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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-acylsphingosine
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Accession:CHEBI:52639 term browser browse the term
Definition:The parent compounds of the ceramide family, composed of sphingosine having an unspecified fatty acyl group attached to the nitrogen.
Synonyms:exact_synonym: N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]alkanamide
 related_synonym: Formula=C19H36NO3R;   N-acylsphingosines;   SMILES=CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@H](CO)NC([*])=O;   an N-acylsphing-4-enine;   ceramide;   ceramide d18:1(4c)
 alt_id: CHEBI:12586;   CHEBI:52573
 xref: KEGG:C00195;   LIPID_MAPS_class:LMSP0201;   PMID:1378088;   PMID:7542630
 cyclic_relationship: is_enantiomer_of CHEBI:83223


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N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine CTD PMID:21436125 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
N-acetylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO N-acetylsphingosine results in increased expression of ABCB1 CTD PMID:11573427 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein]; N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein
N-acetylsphingosine results in decreased phosphorylation of AKT1 protein
CTD PMID:12640124 PMID:16215670 PMID:21821001 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation
multiple interactions
ISO N-acetylsphingosine results in decreased phosphorylation of BAD protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of BAD protein]
CTD PMID:24420784 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO N-acetylsphingosine results in increased expression of BAX mRNA CTD PMID:24420784 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]
N-acetylsphingosine results in decreased expression of BCL2 mRNA; N-acetylsphingosine results in decreased expression of BCL2 protein
CTD PMID:9295281 PMID:16215670 PMID:24420784 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases degradation
ISO LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein] CTD PMID:21821001 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein
N-acetylsphingosine results in increased activity of CASP3 protein
CTD PMID:10919278 PMID:16215670 PMID:21259059 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:12640124 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases localization
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of CEBPB protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased localization of CEBPB protein] CTD PMID:15319326 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cftr CF transmembrane conductance regulator increases activity ISO N-acetylsphingosine results in increased activity of CFTR protein CTD PMID:15474513 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO N-acetylsphingosine results in increased expression of CLK1 mRNA CTD PMID:18270325 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995
JBrowse link
G Ctsd cathepsin D increases secretion EXP N-acetylsphingosine results in increased secretion of CTSD protein CTD PMID:15040013 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Dapk1 death associated protein kinase 1 increases activity ISO
EXP
N-acetylsphingosine results in increased activity of DAPK1 protein CTD PMID:17087515 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
JBrowse link
G Dffb DNA fragmentation factor subunit beta increases activity EXP N-acetylsphingosine results in increased activity of DFFB protein CTD PMID:15040013 NCBI chr 5:171,250,559...171,261,875
Ensembl chr 5:171,249,633...171,262,119
JBrowse link
G Dnm1l dynamin 1-like increases expression EXP N-acetylsphingosine results in increased expression of DNM1L protein CTD PMID:18006463 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Egf epidermal growth factor multiple interactions ISO N-acetylsphingosine inhibits the reaction [EGF protein results in increased abundance of Diglycerides] CTD PMID:11082532 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression
ISO N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein]
N-acetylsphingosine results in increased expression of F3 protein
CTD PMID:27556861 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP N-acetylsphingosine results in increased expression of FIS1 protein CTD PMID:18006463 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases phosphorylation ISO N-acetylsphingosine results in decreased phosphorylation of GSK3A protein CTD PMID:21821001 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
decreases expression
multiple interactions
ISO N-acetylsphingosine results in decreased phosphorylation of GSK3B protein
N-acetylsphingosine results in decreased expression of GSK3B protein modified form
GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]
CTD PMID:21821001 PMID:24420784 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
decreases expression
EXP N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]
N-acetylsphingosine results in decreased expression of GSTA2 protein; N-acetylsphingosine results in decreased expression of GSTA3 protein
CTD PMID:15155840 PMID:15319326 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression EXP N-acetylsphingosine results in decreased expression of GSTA5 protein CTD PMID:15155840 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO N-acetylsphingosine results in decreased expression of HMOX1 mRNA CTD PMID:18270325 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions
decreases ubiquitination
EXP N-acetylsphingosine results in decreased expression of and results in decreased activity of HNF1A protein
