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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-acylsphingosine
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Accession:CHEBI:52639 term browser browse the term
Definition:The parent compounds of the ceramide family, composed of sphingosine having an unspecified fatty acyl group attached to the nitrogen.
Synonyms:exact_synonym: N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]alkanamide
 related_synonym: Formula=C19H36NO3R;   N-acylsphingosines;   SMILES=CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@H](CO)NC([*])=O;   an N-acylsphing-4-enine;   ceramide;   ceramide d18:1(4c)
 alt_id: CHEBI:12586;   CHEBI:52573
 xref: KEGG:C00195;   LIPID_MAPS_class:LMSP0201;   PMID:1378088;   PMID:7542630
 cyclic_relationship: is_enantiomer_of CHEBI:83223


show annotations for term's descendants           Sort by:
N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A increases transport ISO ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine CTD PMID:21436125 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
N-acetylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A increases expression ISO N-acetylsphingosine results in increased expression of ABCB1 CTD PMID:11573427 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation		 ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein]; N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein
N-acetylsphingosine results in decreased phosphorylation of AKT1 protein		 CTD PMID:12640124 PMID:16215670 PMID:21821001 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases phosphorylation		 ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of BAD protein] CTD PMID:24420784 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions		 ISO N-acetylsphingosine results in increased expression of BAX mRNA
N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of BAX protein]		 CTD PMID:24420784 PMID:33959992 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression		 ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]
N-acetylsphingosine results in decreased expression of BCL2 mRNA; N-acetylsphingosine results in decreased expression of BCL2 protein		 CTD PMID:9295281 PMID:16215670 PMID:24420784 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
increases degradation		 ISO LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein] CTD PMID:21821001 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO [C2-ceramide cotreated with paclitaxel] decreases expression of BIRC2 mRNA in non-small cell lung cancer cells RGD PMID:20624405 RGD:152999014 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO [C2-ceramide cotreated with paclitaxel] decreases expression of BIRC3 mRNA in non-small cell lung cancer cells RGD PMID:20624405 RGD:152999014 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of CASP3 protein]; N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein
N-acetylsphingosine results in increased activity of CASP3 protein		 CTD PMID:10919278 PMID:16215670 PMID:21259059 PMID:28052715 PMID:33959992 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cav1 caveolin 1, caveolae protein multiple interactions ISO N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:12640124 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases localization		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of CEBPB protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased localization of CEBPB protein] CTD PMID:15319326 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator increases activity ISO N-acetylsphingosine results in increased activity of CFTR protein CTD PMID:15474513 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Cldn4 claudin 4 decreases expression EXP N-acetylsphingosine results in decreased expression of CLDN4 mRNA; N-acetylsphingosine results in decreased expression of CLDN4 protein CTD PMID:28052715 NCBI chr 5:134,973,977...134,975,788
Ensembl chr 5:134,973,973...134,975,788 		JBrowse link
G Clk1 CDC-like kinase 1 increases expression EXP N-acetylsphingosine results in increased expression of CLK1 mRNA CTD PMID:18270325 NCBI chr 1:58,451,147...58,463,247
Ensembl chr 1:58,449,348...58,463,225 		JBrowse link
G Ctsd cathepsin D increases secretion ISO N-acetylsphingosine results in increased secretion of CTSD protein CTD PMID:15040013 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Dapk1 death associated protein kinase 1 increases activity ISO N-acetylsphingosine results in increased activity of DAPK1 protein CTD PMID:17087515 NCBI chr13:60,749,506...60,911,005
Ensembl chr13:60,749,761...60,911,005 		JBrowse link
G Dffb DNA fragmentation factor, beta subunit increases activity ISO N-acetylsphingosine results in increased activity of DFFB protein CTD PMID:15040013 NCBI chr 4:154,048,904...154,059,578
Ensembl chr 4:154,048,906...154,059,583 		JBrowse link
G Dnm1l dynamin 1-like increases expression ISO N-acetylsphingosine results in increased expression of DNM1L protein CTD PMID:18006463 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO N-acetylsphingosine inhibits the reaction [EGF protein results in increased abundance of Diglycerides] CTD PMID:11082532 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G F3 coagulation factor III increases expression
multiple interactions		 ISO N-acetylsphingosine results in increased expression of F3 protein
