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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-oxyketone
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Accession:CHEBI:52396 term browser browse the term
Definition:An oxyketone with the general formula R2C(=O) (R=/=H) where one or more of the R groups contains an oxy (-O-) group and the oxy and carbonyl groups are bonded to the same carbon atom.
Synonyms:related_synonym: alpha-oxyketones


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aldosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases abundance EXP AGT results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
blebbistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases localization EXP blebbistatin results in decreased localization of ABCB11 protein CTD PMID:15826951 NCBI chr36:13,742,895...13,835,312
Ensembl chr36:13,746,964...13,834,974 		JBrowse link
cortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone increases abundance EXP CRH protein results in increased abundance of Hydrocortisone CTD PMID:2831029 NCBI chr29:15,831,944...15,840,560
Ensembl chr29:15,831,944...15,834,384 		JBrowse link
G INS insulin affects abundance
multiple interactions		 EXP INS protein affects the abundance of Hydrocortisone
Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone]		 CTD PMID:1324617 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Hydrocortisone CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
doxorubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression
multiple interactions
affects response to substance		 EXP Doxorubicin results in increased expression of ABCB1 protein
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]		 CTD PMID:15492788 PMID:24975508 PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G HGF hepatocyte growth factor decreases response to substance EXP HGF protein results in decreased susceptibility to Doxorubicin CTD PMID:15688034 NCBI chr18:21,329,688...21,410,257
Ensembl chr18:21,332,817...21,410,263 		JBrowse link
G TNNT2 troponin T2, cardiac type affects expression EXP Doxorubicin affects the expression of TNNT2 protein CTD PMID:12322705 NCBI chr 7:1,598,306...1,620,531
Ensembl chr 7:1,598,306...1,613,741 		JBrowse link
G VIP vasoactive intestinal peptide decreases expression EXP Doxorubicin results in decreased expression of VIP protein CTD PMID:3711722 NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700 		JBrowse link
G XIAP X-linked inhibitor of apoptosis affects response to substance EXP XIAP affects the susceptibility to Doxorubicin CTD PMID:16953886 NCBI chr  X:95,300,234...95,356,103
Ensembl chr  X:95,331,827...95,351,582 		JBrowse link
phorbol 13-acetate 12-myristate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein CTD PMID:12639917 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein CTD PMID:12639917 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein CTD PMID:12639917 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G SLC6A9 solute carrier family 6 member 9 multiple interactions
affects localization		 EXP Tetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein]
Tetradecanoylphorbol Acetate affects the localization of SLC6A9 protein		 CTD PMID:19473961 NCBI chr15:16,235,342...16,267,161
Ensembl chr15:16,235,482...16,267,933 		JBrowse link
G SOD1 superoxide dismutase 1 affects response to substance EXP SOD1 protein affects the susceptibility to Tetradecanoylphorbol Acetate CTD PMID:6333936 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 503
    chemical entity 503
      group 497
        inorganic group 442
          oxo group 404
            organic oxo compound 404
              carbonyl compound 404
                ketone 48
                  oxyketone 14
                    alpha-oxyketone 14
                      2-methoxyacetophenone 0
                      alpha-hydroxy ketone + 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 503
    subatomic particle 503
      composite particle 503
        hadron 503
          baryon 503
            nucleon 503
              atomic nucleus 503
                atom 503
                  main group element atom 496
                    p-block element atom 496
                      carbon group element atom 485
                        carbon atom 484
                          organic molecular entity 484
                            heteroorganic entity 478
                              organochalcogen compound 430
                                organooxygen compound 428
                                  carbonyl compound 404
                                    ketone 48
                                      oxyketone 14
                                        alpha-oxyketone 14
                                          2-methoxyacetophenone 0
                                          alpha-hydroxy ketone + 14
paths to the root