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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:galangin
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Accession:CHEBI:5262 term browser browse the term
Definition:A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.
Synonyms:exact_synonym: 3,5,7-trihydroxy-2-phenyl-4H-chromen-4-one
 related_synonym: 3,5,7-Trihydroxyflavone;   3,5,7-triOH-flavone;   3,5,7-trihydroxy-2-phenyl-4H-benzopyran-4-one;   Formula=C15H10O5;   InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H;   InChIKey=VCCRNZQBSJXYJD-UHFFFAOYSA-N;   SMILES=Oc1cc(O)c2c(c1)oc(-c1ccccc1)c(O)c2=O;   norizalpinin;   teptochrysin
 xref: Beilstein:272179;   CAS:548-83-4;   HMDB:HMDB0029521;   KEGG:C10044;   KNApSAcK:C00004533;   LIPID_MAPS_instance:LMPK12111653
 xref_mesh: MESH:C037032
 xref: MetaCyc:CPD-13502;   PMID:22887049;   PMID:22908567;   PMID:22985747;   PMID:23143152;   PMID:23363068;   PMID:28166217;   Patent:CN101810812;   Patent:KR20090124397;   Reaxys:272179;   Wikipedia:Galangin


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galangin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
increases activity		 ISO galangin results in increased expression of ABCB1 mRNA; galangin results in increased expression of ABCB1 protein
galangin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; Verapamil promotes the reaction [galangin results in increased activity of ABCB1 protein]		 CTD PMID:26238175 PMID:34217736 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO galangin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Ache acetylcholinesterase decreases activity EXP galangin results in decreased activity of ACHE protein CTD PMID:20452337 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ahr aryl hydrocarbon receptor affects localization
multiple interactions
increases activity		 ISO galangin affects the localization of AHR protein
galangin affects the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; galangin binds to and results in decreased activity of AHR protein; galangin binds to and results in increased activity of AHR protein; galangin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene affects the localization of AHR protein]; galangin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; galangin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]; galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
galangin results in increased activity of AHR protein		 CTD PMID:10953044 PMID:14644660 PMID:17090139 PMID:20435555 PMID:20450880 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO galangin results in decreased phosphorylation of AKT1 protein CTD PMID:18455702 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg12 autophagy related 12 increases expression
multiple interactions		 ISO galangin results in increased expression of ATG12 mRNA; galangin results in increased expression of ATG12 protein
[ATG12 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of ATG12 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG12 protein]		 CTD PMID:25268046 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg16l1 autophagy related 16-like 1 multiple interactions
increases expression		 ISO [ATG16L1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of ATG16L1 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG16L1 protein]
galangin results in increased expression of ATG16L1 mRNA; galangin results in increased expression of ATG16L1 protein		 CTD PMID:25268046 NCBI chr 9:88,420,737...88,457,530
Ensembl chr 9:88,422,038...88,457,529 		JBrowse link
G Atg3 autophagy related 3 multiple interactions
increases expression		 ISO [ATG3 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of ATG3 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG3 protein]
galangin results in increased expression of ATG3 mRNA; galangin results in increased expression of ATG3 protein		 CTD PMID:25268046 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO galangin results in increased expression of BAX protein CTD PMID:25450235 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO galangin results in decreased expression of BCL2 protein CTD PMID:25450235 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO galangin results in decreased expression of BCL2L1 protein CTD PMID:25450235 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO [BECN1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of BECN1 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of BECN1 protein]
galangin results in increased expression of BECN1 mRNA; galangin results in increased expression of BECN1 protein		 CTD PMID:25268046 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP		 galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased activity of CASP1 protein]
galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased activity of CASP1 protein]		 CTD PMID:23535185 PMID:35384154 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO [ATG12 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; [ATG16L1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; [ATG3 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; [BECN1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein
galangin results in increased cleavage of CASP3 protein		 CTD PMID:25268046 PMID:25450235 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein] CTD PMID:35384154 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO galangin results in decreased expression of CCND1 protein CTD PMID:25450235 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO galangin results in decreased expression of CDK4 protein CTD PMID:25450235 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO galangin results in decreased expression of CDK6 protein CTD PMID:25450235 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO galangin results in increased expression of CDKN1A protein CTD PMID:25450235 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression		 ISO galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
galangin results in decreased activity of CYP1A1 protein
galangin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
