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Accession:CHEBI:5280 term browser browse the term
Definition:A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.
Synonyms:exact_synonym: 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: 1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;   1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid;   AM 1155;   Formula=C19H22FN3O4;   InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26);   InChIKey=XUBOMFCQGDBHNK-UHFFFAOYSA-N;   SMILES=COc1c(N2CCNC(C)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1;   gatifloxacine;   gatifloxacino;   gatifloxacinum
 alt_id: CHEBI:101712
 xref: Beilstein:7445861 "Beilstein";   CAS:112811-59-3 "ChemIDplus";   CAS:112811-59-3 "DrugBank";   CAS:112811-59-3 "KEGG COMPOUND";   DrugBank:DB01044;   Drug_Central:1280 "DrugCentral";   Gmelin:2281206 "Gmelin";   KEGG:C07661;   KEGG:D08011;   LINCS:LSM-5139
 xref_mesh: MESH:C078049
 xref: PMID:10737746 "ChEMBL";   PMID:12190308 "ChEMBL";   PMID:12620077 "ChEMBL";   PMID:12873512 "ChEMBL";   PMID:12904069 "ChEMBL";   PMID:15125930 "ChEMBL";   PMID:15745831 "ChEMBL";   PMID:15911273 "ChEMBL";   PMID:16078842 "ChEMBL";   PMID:16337791 "ChEMBL";   PMID:16554151 "ChEMBL";   PMID:16759086 "ChEMBL";   PMID:17043111 "ChEMBL";   PMID:17043131 "ChEMBL";   PMID:17064062 "ChEMBL";   PMID:17116666 "ChEMBL";   PMID:17116668 "ChEMBL";   PMID:17157008 "ChEMBL";   PMID:17220425 "ChEMBL";   PMID:17261623 "ChEMBL";   PMID:17276057 "ChEMBL";   PMID:17296740 "ChEMBL";   PMID:17325221 "ChEMBL";   PMID:17387152 "ChEMBL";   PMID:17804222 "ChEMBL";   PMID:17933535 "ChEMBL";   PMID:17960928 "ChEMBL";   PMID:18078756 "ChEMBL";   PMID:18304818 "ChEMBL";   PMID:26963935 "Europe PMC";   PMID:7473575 "ChEMBL";   Patent:EP230295;   Patent:US4980470;   Reaxys:7445861 "Reaxys";   Wikipedia:Gatifloxacin

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gatifloxacin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gcg glucagon JBrowse link 3 48,442,635 48,451,650 RGD:6480464
G Gcgr glucagon receptor JBrowse link 10 109,707,863 109,716,253 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Pcsk1 proprotein convertase subtilisin/kexin type 1 JBrowse link 2 91,450,162 91,497,091 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19614
    role 19557
      biological role 19550
        antimicrobial agent 17062
          gatifloxacin 4
            (R)-gatifloxacin 0
            (S)-gatifloxacin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19614
    subatomic particle 19610
      composite particle 19610
        hadron 19610
          baryon 19610
            nucleon 19610
              atomic nucleus 19610
                atom 19610
                  main group element atom 19489
                    p-block element atom 19489
                      carbon group element atom 19362
                        carbon atom 19354
                          organic molecular entity 19354
                            organic group 18313
                              organic divalent group 18303
                                organodiyl group 18303
                                  carbonyl group 18188
                                    carbonyl compound 18188
                                      carboxylic acid 17853
                                        aromatic carboxylic acid 10067
                                          quinolinemonocarboxylic acid 89
                                            gatifloxacin 4
                                              (R)-gatifloxacin 0
                                              (S)-gatifloxacin 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.