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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:52450 term browser browse the term
Definition:A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has octadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.
Synonyms:exact_synonym: (2R)-2-acetoxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate;   (2RR)-2-acetoxy-3-(octadecyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
 related_synonym: (-)-1-O-octadeyl-2-O-acetyl-sn-glycerylphosphocholine;   (R)-7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptaconasan-1-aminium hydroxide inner salt 4-oxide;   1-0-octadecyl 2-0-acetyl sn-glycero-3-phosphorylcholine;   1-O-Octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine;   1-O-Octadecyl-platelet-activating factor;   1-O-Stearoyl-2-acetyl-sn-glyceryl-3-phosphorylcholine;   1-O-Stearyl-2-acetyl-sn-glyceryl-3-phosphorylcholine;   1-O-octadecyl 2-O-acetyl sn-glycero-3-phosphorylcholine;   1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine;   1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine;   1-O-octadecyl-PAF;   1-octadecyl-2-acetyl-sn-glycero-3-phosphocholine;   AGEPC;   Blood platelet activating factor-aether;   Blood platelet-activating factor;   C18-PAF-acether;   C18-Paf;   C18:0 PAF;   Formula=C28H58NO7P;   InChI=1S/C28H58NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3,4)5/h28H,6-26H2,1-5H3/t28-/m1/s1;   InChIKey=ZXCIEWBDUAPBJF-MUUNZHRXSA-N;   PAF;   PAF-acether;   PC(O-18:0/2:0);   Ro 14-8161;   SMILES=P(OC[C@@H](COCCCCCCCCCCCCCCCCCC)OC(C)=O)(=O)(OCC[N+](C)(C)C)[O-];   acetyl-glyceryl-ether-phosphorylcholine;   blood platelet activating factor-acether;   phosphatidylcholine (O-18:0/2:0);   platelet activating factor;   platelet activating factor-acether
 alt_id: CHEBI:26164;   CHEBI:52390;   CHEBI:75217
 xref: Beilstein:5364572;   CAS:74389-69-8;   DrugBank:DB02261;   LIPID_MAPS_instance:LMGP01020094;   Reaxys:5364572;   Wikipedia:Platelet-activating_factor

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2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor increases expression EXP platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasma RGD PMID:10452877 RGD:38508900 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            bronchoconstrictor agent 65
              2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  phosphorus oxoacid 9032
                                    phosphoric acids 7794
                                      phosphoric acid 7794
                                        phosphoric acid derivative 7473
                                          phosphate 7473
                                            organic phosphate 7472
                                              phospholipid 289
                                                glycerophospholipid 196
                                                  glycerophosphocholine 115
                                                    alkylacylglycero-3-phosphocholine 29
                                                      alkyl,acyl-sn-glycero-3-phosphocholine 29
                                                        2-acyl-1-alkyl-sn-glycero-3-phosphocholine 29
                                                          2-acetyl-1-alkyl-sn-glycero-3-phosphocholine 29
                                                            2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine 1
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