N-acetylsphingosine results in decreased ubiquitination of HNF1A protein
CTD PMID:15155840 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
JBrowse link
G Hrk harakiri, BCL2 interacting protein increases expression
multiple interactions
ISO N-acetylsphingosine results in increased expression of HRK mRNA
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]
CTD PMID:24420784 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO N-acetylsphingosine results in decreased expression of ID2 mRNA CTD PMID:18270325 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Il16 interleukin 16 increases expression ISO N-acetylsphingosine results in increased expression of IL16 mRNA CTD PMID:18270325 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein] CTD PMID:27556861 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of KDR protein
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]
CTD PMID:15313899 PMID:15741222 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Klf6 Kruppel-like factor 6 increases expression ISO N-acetylsphingosine results in increased expression of KLF6 mRNA CTD PMID:18270325 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Lgals3 galectin 3 multiple interactions
increases expression
decreases response to substance
ISO 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein]
LGALS3 results in decreased susceptibility to N-acetylsphingosine
CTD PMID:21821001 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein; TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein] CTD PMID:18270325 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity EXP N-acetylsphingosine results in increased activity of MAPK1 protein CTD PMID:10700234 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity EXP N-acetylsphingosine results in increased activity of MAPK3 protein CTD PMID:10700234 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein] CTD PMID:18270325 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases degradation
ISO LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein] CTD PMID:21821001 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO N-acetylsphingosine results in decreased expression of MDM2 mRNA; N-acetylsphingosine results in decreased expression of MDM2 protein CTD PMID:18206046 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mfn2 mitofusin 2 decreases response to substance EXP MFN2 protein results in decreased susceptibility to N-acetylsphingosine CTD PMID:18006463 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mir15b microRNA 15b decreases expression ISO N-acetylsphingosine results in decreased expression of MIR15B mRNA CTD PMID:20145152 NCBI chr 2:165,605,923...165,606,020
Ensembl chr 2:165,605,923...165,606,020
JBrowse link
G Mir20a microRNA 20a decreases expression ISO N-acetylsphingosine results in decreased expression of MIR20A mRNA CTD PMID:20145152 NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418
JBrowse link
G Mir25 microRNA 25 decreases expression ISO N-acetylsphingosine results in decreased expression of MIR25 mRNA CTD PMID:20145152 NCBI chr12:19,307,340...19,307,423
Ensembl chr12:19,307,340...19,307,423
JBrowse link
G Mir93 microRNA 93 decreases expression ISO N-acetylsphingosine results in decreased expression of MIR93 mRNA CTD PMID:20145152 NCBI chr12:19,307,543...19,307,629
Ensembl chr12:19,307,543...19,307,629
JBrowse link
G Mirlet7b microRNA let-7b decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7B mRNA CTD PMID:20145152 NCBI chr 7:126,590,627...126,590,711
Ensembl chr 7:126,590,627...126,590,711
JBrowse link
G Mirlet7d microRNA let-7d decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7D mRNA CTD PMID:20145152 NCBI chr17:16,419,980...16,420,077
Ensembl chr17:16,419,980...16,420,077
JBrowse link
G Mirlet7i microRNA let-7i decreases expression ISO N-acetylsphingosine results in decreased expression of MIRLET7I mRNA CTD PMID:20145152 NCBI chr 7:66,802,731...66,802,815
Ensembl chr 7:66,802,732...66,802,821
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases localization
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of NFE2L2 protein]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased localization of NFE2L2 protein] CTD PMID:15319326 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ngf nerve growth factor multiple interactions EXP N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein] CTD PMID:12381813 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity ISO N-acetylsphingosine results in decreased activity of ODC1 protein CTD PMID:17521618 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity ISO N-acetylsphingosine results in increased activity of PARP1 protein CTD PMID:24420784 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pink1 PTEN induced kinase 1 decreases response to substance ISO PINK1 protein results in decreased susceptibility to N-acetylsphingosine CTD PMID:24792327 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [N-acetylsphingosine results in increased abundance of Ceramides] which results in increased secretion of PLAT protein CTD PMID:11107162 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
increases degradation
ISO BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein] CTD PMID:16215670 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases activity EXP N-acetylsphingosine results in increased activity of RAF1 protein CTD PMID:10700234 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects activity ISO N-acetylsphingosine affects the activity of RELA protein CTD PMID:12853972 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhob ras homolog family member B increases expression ISO N-acetylsphingosine results in increased expression of RHOB mRNA CTD PMID:18270325 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [N-acetylsphingosine results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein CTD PMID:11107162 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