N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein]		 CTD PMID:27556861 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Fis1 fission, mitochondrial 1 increases expression ISO N-acetylsphingosine results in increased expression of FIS1 protein CTD PMID:18006463 NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in increased activity of GOT1 protein] CTD PMID:33959992 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:33959992 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased activity of GPX3 protein] CTD PMID:33959992 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases phosphorylation ISO N-acetylsphingosine results in decreased phosphorylation of GSK3A protein CTD PMID:21821001 NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
decreases expression
multiple interactions		 ISO N-acetylsphingosine results in decreased phosphorylation of GSK3B protein
N-acetylsphingosine results in decreased expression of GSK3B protein modified form
GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]		 CTD PMID:21821001 PMID:24420784 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) decreases expression ISO N-acetylsphingosine results in decreased expression of GSTA5 protein CTD PMID:15155840 NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966 		JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) multiple interactions
decreases expression		 ISO N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]
N-acetylsphingosine results in decreased expression of GSTA2 protein		 CTD PMID:15155840 PMID:15319326 NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression EXP N-acetylsphingosine results in decreased expression of HMOX1 mRNA CTD PMID:18270325 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions
decreases ubiquitination		 ISO N-acetylsphingosine results in decreased expression of and results in decreased activity of HNF1A protein
N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of HNF1A mRNA]; N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of HNF1A protein]
N-acetylsphingosine results in decreased ubiquitination of HNF1A protein		 CTD PMID:15155840 PMID:31385618 PMID:33959992 NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153 		JBrowse link
G Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) increases expression
multiple interactions		 ISO N-acetylsphingosine results in increased expression of HRK mRNA
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]		 CTD PMID:24420784 NCBI chr 5:118,307,829...118,327,543
Ensembl chr 5:118,302,713...118,327,543 		JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression EXP N-acetylsphingosine results in decreased expression of ID2 mRNA CTD PMID:18270325 NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139 		JBrowse link
G Il16 interleukin 16 increases expression EXP N-acetylsphingosine results in increased expression of IL16 mRNA CTD PMID:18270325 NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein] CTD PMID:27556861 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Jun jun proto-oncogene multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in increased phosphorylation of JUN protein] CTD PMID:33959992 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Kdr kinase insert domain protein receptor multiple interactions EXP
ISO		 N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of KDR protein
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]		 CTD PMID:15313899 PMID:15741222 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Klf6 Kruppel-like transcription factor 6 increases expression EXP N-acetylsphingosine results in increased expression of KLF6 mRNA CTD PMID:18270325 NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393 		JBrowse link
G Lgals3 lectin, galactose binding, soluble 3 multiple interactions
increases expression
decreases response to substance		 ISO 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein]
LGALS3 results in decreased susceptibility to N-acetylsphingosine		 CTD PMID:21821001 NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein; TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein] CTD PMID:18270325 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases activity ISO N-acetylsphingosine results in increased activity of MAPK1 protein CTD PMID:10700234 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases activity ISO N-acetylsphingosine results in increased activity of MAPK3 protein CTD PMID:10700234 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein] CTD PMID:33959992 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO
EXP		 N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:18270325 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 multiple interactions
increases degradation		 ISO LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein] CTD PMID:21821001 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 decreases expression ISO N-acetylsphingosine results in decreased expression of MDM2 mRNA; N-acetylsphingosine results in decreased expression of MDM2 protein CTD PMID:18206046 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663 		JBrowse link
G Mfn2 mitofusin 2 decreases response to substance ISO MFN2 protein results in decreased susceptibility to N-acetylsphingosine CTD PMID:18006463 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mir15b microRNA 15b decreases expression ISO N-acetylsphingosine results in decreased expression of MIR15B mRNA CTD PMID:20145152 NCBI chr 3:68,917,105...68,917,168
Ensembl chr 3:68,917,105...68,917,168 		JBrowse link
G Mir20a microRNA 20a decreases expression ISO N-acetylsphingosine results in decreased expression of MIR20A mRNA CTD PMID:20145152 NCBI chr14:115,281,589...115,281,695
Ensembl chr14:115,281,589...115,281,695 		JBrowse link
