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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:7,8-dihydro-8-oxoguanine
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Accession:CHEBI:52617 term browser browse the term
Definition:An oxopurine that is guanine in which the hydrogen at position 8 is replaced by an oxo group and in which the nitrogens at positions 7 and 9 each bear a hydrogen.
Synonyms:related_synonym: 2-Amino-7,9-dihydro-1H-Purine-6,8-dione;   8-Hydroxyguanine;   8-oxoguanine;   Formula=C5H5N5O2;   InChI=1S/C5H5N5O2/c6-4-8-2-1(3(11)10-4)7-5(12)9-2/h(H5,6,7,8,9,10,11,12);   InChIKey=CLGFIVUFZRGQRP-UHFFFAOYSA-N;   SMILES=Nc1nc2[nH]c(=O)[nH]c2c(=O)[nH]1
 xref: CAS:5614-64-2
 xref_mesh: MESH:C024829



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7,8-dihydro-8-oxoguanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fxn frataxin multiple interactions ISO [FXN gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased abundance of 8-hydroxyguanine CTD PMID:26954031 NCBI chr 1:221,874,007...221,897,841
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
G Mt3 metallothionein 3 decreases abundance ISO MT3 protein results in decreased abundance of 8-hydroxyguanine CTD PMID:15190073 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases abundance
multiple interactions
ISO OGG1 protein results in decreased abundance of 7,8-dihydro-8-oxoguanine; OGG1 protein results in decreased abundance of 8-hydroxyguanine
OGG1 protein affects the reaction [Methamphetamine results in increased abundance of 7,8-dihydro-8-oxoguanine]
CTD PMID:18768699 PMID:21873502 PMID:21925250 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Wrn WRN RecQ like helicase decreases response to substance ISO WRN protein results in decreased susceptibility to 8-hydroxyguanine CTD PMID:25730140 NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        biochemical role 19630
          metabolite 19611
            eukaryotic metabolite 19318
              algal metabolite 14147
                guanine 4006
                  7,8-dihydro-8-oxoguanine 4
                    7,8-dihydro-8-oxoguanyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic molecule 19819
                              organic cyclic compound 19581
                                organic heterocyclic compound 18804
                                  organic heteropolycyclic compound 18274
                                    organic heterobicyclic compound 17165
                                      imidazopyrimidine 5624
                                        purines 5622
                                          aminopurine 4446
                                            2-aminopurines 4042
                                              guanine 4006
                                                7,8-dihydro-8-oxoguanine 4
                                                  7,8-dihydro-8-oxoguanyl group 0
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