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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine
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Accession:CHEBI:52450 term browser browse the term
Definition:A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has octadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.
Synonyms:exact_synonym: (2R)-2-acetoxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate;   (2RR)-2-acetoxy-3-(octadecyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
 related_synonym: (-)-1-O-octadeyl-2-O-acetyl-sn-glycerylphosphocholine;   (R)-7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptaconasan-1-aminium hydroxide inner salt 4-oxide;   1-0-octadecyl 2-0-acetyl sn-glycero-3-phosphorylcholine;   1-O-Octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine;   1-O-Octadecyl-platelet-activating factor;   1-O-Stearoyl-2-acetyl-sn-glyceryl-3-phosphorylcholine;   1-O-Stearyl-2-acetyl-sn-glyceryl-3-phosphorylcholine;   1-O-octadecyl 2-O-acetyl sn-glycero-3-phosphorylcholine;   1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine;   1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine;   1-O-octadecyl-PAF;   1-octadecyl-2-acetyl-sn-glycero-3-phosphocholine;   AGEPC;   Blood platelet activating factor-aether;   Blood platelet-activating factor;   C18-PAF-acether;   C18-Paf;   C18:0 PAF;   Formula=C28H58NO7P;   InChI=1S/C28H58NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3,4)5/h28H,6-26H2,1-5H3/t28-/m1/s1;   InChIKey=ZXCIEWBDUAPBJF-MUUNZHRXSA-N;   PAF;   PAF-acether;   PC(O-18:0/2:0);   Ro 14-8161;   SMILES=P(OC[C@@H](COCCCCCCCCCCCCCCCCCC)OC(C)=O)(=O)(OCC[N+](C)(C)C)[O-];   acetyl-glyceryl-ether-phosphorylcholine;   blood platelet activating factor-acether;   phosphatidylcholine (O-18:0/2:0);   platelet activating factor;   platelet activating factor-acether
 alt_id: CHEBI:26164;   CHEBI:52390;   CHEBI:75217
 xref: Beilstein:5364572;   CAS:74389-69-8;   DrugBank:DB02261;   LIPID_MAPS_instance:LMGP01020094;   Reaxys:5364572;   Wikipedia:Platelet-activating_factor


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2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor increases expression EXP platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasma RGD PMID:10452877 RGD:38508900 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            bronchoconstrictor agent 65
              2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine 1
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      chalcogen 19469
                        oxygen atom 19445
                          oxygen molecular entity 19445
                            hydroxides 19180
                              oxoacid 18498
                                pnictogen oxoacid 10685
                                  phosphorus oxoacid 9666
                                    phosphoric acids 8466
                                      phosphoric acid 8466
                                        phosphoric acid derivative 8172
                                          phosphate 8172
                                            organic phosphate 8171
                                              phospholipid 302
                                                glycerophospholipid 203
                                                  glycerophosphocholine 118
                                                    alkylacylglycero-3-phosphocholine 33
                                                      alkyl,acyl-sn-glycero-3-phosphocholine 33
                                                        2-acyl-1-alkyl-sn-glycero-3-phosphocholine 33
                                                          2-acetyl-1-alkyl-sn-glycero-3-phosphocholine 33
                                                            2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine 1
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