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ONTOLOGY REPORT - ANNOTATIONS


Term:gatifloxacin
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Accession:CHEBI:5280 term browser browse the term
Definition:A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.
Synonyms:exact_synonym: 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: 1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;   1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid;   AM 1155;   Formula=C19H22FN3O4;   InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26);   InChIKey=XUBOMFCQGDBHNK-UHFFFAOYSA-N;   SMILES=COc1c(N2CCNC(C)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1;   gatifloxacine;   gatifloxacino;   gatifloxacinum
 alt_id: CHEBI:101712
 xref: Beilstein:7445861;   CAS:112811-59-3;   DrugBank:DB01044;   Drug_Central:1280;   Gmelin:2281206;   KEGG:C07661;   KEGG:D08011;   LINCS:LSM-5139
 xref_mesh: MESH:C078049
 xref: PMID:10737746;   PMID:12190308;   PMID:12620077;   PMID:12873512;   PMID:12904069;   PMID:15125930;   PMID:15745831;   PMID:15911273;   PMID:16078842;   PMID:16337791;   PMID:16554151;   PMID:16759086;   PMID:17043111;   PMID:17043131;   PMID:17064062;   PMID:17116666;   PMID:17116668;   PMID:17157008;   PMID:17220425;   PMID:17261623;   PMID:17276057;   PMID:17296740;   PMID:17325221;   PMID:17387152;   PMID:17804222;   PMID:17933535;   PMID:17960928;   PMID:18078756;   PMID:18304818;   PMID:26963935;   PMID:7473575;   Patent:EP230295;   Patent:US4980470;   Reaxys:7445861;   Wikipedia:Gatifloxacin


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gatifloxacin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gcg glucagon JBrowse link 3 48,442,635 48,451,650 RGD:6480464
G Gcgr glucagon receptor JBrowse link 10 109,707,863 109,716,253 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Pcsk1 proprotein convertase subtilisin/kexin type 1 JBrowse link 2 91,450,162 91,497,091 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      biological role 19737
        antimicrobial agent 17320
          gatifloxacin 4
            (R)-gatifloxacin 0
            (S)-gatifloxacin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    p-block element atom 19674
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18475
                              organic divalent group 18468
                                organodiyl group 18468
                                  carbonyl group 18366
                                    carbonyl compound 18366
                                      carboxylic acid 18034
                                        aromatic carboxylic acid 10892
                                          quinolinemonocarboxylic acid 93
                                            gatifloxacin 4
                                              (R)-gatifloxacin 0
                                              (S)-gatifloxacin 0
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