ISO
EXP
N-acetylsphingosine results in increased expression of SOD2 mRNA; N-acetylsphingosine results in increased expression of SOD2 protein
Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 protein]
CTD PMID:9535218 PMID:10428046 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sts steroid sulfatase multiple interactions ISO N-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 multiple interactions ISO N-acetylsphingosine results in decreased phosphorylation of and affects the localization of TFE3 protein CTD PMID:29945972 NCBI chr  X:15,574,579...15,587,826
Ensembl chr  X:15,575,934...15,587,419
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression ISO N-acetylsphingosine results in increased expression of TGIF1 mRNA CTD PMID:18270325 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 protein]
N-acetylsphingosine results in increased expression of TP53 mRNA; N-acetylsphingosine results in increased expression of TP53 protein
CTD PMID:9535218 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txn1 thioredoxin 1 decreases activity
multiple interactions
ISO N-acetylsphingosine results in decreased activity of TXN protein
TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]
CTD PMID:18270325 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnip thioredoxin interacting protein increases expression
multiple interactions
ISO N-acetylsphingosine results in increased expression of TXNIP protein
N-acetylsphingosine results in increased expression of TXNIP mRNA; N-acetylsphingosine results in increased expression of TXNIP protein
TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein]; TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein]
CTD PMID:18270325 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO N-acetylsphingosine results in decreased expression of and results in decreased secretion of VEGFA protein CTD PMID:15313899 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
N-hexadecanoylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asah2 N-acylsphingosine amidohydrolase 2 multiple interactions ISO ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] CTD PMID:15946935 NCBI chr 1:250,557,042...250,665,083
Ensembl chr 1:250,557,044...250,630,677
JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions
ISO N-palmitoylsphingosine results in increased expression of ATF4 mRNA
ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA]
CTD PMID:28223344 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions
ISO N-palmitoylsphingosine results in increased expression of ATF6 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA]
CTD PMID:28223344 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Cs citrate synthase decreases expression
multiple interactions
ISO N-palmitoylsphingosine results in decreased expression of CS mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in decreased expression of CS mRNA]
CTD PMID:28223344 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of DDIT3 mRNA] CTD PMID:28223344 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA] CTD PMID:28223344 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
ISO Win 55212-2 inhibits the reaction [IL1B protein results in increased abundance of N-palmitoylsphingosine] CTD PMID:27556861 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions
increases expression
ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA] CTD PMID:28223344 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 increases expression
multiple interactions
ISO N-palmitoylsphingosine results in increased expression of ITPR2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA]
CTD PMID:28223344 NCBI chr 4:180,423,452...180,800,088
Ensembl chr 4:180,538,389...180,722,358
JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Lipg lipase G, endothelial type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708
JBrowse link
G Mfn2 mitofusin 2 increases expression
multiple interactions
ISO N-palmitoylsphingosine results in increased expression of MFN2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA]
CTD PMID:28223344 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Pacs2 phosphofurin acidic cluster sorting protein 2 increases expression
multiple interactions
ISO N-palmitoylsphingosine results in increased expression of PACS2 mRNA
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA]
CTD PMID:28223344 NCBI chr 6:137,824,136...137,889,144
Ensembl chr 6:137,824,213...137,887,418
JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein] CTD PMID:28223344 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Tnf tumor necrosis factor increases abundance
multiple interactions
ISO TNF protein results in increased abundance of N-palmitoylsphingosine
ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]
Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]
CTD PMID:15946935 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA] CTD PMID:28223344 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      biological role 19804
        biochemical role 19339
          metabolite 19319
            eukaryotic metabolite 18976
              animal metabolite 18776
                mammalian metabolite 18775
                  human metabolite 18274
                    N-acylsphingosine 80
                      2-(2-hydroxyacyl)sphingosine + 0
                      Cer(d16:2(4E,6E)/22:0(2OH)) 0
                      N-(17Z-hexacosenoyl)sphingosine 0