G Mir25 microRNA 25 decreases expression ISO N-acetylsphingosine results in decreased expression of MIR25 mRNA CTD PMID:20145152 NCBI chr 5:138,163,583...138,163,666
Ensembl chr 5:138,163,583...138,163,666 		JBrowse link
G Mir93 microRNA 93 decreases expression ISO N-acetylsphingosine results in decreased expression of MIR93 mRNA CTD PMID:20145152 NCBI chr 5:138,163,785...138,163,872
Ensembl chr 5:138,163,785...138,163,872 		JBrowse link
G Mirlet7b microRNA let7b decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7B mRNA CTD PMID:20145152 NCBI chr15:85,591,520...85,591,604
Ensembl chr15:85,591,520...85,591,604 		JBrowse link
G Mirlet7d microRNA let7d decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7D mRNA CTD PMID:20145152 NCBI chr13:48,689,488...48,689,590
Ensembl chr13:48,689,488...48,689,590 		JBrowse link
G Mirlet7e microRNA let7e decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7E mRNA CTD PMID:20145152 NCBI chr17:18,050,614...18,050,706
Ensembl chr17:18,050,614...18,050,706 		JBrowse link
G Mirlet7i microRNA let7i decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7I mRNA CTD PMID:20145152 NCBI chr10:122,821,545...122,821,629
Ensembl chr10:122,821,545...122,821,629 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
decreases localization		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of NFE2L2 protein]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased localization of NFE2L2 protein] CTD PMID:15319326 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein] CTD PMID:12381813 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844 		JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 1:62,742,476...62,857,851
Ensembl chr 1:62,742,444...62,857,854 		JBrowse link
G Ocln occludin decreases expression EXP N-acetylsphingosine results in decreased expression of OCLN mRNA; N-acetylsphingosine results in decreased expression of OCLN protein CTD PMID:28052715 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Odc1 ornithine decarboxylase, structural 1 decreases activity ISO N-acetylsphingosine results in decreased activity of ODC1 protein CTD PMID:17521618 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases activity ISO N-acetylsphingosine results in increased activity of PARP1 protein CTD PMID:24420784 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pink1 PTEN induced putative kinase 1 decreases response to substance EXP
ISO		 PINK1 protein results in decreased susceptibility to N-acetylsphingosine CTD PMID:24792327 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618 		JBrowse link
G Plat plasminogen activator, tissue multiple interactions ISO [N-acetylsphingosine results in increased abundance of Ceramides] which results in increased secretion of PLAT protein CTD PMID:11107162 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
increases degradation		 ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein] CTD PMID:16215670 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680 		JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 increases activity ISO N-acetylsphingosine results in increased activity of RAF1 protein CTD PMID:10700234 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) affects activity ISO N-acetylsphingosine affects the activity of RELA protein CTD PMID:12853972 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rhob ras homolog family member B increases expression EXP N-acetylsphingosine results in increased expression of RHOB mRNA CTD PMID:18270325 NCBI chr12:8,547,661...8,550,009
Ensembl chr12:8,547,661...8,550,009 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO [N-acetylsphingosine results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein CTD PMID:11107162 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased activity of SOD1 protein] CTD PMID:33959992 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression
multiple interactions		 ISO N-acetylsphingosine results in increased expression of SOD2 mRNA; N-acetylsphingosine results in increased expression of SOD2 protein
Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 protein]		 CTD PMID:9535218 PMID:10428046 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO N-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:168,856,332...169,015,037
Ensembl chr  X:168,909,030...169,014,924 		JBrowse link
G Tfe3 transcription factor E3 multiple interactions ISO N-acetylsphingosine results in decreased phosphorylation of and affects the localization of TFE3 protein CTD PMID:29945972 NCBI chr  X:7,628,769...7,641,441
Ensembl chr  X:7,628,799...7,641,441 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression EXP N-acetylsphingosine results in increased expression of TGIF1 mRNA CTD PMID:18270325 NCBI chr17:71,151,200...71,160,527
Ensembl chr17:71,151,200...71,160,541 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP N-acetylsphingosine results in decreased expression of TJP1 mRNA; N-acetylsphingosine results in decreased expression of TJP1 protein CTD PMID:28052715 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 protein]
N-acetylsphingosine results in increased expression of TP53 mRNA; N-acetylsphingosine results in increased expression of TP53 protein		 CTD PMID:9535218 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Txn1 thioredoxin 1 decreases activity
multiple interactions		 ISO N-acetylsphingosine results in decreased activity of TXN protein
TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]		 CTD PMID:18270325 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
G Txnip thioredoxin interacting protein increases expression
