CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: zineb
Accession: CHEBI:52498
browse the term
Definition: A polymeric complex of zinc with the ethylene bis(dithiocarbamate) anionic ligand. Formerly used as an agricultural fungicide for the control of downy mildews and rusts, its use is no longer permitted in the US or the EU.
Synonyms: exact_synonym: [{2-[(sulfanylcarbothioyl)amino]ethyl}carbamodithioato(2-)-kappa(2)S,S']zinc
related_synonym: Formula=C4H6N2S4Zn; InChI=1S/C4H8N2S4.Zn/c7-3(8)5-1-2-6-4(9)10;/h1-2H2,(H2,5,7,8)(H2,6,9,10);/q;+2/p-2; InChIKey=AMHNZOICSMBGDH-UHFFFAOYSA-L; SMILES=[Zn++].[S-]C(=S)NCCNC([S-])=S; zinc ethane-1,2-diyldicarbamodithioate
xref: Beilstein:4165797; CAS:12122-67-7; KEGG:C15232
xref_mesh: MESH:D015038
xref: PMID:22155123; PMID:23871785; PMID:465777; PPDB:683; Patent:CN1648120; Patent:US2690448; Pesticides:zineb; Reaxys:4165797; Wikipedia:Zineb
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Ache
acetylcholinesterase
decreases expression
EXP
Zineb results in decreased expression of ACHE protein
CTD
PMID:3868355
NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
ISO
Zineb inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]
CTD
PMID:29149346
NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
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Casp3
caspase 3
increases activity
ISO
Zineb results in increased activity of CASP3 protein
CTD
PMID:17189834
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
decreases activity
ISO
Zineb results in decreased activity of HSD11B2 protein
CTD
PMID:22796344
NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions increases activity
ISO
[Endosulfan co-treated with Zineb] results in increased activity of NFKB1 protein Zineb results in increased activity of NFKB1 protein
CTD
PMID:17189834
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
multiple interactions
ISO
Zineb inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Zineb inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
CTD
PMID:29149346
NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
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Tnf
tumor necrosis factor
multiple interactions
ISO
Zineb inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Zineb promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:15256756 PMID:16112155
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tpo
thyroid peroxidase
decreases activity
ISO
Zineb results in decreased activity of TPO protein
CTD
PMID:9248629
NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
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Ache
acetylcholinesterase
affects activity
EXP
mancozeb affects the activity of ACHE protein
CTD
PMID:10641187
NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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Actg1
actin, gamma 1
increases expression
ISO
mancozeb results in increased expression of ACTG1 protein
CTD
PMID:21375462
NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954 Ensembl chr10:75,643,054...75,644,954
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein
CTD
PMID:19883720
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Alb
albumin
decreases expression
ISO
mancozeb results in decreased expression of ALB protein
CTD
PMID:21375462
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Aldh2
aldehyde dehydrogenase 2 family member
decreases activity
EXP
mancozeb results in decreased activity of ALDH2 protein
CTD
PMID:17010440
NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
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Aldh5a1
aldehyde dehydrogenase 5 family, member A1
decreases activity
EXP
mancozeb results in decreased activity of ALDH5A1 protein
CTD
PMID:17010440
NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
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Anxa2
annexin A2
decreases expression
ISO
mancozeb results in decreased expression of ANXA2 protein
CTD
PMID:21375462
NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
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Apaf1
apoptotic peptidase activating factor 1
increases expression
ISO
mancozeb results in increased expression of APAF1 protein
CTD
PMID:22289270
NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
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Ar
androgen receptor
multiple interactions decreases activity
ISO
mancozeb inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; mancozeb inhibits the reaction [Metribolone binds to and results in increased activity of AR protein] mancozeb results in decreased activity of AR protein
CTD
PMID:23871939
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO
mancozeb results in increased expression of BAX mRNA; mancozeb results in increased expression of BAX protein lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA]
CTD
PMID:22289270 PMID:27235710
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO EXP
mancozeb results in decreased expression of BCL2 mRNA; mancozeb results in decreased expression of BCL2 protein lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA] alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]
CTD
PMID:16005924 PMID:22289270 PMID:27235710
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Ca3
carbonic anhydrase 3
