CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: zineb
Accession: CHEBI:52498
browse the term
Definition: A polymeric complex of zinc with the ethylene bis(dithiocarbamate) anionic ligand. Formerly used as an agricultural fungicide for the control of downy mildews and rusts, its use is no longer permitted in the US or the EU.
Synonyms: exact_synonym: [{2-[(sulfanylcarbothioyl)amino]ethyl}carbamodithioato(2-)-kappa(2)S,S']zinc
related_synonym: Formula=C4H6N2S4Zn; InChI=1S/C4H8N2S4.Zn/c7-3(8)5-1-2-6-4(9)10;/h1-2H2,(H2,5,7,8)(H2,6,9,10);/q;+2/p-2; InChIKey=AMHNZOICSMBGDH-UHFFFAOYSA-L; SMILES=[Zn++].[S-]C(=S)NCCNC([S-])=S; zinc ethane-1,2-diyldicarbamodithioate
xref: Beilstein:4165797; CAS:12122-67-7; KEGG:C15232
xref_mesh: MESH:D015038
xref: PMID:22155123; PMID:23871785; PMID:465777; PPDB:683; Patent:CN1648120; Patent:US2690448; Pesticides:zineb; Reaxys:4165797; Wikipedia:Zineb
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Ache
acetylcholinesterase
decreases expression
EXP
Zineb results in decreased expression of ACHE protein
CTD
PMID:3868355
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
ISO
Zineb inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]
CTD
PMID:29149346
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Casp3
caspase 3
increases activity
ISO
Zineb results in increased activity of CASP3 protein
CTD
PMID:17189834
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
decreases activity
ISO
Zineb results in decreased activity of HSD11B2 protein
CTD
PMID:22796344
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions increases activity
ISO
[Endosulfan co-treated with Zineb] results in increased activity of NFKB1 protein Zineb results in increased activity of NFKB1 protein
CTD
PMID:17189834
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
multiple interactions
ISO
Zineb inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Zineb inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
CTD
PMID:29149346
NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
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Tnf
tumor necrosis factor
multiple interactions
ISO
Zineb inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Zineb promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:15256756 PMID:16112155
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tpo
thyroid peroxidase
decreases activity
ISO
Zineb results in decreased activity of TPO protein
CTD
PMID:9248629
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
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Ache
acetylcholinesterase
affects activity multiple interactions
EXP
mancozeb affects the activity of ACHE protein [carbendazim co-treated with mancozeb] results in increased activity of ACHE protein
CTD
PMID:10641187 PMID:33217513
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Actg1
actin, gamma 1
increases expression
ISO
mancozeb results in increased expression of ACTG1 protein
CTD
PMID:21375462
NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein
CTD
PMID:19883720
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alb
albumin
decreases expression
ISO
mancozeb results in decreased expression of ALB protein
CTD
PMID:21375462
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldh2
aldehyde dehydrogenase 2 family member
decreases activity
EXP
mancozeb results in decreased activity of ALDH2 protein
CTD
PMID:17010440
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Aldh5a1
aldehyde dehydrogenase 5 family, member A1
decreases activity
EXP
mancozeb results in decreased activity of ALDH5A1 protein
CTD
PMID:17010440
NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677
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Angptl1
angiopoietin-like 1
decreases expression
ISO
mancozeb results in decreased expression of ANGPTL1 mRNA
CTD
PMID:33396126
NCBI chr13:68,963,198...68,969,742
Ensembl chr13:68,962,991...68,992,570
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Anxa2
annexin A2
decreases expression
ISO
mancozeb results in decreased expression of ANXA2 protein
CTD
PMID:21375462
NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
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Apaf1
apoptotic peptidase activating factor 1
increases expression
ISO
mancozeb results in increased expression of APAF1 protein
CTD
PMID:22289270
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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Ar
androgen receptor
multiple interactions decreases expression decreases activity
ISO
mancozeb inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; mancozeb inhibits the reaction [Metribolone binds to and results in increased activity of AR protein] mancozeb results in decreased expression of AR mRNA mancozeb results in decreased activity of AR protein
CTD
PMID:23871939 PMID:33396126
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atp1a2
ATPase Na+/K+ transporting subunit alpha 2
decreases expression
ISO
mancozeb results in decreased expression of ATP1A2 mRNA
CTD
PMID:33396126
NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO
mancozeb results in increased expression of BAX mRNA; mancozeb results in increased expression of BAX protein lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA]
CTD
PMID:22289270 PMID:27235710
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO EXP