multiple interactions		 ISO
EXP		 N-acetylsphingosine results in increased expression of TXNIP protein
N-acetylsphingosine results in increased expression of TXNIP mRNA; N-acetylsphingosine results in increased expression of TXNIP protein
TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein]; TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein]		 CTD PMID:18270325 NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP N-acetylsphingosine results in decreased expression of and results in decreased secretion of VEGFA protein CTD PMID:15313899 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
N-hexadecanoylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asah2 N-acylsphingosine amidohydrolase 2 multiple interactions ISO ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] CTD PMID:15946935 NCBI chr19:31,962,046...32,080,540
Ensembl chr19:31,959,997...32,085,611 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 EXP ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA] CTD PMID:28223344 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions		 EXP N-palmitoylsphingosine results in increased expression of ATF6 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA]		 CTD PMID:28223344 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340 		JBrowse link
G Cs citrate synthase multiple interactions
decreases expression		 EXP [N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in decreased expression of CS mRNA] CTD PMID:28223344 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 EXP N-palmitoylsphingosine results in increased expression of DDIT3 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of DDIT3 mRNA]		 CTD PMID:28223344 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Hspa5 heat shock protein 5 increases expression
multiple interactions		 EXP N-palmitoylsphingosine results in increased expression of HSPA5 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA]		 CTD PMID:28223344 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Il1b interleukin 1 beta increases abundance
multiple interactions		 ISO IL1B protein results in increased abundance of N-palmitoylsphingosine
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [IL1B protein results in increased abundance of N-palmitoylsphingosine]		 CTD PMID:27556861 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 multiple interactions
increases expression		 EXP [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA] CTD PMID:28223344 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070 		JBrowse link
G Itpr2 inositol 1,4,5-triphosphate receptor 2 increases expression
multiple interactions		 EXP N-palmitoylsphingosine results in increased expression of ITPR2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA]		 CTD PMID:28223344 NCBI chr 6:146,009,797...146,403,757
Ensembl chr 6:146,009,797...146,403,721 		JBrowse link
G Lipc lipase, hepatic multiple interactions EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine CTD PMID:24777581 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508 		JBrowse link
G Lipg lipase, endothelial multiple interactions EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine CTD PMID:24777581 NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334 		JBrowse link
G Mfn2 mitofusin 2 increases expression
multiple interactions		 EXP N-palmitoylsphingosine results in increased expression of MFN2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA]		 CTD PMID:28223344 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Pacs2 phosphofurin acidic cluster sorting protein 2 increases expression
multiple interactions		 EXP N-palmitoylsphingosine results in increased expression of PACS2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA]		 CTD PMID:28223344 NCBI chr12:112,977,998...113,038,021
Ensembl chr12:112,978,128...113,038,021 		JBrowse link
G Pcx pyruvate carboxylase multiple interactions EXP [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein] CTD PMID:28223344 NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780 		JBrowse link
G Tnf tumor necrosis factor increases abundance
multiple interactions		 EXP
ISO		 TNF protein results in increased abundance of N-palmitoylsphingosine
Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]
ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]		 CTD PMID:15946935 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions EXP [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA] CTD PMID:28223344 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        biochemical role 21431
          metabolite 21379
            eukaryotic metabolite 21238
              animal metabolite 20858
                mammalian metabolite 20847
                  human metabolite 19970
                    N-acylsphingosine 92
                      2-(2-hydroxyacyl)sphingosine + 0
                      Cer(d16:2(4E,6E)/22:0(2OH)) 0
                      N-(17Z-hexacosenoyl)sphingosine 0
                      N-(30-(9Z,12Z-octadecadienoyloxy)-tricontanoyl)-sphing-4-enine 0
                      N-(hexanoyl)sphing-4-enine 0
                      N-(omega-hydroxy-ultra-long chain fatty acyl)sphingosine + 0
                      N-(omega-hydroxyacyl)-sphingosine + 0
                      N-(omega-hydroxytriacontanoyl)sphingosine 0
                      N-(omega-linoleoyloxy-ultra-long chain fatty acyl)sphingosine + 0
                      N-[(13Z)-docosenoyl]sphingosine 0
                      N-[omega-(acylyloxy)]acylsphin-4-enine + 0
                      N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine 1