increases expression
ISO
mancozeb results in increased expression of CAR3 protein
CTD
PMID:21375462
NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
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Casp3
caspase 3
increases activity multiple interactions increases cleavage
ISO
mancozeb results in increased activity of CASP3 protein Acetylcysteine inhibits the reaction [mancozeb results in increased cleavage of CASP3 protein] mancozeb results in increased cleavage of and results in increased activity of CASP3 protein
CTD
PMID:22289270 PMID:22824503 PMID:30037311
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp7
caspase 7
increases activity
ISO
mancozeb results in increased activity of CASP7 protein
CTD
PMID:22824503
NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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Casp8
caspase 8
increases activity
ISO
mancozeb results in increased activity of CASP8 protein
CTD
PMID:22289270 PMID:22824503
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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Casp9
caspase 9
increases activity multiple interactions
ISO
mancozeb results in increased activity of CASP9 protein mancozeb results in increased cleavage of and results in increased activity of CASP9 protein
CTD
PMID:22289270 PMID:22824503
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Cat
catalase
multiple interactions decreases activity
ISO EXP
Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Quercetin inhibits the reaction [mancozeb results in decreased activity of CAT protein] Colforsin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
CTD
PMID:23024109 PMID:27235710 PMID:29283200 PMID:30037311
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Ccnd1
cyclin D1
multiple interactions increases expression
ISO
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein mancozeb results in increased expression of CCND1 protein
CTD
PMID:19883720 PMID:21375462
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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Cdc25c
cell division cycle 25C
increases phosphorylation
ISO
mancozeb results in increased phosphorylation of CDC25C protein
CTD
PMID:21375462
NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions increases expression
ISO
lupeol inhibits the reaction [mancozeb results in increased expression of CDKN1A mRNA]
CTD
PMID:27235710
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Cycs
cytochrome c, somatic
increases expression
ISO
mancozeb results in increased expression of CYCS protein
CTD
PMID:27016407
NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity decreases expression
EXP ISO
mancozeb results in decreased activity of CYP1A1 protein mancozeb results in decreased expression of CYP1A1 protein
CTD
PMID:1946188 PMID:31096615
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
decreases expression
ISO
mancozeb results in decreased expression of CYP2B6 protein
CTD
PMID:31096615
NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases expression
ISO
mancozeb results in decreased expression of CYP2E1 mRNA
CTD
PMID:31096615
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
decreases expression
ISO
mancozeb results in decreased expression of CYP3A4 mRNA; mancozeb results in decreased expression of CYP3A4 protein
CTD
PMID:31096615
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Ddit4
DNA-damage-inducible transcript 4
increases expression
EXP
mancozeb results in increased expression of DDIT4 protein
CTD
PMID:24764117
NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
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Elk1
ETS transcription factor ELK1
increases phosphorylation
ISO
mancozeb results in increased phosphorylation of ELK1 protein
CTD
PMID:21375462
NCBI chr X:1,287,875...1,304,822
Ensembl chr X:1,297,099...1,304,822
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F3
coagulation factor III, tissue factor
increases expression
ISO
mancozeb results in increased expression of F3 protein
CTD
PMID:25569083
NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
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Fas
Fas cell surface death receptor
increases expression
ISO
mancozeb results in increased expression of FAS protein
CTD
PMID:22289270
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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Faslg
Fas ligand
increases expression
ISO
mancozeb results in increased expression of FASLG protein
CTD
PMID:22289270
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
multiple interactions increases expression
ISO
lupeol inhibits the reaction [mancozeb results in increased expression of GADD45A mRNA]
CTD
PMID:27235710
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
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Got1
glutamic-oxaloacetic transaminase 1
affects activity
EXP
mancozeb affects the activity of GOT1 protein
CTD
PMID:10641187
NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
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Gpt
glutamic--pyruvic transaminase
affects activity
EXP
mancozeb affects the activity of GPT protein
CTD
PMID:10641187
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
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Gpx1
glutathione peroxidase 1