mancozeb results in decreased expression of BCL2 mRNA; mancozeb results in decreased expression of BCL2 protein lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA] alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]
CTD
PMID:16005924 PMID:22289270 PMID:27235710
NCBI chr13:22,689,783...22,853,920
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Car3
carbonic anhydrase 3
increases expression
ISO
mancozeb results in increased expression of CAR3 protein
CTD
PMID:21375462
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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Casp3
caspase 3
increases activity multiple interactions increases cleavage
ISO
mancozeb results in increased activity of CASP3 protein Acetylcysteine inhibits the reaction [mancozeb results in increased cleavage of CASP3 protein] mancozeb results in increased cleavage of and results in increased activity of CASP3 protein
CTD
PMID:22289270 PMID:22824503 PMID:30037311
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
increases activity
ISO
mancozeb results in increased activity of CASP7 protein
CTD
PMID:22824503
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp8
caspase 8
increases activity
ISO
mancozeb results in increased activity of CASP8 protein
CTD
PMID:22289270 PMID:22824503
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity multiple interactions
ISO
mancozeb results in increased activity of CASP9 protein mancozeb results in increased cleavage of and results in increased activity of CASP9 protein
CTD
PMID:22289270 PMID:22824503
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions decreases activity
ISO EXP
Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Quercetin inhibits the reaction [mancozeb results in decreased activity of CAT protein] Colforsin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
CTD
PMID:23024109 PMID:27235710 PMID:29283200 PMID:30037311
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccdc106
coiled-coil domain containing 106
decreases expression
ISO
mancozeb results in decreased expression of CCDC106 mRNA
CTD
PMID:33396126
NCBI chr 1:68,779,882...68,791,140
Ensembl chr 1:68,779,882...68,786,846
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Ccnd1
cyclin D1
multiple interactions increases expression
ISO
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein mancozeb results in increased expression of CCND1 protein
CTD
PMID:19883720 PMID:21375462
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdc25c
cell division cycle 25C
increases phosphorylation
ISO
mancozeb results in increased phosphorylation of CDC25C protein
CTD
PMID:21375462
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions increases expression
ISO
lupeol inhibits the reaction [mancozeb results in increased expression of CDKN1A mRNA]
CTD
PMID:27235710
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cfap126
cilia and flagella associated protein 126
decreases expression
ISO
mancozeb results in decreased expression of CFAP126 mRNA
CTD
PMID:33396126
NCBI chr13:83,526,657...83,542,552
Ensembl chr13:83,526,657...83,542,552
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Cldn16
claudin 16
decreases expression
ISO
mancozeb results in decreased expression of CLDN16 mRNA
CTD
PMID:33396126
NCBI chr11:74,290,298...74,309,588
Ensembl chr11:74,290,298...74,309,588
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Ctf1
cardiotrophin 1
decreases expression
ISO
mancozeb results in decreased expression of CTF1 mRNA
CTD
PMID:33396126
NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
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Cycs
cytochrome c, somatic
increases expression
ISO
mancozeb results in increased expression of CYCS protein
CTD
PMID:27016407
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity decreases expression
EXP ISO
mancozeb results in decreased activity of CYP1A1 protein mancozeb results in decreased expression of CYP1A1 protein
CTD
PMID:1946188 PMID:31096615
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
decreases expression
ISO
mancozeb results in decreased expression of CYP2B6 protein
CTD
PMID:31096615
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases expression
ISO
mancozeb results in decreased expression of CYP2E1 mRNA
CTD
PMID:31096615
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases expression
ISO
mancozeb results in decreased expression of CYP3A4 mRNA; mancozeb results in decreased expression of CYP3A4 protein
CTD
PMID:31096615
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Ddit4
DNA-damage-inducible transcript 4
increases expression
EXP
mancozeb results in increased expression of DDIT4 protein
CTD
PMID:24764117
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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Efcab12
EF-hand calcium binding domain 12
decreases expression
ISO
mancozeb results in decreased expression of EFCAB12 mRNA
CTD
PMID:33396126
NCBI chr 4:148,869,381...148,892,922
Ensembl chr 4:148,869,387...148,890,560
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Elk1
ETS transcription factor ELK1
increases phosphorylation
ISO
mancozeb results in increased phosphorylation of ELK1 protein
CTD
PMID:21375462
NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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Esr1
estrogen receptor 1
decreases expression
ISO
mancozeb results in decreased expression of ESR1 mRNA
CTD
PMID:33396126
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
decreases expression
