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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:5280 term browser browse the term
Definition:A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.
Synonyms:exact_synonym: 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: 1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;   1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid;   AM 1155;   Formula=C19H22FN3O4;   InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26);   InChIKey=XUBOMFCQGDBHNK-UHFFFAOYSA-N;   SMILES=COc1c(N2CCNC(C)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1;   gatifloxacine;   gatifloxacino;   gatifloxacinum
 alt_id: CHEBI:101712
 xref: Beilstein:7445861;   CAS:112811-59-3;   DrugBank:DB01044;   Drug_Central:1280;   Gmelin:2281206;   KEGG:C07661;   KEGG:D08011;   LINCS:LSM-5139
 xref_mesh: MESH:C078049
 xref: PMID:10737746;   PMID:12190308;   PMID:12620077;   PMID:12873512;   PMID:12904069;   PMID:15125930;   PMID:15745831;   PMID:15911273;   PMID:16078842;   PMID:16337791;   PMID:16554151;   PMID:16759086;   PMID:17043111;   PMID:17043131;   PMID:17064062;   PMID:17116666;   PMID:17116668;   PMID:17157008;   PMID:17220425;   PMID:17261623;   PMID:17276057;   PMID:17296740;   PMID:17325221;   PMID:17387152;   PMID:17804222;   PMID:17933535;   PMID:17960928;   PMID:18078756;   PMID:18304818;   PMID:26963935;   PMID:7473575;   Patent:EP230295;   Patent:US4980470;   Reaxys:7445861;   Wikipedia:Gatifloxacin

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gatifloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcg glucagon increases secretion
increases expression
multiple interactions
gatifloxacin results in increased secretion of GCG protein
gatifloxacin results in increased expression of GCG mRNA
Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein]
[gatifloxacin co-treated with GCG protein] affects the secretion of INS1 protein; GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA]; GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA]
gatifloxacin results in increased expression of GCG protein
CTD PMID:23200776 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gcgr glucagon receptor multiple interactions
affects expression
EXP GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA] CTD PMID:23200776 NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression
EXP GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA] CTD PMID:23200776 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO [Gatifloxacin binds to and results in decreased activity of KCNH2 protein] which results in decreased export of Potassium; Gatifloxacin binds to and results in decreased activity of KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 increases expression ISO gatifloxacin results in increased expression of PCSK1 mRNA CTD PMID:23200776 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20057
    role 20023
      biological role 20010
        antimicrobial agent 17808
          gatifloxacin 5
            (R)-gatifloxacin 0
            (S)-gatifloxacin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19889
                        carbon atom 19894
                          organic molecular entity 19882
                            organic group 18982
                              organic divalent group 18968
                                organodiyl group 18968
                                  carbonyl group 18923
                                    carbonyl compound 18923
                                      carboxylic acid 18620
                                        aromatic carboxylic acid 11818
                                          quinolinemonocarboxylic acid 103
                                            gatifloxacin 5
                                              (R)-gatifloxacin 0
                                              (S)-gatifloxacin 0
paths to the root