795,649...26,795,732
JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR206 mRNA CTD PMID:30853469 NCBI chr 9:26,791,764...26,791,847
Ensembl chr 9:26,791,764...26,791,847
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases methylation ISO Gemfibrozil results in decreased methylation of MYC promoter CTD PMID:11857776 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 increases expression EXP Gemfibrozil results in increased expression of NCEH1 mRNA CTD PMID:27665778 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:12244038 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 increases expression ISO Gemfibrozil results in increased expression of NR1H2 mRNA CTD PMID:19201410 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression
affects response to substance
multiple interactions
EXP
ISO
Gemfibrozil results in increased expression of NR1H3 protein
Gemfibrozil results in increased expression of NR1H3 mRNA
NR1H3 protein affects the susceptibility to Gemfibrozil
NR1H3 protein affects the reaction [Gemfibrozil results in increased expression of PPARA mRNA]
CTD PMID:15998575, PMID:19201410 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization ISO Gemfibrozil affects the localization of NR1I3 protein CTD PMID:17962186 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP Gemfibrozil results in increased expression of PCNA protein CTD PMID:9007043 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP Gemfibrozil results in decreased expression of PDK4 mRNA CTD PMID:27665778 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha increases expression EXP Gemfibrozil results in increased expression of PEX11A mRNA CTD PMID:27665778 NCBI chr 1:141,474,189...141,481,270
Ensembl chr 1:141,474,180...141,481,315
JBrowse link
G Plin2 perilipin 2 increases expression EXP Gemfibrozil results in increased expression of PLIN2 mRNA CTD PMID:27665778 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Por cytochrome p450 oxidoreductase increases activity EXP Gemfibrozil results in increased activity of POR protein CTD PMID:7606338 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
affects response to substance
multiple interactions
increases activity
EXP
ISO
Gemfibrozil results in increased expression of PPARA protein
PPARA protein affects the susceptibility to Gemfibrozil
Gemfibrozil binds to and results in increased activity of PPARA protein
Gemfibrozil binds to and results in increased activity of PPARA protein; PPARA gene mutant form inhibits the reaction [Gemfibrozil results in increased abundance of tauromuricholic acid]
Gemfibrozil results in increased activity of PPARA protein
Gemfibrozil results in increased expression of PPARA mRNA
Gemfibrozil binds to and results in increased activity of PPARA protein; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased activity of PPARA protein]; NR1H3 protein affects the reaction [Gemfibrozil results in increased expression of PPARA mRNA]
CTD PMID:12244038, PMID:15968640, PMID:15998575, PMID:19201410, PMID:20953357, PMID:24385052, PMID:27506419, PMID:28743512 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO Gemfibrozil results in increased expression of PPARD mRNA CTD PMID:19201410 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Gemfibrozil results in increased expression of PPARG mRNA CTD PMID:19201410 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase increases expression EXP Gemfibrozil results in increased expression of PPCS mRNA CTD PMID:27665778 NCBI chr 5:138,466,298...138,470,108
Ensembl chr 5:138,466,293...138,470,096
JBrowse link
G Qpct glutaminyl-peptide cyclotransferase increases expression EXP Gemfibrozil results in increased expression of QPCT mRNA CTD PMID:27665778 NCBI chr 6:1,657,110...1,689,575
Ensembl chr 6:1,657,331...1,689,559
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A8 mRNA CTD PMID:30853469 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A9 mRNA CTD PMID:30853469 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Scd stearoyl-CoA desaturase increases expression
increases activity
ISO
EXP
Gemfibrozil results in increased expression of SCD1 mRNA
Gemfibrozil results in increased expression of SCD mRNA
Gemfibrozil results in increased activity of SCD protein
CTD PMID:7606338, PMID:8790349, PMID:27665778 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpine1 serpin family E member 1 decreases secretion
decreases expression
increases activity
ISO Gemfibrozil results in decreased secretion of SERPINE1 protein
Gemfibrozil results in decreased expression of SERPINE1 mRNA
Gemfibrozil results in increased activity of SERPINE1 protein
CTD PMID:9678787, PMID:10364093 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression EXP Gemfibrozil results in increased expression of SLC22A5 mRNA CTD PMID:27665778 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc26a5 solute carrier family 26 member 5 decreases expression EXP Gemfibrozil results in decreased expression of SLC26A5 mRNA CTD PMID:20006695 NCBI chr 4:9,795,811...9,860,904
Ensembl chr 4:9,821,541...9,860,571
JBrowse link
G Slc27a2 solute carrier family 27 member 2 affects expression EXP Gemfibrozil affects the expression of SLC27A2 mRNA CTD PMID:27665778 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]; KLF4 mRNA affects the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]
Gemfibrozil results in increased expression of SOCS3 mRNA; Gemfibrozil results in increased expression of SOCS3 protein
CTD PMID:22685291 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Stmn1 stathmin 1 affects expression EXP Gemfibrozil affects the expression of STMN1 mRNA CTD PMID:12011481 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Gemfibrozil inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Gemfibrozil results in decreased expression of TNF protein
CTD PMID:15968640, PMID:25051504 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Gemfibrozil results in increased expression of UGT1A1 mRNA CTD PMID:15771232 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP Gemfibrozil results in decreased expression of VCAM1 protein CTD PMID:25051504 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vnn1 vanin 1 increases expression EXP Gemfibrozil results in increased expression of VNN1 mRNA CTD PMID:27665778 NCBI chr 1:22,614,832...22,625,134
Ensembl chr 1:22,614,783...22,625,204
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antilipemic drug 6409
              gemfibrozil 93
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            saturated fatty acid 15812
                                              straight-chain saturated fatty acid 15227
                                                valeric acid 14336
                                                  gemfibrozil 93
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.