ISO
mancozeb results in decreased expression of ESR2 mRNA; mancozeb results in decreased expression of ESR2 protein
CTD
PMID:33396126
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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F3
coagulation factor III, tissue factor
increases expression
ISO
mancozeb results in increased expression of F3 protein
CTD
PMID:25569083
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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Fas
Fas cell surface death receptor
increases expression
ISO
mancozeb results in increased expression of FAS protein
CTD
PMID:22289270
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
increases expression
ISO
mancozeb results in increased expression of FASLG protein
CTD
PMID:22289270
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
multiple interactions increases expression
ISO
lupeol inhibits the reaction [mancozeb results in increased expression of GADD45A mRNA]
CTD
PMID:27235710
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Glyatl3
glycine-N-acyltransferase-like 3
decreases expression
ISO
mancozeb results in decreased expression of GLYATL3 mRNA
CTD
PMID:33396126
NCBI chr 9:19,984,239...19,994,762
Ensembl chr 9:19,977,302...19,995,650
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Got1
glutamic-oxaloacetic transaminase 1
affects activity
EXP
mancozeb affects the activity of GOT1 protein
CTD
PMID:10641187
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpt
glutamic--pyruvic transaminase
affects activity
EXP
mancozeb affects the activity of GPT protein
CTD
PMID:10641187
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx1
glutathione peroxidase 1
decreases expression multiple interactions
ISO
mancozeb results in decreased expression of GPX1 mRNA Acetylcysteine inhibits the reaction [mancozeb results in decreased expression of GPX1 mRNA]
CTD
PMID:30037311
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Gsk3b
glycogen synthase kinase 3 beta
multiple interactions
ISO
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein
CTD
PMID:19883720
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Hdac3
histone deacetylase 3
decreases activity
ISO
mancozeb results in decreased activity of HDAC3 protein
CTD
PMID:21251949
NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
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Hdac6
histone deacetylase 6
decreases activity
ISO
mancozeb results in decreased activity of HDAC6 protein
CTD
PMID:21251949
NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441
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Hnrnpm
heterogeneous nuclear ribonucleoprotein M
increases expression
ISO
mancozeb results in increased expression of HNRNPM protein
CTD
PMID:21375462
NCBI chr 7:14,438,703...14,476,781
Ensembl chr 7:14,438,688...14,476,762
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Ifitm2
interferon induced transmembrane protein 2
decreases expression
ISO
mancozeb results in decreased expression of IFITM2 mRNA
CTD
PMID:33396126
NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741
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Ifng
interferon gamma
multiple interactions
ISO
mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]
CTD
PMID:15742816
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il1b
interleukin 1 beta
multiple interactions
ISO
mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD
PMID:16112155
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
affects expression
ISO
mancozeb affects the expression of IL2 protein
CTD
PMID:9012323
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Itgb3
integrin subunit beta 3
decreases expression
ISO
mancozeb results in decreased expression of ITGB3 mRNA; mancozeb results in decreased expression of ITGB3 protein
CTD
PMID:33396126
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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Kb15
type II keratin Kb15
decreases expression
ISO
mancozeb results in decreased expression of KRT6A protein
CTD
PMID:21375462
NCBI chr 7:132,677,994...132,686,634
Ensembl chr 7:132,677,751...132,686,759
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Kcnq2
potassium voltage-gated channel subfamily Q member 2
increases activity
EXP
mancozeb results in increased activity of KCNQ2 protein
CTD
PMID:23542819
NCBI chr 3:168,194,776...168,253,831
Ensembl chr 3:168,195,357...168,275,071
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Kiss1
KiSS-1 metastasis-suppressor
affects expression
EXP
mancozeb affects the expression of KISS1 mRNA
CTD
PMID:23660487
NCBI chr13:44,774,823...44,780,707
Ensembl chr13:44,774,823...44,780,612
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LOC120094883
small nucleolar RNA SNORD82
increases expression
ISO
mancozeb results in increased expression of SNORD82 mRNA
CTD
PMID:33396126
NCBI chr 9:87,004,515...87,004,586
Ensembl chr 9:87,004,515...87,004,586
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Ltb4r2
leukotriene B4 receptor 2
increases expression
ISO
mancozeb results in increased expression of LTB4R2 mRNA
CTD
PMID:33396126
NCBI chr15:29,258,427...29,260,340
Ensembl chr15:29,259,240...29,260,316
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK1 protein]; mancozeb results in increased localization of and results in increased activity of MAPK1 protein
CTD
PMID:21375462