                      N-acetylsphingosine + 78
                      N-arachidonoylsphingosine 0
                      N-decanoylsphingosine 0
                      N-docosanoylsphingosine 0
                      N-dodecanoylsphingosine 0
                      N-heptadecanoylsphingosine 0
                      N-hexacosahexaenoylsphingosine 0
                      N-hexacosanoylsphingosine 0
                      N-hexacosenoylsphingosine 0
                      N-hexadecanoylsphingosine 16
                      N-icosanoylsphingosine 0
                      N-icosenoylsphingosine + 0
                      N-octacosanoylsphingosine 0
                      N-octadecanoylsphingosine 0
                      N-octanoylsphingosine 0
                      N-oleoylsphingosine + 0
                      N-omega-hydroxyacylsphingosine + 0
                      N-pentacosanoylsphingosine 0
                      N-tetracosadienoylsphingosine 0
                      N-tetracosanoylsphingosine 0
                      N-tetracosenoylsphingosine + 0
                      N-tetradecanoylsphingosine 0
                      N-tricosanoylsphingosine 0
                      xylosyl-beta-D-ceramide(d18:1(4E)) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    main group molecular entity 22104
                      s-block molecular entity 21729
                        hydrogen molecular entity 21646
                          hydrides 20758
                            inorganic hydride 18672
                              pnictogen hydride 18652
                                nitrogen hydride 18519
                                  azane 18426
                                    ammonia 18425
                                      organic amino compound 18425
                                        amino alcohol 1078
                                          aminodiol 190
                                            2-aminooctadecene-1,3-diol 139
                                              2-aminooctadec-4-ene-1,3-diol 139
                                                sphing-4-enine 139
                                                  sphingosine 139
                                                    sphingosine-based sphingolipid 92
                                                      N-acylsphingosine 92
                                                        2-(2-hydroxyacyl)sphingosine + 0
                                                        Cer(d16:2(4E,6E)/22:0(2OH)) 0
                                                        N-(17Z-hexacosenoyl)sphingosine 0
                                                        N-(30-(9Z,12Z-octadecadienoyloxy)-tricontanoyl)-sphing-4-enine 0
                                                        N-(hexanoyl)sphing-4-enine 0
                                                        N-(omega-hydroxy-ultra-long chain fatty acyl)sphingosine + 0
                                                        N-(omega-hydroxyacyl)-sphingosine + 0
                                                        N-(omega-hydroxytriacontanoyl)sphingosine 0
                                                        N-(omega-linoleoyloxy-ultra-long chain fatty acyl)sphingosine + 0
                                                        N-[(13Z)-docosenoyl]sphingosine 0
                                                        N-[omega-(acylyloxy)]acylsphin-4-enine + 0
                                                        N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine 1
                                                        N-acetylsphingosine + 78
                                                        N-arachidonoylsphingosine 0
                                                        N-decanoylsphingosine 0
                                                        N-docosanoylsphingosine 0
                                                        N-dodecanoylsphingosine 0
                                                        N-heptadecanoylsphingosine 0
                                                        N-hexacosahexaenoylsphingosine 0
                                                        N-hexacosanoylsphingosine 0
                                                        N-hexacosenoylsphingosine 0
                                                        N-hexadecanoylsphingosine 16
                                                        N-icosanoylsphingosine 0
                                                        N-icosenoylsphingosine + 0
                                                        N-octacosanoylsphingosine 0
                                                        N-octadecanoylsphingosine 0
                                                        N-octanoylsphingosine 0
                                                        N-oleoylsphingosine + 0
                                                        N-omega-hydroxyacylsphingosine + 0
                                                        N-pentacosanoylsphingosine 0
                                                        N-tetracosadienoylsphingosine 0
                                                        N-tetracosanoylsphingosine 0
                                                        N-tetracosenoylsphingosine + 0
                                                        N-tetradecanoylsphingosine 0
                                                        N-tricosanoylsphingosine 0
                                                        xylosyl-beta-D-ceramide(d18:1(4E)) + 0
paths to the root