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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gatifloxacin
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Accession:CHEBI:5280 term browser browse the term
Definition:A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.
Synonyms:exact_synonym: 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: 1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;   1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid;   AM 1155;   Formula=C19H22FN3O4;   InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26);   InChIKey=XUBOMFCQGDBHNK-UHFFFAOYSA-N;   SMILES=COc1c(N2CCNC(C)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1;   gatifloxacine;   gatifloxacino;   gatifloxacinum
 alt_id: CHEBI:101712
 xref: Beilstein:7445861;   CAS:112811-59-3;   DrugBank:DB01044;   Drug_Central:1280;   Gmelin:2281206;   KEGG:C07661;   KEGG:D08011;   LINCS:LSM-5139
 xref_mesh: MESH:C078049
 xref: PMID:10737746;   PMID:12190308;   PMID:12620077;   PMID:12873512;   PMID:12904069;   PMID:15125930;   PMID:15745831;   PMID:15911273;   PMID:16078842;   PMID:16337791;   PMID:16554151;   PMID:16759086;   PMID:17043111;   PMID:17043131;   PMID:17064062;   PMID:17116666;   PMID:17116668;   PMID:17157008;   PMID:17220425;   PMID:17261623;   PMID:17276057;   PMID:17296740;   PMID:17325221;   PMID:17387152;   PMID:17804222;   PMID:17933535;   PMID:17960928;   PMID:18078756;   PMID:18304818;   PMID:26963935;   PMID:7473575;   Patent:EP230295;   Patent:US4980470;   Reaxys:7445861;   Wikipedia:Gatifloxacin


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gatifloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcg glucagon increases secretion
increases expression
multiple interactions		 ISO
EXP		 gatifloxacin results in increased secretion of GCG protein
gatifloxacin results in increased expression of GCG mRNA
Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein]
[gatifloxacin co-treated with GCG protein] affects the secretion of INS1 protein; GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA]; GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA]
gatifloxacin results in increased expression of GCG protein		 CTD PMID:23200776 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gcgr glucagon receptor multiple interactions
affects expression		 EXP GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA] CTD PMID:23200776 NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640 		JBrowse link
G Ins1 insulin 1 multiple interactions
affects secretion		 EXP [Gatifloxacin co-treated with GCG protein] affects the secretion of INS1 protein
Gatifloxacin affects the secretion of INS1 protein		 CTD PMID:23200776 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression		 EXP GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA] CTD PMID:23200776 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO [Gatifloxacin binds to and results in decreased activity of KCNH2 protein] which results in decreased export of Potassium; Gatifloxacin binds to and results in decreased activity of KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 increases expression ISO gatifloxacin results in increased expression of PCSK1 mRNA CTD PMID:23200776 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      biological role 19894
        antimicrobial agent 18062
          gatifloxacin 6
            (R)-gatifloxacin 0
            (S)-gatifloxacin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      carbon group element atom 19812
                        carbon atom 19807
                          organic molecular entity 19807
                            organic group 18971
                              organic divalent group 18952
                                organodiyl group 18952
                                  carbonyl group 18905
                                    carbonyl compound 18905
                                      carboxylic acid 18622
                                        aromatic carboxylic acid 12042
                                          quinolinemonocarboxylic acid 106
                                            gatifloxacin 6
                                              (R)-gatifloxacin 0
                                              (S)-gatifloxacin 0
paths to the root