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK3 protein]; mancozeb results in increased localization of and results in increased activity of MAPK3 protein
CTD
PMID:21375462
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mdm2
MDM2 proto-oncogene
multiple interactions increases expression
ISO
lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA]
CTD
PMID:27235710
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Muc1
mucin 1, cell surface associated
decreases expression
ISO
mancozeb results in decreased expression of MUC1 mRNA; mancozeb results in decreased expression of MUC1 protein
CTD
PMID:33396126
NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions increases expression decreases expression
ISO EXP
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein mancozeb results in increased expression of MYC protein mancozeb results in decreased expression of MYC protein alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein]
CTD
PMID:16005924 PMID:19883720
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nhlrc1
NHL repeat containing E3 ubiquitin protein ligase 1
decreases expression
ISO
mancozeb results in decreased expression of NHLRC1 mRNA
CTD
PMID:33396126
NCBI chr17:17,674,375...17,675,565
Ensembl chr17:17,674,319...17,677,148
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Nos2
nitric oxide synthase 2
increases expression multiple interactions
ISO
mancozeb results in increased expression of NOS2 mRNA Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOS2 mRNA]
CTD
PMID:30037311
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nox4
NADPH oxidase 4
multiple interactions increases expression
ISO
Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOX4 mRNA]
CTD
PMID:30037311
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Odc1
ornithine decarboxylase 1
increases activity
ISO
mancozeb results in increased activity of ODC1 protein
CTD
PMID:1733566
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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Ogg1
8-oxoguanine DNA glycosylase
multiple interactions decreases expression
ISO
lupeol inhibits the reaction [mancozeb results in decreased expression of OGG1 mRNA]
CTD
PMID:27235710
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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Olr376
olfactory receptor 376
increases expression
ISO
mancozeb results in increased expression of OR1S1 mRNA
CTD
PMID:33396126
NCBI chr 1:210,913,992...210,914,939
Ensembl chr 1:210,911,289...210,915,657
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Pcdhb20
protocadherin beta 20
decreases expression
ISO
mancozeb results in decreased expression of PCDHB14 mRNA
CTD
PMID:33396126
NCBI chr18:29,211,883...29,215,258
Ensembl chr18:29,211,883...29,215,258
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Prdx2
peroxiredoxin 2
increases expression
ISO
mancozeb results in increased expression of PRDX2 protein
CTD
PMID:21375462
NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
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Prl
prolactin
multiple interactions increases expression
ISO
[mancozeb co-treated with imidacloprid] results in increased expression of PRL protein mancozeb results in increased expression of PRL mRNA
CTD
PMID:24530807 PMID:33396126
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Ptges
prostaglandin E synthase
increases expression decreases expression multiple interactions
ISO
mancozeb results in increased expression of PTGES mRNA mancozeb results in decreased expression of PTGES protein lupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA]
CTD
PMID:27235710 PMID:32446389
NCBI chr 3:14,177,892...14,189,236
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Ptges3
prostaglandin E synthase 3
decreases expression
ISO
mancozeb results in decreased expression of PTGES3 mRNA
CTD
PMID:32446389
NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
mancozeb results in increased expression of PTGS2 protein
CTD
PMID:21375462 PMID:32446389
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Ptk2b
protein tyrosine kinase 2 beta
multiple interactions
ISO
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form
CTD
PMID:19883720
NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
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Pvalb
parvalbumin
increases expression
ISO
mancozeb results in increased expression of PVALB protein
CTD
PMID:21375462
NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
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Rela
RELA proto-oncogene, NF-kB subunit
increases phosphorylation affects localization multiple interactions increases localization
ISO
mancozeb results in increased phosphorylation of RELA protein mancozeb affects the localization of RELA protein Acetylcysteine inhibits the reaction [mancozeb affects the localization of RELA protein]; lupeol inhibits the reaction [mancozeb affects the localization of RELA protein]; mancozeb inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein] mancozeb results in increased localization of RELA protein
CTD
PMID:16112155 PMID:21375462 PMID:22289270 PMID:27235710
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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RGD1560854
similar to FLJ41131 protein
decreases expression
ISO
mancozeb results in decreased expression of C19ORF54 mRNA
CTD
PMID:33396126
NCBI chr 1:82,490,313...82,499,841
Ensembl chr 1:82,490,363...82,499,841