                      N-(30-(9Z,12Z-octadecadienoyloxy)-tricontanoyl)-sphing-4-enine 0
                      N-(hexanoyl)sphing-4-enine 0
                      N-(omega-hydroxy-ultra-long chain fatty acyl)sphingosine + 0
                      N-(omega-hydroxytriacontanoyl)sphingosine 0
                      N-(omega-linoleoyloxy-ultra-long chain fatty acyl)sphingosine + 0
                      N-[(13Z)-docosenoyl]sphingosine 0
                      N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine 1
                      N-acetylsphingosine + 66
                      N-arachidonoylsphingosine 0
                      N-decanoylsphingosine 0
                      N-docosanoylsphingosine 0
                      N-dodecanoylsphingosine 0
                      N-heptadecanoylsphingosine 0
                      N-hexacosahexaenoylsphingosine 0
                      N-hexacosanoylsphingosine 0
                      N-hexacosenoylsphingosine 0
                      N-hexadecanoylsphingosine 16
                      N-icosanoylsphingosine 0
                      N-icosenoylsphingosine + 0
                      N-octacosanoylsphingosine 0
                      N-octadecanoylsphingosine 0
                      N-octanoylsphingosine 0
                      N-oleoylsphingosine 0
                      N-omega-hydroxyacylsphingosine + 0
                      N-pentacosanoylsphingosine 0
                      N-tetracosadienoylsphingosine 0
                      N-tetracosanoylsphingosine 0
                      N-tetracosenoylsphingosine + 0
                      N-tetradecanoylsphingosine 0
                      N-tricosanoylsphingosine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    main group molecular entity 19744
                      s-block molecular entity 19491
                        hydrogen molecular entity 19483
                          hydrides 18748
                            inorganic hydride 17481
                              pnictogen hydride 17454
                                nitrogen hydride 17296
                                  azane 17015
                                    ammonia 17014
                                      organic amino compound 17013
                                        amino alcohol 892
                                          aminodiol 153
                                            2-aminooctadecene-1,3-diol 112
                                              2-aminooctadec-4-ene-1,3-diol 112
                                                sphing-4-enine 112
                                                  sphingosine 112
                                                    sphingosine-based sphingolipid 80
                                                      N-acylsphingosine 80
                                                        2-(2-hydroxyacyl)sphingosine + 0
                                                        Cer(d16:2(4E,6E)/22:0(2OH)) 0
                                                        N-(17Z-hexacosenoyl)sphingosine 0
                                                        N-(30-(9Z,12Z-octadecadienoyloxy)-tricontanoyl)-sphing-4-enine 0
                                                        N-(hexanoyl)sphing-4-enine 0
                                                        N-(omega-hydroxy-ultra-long chain fatty acyl)sphingosine + 0
                                                        N-(omega-hydroxytriacontanoyl)sphingosine 0
                                                        N-(omega-linoleoyloxy-ultra-long chain fatty acyl)sphingosine + 0
                                                        N-[(13Z)-docosenoyl]sphingosine 0
                                                        N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine 1
                                                        N-acetylsphingosine + 66
                                                        N-arachidonoylsphingosine 0
                                                        N-decanoylsphingosine 0
                                                        N-docosanoylsphingosine 0
                                                        N-dodecanoylsphingosine 0
                                                        N-heptadecanoylsphingosine 0
                                                        N-hexacosahexaenoylsphingosine 0
                                                        N-hexacosanoylsphingosine 0
                                                        N-hexacosenoylsphingosine 0
                                                        N-hexadecanoylsphingosine 16
                                                        N-icosanoylsphingosine 0
                                                        N-icosenoylsphingosine + 0
                                                        N-octacosanoylsphingosine 0
                                                        N-octadecanoylsphingosine 0
                                                        N-octanoylsphingosine 0
                                                        N-oleoylsphingosine 0
                                                        N-omega-hydroxyacylsphingosine + 0
                                                        N-pentacosanoylsphingosine 0
                                                        N-tetracosadienoylsphingosine 0
                                                        N-tetracosanoylsphingosine 0
                                                        N-tetracosenoylsphingosine + 0
                                                        N-tetradecanoylsphingosine 0
                                                        N-tricosanoylsphingosine 0
paths to the root