decreases expression multiple interactions
ISO
mancozeb results in decreased expression of GPX1 mRNA Acetylcysteine inhibits the reaction [mancozeb results in decreased expression of GPX1 mRNA]
CTD
PMID:30037311
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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Gsk3b
glycogen synthase kinase 3 beta
multiple interactions
ISO
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein
CTD
PMID:19883720
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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Hdac3
histone deacetylase 3
decreases activity
ISO
mancozeb results in decreased activity of HDAC3 protein
CTD
PMID:21251949
NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
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Hdac6
histone deacetylase 6
decreases activity
ISO
mancozeb results in decreased activity of HDAC6 protein
CTD
PMID:21251949
NCBI chr X:15,295,372...15,316,673
Ensembl chr X:15,295,473...15,316,671
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Hnrnpm
heterogeneous nuclear ribonucleoprotein M
increases expression
ISO
mancozeb results in increased expression of HNRNPM protein
CTD
PMID:21375462
NCBI chr 7:18,516,253...18,554,536
Ensembl chr 7:18,516,512...18,554,227
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Ifng
interferon gamma
multiple interactions
ISO
mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]
CTD
PMID:15742816
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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Il1b
interleukin 1 beta
multiple interactions
ISO
mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD
PMID:16112155
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il2
interleukin 2
affects expression
ISO
mancozeb affects the expression of IL2 protein
CTD
PMID:9012323
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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Kb15
type II keratin Kb15
decreases expression
ISO
mancozeb results in decreased expression of KRT6A protein
CTD
PMID:21375462
NCBI chr 7:143,208,034...143,217,771
Ensembl chr 7:143,208,527...143,217,535
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Kcnq2
potassium voltage-gated channel subfamily Q member 2
increases activity
EXP
mancozeb results in increased activity of KCNQ2 protein
CTD
PMID:23542819
NCBI chr 3:176,585,897...176,645,029
Ensembl chr 3:176,589,906...176,644,951
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Kiss1
KiSS-1 metastasis-suppressor
affects expression
EXP
mancozeb affects the expression of KISS1 mRNA
CTD
PMID:23660487
NCBI chr13:50,529,506...50,537,603
Ensembl chr13:50,529,510...50,535,389
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK1 protein]; mancozeb results in increased localization of and results in increased activity of MAPK1 protein
CTD
PMID:21375462
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK3 protein]; mancozeb results in increased localization of and results in increased activity of MAPK3 protein
CTD
PMID:21375462
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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Mdm2
MDM2 proto-oncogene
multiple interactions increases expression
ISO
lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA]
CTD
PMID:27235710
NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions increases expression decreases expression
ISO EXP
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein mancozeb results in increased expression of MYC protein mancozeb results in decreased expression of MYC protein alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein]
CTD
PMID:16005924 PMID:19883720
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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Nos2
nitric oxide synthase 2
increases expression multiple interactions
ISO
mancozeb results in increased expression of NOS2 mRNA Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOS2 mRNA]
CTD
PMID:30037311
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Nox4
NADPH oxidase 4
multiple interactions increases expression
ISO
Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOX4 mRNA]
CTD
PMID:30037311
NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
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Odc1
ornithine decarboxylase 1
increases activity
ISO
mancozeb results in increased activity of ODC1 protein
CTD
PMID:1733566
NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
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Ogg1
8-oxoguanine DNA glycosylase
multiple interactions decreases expression
ISO
lupeol inhibits the reaction [mancozeb results in decreased expression of OGG1 mRNA]
CTD
PMID:27235710
NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
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Prdx2
peroxiredoxin 2
increases expression
ISO
mancozeb results in increased expression of PRDX2 protein
CTD
PMID:21375462
NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
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Prl
prolactin
multiple interactions
ISO
[mancozeb co-treated with imidacloprid] results in increased expression of PRL protein
CTD
PMID:24530807
NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
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Ptges