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S100a6
S100 calcium binding protein A6
increases expression
ISO
mancozeb results in increased expression of S100A6 protein
CTD
PMID:21375462
NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
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S100a9
S100 calcium binding protein A9
increases expression
ISO
mancozeb results in increased expression of S100A9 protein
CTD
PMID:21375462
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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Scx
scleraxis bHLH transcription factor
decreases expression
ISO
mancozeb results in decreased expression of SCX mRNA
CTD
PMID:33396126
NCBI chr 7:108,176,608...108,178,626
Ensembl chr 7:108,176,608...108,178,626
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Septin11
septin 11
increases expression
ISO
mancozeb results in increased expression of SEPTIN11 mRNA
CTD
PMID:33396126
NCBI chr14:14,844,759...14,990,856
Ensembl chr14:14,844,580...14,990,853
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Serpinf1
serpin family F member 1
decreases expression
ISO
mancozeb results in decreased expression of SERPINF1 mRNA
CTD
PMID:33396126
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
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Sirt1
sirtuin 1
decreases activity
ISO
mancozeb results in decreased activity of SIRT1 protein
CTD
PMID:21251949
NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
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Sirt2
sirtuin 2
decreases activity
ISO
mancozeb results in decreased activity of SIRT2 protein
CTD
PMID:21251949
NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
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Sirt3
sirtuin 3
decreases activity
ISO
mancozeb results in decreased activity of SIRT3 protein
CTD
PMID:21251949
NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
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Slc14a1
solute carrier family 14 member 1 (Kidd blood group)
decreases expression
ISO
mancozeb results in decreased expression of SLC14A1 mRNA
CTD
PMID:33396126
NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146
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Slc5a5
solute carrier family 5 member 5
multiple interactions
ISO
mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]
CTD
PMID:27979590
NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
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Sod1
superoxide dismutase 1
decreases expression
ISO
mancozeb results in decreased expression of SOD1 protein
CTD
PMID:21375462
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sult2b1
sulfotransferase family 2B member 1
decreases expression
ISO
mancozeb results in decreased expression of SULT2B1 mRNA
CTD
PMID:33396126
NCBI chr 1:96,200,155...96,261,295
Ensembl chr 1:96,200,156...96,261,295
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Tek
TEK receptor tyrosine kinase
increases activity
ISO
mancozeb results in increased activity of TEK protein
CTD
PMID:21251949
NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
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Tgfb1i1
transforming growth factor beta 1 induced transcript 1
decreases expression
ISO
mancozeb results in decreased expression of TGFB1I1 mRNA
CTD
PMID:33396126
NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080
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Tnf
tumor necrosis factor
multiple interactions
ISO
mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein] mancozeb inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; mancozeb inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
CTD
PMID:15742816 PMID:15893782 PMID:16112155
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
decreases expression increases expression multiple interactions
ISO
mancozeb results in decreased expression of TRP53 mRNA; mancozeb results in decreased expression of TRP53 protein mancozeb results in increased expression of TP53 mRNA lupeol inhibits the reaction [mancozeb results in increased expression of TP53 mRNA]
CTD
PMID:22369882 PMID:27235710
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tpi1
triosephosphate isomerase 1
increases expression
ISO
mancozeb results in increased expression of TPI1 protein
CTD
PMID:21375462
NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
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Tpo
thyroid peroxidase
decreases activity
EXP
mancozeb results in decreased activity of TPO protein
CTD
PMID:9418944
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
G
Tshb
thyroid stimulating hormone subunit beta
multiple interactions
ISO
[mancozeb co-treated with imidacloprid] results in increased expression of TSHB protein
CTD
PMID:24530807
NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
G
Xrcc1
X-ray repair cross complementing 1
decreases expression multiple interactions
ISO
mancozeb results in decreased expression of XRCC1 mRNA lupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA]
CTD
PMID:27235710
NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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Zfp358
zinc finger protein 358
decreases expression
ISO
mancozeb results in decreased expression of ZNF358 mRNA
CTD
PMID:33396126
NCBI chr12:1,552,367...1,556,460
Ensembl chr12:1,552,366...1,556,460
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