galangin results in increased expression of CYP1A1 mRNA		 CTD PMID:10953044 PMID:17090139 PMID:20930378 PMID:21053930 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
galangin results in decreased activity of CYP1A2 protein		 CTD PMID:17090139 PMID:20806393 PMID:21053930 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO galangin binds to and results in decreased activity of CYP1B1 protein CTD PMID:21053930 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO galangin results in increased expression of CYP2B6 mRNA CTD PMID:25625231 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases activity
decreases activity
multiple interactions		 ISO galangin results in increased expression of CYP3A4 mRNA
galangin results in increased activity of CYP3A4 protein
galangin results in decreased activity of CYP3A4 protein
[[galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; galangin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; galangin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]		 CTD PMID:21053930 PMID:26238175 PMID:31756459 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO galangin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; galangin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO galangin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:25625231 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO galangin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO galangin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions
increases expression		 ISO ferrous sulfate inhibits the reaction [galangin results in increased expression of EPAS1 protein]; Iron inhibits the reaction [galangin results in increased expression of EPAS1 protein] CTD PMID:17973296 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Esr1 estrogen receptor 1 increases phosphorylation EXP galangin results in increased phosphorylation of ESR1 protein CTD PMID:17323972 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO galangin results in decreased expression of and results in decreased activity of GLO1 protein CTD PMID:29113808 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of GSR protein] CTD PMID:35384154 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO galangin results in decreased activity of GSTP1 protein CTD PMID:15041478 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HAVCR1 protein] CTD PMID:35384154 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 ISO ferrous sulfate inhibits the reaction [galangin results in increased expression of HIF1A protein]; galangin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; galangin promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Iron inhibits the reaction [galangin results in increased expression of HIF1A protein] CTD PMID:17973296 PMID:20153296 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [Cadmium co-treated with galangin] results in increased expression of HMOX1 protein CTD PMID:35384154 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hrh1 histamine receptor H 1 decreases expression ISO galangin results in decreased expression of HRH1 mRNA CTD PMID:23535185 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO galangin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:16987811 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]
galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein]		 CTD PMID:23535185 PMID:35384154 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 galangin inhibits the reaction [Fructose results in increased expression of IL6 protein]
galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]		 CTD PMID:21708140 PMID:23535185 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO galangin results in decreased phosphorylation of MTOR protein CTD PMID:25450235 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO galangin promotes the reaction [NCOA1 protein binds to NR1I2 protein] CTD PMID:26238175 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO galangin promotes the reaction [NCOA2 protein binds to NR1I2 protein] CTD PMID:26238175 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO galangin promotes the reaction [NCOA3 protein binds to NR1I2 protein] CTD PMID:26238175 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions		 ISO
EXP		 galangin results in decreased expression of NFE2L2 protein
[Cadmium co-treated with galangin] results in increased expression of NFE2L2 protein		 CTD PMID:29113808 PMID:35384154 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased degradation of NFKBIA protein] CTD PMID:23535185 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein] CTD PMID:35384154 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Cadmium co-treated with galangin] results in increased expression of NQO1 protein CTD PMID:35384154 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO galangin results in increased activity of NR1I2 protein
galangin binds to and results in increased activity of NR1I2 protein; galangin promotes the reaction [NCOA1 protein binds to NR1I2 protein]; galangin promotes the reaction [NCOA2 protein binds to NR1I2 protein]; galangin promotes the reaction [NCOA3 protein binds to NR1I2 protein]		 CTD PMID:26238175 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
affects localization		 ISO galangin results in increased expression of NR1I3 mRNA
galangin affects the localization of NR1I3 protein		 CTD PMID:25625231 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO galangin results in increased cleavage of PARP1 protein CTD PMID:18455702 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PYCARD protein] CTD PMID:35384154 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO galangin results in decreased phosphorylation of RB1 protein CTD PMID:25450235 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which affects the localization of RELA protein]; galangin inhibits the reaction [Fructose affects the localization of RELA protein]
galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of RELA protein]		 CTD PMID:21708140 PMID:23535185 PMID:35384154 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO galangin results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25450235 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Sele selectin E multiple interactions ISO galangin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16987811 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Smad1 SMAD family member 1 multiple interactions
increases phosphorylation
increases expression		 ISO LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD1 protein]
galangin results in increased expression of SMAD1 mRNA		 CTD PMID:25268046 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad2 SMAD family member 2 increases phosphorylation
multiple interactions
increases expression		 ISO galangin results in increased phosphorylation of SMAD2 protein
LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD2 protein]
galangin results in increased expression of SMAD2 mRNA		 CTD PMID:25268046 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions
increases expression
increases phosphorylation		 ISO LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD3 protein]
galangin results in increased expression of SMAD3 mRNA		 CTD PMID:25268046 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad4 SMAD family member 4 increases expression
multiple interactions		 ISO galangin results in increased expression of SMAD4 mRNA
SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG12 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG16L1 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG3 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of BECN1 protein]		 CTD PMID:25268046 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Smad6 SMAD family member 6 decreases expression ISO galangin results in decreased expression of SMAD6 mRNA CTD PMID:25268046 NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763 		JBrowse link
G Smad7 SMAD family member 7 decreases expression ISO galangin results in decreased expression of SMAD7 mRNA CTD PMID:25268046 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO galangin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein] CTD PMID:20153296 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP galangin inhibits the reaction [Fructose results in increased expression of TGFB1 protein] CTD PMID:21708140 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO galangin results in increased expression of TGFBR1 mRNA CTD PMID:25268046 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression ISO galangin results in increased expression of TGFBR2 mRNA CTD PMID:25268046 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; galangin inhibits the reaction [Fructose results in increased expression of TNF mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TNF protein]
galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; galangin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; galangin inhibits the reaction [TNF protein results in increased expression of SELE protein]		 CTD PMID:16987811 PMID:21708140 PMID:23535185 PMID:35384154 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tyr tyrosinase increases expression ISO galangin results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of galangin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO galangin results in decreased activity of UGT1A3 protein CTD PMID:35063619 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases activity ISO galangin results in decreased activity of UGT1A6 protein CTD PMID:35063619 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
decreases activity		 ISO UGT1A9 protein results in increased glucuronidation of galangin
galangin results in decreased activity of UGT1A9 protein		 CTD PMID:14557274 PMID:35063619 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases activity ISO galangin results in decreased activity of UGT2B7 protein CTD PMID:35063619 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO galangin promotes the reaction [Oxygen deficiency results in increased expression of and results in increased localization of VEGFA protein] CTD PMID:20153296 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      biological role 19722
        antimicrobial agent 17897
          galangin 74
            2-(3-benzoylphenyl)-3,5,7-trihydroxychromen-4-one 0
            3-O-methyl-8-prenylgalangin 0
            3-methylgalangin 0
            6-(3,3-dimethylallyl)galangin 0
            8-(1,1-dimethylallyl)-3-methylgalangin 0
            8-(1,1-dimethylallyl)galangin 0
            galangin 3,5,7-trimethyl ether 0
            glepidotin A 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19644
                        carbon atom 19640
                          organic molecular entity 19640
                            organic molecule 19602
                              organic cyclic compound 19412
                                organic heterocyclic compound 18771
                                  oxacycle 17731
                                    benzopyran 11679
                                      1-benzopyran 11445
                                        flavonoid 6795
                                          anthoxanthin 4493
                                            flavones 4493
                                              hydroxyflavone 4478
                                                flavonols 4379
                                                  7-hydroxyflavonol 4356
                                                    galangin 74
                                                      2-(3-benzoylphenyl)-3,5,7-trihydroxychromen-4-one 0
                                                      3-O-methyl-8-prenylgalangin 0
                                                      3-methylgalangin 0
                                                      6-(3,3-dimethylallyl)galangin 0
                                                      8-(1,1-dimethylallyl)-3-methylgalangin 0
                                                      8-(1,1-dimethylallyl)galangin 0
                                                      galangin 3,5,7-trimethyl ether 0
                                                      glepidotin A 0
paths to the root