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ONTOLOGY REPORT - ANNOTATIONS
Term:hycanthone
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Accession:CHEBI:52768 term browser browse the term
Definition:A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.
Synonyms:related_synonym: 1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)-9H-thioxanthen-9-one;   1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one;   1-(2-diethylaminoethylamino)-4-(hydroxymethyl)thioxanthen-9-one;   Formula=C20H24N2O2S;   Hycanthon;   InChI=1S/C20H24N2O2S/c1-3-22(4-2)12-11-21-16-10-9-14(13-23)20-18(16)19(24)15-7-5-6-8-17(15)25-20/h5-10,21,23H,3-4,11-13H2,1-2H3;   InChIKey=MFZWMTSUNYWVBU-UHFFFAOYSA-N;   Lucanthone metabolite;   SMILES=CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12;   hicantona;   hycanthonum
 xref: Beilstein:1402722 "Beilstein";   CAS:3105-97-3 "ChemIDplus";   CAS:3105-97-3 "KEGG DRUG";   Drug_Central:1383 "DrugCentral";   KEGG:D00541;   LINCS:LSM-5614
 xref_mesh: MESH:D006826
 xref: PMID:1888160 "Europe PMC";   PMID:21935361 "Europe PMC";   PMID:2957147 "Europe PMC";   PMID:5573958 "Europe PMC";   PMID:626982 "Europe PMC";   PMID:7369442 "Europe PMC";   Patent:NL6410359;   Patent:US3294803;   Patent:US3312598;   Reaxys:1402722 "Reaxys";   Wikipedia:Hycanthone
 cyclic_relationship: is_conjugate_base_of CHEBI:67141

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hycanthone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        aetiopathogenetic role 18793
          genotoxin 16051
            mutagen 15672
              hycanthone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic molecule 19431
                              organic cyclic compound 19197
                                organic heterocyclic compound 18267
                                  organic heteropolycyclic compound 17574
                                    organic heterotricyclic compound 13723
                                      thioxanthenes 198
                                        lucanthone 191
                                          hycanthone 1
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