prostaglandin E synthase
increases expression multiple interactions
ISO
mancozeb results in increased expression of PTGES mRNA lupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA]
CTD
PMID:27235710
NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
mancozeb results in increased expression of PTGS2 protein
CTD
PMID:21375462
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Ptk2b
protein tyrosine kinase 2 beta
multiple interactions
ISO
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form
CTD
PMID:19883720
NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
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Pvalb
parvalbumin
increases expression
ISO
mancozeb results in increased expression of PVALB protein
CTD
PMID:21375462
NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
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Rela
RELA proto-oncogene, NF-kB subunit
increases phosphorylation affects localization multiple interactions increases localization
ISO
mancozeb results in increased phosphorylation of RELA protein mancozeb affects the localization of RELA protein Acetylcysteine inhibits the reaction [mancozeb affects the localization of RELA protein]; lupeol inhibits the reaction [mancozeb affects the localization of RELA protein]; mancozeb inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein] mancozeb results in increased localization of RELA protein
CTD
PMID:16112155 PMID:21375462 PMID:22289270 PMID:27235710
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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S100a6
S100 calcium binding protein A6
increases expression
ISO
mancozeb results in increased expression of S100A6 protein
CTD
PMID:21375462
NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
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S100a9
S100 calcium binding protein A9
increases expression
ISO
mancozeb results in increased expression of S100A9 protein
CTD
PMID:21375462
NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
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Sirt1
sirtuin 1
decreases activity
ISO
mancozeb results in decreased activity of SIRT1 protein
CTD
PMID:21251949
NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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Sirt2
sirtuin 2
decreases activity
ISO
mancozeb results in decreased activity of SIRT2 protein
CTD
PMID:21251949
NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952
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Sirt3
sirtuin 3
decreases activity
ISO
mancozeb results in decreased activity of SIRT3 protein
CTD
PMID:21251949
NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
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Slc5a5
solute carrier family 5 member 5
multiple interactions
ISO
mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]
CTD
PMID:27979590
NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
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Sod1
superoxide dismutase 1
decreases expression
ISO
mancozeb results in decreased expression of SOD1 protein
CTD
PMID:21375462
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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Tek
TEK receptor tyrosine kinase
increases activity
ISO
mancozeb results in increased activity of TEK protein
CTD
PMID:21251949
NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799
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Tnf
tumor necrosis factor
multiple interactions
ISO
mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein] mancozeb inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; mancozeb inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
CTD
PMID:15742816 PMID:15893782 PMID:16112155
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tp53
tumor protein p53
decreases expression increases expression multiple interactions
ISO
mancozeb results in decreased expression of TRP53 mRNA; mancozeb results in decreased expression of TRP53 protein mancozeb results in increased expression of TP53 mRNA lupeol inhibits the reaction [mancozeb results in increased expression of TP53 mRNA]
CTD
PMID:22369882 PMID:27235710
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Tpi1
triosephosphate isomerase 1
increases expression
ISO
mancozeb results in increased expression of TPI1 protein
CTD
PMID:21375462
NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
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Tpo
thyroid peroxidase
decreases activity
EXP
mancozeb results in decreased activity of TPO protein
CTD
PMID:9418944
NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
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Tshb
thyroid stimulating hormone subunit beta
multiple interactions
ISO
[mancozeb co-treated with imidacloprid] results in increased expression of TSHB protein
CTD
PMID:24530807
NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
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Xrcc1
X-ray repair cross complementing 1
decreases expression multiple interactions
ISO
mancozeb results in decreased expression of XRCC1 mRNA lupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA]
CTD
PMID:27235710
NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
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